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    • 13. 发明申请
    • Dental materials based on radically polymerizable macromers with antimicrobial effect
    • 基于可自由基聚合的大分子单体的牙科材料具有抗菌作用
    • US20070254979A1
    • 2007-11-01
    • US11502420
    • 2006-08-11
    • Ulrich SalzJorg ZimmermannDirk PoppeVolker RheinbergerJorg TillerChristian Waschinski
    • Ulrich SalzJorg ZimmermannDirk PoppeVolker RheinbergerJorg TillerChristian Waschinski
    • A61K6/08
    • A61K6/0017A61K6/0023A61K6/083A61K6/09C08L33/00C08L75/16
    • Dental material which contains at least one compound of the formula [PG]m-R1-Z-SP—Y—R2—[WG]p, in which m=1, 2 or 3; p=1, 2 or 3; R1=is absent, a linear or branched C1 to C20 alkylene radical which can be interrupted one or more times by O, S, NH, SiR′, CONH CONR′, COO and/or OCONH, a substituted or unsubstituted, aromatic C6 to C14 radical or a combination thereof; R2=is absent, a linear or branched C1 to C20 alkylene radical which can be interrupted one or more times by O, S, NH, SiR′, CONH CONR′, COO and/or OCONH, a substituted or unsubstituted, aromatic C6 to C14 radical or a combination thereof; PG=a radically polymerizable group; SP=a polymeric spacer which is selected from polyethylene glycol, polypropylene glycol, polyglycerol, polyalkyloxazoline, polyethyleneimine, polyacrylic acid, polymethacrylic acid, polyvinyl alcohol, polyvinyl acetate, poly-(2-hydroxyethyl)acrylate, poly-(2-hydroxyethyl)methacrylate groups, hydrophilic polypeptide groups and copolymers of the corresponding monomers; WG=antimicrobially active group; Z=is absent, O, S, an ester, amide or urethane group; Y=is absent, O, S, an ester, amide or urethane group, and which has a molecular weight of at least 1.000.
    • 含有至少一种式[PG] m -R 1的化合物的牙科材料-Z-SP-YR 2 - [WG] 其中m = 1,2或3; p = 1,2或3; R 1不存在,可以被O,S中断一次或多次的直链或支链C 1至C 20亚烷基 ,NH,SiR',CONH CONR',COO和/或OCONH,取代或未取代的芳族C 6至C 14个基团或其组合; R 2不存在,可以被O,S中断一次或多次的直链或支链C 1至C 20亚烷基 ,NH,SiR',CONH CONR',COO和/或OCONH,取代或未取代的芳族C 6至C 14个基团或其组合; PG =自由基聚合性基团; SP =选自聚乙二醇,聚丙二醇,聚甘油,聚烷基恶唑啉,聚乙烯亚胺,聚丙烯酸,聚甲基丙烯酸,聚乙烯醇,聚乙酸乙烯酯,聚(2-羟乙基)丙烯酸酯,聚(2-羟乙基)甲基丙烯酸酯 基团,亲水性多肽组和相应单体的共聚物; WG =抗微生物活性组; Z =不存在,O,S,酯,酰胺或氨基甲酸酯基; Y =不存在,O,S,酯,酰胺或氨基甲酸酯基,其分子量至少为1.000。