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11. 发明申请

US20050192293A1 Amide compounds as ion channel ligands and uses thereof 失效
公开(公告)号：US20050192293A1
公开(公告)日：2005-09-01
申请号：US10962195
申请日：2004-10-07
申请人： Michael Kelly , Satyanarayana Janagani , Guoxian Wu , John Kincaid
发明人： Michael Kelly , Satyanarayana Janagani , Guoxian Wu , John Kincaid
IPC分类号： A61K31/4439 , A61K31/444 , A61K31/506 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/75 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D417/12 , C07D417/14 , C07D41/04 , C07D43/04
CPC分类号： C07D405/12 , C04B35/632 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/75 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

12. 发明申请

US20130069463A1 ELECTRIC MOTOR 有权
标题翻译：电动马达
公开(公告)号：US20130069463A1
公开(公告)日：2013-03-21
申请号：US13239130
申请日：2011-09-21
申请人： Weirong Zhang , Christof Frick , Zhendong Mi , Guoxian Wu
发明人： Weirong Zhang , Christof Frick , Zhendong Mi , Guoxian Wu
IPC分类号： H02K13/00 , H02K7/08
CPC分类号： H02K13/006 , H02K2205/06
摘要： An electric motor for moving a vehicle part, the electric motor having a stator with a stator housing, a drive shaft rotatable with respect to the stator, a rotor on the drive shaft and having a rotor winding, a commutator on the drive shaft for supplying an electric current to the rotor winding, at least two brushes mounted on the stator housing, the brushes in sliding contact with the commutator for supplying electric current to the rotor winding, a bushing mounted on the drive shaft adjacent to the commutator, and a cone element mounted on the drive shaft adjacent to the bushing on a side of the bushing facing away from the commutator, the cone element having an outer surface which conforms to the shape of a cone concentrical to the drive shaft and having a tip pointing away from the bushing.
摘要翻译：一种用于移动车辆部件的电动机，具有定子的电动机具有定子壳体，相对于定子可旋转的驱动轴，驱动轴上的转子，具有转子绕组，在驱动轴上的换向器，用于供给到转子绕组的电流，安装在定子壳体上的至少两个电刷，电刷与换向器滑动接触，用于向转子绕组提供电流，安装在驱动轴上的与换向器相邻的衬套，以及锥体所述元件安装在所述驱动轴上，所述驱动轴在所述衬套的相对于所述换向器的一侧的所述驱动轴上相邻，所述锥形元件具有与所述驱动轴同心的锥体形状的外表面，并且具有远离所述换向器的尖端衬套。

13. 发明申请

US20090175888A1 METHODS OF TREATING CANCER WITH AN ANTIBODY-DRUG CONJUGATE 有权
标题翻译：用抗体药物治疗癌症的方法
公开(公告)号：US20090175888A1
公开(公告)日：2009-07-09
申请号：US12396266
申请日：2009-03-02
申请人： Howard P. Ng , Zhihong Li , Danny P.C. McGee , Oliver L. Saunders , Guoxian Wu , David J. King , Valeri Martichonok , Sharon Boyd , Thomas J. Lobl
发明人： Howard P. Ng , Zhihong Li , Danny P.C. McGee , Oliver L. Saunders , Guoxian Wu , David J. King , Valeri Martichonok , Sharon Boyd , Thomas J. Lobl
IPC分类号： A61K39/395 , C07D487/04 , A61P35/00
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
摘要翻译：本发明提供了作为有效的细胞毒素的杜卡霉素的类似物。还提供了在体内被切割的肽基和二硫键接头。连接体可用于形成本发明的细胞毒素的前药和缀合物以及其它诊断和治疗部分。本发明提供了杜卡霉素类似物与本发明的连接臂的前药和缀合物。

14. 发明授权

US07087600B2 Peptidyl prodrugs and linkers and stabilizers useful therefor 有权
公开(公告)号：US07087600B2
公开(公告)日：2006-08-08
申请号：US10161234
申请日：2002-05-31
申请人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhihong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
发明人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhihong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
IPC分类号： A61K31/535 , A61K31/407 , C07D487/02
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.

15. 发明授权

US06989452B2 Disulfide prodrugs and linkers and stabilizers useful therefor 有权
公开(公告)号：US06989452B2
公开(公告)日：2006-01-24
申请号：US10161233
申请日：2002-05-31
申请人： Howard P. Ng , Zhihong Li , Danny P. C. McGee , Oliver L. Saunders , Guoxian Wu , David J. King , Valeri Martichonok , Sharon Boyd , Thomas J. Lobl
发明人： Howard P. Ng , Zhihong Li , Danny P. C. McGee , Oliver L. Saunders , Guoxian Wu , David J. King , Valeri Martichonok , Sharon Boyd , Thomas J. Lobl
IPC分类号： C07D487/00 , C07D487/02
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.

