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11. 发明申请

US20130243862A1 PHOTOCHEMICAL ACTIVATION OF SURFACES FOR ATTACHING BIOMATERIAL 审中-公开
标题翻译：用于连接生物材料的表面的光化学活化
公开(公告)号：US20130243862A1
公开(公告)日：2013-09-19
申请号：US13606672
申请日：2012-09-07
申请人： Ivan Alferiev , Ilia Fishbein , Michael Chorny , Robert J. Levy , Benjamin Yellen , Darryl Williams
发明人： Ivan Alferiev , Ilia Fishbein , Michael Chorny , Robert J. Levy , Benjamin Yellen , Darryl Williams
IPC分类号： A61L27/16 , C08F120/06 , A61L27/54 , C08F126/02
CPC分类号： A61L27/16 , A61K31/765 , A61K31/785 , A61L27/50 , A61L27/54 , A61L2400/18 , B01J2219/00637 , B01J2219/00648 , C07K17/02 , C07K17/06 , C08F8/10 , C08F8/32 , C08F8/34 , C08F120/06 , C08F126/02 , C08F226/02 , C08F271/02 , C08F290/00 , C08F291/00 , C08G63/91 , C08J7/18 , C08L75/04
摘要： A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.
摘要翻译：一种水溶性可光活化聚合物，其包括：适于被辐照源活化并在所述水溶性可光活化聚合物与具有至少一个碳的基质之间形成共价键的可光致活化基团; 适于与生物材料共价反应的反应性基团，用于随后将生物材料递送至细胞; 亲水基团; 和聚合物前体。一种组合物，其包含水溶性可光活化聚合物的单分子层和具有至少一个碳的基质，其中单分子层通过可光致活化基团和至少一个碳之间的共价键共价连接到基质上。组合物还包括具有多个活性基团的生物材料，其中生物材料通过活性基团和反应性基团之间的共价键共价连接到单分子层上。还提供了将生物材料递送到细胞的方法。

12. 发明授权

US08263127B2 Photochemical activation of surfaces for attaching biomaterial 有权
标题翻译：用于附着生物材料的表面的光化学活化
公开(公告)号：US08263127B2
公开(公告)日：2012-09-11
申请号：US12633593
申请日：2009-12-08
申请人： Ivan Alferiev , Ilia Fishbein , Michael Chorny , Robert J. Levy , Benjamin Yellen , Darryl Williams
发明人： Ivan Alferiev , Ilia Fishbein , Michael Chorny , Robert J. Levy , Benjamin Yellen , Darryl Williams
IPC分类号： A61K9/14 , A61K47/48
CPC分类号： C08G63/91 , A61K31/765 , A61K31/785 , A61L27/50 , A61L2400/18 , C07K17/02 , C08F8/10 , C08F8/32 , C08F8/34 , C08F226/02 , C08F271/02 , C08F290/00 , C08F291/00 , C08J7/18 , C08L75/04 , C08F120/06 , C08F126/02
摘要： A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.
摘要翻译：一种水溶性可光活化聚合物，其包括：适于被辐照源活化并在所述水溶性可光活化聚合物与具有至少一个碳的基质之间形成共价键的可光致活化基团; 适于与生物材料共价反应的反应性基团，用于随后将生物材料递送至细胞; 亲水基团; 和聚合物前体。一种组合物，其包含水溶性可光活化聚合物的单分子层和具有至少一个碳的基质，其中单分子层通过可光致活化基团和至少一个碳之间的共价键共价连接到基质上。组合物还包括具有多个活性基团的生物材料，其中生物材料通过活性基团和反应性基团之间的共价键共价连接到单分子层上。还提供了将生物材料递送到细胞的方法。

