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11. 发明申请

US20140048702A1 Ion Guide With Orthogonal Sampling 有权
标题翻译：离子指南与正交采样
公开(公告)号：US20140048702A1
公开(公告)日：2014-02-20
申请号：US14004529
申请日：2012-03-13
申请人： Martin Raymond Green , David J. Langridge , Jason Lee Wildgoose
发明人： Martin Raymond Green , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/02
CPC分类号： H01J49/065 , G01N27/622 , H01J49/0031 , H01J49/022 , H01J49/062 , H01J49/063 , H01J49/36
摘要： A mass spectrometer is disclosed comprising a RF ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the RF ion guide. The Ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001-0.001 mbar; (ii) 0.001-0.01 mbar; (iii) 0.01-0.1 mbar; (iv) 0.1-1 mbar; (v) 1-10 mbar; (vi) 10-100 mbar; and (vii) >100 mbar.
摘要翻译：公开了一种质谱仪，其包括RF离子导向器，其中在操作模式中，连续的，准连续的或脉冲的离子束从离子导向器正交地采样，并且其中连续的，准连续的或脉冲的离子束不是轴向的被捕获或以其它方式轴向限制在RF离子导向器内。离子导向器在使用中以选自以下的压力保持：（i）0.0001-0.001毫巴; （ii）0.001-0.01毫巴; （iii）0.01-0.1毫巴; （iv）0.1-1毫巴; （v）1-10毫巴; （vi）10-100毫巴; 和（vii）> 100mbar。

12. 发明授权

US09425035B2 Ion trap with spatially extended ion trapping region 有权
标题翻译：离子阱具有空间延伸的离子捕获区域
公开(公告)号：US09425035B2
公开(公告)日：2016-08-23
申请号：US14240586
申请日：2012-08-22
申请人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/00 , H01J49/42 , H01J49/40
CPC分类号： H01J49/4285 , H01J49/0031 , H01J49/062 , H01J49/063 , H01J49/40 , H01J49/422
摘要： A mass or mass to charge ratio selective ion trap is disclosed which directs ions into a small ejection region. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC or RF voltage acts to confine ions in a second (x) direction. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. The profile of the quadratic DC potential well progressively varies along the second (x) direction.
摘要翻译：公开了将离子引导到小的喷射区域中的质量或质量比的选择性离子阱。 RF电压用于将离子限制在离子阱内的第一（y）方向。 DC或RF电压用于将离子限制在第二（x）方向。二次直流势阱用于将离子限制在离子阱内的第三（z）方向。二次直流电势的曲线沿着第二（x）方向逐渐变化。

13. 发明授权

US09048081B2 Fast pushing time of flight mass spectrometer combined with restricted mass to charge ratio range delivery 有权
标题翻译：快速推进飞行时间质谱仪结合限制质量与电荷比范围传送
公开(公告)号：US09048081B2
公开(公告)日：2015-06-02
申请号：US13997556
申请日：2011-12-22
申请人： Martin Raymond Green , Daniel James Kenny , Jason Lee Wildgoose
发明人： Martin Raymond Green , Daniel James Kenny , Jason Lee Wildgoose
IPC分类号： H01J49/40 , H01J49/02 , H01J49/00
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/0086
摘要： Ions having a restricted range of mass to charge ratios are transmitted to the acceleration region of a Time of Flight mass analyzer. A control system applies a first extraction pulse to an acceleration electrode in order to accelerate a first group of ions into the time of flight region at a first time T1, wherein ions having the lowest mass to charge ratio in the first group of ions have a time of flight ΔT1min through the time of flight region and ions having the highest mass to charge ratio in the first group of ions have a time of flight ΔT1max through the time of flight region. The control system applies a second extraction pulse to the acceleration electrode at a subsequent second time T2, wherein ΔT1max−ΔT1min≦T2−T1
摘要翻译：具有有限范围的质荷比的离子被传送到飞行时间质量分析器的加速区域。控制系统将第一提取脉冲施加到加速电极，以便在第一时间T1将第一组离子加速到飞行时间区域，其中在第一组离子中具有最低质荷比的离子具有飞行时间Dgr;飞行时间T1min，第一组离子具有最高质荷比的离子在飞行时间段内具有飞行时间Dgr; T1max。控制系统在随后的第二时间T2向加速电极施加第二提取脉冲，其中＆Dgr; T1max-＆Dgr; T1min＆N1; T2-T1 <＆Dgr; T1max。

