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    • 19. 发明授权
    • Microfluidic apparatuses with nanochannels
    • 具有纳米通道的微流控装置
    • US08168140B2
    • 2012-05-01
    • US11669682
    • 2007-01-31
    • Timothy BeerlingKarsten G. KraiczekReid A. Brennen
    • Timothy BeerlingKarsten G. KraiczekReid A. Brennen
    • B01L3/00B01L3/18G01N1/10
    • G01N30/6095B01L3/5027B01L2200/12B01L2300/0877B01L2300/0887B82Y15/00Y10T436/2575
    • In some embodiments of the present invention, the buried silicon oxide technology is employed in the fabrication of fluid channels, particularly nanochannels. For example, a fluid channel can be made in a buried silicon oxide layer by etching the buried oxide layer with a method that selectively removes silicon oxide but not silicon. Thus, one dimension of the resulting fluid channel is limited by the thickness of the buried oxide layer. It is possible to manufacture a very thin buried oxide layer with great precision, thus a nanochannel can be fabricated in a controlled manner. Moreover, in addition to buried oxide, any pairs of substances with a high etch ratio with respect to each other can be used in the same way. Further provided are the fluid channels, apparatuses, devices and systems comprising the fluid channels, and uses thereof.
    • 在本发明的一些实施例中,掩埋氧化硅技术用于制造流体通道,特别是纳米通道。 例如,通过用选择性地去除氧化硅而不是硅的方法蚀刻掩埋氧化物层,可以在掩埋氧化硅层中制造流体通道。 因此,所得流体通道的一个尺寸受到掩埋氧化物层的厚度的限制。 可以以很高的精度制造非常薄的掩埋氧化物层,因此可以以受控的方式制造纳米通道。 此外,除了掩埋氧化物之外,可以以相同的方式使用具有相对于彼此的高蚀刻比的任何物质对。 进一步提供了包括流体通道的流体通道,装置,装置和系统及其用途。
    • 20. 发明申请
    • Composite Stylet
    • 复合探针
    • US20120035615A1
    • 2012-02-09
    • US12470990
    • 2009-05-22
    • Kurt J. KoesterChuladatta ThenuwaraTimothy Beerling
    • Kurt J. KoesterChuladatta ThenuwaraTimothy Beerling
    • A61B17/00A61N1/05
    • A61B17/3468A61N1/0541
    • A composite stylet for facilitating insertion of an implantable electrode array into either a left or right cochlea comprises a composite having a glass transition temperature between room temperature and body temperature. While relatively stiff and straight at room temperature, the composite stylet is slidably inserted into a longitudinal lumen of the electrode array. The electrode array is then inserted into the cochlea. As the composite stylet within the electrode array warms to body temperature, it becomes compliant, allowing the electrode array to assume a spiral shape. The proximal end of the composite stylet, which is not inserted into the body, retains its stiffness to aid the implanter in inserting the electrode array.
    • 用于促进可植入电极阵列插入左耳蜗或右耳蜗的复合探针包括具有室温和体温之间的玻璃化转变温度的复合物。 虽然在室温下相对刚性和直线,但是复合探针可滑动地插入电极阵列的纵向内腔中。 然后将电极阵列插入耳蜗。 由于电极阵列内的复合管心针加热到体温,所以它变得顺从,允许电极阵列呈现螺旋状。 未插入到主体中的复合管心针的近端保持其刚度以帮助注入机插入电极阵列。