16. 发明申请

US20140038948A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
公开(公告)号：US20140038948A1
公开(公告)日：2014-02-06
申请号：US13926959
申请日：2013-06-25
申请人： Guoxian Wu , Jiazhong Zhang , Yong-Liang Zhu , Chao Zhang , Prabha N. Ibrahim , Songyuan Shi , Wayne Spevak , Dean R. Artis , James Tsai
发明人： Guoxian Wu , Jiazhong Zhang , Yong-Liang Zhu , Chao Zhang , Prabha N. Ibrahim , Songyuan Shi , Wayne Spevak , Dean R. Artis , James Tsai
IPC分类号： C07D285/16 , A61K31/5377 , A61K31/505 , A61K31/437 , A61K31/47 , C07D213/76 , A61K31/44 , C07D239/49 , C07D471/04 , C07D215/38 , C07D417/12 , A61K31/549 , A61K31/4439
CPC分类号： A61K31/44 , A61K31/415 , A61K31/42 , A61K31/433 , A61K31/437 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/82 , C07D215/12 , C07D215/14 , C07D215/20 , C07D215/38 , C07D231/40 , C07D239/48 , C07D239/49 , C07D261/14 , C07D263/48 , C07D285/135 , C07D285/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , A61K31/4427 , A61K2300/00
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

17. 发明授权

US08461169B2 Compounds modulating c-fms and/or c-kit activity 有权
标题翻译：调节c-fms和/或c-kit活性的化合物
公开(公告)号：US08461169B2
公开(公告)日：2013-06-11
申请号：US12958379
申请日：2010-12-01
申请人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
发明人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
IPC分类号： A61K31/505 , A61K31/44
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
摘要翻译：本文提供了对受体蛋白酪氨酸激酶c-kit和/或c-fms活性的化合物。本文还提供了可用于治疗c-kit介导的疾病或病症和/或c-fms介导的疾病或病症的组合物及其使用方法。

18. 发明申请

US20110230482A1 COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY 有权
标题翻译：化合物调节C-FMS和/或C-kit活性
公开(公告)号：US20110230482A1
公开(公告)日：2011-09-22
申请号：US12958379
申请日：2010-12-01
申请人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
发明人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
IPC分类号： A61K31/437 , A61K31/497 , A61K31/5377 , A61K31/506 , A61P35/00 , A61P35/02 , A61P35/04 , A61P19/02 , A61P11/06 , A61P3/10 , A61P3/04 , A61P19/08 , A61P19/10
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
摘要翻译：本文提供了对受体蛋白酪氨酸激酶c-kit和/或c-fms活性的化合物。本文还提供了可用于治疗c-kit介导的疾病或病症和/或c-fms介导的疾病或病症的组合物及其使用方法。

19. 发明授权

US07977465B2 Peptidyl prodrugs and linkers and stabilizers useful therefor 有权
标题翻译：肽基前体药物和可用于其的接头和稳定剂
公开(公告)号：US07977465B2
公开(公告)日：2011-07-12
申请号：US12397834
申请日：2009-03-04
申请人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhi-Hong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
发明人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhi-Hong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
IPC分类号： C07K16/00 , C12P21/08 , C07D487/02
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
摘要翻译：本发明提供了作为有效的细胞毒素的杜卡霉素的类似物。还提供了在体内被切割的肽基和二硫键接头。连接体可用于形成本发明的细胞毒素的前药和缀合物以及其它诊断和治疗部分。本发明提供了杜卡霉素类似物与本发明的连接臂的前药和缀合物。

20. 发明授权

US07846941B2 Compounds modulating c-kit and c-fms activity and uses therefor 有权
标题翻译：调节c-kit和c-fms活性的化合物及其用途
公开(公告)号：US07846941B2
公开(公告)日：2010-12-07
申请号：US11435381
申请日：2006-05-16
申请人： Chao Zhang , Jiazhong Zhang , Prabha N. Ibrahim , Clarence R. Hurt , Rebecca Zuckerman , Dean R. Artis , Ryan Bremer , Wayne Spevak , Guoxian Wu , Hongyao Zhu
发明人： Chao Zhang , Jiazhong Zhang , Prabha N. Ibrahim , Clarence R. Hurt , Rebecca Zuckerman , Dean R. Artis , Ryan Bremer , Wayne Spevak , Guoxian Wu , Hongyao Zhu
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or condition and c-fms-mediated diseases or condition, and methods for the use thereof.
摘要翻译：本文提供了对受体蛋白酪氨酸激酶c-kit和c-fms有活性的化合物。本文还提供了可用于治疗c-kit介导的疾病或病症和c-fms介导的疾病或病症的组合物及其使用方法。

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