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1. 发明申请

US20070254979A1 Dental materials based on radically polymerizable macromers with antimicrobial effect 有权
标题翻译：基于可自由基聚合的大分子单体的牙科材料具有抗菌作用
公开(公告)号：US20070254979A1
公开(公告)日：2007-11-01
申请号：US11502420
申请日：2006-08-11
申请人： Ulrich Salz , Jorg Zimmermann , Dirk Poppe , Volker Rheinberger , Jorg Tiller , Christian Waschinski
发明人： Ulrich Salz , Jorg Zimmermann , Dirk Poppe , Volker Rheinberger , Jorg Tiller , Christian Waschinski
IPC分类号： A61K6/08
CPC分类号： A61K6/0017 , A61K6/0023 , A61K6/083 , A61K6/09 , C08L33/00 , C08L75/16
摘要： Dental material which contains at least one compound of the formula [PG]m-R1-Z-SP—Y—R2—[WG]p, in which m=1, 2 or 3; p=1, 2 or 3; R1=is absent, a linear or branched C1 to C20 alkylene radical which can be interrupted one or more times by O, S, NH, SiR′, CONH CONR′, COO and/or OCONH, a substituted or unsubstituted, aromatic C6 to C14 radical or a combination thereof; R2=is absent, a linear or branched C1 to C20 alkylene radical which can be interrupted one or more times by O, S, NH, SiR′, CONH CONR′, COO and/or OCONH, a substituted or unsubstituted, aromatic C6 to C14 radical or a combination thereof; PG=a radically polymerizable group; SP=a polymeric spacer which is selected from polyethylene glycol, polypropylene glycol, polyglycerol, polyalkyloxazoline, polyethyleneimine, polyacrylic acid, polymethacrylic acid, polyvinyl alcohol, polyvinyl acetate, poly-(2-hydroxyethyl)acrylate, poly-(2-hydroxyethyl)methacrylate groups, hydrophilic polypeptide groups and copolymers of the corresponding monomers; WG=antimicrobially active group; Z=is absent, O, S, an ester, amide or urethane group; Y=is absent, O, S, an ester, amide or urethane group, and which has a molecular weight of at least 1.000.
摘要翻译：含有至少一种式[PG] m -R 1的化合物的牙科材料-Z-SP-YR 2 - [WG] 其中m = 1,2或3; p = 1,2或3; R 1不存在，可以被O，S中断一次或多次的直链或支链C 1至C 20亚烷基，NH，SiR'，CONH CONR'，COO和/或OCONH，取代或未取代的芳族C 6至C 14个基团或其组合; R 2不存在，可以被O，S中断一次或多次的直链或支链C 1至C 20亚烷基，NH，SiR'，CONH CONR'，COO和/或OCONH，取代或未取代的芳族C 6至C 14个基团或其组合; PG =自由基聚合性基团; SP =选自聚乙二醇，聚丙二醇，聚甘油，聚烷基恶唑啉，聚乙烯亚胺，聚丙烯酸，聚甲基丙烯酸，聚乙烯醇，聚乙酸乙烯酯，聚（2-羟乙基）丙烯酸酯，聚（2-羟乙基）甲基丙烯酸酯基团，亲水性多肽组和相应单体的共聚物; WG =抗微生物活性组; Z =不存在，O，S，酯，酰胺或氨基甲酸酯基; Y =不存在，O，S，酯，酰胺或氨基甲酸酯基，其分子量至少为1.000。

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