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11. 发明申请

US20100241208A1 Pacemaker Lead and Method of Making Same 失效
标题翻译：起搏器牵头及其制作方法
公开(公告)号：US20100241208A1
公开(公告)日：2010-09-23
申请号：US12690997
申请日：2010-01-21
申请人： Leonard Pinchuk
发明人： Leonard Pinchuk
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61B5/042 , A61B2562/125
摘要： An improved pacemaker lead including a lead body supporting at least one flexible conductor element that provides an electrical signal path between a proximal connector element and a distal electrode. The lead body includes an insulating structure that protects the flexible conductor element(s) wherein the insulating structure is realized from a polymer blend of a thermoplastic polyurethane elastomer and an isobutylene block copolymer. The mole fraction of the isobutylene block copolymer of the polymer blend is in the range of 2-15% (most preferably on the order of 10%). The polymer blend of the insulating structure has a maximum tensile strength in the range of 20-40 MPa (most preferably in a range of 25-35 MPa). In the preferred embodiment, the hardness of the polymer blend can be characterized by a Shore hardness in a range of 70-80 A. The flexible conductor element(s) preferably include a coiled wire conductor defining a central axis with an outer surface facing radially outward away from the central axis and an inner surface facing radially inward toward the central axis, and the insulating structure surrounds at least the outer surface of the coiled wire conductor (and more preferably encapsulates the coiled wire conductor). The polymer blend of the insulating structure has reduced oxygen permeability, and thus provides improved resistance to environmental stress cracking and metal ion induced oxidation while maintaining the flexibility and desired tensile strength of the lead body.
摘要翻译：一种改进的起搏器引线，包括引导体，其支撑至少一个柔性导体元件，其提供近端连接器元件和远端电极之间的电信号路径。引线体包括保护柔性导体元件的绝缘结构，其中由热塑性聚氨酯弹性体和异丁烯嵌段共聚物的聚合物共混物实现绝缘结构。聚合物共混物的异丁烯嵌段共聚物的摩尔分数在2-15％（最优选约10％）的范围内。绝缘结构的聚合物共混物的最大拉伸强度在20-40MPa的范围内（最优选在25-35MPa的范围内）。在优选实施方案中，聚合物共混物的硬度可以通过肖氏硬度在70-80A的范围内表征。柔性导体元件优选包括限定中心轴线的线圈状导体，其外表面面向径向远离中心轴线的外表面和朝向中心轴线径向向内的内表面，并且绝缘结构至少围绕线圈导线的外表面（更优选地包围线圈导线）。绝缘结构的聚合物共混物具有降低的透氧性，从而提供改善的耐环境应力开裂性和金属离子诱导氧化性，同时保持引线体的柔软性和所需拉伸强度。

12. 发明申请

US20100241046A1 APPARATUS, METHODS AND DEVICES FOR TREATMENT OF OCULAR DISORDERS 审中-公开
标题翻译：用于治疗眼病的装置，方法和装置
公开(公告)号：US20100241046A1
公开(公告)日：2010-09-23
申请号：US12440096
申请日：2007-09-06
申请人： Leonard Pinchuk , Jean-Marie A. Parel , Francisco Fantes
发明人： Leonard Pinchuk , Jean-Marie A. Parel , Francisco Fantes
IPC分类号： A61M1/00
CPC分类号： A61L27/56 , A61F9/00781 , A61L27/48 , A61L31/129 , A61L31/146 , C08L53/02
摘要： Apparatus and methods for relieving and treating glaucoma and other ocular disorders are disclosed. The apparatus includes a thin flexible membrane and preferably a tubular member. In another aspect of the invention, a surgical device for repairing ocular tissue includes a flexible membrane of a polymeric material comprising polyisobutylene. In the preferred embodiment, the polymeric material of the membrane is porous.
摘要翻译：公开了用于缓解和治疗青光眼和其它眼部疾病的装置和方法。该装置包括薄的柔性膜并且优选地为管状构件。在本发明的另一方面，用于修复眼组织的手术装置包括包含聚异丁烯的聚合物材料的柔性膜。在优选的实施方案中，膜的聚合物材料是多孔的。