13. 发明申请

US20100210015A1 PHOTOCHEMICAL ACTIVATION OF SURFACES FOR ATTACHING BIOMATERIAL 有权
标题翻译：用于连接生物材料的表面的光化学活化
公开(公告)号：US20100210015A1
公开(公告)日：2010-08-19
申请号：US12633593
申请日：2009-12-08
申请人： Ivan Alferiev , Ilia Fishbein , Michael Chorny , Robert J. Levy , Benjamin Yellen , Darryl Williams
发明人： Ivan Alferiev , Ilia Fishbein , Michael Chorny , Robert J. Levy , Benjamin Yellen , Darryl Williams
IPC分类号： C12N5/07 , C08F16/36 , C12N15/63 , C08L61/00
CPC分类号： C08G63/91 , A61K31/765 , A61K31/785 , A61L27/50 , A61L2400/18 , C07K17/02 , C08F8/10 , C08F8/32 , C08F8/34 , C08F226/02 , C08F271/02 , C08F290/00 , C08F291/00 , C08J7/18 , C08L75/04 , C08F120/06 , C08F126/02
摘要： A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.
摘要翻译：一种水溶性可光活化聚合物，其包括：适于被辐照源活化并在所述水溶性可光活化聚合物与具有至少一个碳的基质之间形成共价键的可光致活化基团; 适于与生物材料共价反应的反应性基团，用于随后将生物材料递送至细胞; 亲水基团; 和聚合物前体。一种组合物，其包含水溶性可光活化聚合物的单分子层和具有至少一个碳的基质，其中单分子层通过可光致活化基团和至少一个碳之间的共价键共价连接到基质上。组合物还包括具有多个活性基团的生物材料，其中生物材料通过活性基团和反应性基团之间的共价键共价连接到单分子层上。还提供了将生物材料递送到细胞的方法。

14. 发明申请

US20070293927A1 Gene and Cell Delivery Self Expanding Polymer Stents 审中-公开
标题翻译：基因和细胞递送自扩张聚合物支架
公开(公告)号：US20070293927A1
公开(公告)日：2007-12-20
申请号：US10589711
申请日：2004-04-16
申请人： Ko Frank , Robert Levy , Ivan Alferiev , Ilia Fishbein
发明人： Ko Frank , Robert Levy , Ivan Alferiev , Ilia Fishbein
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2250/0067 , A61L31/16 , A61L2300/80
摘要： A device having polymeric filaments, wherein at least one of the filaments includes at least one groove for slidably retaining at least one other filament, such that the device is adapted to revert to a tubular lattice structure when allowed to expand from a collapsed state. A device as described above and further including a biologically active function, wherein the polymeric filaments of the device include an agent having a reactive group or a fiber adapted to covalently react with a biomaterial. Thus, the device of the invention has an active structural function such as the ability to regain a shape and, optionally, a biologically active function such as the ability to deliver a biomaterial to an organism or a cell. A process of manufacturing the device is also described.
摘要翻译：一种具有聚合物长丝的装置，其中至少一根长丝包括至少一个用于可滑动地保持至少一个其它细丝的凹槽，使得该装置适于在允许从折叠状态膨胀时回复到管状格子结构。如上所述的装置并且还包括生物活性功能，其中所述装置的聚合长丝包括具有反应性基团的试剂或适于与生物材料共价反应的纤维。因此，本发明的装置具有活性结构功能，例如恢复形状和任选的生物活性功能的能力，例如将生物材料递送到生物体或细胞的能力。还描述了制造该装置的过程。

15. 发明申请

US20070298066A1 Biodegradable linkers for molecular therapies 有权
标题翻译：用于分子疗法的生物可降解接头
公开(公告)号：US20070298066A1
公开(公告)日：2007-12-27
申请号：US11799861
申请日：2007-05-03
申请人： Ivan Alferiev , Robert Levy , Ilia Fishbein
发明人： Ivan Alferiev , Robert Levy , Ilia Fishbein
IPC分类号： A61K47/48 , A61K35/00 , A61K48/00 , A61K9/10 , A61K38/00
CPC分类号： A61K47/6957 , A61K47/6901 , C12N2799/022
摘要： A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently bound to the biomaterial; and (c) a substrate, wherein the substrate is covalently bound to the biodegradable cross-linker portion, provided that the biodegradable cross-linker is adapted to hydrolyze by breaking the hydrolyzable bond and thereby release and deliver the biomaterial. A process of making the composition is also provided.
摘要翻译：用于将生物材料递送到动物细胞或组织的方法和组合物，所述组合物包括（a）生物材料; （b）具有可水解键的可生物降解的交联剂部分，其中所述可生物降解的交联剂部分与所述生物材料共价结合; 并且（c）底物，其中所述底物共价结合到所述可生物降解的交联剂部分，条件是所述可生物降解的交联剂适于通过破坏所述可水解键从而水解，从而释放和递送所述生物材料。还提供了制备组合物的方法。

