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11. 发明授权

US07335153B2 Arrays of microparticles and methods of preparation thereof 有权
标题翻译：微粒阵列及其制备方法
公开(公告)号：US07335153B2
公开(公告)日：2008-02-26
申请号：US10192352
申请日：2002-07-09
申请人： Michael Seul , Chiu Wo Chau , Hui Huang , Sukanta Banerjee , Jiacheng Yang , Ye Hong
发明人： Michael Seul , Chiu Wo Chau , Hui Huang , Sukanta Banerjee , Jiacheng Yang , Ye Hong
IPC分类号： C40B20/02
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00545 , B01J2219/00648 , B01J2219/00662 , G01N33/54306 , C12Q2563/149
摘要： This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities specific to a given target analyte. The high unit density arrays of this invention are formed on chips which may be combined to form multichip arrays according to the methods described herein. The chips and/or multichip arrays of this invention are useful for chemical and biological assays.
摘要翻译：本发明提供高单位密度的微粒阵列和组装这种阵列的方法。阵列中的微粒可以用给定靶分析物特异性的化学或生物实体来官能化。本发明的高单位密度阵列形成在芯片上，芯片可以根据本文所述的方法组合以形成多芯片阵列。本发明的芯片和/或多芯片阵列可用于化学和生物测定。

12. 发明授权

US07156315B2 Encoded random arrays and matrices 有权
公开(公告)号：US07156315B2
公开(公告)日：2007-01-02
申请号：US10365993
申请日：2003-02-13
申请人： Michael Seul , Chiu Wo Chau
发明人： Michael Seul , Chiu Wo Chau
IPC分类号： G06K19/06
CPC分类号： H05H3/04 , B01J19/0046 , B01J2219/00466 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00572 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00713 , B01J2219/00722 , B01J2219/00725 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502792 , B01L2200/0652 , B01L2200/0663 , B01L2200/0668 , B01L2300/0819 , B01L2300/089 , B01L2400/0415 , B01L2400/0454 , B01L2400/086 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B60/10 , G01N15/0266 , G01N30/0005 , G01N33/54313 , G01N2015/0288 , G01N2015/149 , G01N2030/0035 , G02B3/0012 , G02B3/0056 , Y10T436/25125 , C12Q2565/501 , C12Q2563/155 , C12Q2565/607
摘要： A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. The invention is also for a system and method for programmable illumination pattern generation, including a novel method and apparatus to generate patterns of illumination and project them onto planar surfaces or onto planar interfaces such as the interface formed by an electrolyte-insulator-semiconductor (EIS), e.g., as described herein. This enables the creation of patterns or sequences of patterns using graphical design or drawing software on a personal computer and the projection of said patterns, or sequences of patterns (“time-varying patterns”), onto the interface using a liquid crystal display (LCD) panel and an optical design which images the LCD panel onto the surface of interest. The use of the LCD technology provides flexibility and control over spatial layout, temporal sequences and intensities (“gray scales”) of illumination patterns. The latter capability permits the creation of patterns with abruptly changing light intensities or patterns with gradually changing intensity profiles.

13. 发明申请

US20120157346A1 Programmable illumination pattern for transporting microparticles 有权
标题翻译：用于运输微粒的可编程照明图案
公开(公告)号：US20120157346A1
公开(公告)日：2012-06-21
申请号：US13332715
申请日：2011-12-21
申请人： Michael Seul , Chiu Wo Chau
发明人： Michael Seul , Chiu Wo Chau
IPC分类号： C40B40/00
CPC分类号： B01L3/502792 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L2200/0668 , B01L2300/0819 , B01L2300/089 , B01L2400/0454 , C12Q1/6837 , G01N15/0266 , G01N30/0005 , G01N33/54313 , G01N2015/0288 , G01N2015/149 , C12Q2565/607 , C12Q2563/155
摘要： The present application provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.
摘要翻译：本申请提供了一组基本操作，使得能够对几种类型的颗粒和生物分子的平面阵列的创建和放置以及阵列形状和尺寸的操纵进行交互式控制。本发明使得能够以阵列格式进行诊断测定和生化分析的样品制备和处理以及这些操作的功能整合。此外，本发明提供了用于产生具有所需性质的材料表面和用于制造表面安装光学部件的步骤。