13. 发明申请

US20090156893A1 FLATTENED TUBULAR MESH SLING AND RELATED METHODS 有权
标题翻译：扁平管网和相关方法
公开(公告)号：US20090156893A1
公开(公告)日：2009-06-18
申请号：US12391995
申请日：2009-02-24
申请人： George Bourne , Leonard Pinchuk
发明人： George Bourne , Leonard Pinchuk
IPC分类号： A61F2/02 , B32B37/00
CPC分类号： A61F2/0045 , A61F2002/0068 , A61F2250/0028 , Y10T156/10
摘要： The invention generally relates to surgically implantable supportive slings. More specifically, in various embodiments, the invention is directed to multilayer mesh slings formed from a tubular mesh material.
摘要翻译：本发明一般涉及可手术植入的支撑吊索。更具体地，在各种实施例中，本发明涉及由管状网状材料形成的多层网状吊索。

14. 发明申请

US20090138067A1 Expandable supportive branched endoluminal grafts 审中-公开
标题翻译：可扩展支持性支气管内移植物
公开(公告)号：US20090138067A1
公开(公告)日：2009-05-28
申请号：US11906703
申请日：2007-10-03
申请人： Leonard Pinchuk , Rysler Alcime , Yasushi Kato
发明人： Leonard Pinchuk , Rysler Alcime , Yasushi Kato
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2/07 , A61F2/88 , A61F2/885 , A61F2/89 , A61F2/91 , A61F2002/065 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2002/30329 , A61F2002/826 , A61F2220/0008 , A61F2220/0025 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/001 , A61F2230/0078 , A61F2240/001 , A61F2250/0039
摘要： An endoluminal graft which is both expandable and supportive is provided in a form suitable for use in a branched body vessel location. The graft expands between a first diameter and a second, larger diameter. The support component is an expandable stent endoprosthesis. A liner is applied to the endoprosthesis in the form of a compliant wall material that is porous and biocompatible in order to allow normal cellular invasion upon implantation, without stenosis, when the expandable and supportive graft is at its second diameter. The supportive endoluminal graft is preferably provided as a plurality of components that are deployed separately at the branching body vessel location, one of which has a longitudinal seam defining leg portions within which the other components fit in a telescoping manner.
摘要翻译：可膨胀和支持的腔内移植物以适合用于分支体血管位置的形式提供。移植物在第一直径和第二直径较大的直径之间膨胀。支撑部件是可扩张的支架内置假体。将内衬施用于多孔且生物相容的柔性壁材料形式的内用假体，以便当可扩张和支持性移植物处于其第二直径时，在植入时允许正常的细胞侵入而没有狭窄。支持性腔内移植物优选地被设置为在分支体血管位置处分开设置的多个部件，其中一个部件具有限定腿部的纵向接缝，其中其它部件可以以伸缩方式配合。

15. 发明申请

US20080066771A1 Nail Clipper Apparatus 审中-公开
标题翻译：指甲钳装置
公开(公告)号：US20080066771A1
公开(公告)日：2008-03-20
申请号：US11854704
申请日：2007-09-13
申请人： Leonard Pinchuk
发明人： Leonard Pinchuk
IPC分类号： A45D29/02
CPC分类号： A45D29/02 , A45D2029/026
摘要： A remotely actuated nail clipping apparatus includes a nail clipper body having upper and lower jaws with opposed cutting surfaces. An actuating lever is remotely disposed from the nail clipper body. A linkage, which operably couples the actuating lever to the nail clipper body, passes through the upper jaw of the nail clipper body and interfaces with the lower jaw and enables the user to pull the lower jaw upward toward the upper jaw into a cutting configuration whereby the opposed cutting surfaces of the two jaws engage one another to thereby clip a nail disposed therebetween. Preferably, a hollow vertical shaft rigidly couples the upper jaw of the nail clipper body to the actuating lever and the linkage extends through the interior of the shaft. A platform is preferably secured to the top end of the shaft and provides a support surface for the actuation lever.
摘要翻译：远程致动的指甲夹装置包括具有相对的切割表面的上下爪的指甲钳本体。致动杠杆远离指甲钳主体。将致动杆可操作地连接到指甲钳主体的连杆通过指甲钳主体的上颚并与下钳口相接合，并且使得使用者能够将下颚向上朝向上颚拉动成切割构型，由此两个爪的相对的切割表面彼此接合，从而夹住设置在其间的指甲。优选地，空心竖直轴将指甲钳主体的上颚刚性地联接到致动杆，并且连杆延伸穿过轴的内部。平台优选地固定到轴的顶端并提供用于致动杆的支撑表面。