16. 发明申请

US20070092489A1 Use of receptor sequences for immobilizing gene vectors on surfaces 审中-公开
标题翻译：使用受体序列将基因载体固定在表面上
公开(公告)号：US20070092489A1
公开(公告)日：2007-04-26
申请号：US10567872
申请日：2004-08-13
申请人： Ilia Fishbein , Ivan Alferiev , Robert Levy , Origene Nyanguile
发明人： Ilia Fishbein , Ivan Alferiev , Robert Levy , Origene Nyanguile
IPC分类号： A61K48/00 , C12N15/861
CPC分类号： A61K48/0008 , A61K47/551 , A61K47/64 , A61K47/65 , A61K48/00 , A61K48/0075 , C07K14/705 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2710/10345 , C12N2810/405 , C12N2810/80
摘要： The present invention relates to compositions and methods of immobilizing a viral vector to an implantable medical device, for example a vascular stent. Specifically, a composition for delivery of a therapeutic agent is provided which includes: a gene transfer vector, a surface and a modified protein, wherein the gene transfer vector is bound to the modified protein and the modified protein is covalently bound to the surface and wherein the composition is adapted to deliver the gene transfer vector to a mammalian cell. The viral vector is preferably an adenoviral vector and the modified protein is preferably CAR D1.
摘要翻译：本发明涉及将病毒载体固定到可植入医疗装置（例如血管支架）上的组合物和方法。具体地说，提供了用于递送治疗剂的组合物，其包括：基因转移载体，表面和修饰的蛋白质，其中所述基因转移载体与修饰的蛋白质结合，并且所述修饰的蛋白质与所述表面共价结合，并且其中该组合物适于将基因转移载体递送至哺乳动物细胞。病毒载体优选为腺病毒载体，修饰的蛋白质优选为CAR D1。

17. 发明授权

US06890998B2 Thiol activation of polyurethanes and methods of making the same 有权
标题翻译：聚氨酯的硫醇活化及其制备方法
公开(公告)号：US06890998B2
公开(公告)日：2005-05-10
申请号：US10672893
申请日：2003-09-26
申请人： Ivan Alferiev , Ilia Fishbein , Robert J. Levy
发明人： Ivan Alferiev , Ilia Fishbein , Robert J. Levy
IPC分类号： A61L27/18 , A61L29/06 , A61L31/06 , C08G18/44 , C08G18/48 , C08G18/81 , C08G18/82 , C08G18/83 , G01N21/64
CPC分类号： A61L27/18 , A61L29/06 , A61L31/06 , C08G18/44 , C08G18/4854 , C08G18/838 , G01N21/6428 , C08L75/04
摘要： A polyurethane having a thiol substituent pendant from at least one nitrogen and/or at least one carbon atom of the polyurethane.A polyurethane having a thiol substituent pendant from at least one nitrogen and/or at least one carbon atom of the polyurethane, wherein the thiol substituent has a formula: —RL—(S—R1)n wherein n is an integer from 1 to 3; RL is an (n+1)-valent organic radical having at least one carbon atom; and R1 is a member selected from the group consisting of H, C(O)R3, and SR4, wherein R3 is a member selected from the group consisting of C1 to C6 alkyl and R4 is a heterocyclic group or an electron deficient aromatic group.
摘要翻译：具有聚氨酯的至少一个氮原子和/或至少一个碳原子的硫醇取代基的聚氨酯。聚氨酯，其具有来自聚氨酯的至少一个氮原子和/或至少一个碳原子的硫醇取代基，其中所述硫醇取代基具有下式：<？in-line-formula description =“In-line Formulas”end =“ （“1”）在线公式描述=“在线公式”结束 =“尾”→其中n是1至3的整数; R L是具有至少一个碳原子的（n + 1）价有机基团; 和R 1是选自H，C（O）R 3和SR 4的成员，其中R SUP > 3 是选自C 1至C 6烷基的基团，R 4是杂环基或电子缺乏芳族基团。