14. 发明授权

US08829433B2 Ion mobility separator with variable effective length 有权
标题翻译：具有可变有效长度的离子迁移分离器
公开(公告)号：US08829433B2
公开(公告)日：2014-09-09
申请号：US14004486
申请日：2012-03-13
申请人： Martin Raymond Green , David J. Langridge , Jason Lee Wildgoose
发明人： Martin Raymond Green , David J. Langridge , Jason Lee Wildgoose
IPC分类号： B01D59/44 , H01J49/36
CPC分类号： H01J49/36 , G01N27/624 , H01J49/06 , H01J49/42 , H01J49/426
摘要： An ion mobility separator or spectrometer is disclosed comprising an inner cylinder and an outer cylinder defining an annular volume through which ions are transmitted. Spiral electrodes a-f are arranged on a surface of the inner cylinder and/or on a surface of the outer cylinder. A first device is arranged and adapted to maintain a DC electric field or a pseudo-potential force which acts to urge ions from a first end of the ion mobility separator or spectrometer to a second end of the ion mobility separator or spectrometer. A second device is arranged and adapted to apply one or more transient DC voltages to the spiral electrodes in order to urge ions towards the first end of the ion mobility separator or spectrometer. The net effect is to extend the effective path length of the ion mobility separator.
摘要翻译：公开了一种离子迁移率分离器或光谱仪，其包括限定通过离子传播的环形体积的内圆筒和外圆筒。螺旋电极a-f布置在内筒的表面上和/或外筒的表面上。第一装置被布置并适于维持DC电场或伪电势力，其作用是将离子从离子迁移率分离器或光谱仪的第一端推到离子迁移率分离器或光谱仪的第二端。第二装置被布置并适于将一个或多个瞬态DC电压施加到螺旋电极，以促使离子朝向离子迁移分离器或光谱仪的第一端。净效应是延长离子迁移率分离器的有效路径长度。

15. 发明授权

US08344316B2 Method of avoiding space charge saturation effects in an ion trap 有权
标题翻译：避免离子阱中空间电荷饱和效应的方法
公开(公告)号：US08344316B2
公开(公告)日：2013-01-01
申请号：US12997347
申请日：2009-06-08
申请人： Martin Raymond Green , Jason Lee Wildgoose
发明人： Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： H01J49/26 , H01J49/42 , B01D59/44
CPC分类号： H01J49/02 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/4265
摘要： A mass spectrometer includes a first ion trap arranged upstream of an analytical second ion trap. The charge capacity of the first ion trap is set at a value such that if all the ions stored within the first ion trap up to the charge capacity limit of the first ion trap are then transferred to the second ion trap, then the analytical performance of the second ion trap is not substantially degraded due to space charge effects.
摘要翻译：质谱仪包括布置在分析第二离子阱的上游的第一离子阱。第一离子阱的充电容量被设定为使得如果存储在第一离子阱内的所有离子直到第一离子阱的充电容量极限，则转移到第二离子阱，则分析性能由于空间电荷效应，第二离子阱基本上不会劣化。

16. 发明申请

US20110303838A1 Method Of Avoiding Space Charge Saturation Effects In An Ion Trap 有权
标题翻译：在离子阱中避免空间电荷饱和效应的方法
公开(公告)号：US20110303838A1
公开(公告)日：2011-12-15
申请号：US12997347
申请日：2009-06-08
申请人： Martin Raymond Green , Jason Lee Wildgoose
发明人： Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： H01J49/26
CPC分类号： H01J49/02 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/4265
摘要： A mass spectrometer is provided comprising a first ion trap (2) arranged upstream of an analytical second ion trap (5). The charge capacity of the first ion trap (2) is set at a value such that if all the ions stored within the first ion trap (2) up to the charge capacity limit of the first ion trap (2) are then transferred to the second ion trap (5), then the analytical performance of the second ion trap (5) is not substantially degraded due to space charge effects.
摘要翻译：提供质谱仪，其包括布置在分析性第二离子阱（5）上游的第一离子阱（2）。将第一离子阱（2）的充电容量设定为使得如果存储在第一离子阱（2）内的所有离子直到第一离子阱（2）的充电容量极限，则转移到第二离子阱（5），则由于空间电荷效应，第二离子阱（5）的分析性能基本上不劣化。