16. 发明申请

US20080051805A1 Hair Follicle Coring Tool and System Based Thereon 审中-公开
标题翻译：毛囊取芯工具及其系统
公开(公告)号：US20080051805A1
公开(公告)日：2008-02-28
申请号：US11467733
申请日：2006-08-28
申请人： Leonard Pinchuk
发明人： Leonard Pinchuk
IPC分类号： A61B17/50
CPC分类号： A61B17/3468 , A61B2017/00752 , A61B2017/00969 , A61F2/10
摘要： A tool for coring a portion of one or more hair follicles incorporates an elongate hollow tubular member with at least one cut-out disposed between its distal end and proximal end. The cut-out allows for removal of debris that moves it way up the hollow tubular member from the opened distal tip. The needle can also include a radially-extending projection that cooperates with zero or more ring-shaped members that are slipped concentrically over the distal end of the hollow tubular member to set the penetration depth of the coring needle. The tool can also include a stepped interface that is adapted to snag a root of a hair follicle unit cored by the hollow tubular member upon its withdrawal away from the patient's body.
摘要翻译：用于使一个或多个毛囊的一部分取芯的工具包括细长的中空管状构件，其中至少一个切口设置在其远端和近端之间。切口允许去除从开口的远侧末端向中空管状构件移动的碎屑。针还可以包括径向延伸的突起，其与零个或更多个环形构件配合，所述环形构件同心地滑过中空管状构件的远端以设定取芯针的穿透深度。该工具还可以包括阶梯式界面，该阶梯式界面适于在中空管状构件从患者身体撤出时由中空管状构件锁住毛囊单元的根部。

17. 发明申请

US20060189930A1 Methods and Apparatus for Sclerosing the Wall of a Varicose Vein 有权
标题翻译：用于硬化静脉曲张壁的方法和装置
公开(公告)号：US20060189930A1
公开(公告)日：2006-08-24
申请号：US11381372
申请日：2006-05-03
申请人： Banning Lary , Leonard Pinchuk , Saul Gottlieb , Charles Slater
发明人： Banning Lary , Leonard Pinchuk , Saul Gottlieb , Charles Slater
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61B17/320725 , A61B2017/22038 , A61B2017/22067 , A61B2017/22082 , A61M25/1011 , A61M2025/0004 , A61M2025/0175 , A61M2025/105 , A61M2025/1052 , A61M2025/1068
摘要： A preferred apparatus for delivering an intravascular drug such as a sclerosing agent (or a microfoam sclerosing agent) to a varicose vein includes a catheter having three concentric tubes. The innermost tube has a guide wire lumen and an inflation lumen. The distal end of the innermost tube has an integral inflatable occlusion balloon in fluid communication with the inflation lumen. The intermediate tube has a lumen through which the innermost tube extends. The distal end of the intermediate tube has a self-expanding balloon with a plurality of fluid pores in fluid communication with the intermediate tube lumen. The outer tube has a lumen through which the intermediate tube extends. Sclerosing agent is dispensed through the intermediate tube to pores located at the distal end of the intermediate tube or in the self-expanding balloon. Veins are sclerosed as the self-expanding balloon is pulled through and ultimately out of the vein.
摘要翻译：用于将诸如硬化剂（或微泡硬化剂）的血管内药物递送到静脉曲张的优选装置包括具有三个同心管的导管。最内管具有导丝管腔和充气腔。最内管的远端具有与膨胀腔流体连通的整体充气闭塞球囊。中间管具有内管，最内管延伸通过该内腔。中间管的远端具有自膨胀气囊，其具有与中间管腔流体连通的多个流体孔。外管具有中空管延伸通过的内腔。硬化剂通过中间管分配到位于中间管的远端或自膨胀气囊中的孔。静脉由于自膨胀的气囊被拉过并最终脱离静脉，因此是硬化的。