18. 发明授权

US08580545B2 Biodegradable linkers for molecular therapies 有权
标题翻译：用于分子疗法的生物可降解接头
公开(公告)号：US08580545B2
公开(公告)日：2013-11-12
申请号：US13306459
申请日：2011-11-29
申请人： Ivan Alferiev , Robert J. Levy , Ilia Fishbein
发明人： Ivan Alferiev , Robert J. Levy , Ilia Fishbein
IPC分类号： C12N11/06 , C12N11/00
CPC分类号： A61K47/6957 , A61K47/6901 , C12N2799/022
摘要： A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently bound to the biomaterial; and (c) a substrate, wherein the substrate is covalently bound to the biodegradable cross-linker portion, provided that the biodegradable cross-linker is adapted to hydrolyze by breaking the hydrolyzable bond and thereby release and deliver the biomaterial. A process of making the composition is also provided.
摘要翻译：用于将生物材料递送到动物细胞或组织的方法和组合物，所述组合物包括（a）生物材料; （b）具有可水解键的可生物降解的交联剂部分，其中所述可生物降解的交联剂部分与所述生物材料共价结合; 并且（c）底物，其中所述底物共价结合到所述可生物降解的交联剂部分，条件是所述可生物降解的交联剂适于通过破坏所述可水解键从而水解，从而释放和递送所述生物材料。还提供了制备组合物的方法。

19. 发明授权

US08084435B2 Biodegradable linkers for molecular therapies 有权
标题翻译：用于分子疗法的生物可降解接头
公开(公告)号：US08084435B2
公开(公告)日：2011-12-27
申请号：US11799861
申请日：2007-05-03
申请人： Ivan Alferiev , Robert J. Levy , Ilia Fishbein
发明人： Ivan Alferiev , Robert J. Levy , Ilia Fishbein
IPC分类号： A61K31/70 , C12N11/06 , C12N11/00 , A01N43/04 , A61F2/00
CPC分类号： A61K47/6957 , A61K47/6901 , C12N2799/022
摘要： A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently bound to the biomaterial; and (c) a substrate, wherein the substrate is covalently bound to the biodegradable cross-linker portion, provided that the biodegradable cross-linker is adapted to hydrolyze by breaking the hydrolyzable bond and thereby release and deliver the biomaterial. A process of making the composition is also provided.
摘要翻译：用于将生物材料递送到动物细胞或组织的方法和组合物，所述组合物包括（a）生物材料; （b）具有可水解键的可生物降解的交联剂部分，其中所述可生物降解的交联剂部分与所述生物材料共价结合; 并且（c）底物，其中所述底物共价结合到所述可生物降解的交联剂部分，条件是所述可生物降解的交联剂适于通过破坏所述可水解键从而水解，从而释放和递送所述生物材料。还提供了制备组合物的方法。

20. 发明授权

US07589070B2 Surface modification for improving biocompatibility 有权
标题翻译：改善生物相容性的表面改性
公开(公告)号：US07589070B2
公开(公告)日：2009-09-15
申请号：US10170411
申请日：2002-06-14
申请人： Robert J. Levy , Ivan Alferiev , Cunxian Song , Ilia Fishbein
发明人： Robert J. Levy , Ivan Alferiev , Cunxian Song , Ilia Fishbein
IPC分类号： A61K31/70 , A01N43/04 , A61K39/395 , A61F2/00
CPC分类号： C12N15/87 , A61K38/00 , A61K39/00 , A61K47/69 , A61K48/00
摘要： A therapeutic delivery system efficiently introduces biologically active molecules to mammalian cells without the use of synthetic polymers or biopolymer coatings. Surface modification of a metal support, such as a medical device, results in a single molecular layer that can fasten various molecules, thereby minimizing any cellular inflammatory response while enhancing biocompatibility.
摘要翻译：治疗递送系统在不使用合成聚合物或生物聚合物涂层的情况下有效地将生物活性分子引入哺乳动物细胞。金属载体（例如医疗装置）的表面改性导致单个分子层，其可以固定各种分子，从而最小化任何细胞炎性反应，同时增强生物相容性。

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