17. 发明申请

US20090114808A1 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20090114808A1
公开(公告)日：2009-05-07
申请号：US11916430
申请日：2006-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Raymond Green , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analysed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.
摘要翻译：公开了一种质谱法，其中分析了来自离子检测器的电压信号。获得每个电压信号的第二差分，并且确定观察到的电压峰值的开始和结束时间。然后确定每个电压峰值的强度和平均时间，并存储强度和时间值。然后通过组合与多个实验运行中观察到的每个电压峰值相关的强度和时间值来形成中间复合质谱。然后将各种时间和强度数据对被整合以产生平滑的连续质谱。然后可以通过确定连续质谱的第二差分来进一步处理连续质谱。可以确定在连续质谱中观察到的质量峰的开始和结束时间。然后可以确定在连续质谱中观察到的每个质量峰的强度和质荷比。然后可以显示或输出包括仅每个离子种类的强度值和质荷比的最终离散质谱。

18. 发明授权

US09190251B2 Pre-scan for mass to charge ratio range 有权
标题翻译：预扫描质量与充电比例范围
公开(公告)号：US09190251B2
公开(公告)日：2015-11-17
申请号：US14004520
申请日：2012-03-13
申请人： Martin Raymond Green , Jason Lee Wildgoose
发明人： Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： H01J49/00
CPC分类号： H01J49/004 , H01J49/0031
摘要： A method of mass spectrometry is disclosed comprising performing a first analysis of a sample of ions wherein one or more parameters are scanned and/or ions are sorted according to one or more parameters during the first analysis. One or more ranges of interest of the one or more parameters from the first analysis are then automatically determined. A second subsequent analysis of the sample of ions is then automatically performed, wherein the second analysis is restricted to one or more of the ranges of interest of the one or more parameters.
摘要翻译：公开了一种质谱法，其包括在第一次分析期间根据一个或多个参数对离子样品进行第一次分析，其中扫描一个或多个参数和/或离子。然后自动确定来自第一次分析的一个或多个参数的一个或多个感兴趣范围。然后自动执行离子样品的第二次后续分析，其中第二分析限于一个或多个参数的一个或多个感兴趣的范围。

19. 发明授权

US09111654B2 DC ion guide for analytical filtering/separation 有权
标题翻译：用于分析过滤/分离的直流离子导向器
公开(公告)号：US09111654B2
公开(公告)日：2015-08-18
申请号：US14003487
申请日：2012-03-07
申请人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/26 , G21K1/00 , H01J49/42 , H01J49/28
CPC分类号： G21K1/00 , H01J49/062 , H01J49/28 , H01J49/427
摘要： An ion guide is disclosed comprising a plurality of electrodes. A first device is arranged and adapted to apply a RF voltage to at least some of the electrodes in order to form, in use, a pseudo-potential well which acts to confine ions in a first direction within the ion guide. A second device is arranged and adapted to apply a DC voltage to at least some of the electrodes in order to form, in use, a DC potential well which acts to confine ions in a second direction within the ion guide. A third device is arranged and adapted to cause ions having desired or undesired mass to charge ratios to be mass to charge ratio selectively ejected from the ion guide in the second direction.
摘要翻译：公开了一种离子导向器，其包括多个电极。第一装置被布置并适于将RF电压施加到至少一些电极，以在使用中形成用于将离子限制在离子导向器内的第一方向上的伪电位阱。第二装置被布置并适于将DC电压施加到至少一些电极，以在使用中形成用于在离子导向器内沿第二方向限制离子的DC势阱。第三装置被布置并适于使具有期望或不需要的质量的充电比例的离子成为从第二方向从离子导向器选择性地喷射的质荷比。

20. 发明申请

US20140299761A1 Ion Trap With Spatially Extended Ion Trapping Region 有权
标题翻译：离子阱与空间扩展的离子捕获区域
公开(公告)号：US20140299761A1
公开(公告)日：2014-10-09
申请号：US14240667
申请日：2012-08-22
申请人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/42
CPC分类号： H01J49/424 , H01J49/421 , H01J49/422 , H01J49/4285
摘要： A mass or mass to charge ratio selective ion trap is disclosed having an increased charge storage capacity. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC voltage and/or an RF voltage acts to confine ions in a second (x) direction within the ion trap. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. Ions are excited in the third (z) direction and are caused to be mass or mass to charge ratio selectively ejected in the third (z) direction.
摘要翻译：公开了具有增加的电荷存储容量的质量或质量 - 电荷比选择性离子阱。 RF电压用于将离子限制在离子阱内的第一（y）方向。 DC电压和/或RF电压用于将离子限制在离子阱内的第二（x）方向。二次直流势阱用于将离子限制在离子阱内的第三（z）方向。离子在第三（z）方向上被激发，并且被导致在第三（z）方向上选择性地喷射的质量或质量 - 充电比。

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