18. 发明授权

US07077836B2 Methods and apparatus for sclerosing the wall of a varicose vein 有权
公开(公告)号：US07077836B2
公开(公告)日：2006-07-18
申请号：US09898867
申请日：2001-07-03
申请人： Banning G. Lary , Leonard Pinchuk , Saul Gottlieb , Charles R. Slater
发明人： Banning G. Lary , Leonard Pinchuk , Saul Gottlieb , Charles R. Slater
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61B17/320725 , A61B2017/22038 , A61B2017/22067 , A61B2017/22082 , A61M25/1011 , A61M2025/0004 , A61M2025/0175 , A61M2025/105 , A61M2025/1052 , A61M2025/1068
摘要： A preferred apparatus for delivering an intravascular drug such as a sclerosing agent (or a microfoam sclerosing agent) to a varicose vein includes a catheter having three concentric tubes. The innermost tube has a guide wire lumen and an inflation lumen. The distal end of the innermost tube has an integral inflatable occlusion balloon in fluid communication with the inflation lumen. The intermediate tube has a lumen through which the innermost tube extends. The distal end of the intermediate tube has a self-expanding balloon with a plurality of fluid pores in fluid communication with the intermediate tube lumen. The outer tube has a lumen through which the intermediate tube extends. Sclerosing agent is dispensed through the intermediate tube to pores located at the distal end of the intermediate tube or in the self-expanding balloon. Veins are sclerosed as the self-expanding balloon is pulled through and ultimately out of the vein.

19. 发明申请

US20050125059A1 Ocular lens 有权
标题翻译：眼镜片
公开(公告)号：US20050125059A1
公开(公告)日：2005-06-09
申请号：US11004538
申请日：2004-12-03
申请人： Leonard Pinchuk , Jean-Marie Parel
发明人： Leonard Pinchuk , Jean-Marie Parel
IPC分类号： A61F2/16 , A61F9/00 , A61L27/16 , G02C20060101
CPC分类号： A61L27/16 , A61F2/1613 , A61F2/1629 , A61F2/1648 , A61F9/0017 , A61F2250/0067 , A61L27/54 , A61L2300/416 , A61L2430/16 , G02B1/041 , C08L53/02 , C08L23/22 , C08L25/08
摘要： An ocular lens has a refractive optics structure formed from a polyisobutylene-based material and a glassy segment that is non-reactive to ocular fluid and that maintains in vivo transparency for a substantial time period. The material has a central elastomeric polyolefinic block and thermoplastic end blocks (such as a triblock polymer backbone comprising polystyrene-polyisobutylene-polystyrene). The material is preferably flexible such that the refractive optics structure can be folded upon itself and introduced through a small scleral incision. The lens device includes an optic portion and preferably either an annular haptic element or one or more haptic elements adapted to rest within a capsular bag formed by a surgical procedure. A portion of the lens device may be loaded with at least one therapeutic agent that interferes with proliferation of the epithelial cells of the eye to protect against PCO.
摘要翻译：眼透镜具有由聚异丁烯基材料形成的折射光学结构和与眼液无反应性的玻璃质片段，并且在相当长的时间内维持体内透明度。该材料具有中心弹性聚烯烃嵌段和热塑性端嵌段（例如包含聚苯乙烯 - 聚异丁烯 - 聚苯乙烯的三嵌段聚合物主链）。该材料优选是柔性的，使得折射光学结构可以自身折叠并通过小的巩膜切口引入。透镜装置包括光学部分，并且优选地是环形触觉元件或适于搁置在通过外科手术形成的囊袋内的一个或多个触觉元件。透镜装置的一部分可以装载有至少一种治疗剂，其干扰眼睛上皮细胞的增殖以防止PCO。

20. 发明申请

US20050074399A1 Minimally invasive vascular surgery 有权
标题翻译：微创血管手术
公开(公告)号：US20050074399A1
公开(公告)日：2005-04-07
申请号：US10901409
申请日：2004-07-27
申请人： G. Lary , Leonard Pinchuk
发明人： G. Lary , Leonard Pinchuk
IPC分类号： A61M36/14
CPC分类号： A61K9/0019 , A61K47/02
摘要： A mixture for intravenous injection to treat damaged vascular structures contains a mixture of carbamide peroxide and a sclerosing agent. The injected mixture expresses blood from the affected vascular structure by formation of bubbles, in situ. The bubbles carry the sclerosing agent into contact with the lining of the vascular structure resulting in destruction. The size of the bubbles may be varied by adding hydrogen peroxide and varying the proportions of carbamide peroxide and hydrogen peroxide in the mixture.
摘要翻译：用于静脉注射以治疗受损血管结构的混合物含有过氧化脲和硬化剂的混合物。注射的混合物通过原位形成气泡从受影响的血管结构中表达血液。气泡携带硬化剂与血管结构的衬里接触导致破坏。可以通过加入过氧化氢和改变混合物中过氧化脲和过氧化氢的比例来改变气泡的大小。

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