14. 发明申请

US20080173544A1 Programmable Illumination Pattern for Transporting Microparticles 有权
标题翻译：用于运输微粒的可编程照明模式
公开(公告)号：US20080173544A1
公开(公告)日：2008-07-24
申请号：US12029189
申请日：2008-02-11
申请人： Michael Seul , Chiu Wo Chau
发明人： Michael Seul , Chiu Wo Chau
IPC分类号： C25D13/00
CPC分类号： B01L3/502792 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L2200/0668 , B01L2300/0819 , B01L2300/089 , B01L2400/0454 , C12Q1/6837 , G01N15/0266 , G01N30/0005 , G01N33/54313 , G01N2015/0288 , G01N2015/149 , C12Q2565/607 , C12Q2563/155
摘要： An apparatus providing programmable illumination pattern generation for the manipulation of colloidal particulates and biomolecules in suspension between electrodes, is disclosed. The apparatus implements LEAPS (Light-controlled electrokinetic assembly of particles near surfaces), which relies on: AC electric field-induced assembly of particles: the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The apparatus generates patterns of illumination and projects them onto planar surfaces. i.e., a LEAPS electrode. This enables the creation of patterns using graphical design or drawing software on a personal computer and the projection of said patterns, or sequences of patterns (“time-varying patterns”), onto the interface using a liquid crystal display (LCD) panel and an optical design which images the LCD panel onto the surface of interest, to provide for arrangements and assembly of particles in such patterns.
摘要翻译：公开了一种提供用于在电极之间悬浮的胶体颗粒和生物分子的操作的可编程照明图案生成的装置。该装置实现LEAPS（表面附近的颗粒的光控电动组装），其依赖于：AC电场引起的颗粒组装：电解质/氧化硅/硅界面的图案化以对组装过程施加空间控制; 并通过外部照明实现对装配过程的实时控制。该设备产生照明模式并将其投影到平面上。即LEAPS电极。这使得能够使用个人计算机上的图形设计或绘图软件来创建图案，并且使用液晶显示器（LCD）面板将所述图案或图案序列（“时变图案”）投影到界面上将LCD面板成像到感兴趣的表面上的光学设计，以提供这种图案中的颗粒的布置和装配。

15. 发明授权

US07390676B2 System and method for programmable illumination pattern generation 有权
公开(公告)号：US07390676B2
公开(公告)日：2008-06-24
申请号：US10624020
申请日：2003-07-21
申请人： Michael Seul , Chiu Wo Chau
发明人： Michael Seul , Chiu Wo Chau
IPC分类号： G01N33/543 , G01N33/553
CPC分类号： H05H3/04 , B01J19/0046 , B01J2219/00466 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00572 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00713 , B01J2219/00722 , B01J2219/00725 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502792 , B01L2200/0652 , B01L2200/0663 , B01L2200/0668 , B01L2300/0819 , B01L2300/089 , B01L2400/0415 , B01L2400/0454 , B01L2400/086 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B60/10 , G01N15/0266 , G01N30/0005 , G01N33/54313 , G01N2015/0288 , G01N2015/149 , G01N2030/0035 , G02B3/0012 , G02B3/0056 , Y10T436/25125 , C12Q2565/501 , C12Q2563/155 , C12Q2565/607
摘要： A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. The invention is also for a system and method for programmable illumination pattern generation, including a novel method and apparatus to generate patterns of illumination and project them onto planar surfaces or onto planar interfaces such as the interface formed by an electrolyte-insulator-semiconductor (EIS), e.g., as described herein. This enables the creation of patterns or sequences of patterns using graphical design or drawing software on a personal computer and the projection of said patterns, or sequences of patterns (“time-varying patterns”), onto the interface using a liquid crystal display (LCD) panel and an optical design which images the LCD panel onto the surface of interest. The use of the LCD technology provides flexibility and control over spatial layout, temporal sequences and intensities (“gray scales”) of illumination patterns. The latter capability permits the creation of patterns with abruptly changing light intensities or patterns with gradually changing intensity profiles.

16. 发明授权

US07358097B2 Making a matrix of random encoded arrays 有权
标题翻译：制作一个随机编码数组的矩阵
公开(公告)号：US07358097B2
公开(公告)日：2008-04-15
申请号：US10656535
申请日：2003-09-05
申请人： Michael Seul , Chiu Wo Chau
发明人： Michael Seul , Chiu Wo Chau
IPC分类号： G01N33/543
CPC分类号： H05H3/04 , B01J19/0046 , B01J2219/00466 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00572 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00713 , B01J2219/00722 , B01J2219/00725 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502792 , B01L2200/0652 , B01L2200/0663 , B01L2200/0668 , B01L2300/0819 , B01L2300/089 , B01L2400/0415 , B01L2400/0454 , B01L2400/086 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B60/10 , G01N15/0266 , G01N30/0005 , G01N33/54313 , G01N2015/0288 , G01N2015/149 , G01N2030/0035 , G02B3/0012 , G02B3/0056 , Y10T436/25125 , C12Q2565/501 , C12Q2563/155 , C12Q2565/607
摘要： Disclosed is an apparatus and method of maintaining chips or arrays of particles, or arrays of particles deposited on chip surfaces, in a designated area on a substrate surface. This is accomplished by having hydrophilic chips or arrays of particles, and a substrate which has a series of hydrophilic regions designed to accommodate the chips/arrays of particles, surrounded by hydrophobic regions. In the presence of aqueous solution, the chips or arrays of particles are held in the designated regions.
摘要翻译：公开了一种在衬底表面上的指定区域中保持颗粒或芯片阵列的芯片或芯片阵列的装置和方法。这通过具有亲水性芯片或颗粒阵列以及具有被设计成容纳由疏水区域包围的颗粒/颗粒阵列而设计的一系列亲水区域的基底来实现。在水溶液的存在下，颗粒或颗粒阵列保持在指定的区域中。

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