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11. 发明授权

US06745960B1 Centrifugally rolling granulating device and method of treating powder and granular material using the device 有权
标题翻译：离心轧制造粒装置及使用该装置处理粉末和颗粒材料的方法
公开(公告)号：US06745960B1
公开(公告)日：2004-06-08
申请号：US10009299
申请日：2001-12-04
申请人： Nagayoshi Myo , Akira Iwasaki , Hiroshi Okada , Kuniaki Yamanaka , Koji Nagaoka , Mamoru Shiratori
发明人： Nagayoshi Myo , Akira Iwasaki , Hiroshi Okada , Kuniaki Yamanaka , Koji Nagaoka , Mamoru Shiratori
IPC分类号： B02C2324
CPC分类号： C04B41/009 , B01J2/14 , C04B41/52 , F27D1/0009 , F27D1/1652 , C04B41/4539 , C04B41/5031 , C04B41/5035 , C04B41/4527 , C04B41/5029 , C04B41/522 , C04B14/4625 , C04B30/02 , C04B14/4631
摘要： A centrifugal tumbling granulating apparatus 1 comprises a fixed wall 7 having a grain contact portion 7a which is in contact with powder grains 2 and of which a horizontal section is formed in a circular shape, and a rotating disk 5 provided a clearance 12 away from an inner side of the fixed wall 7 and rotating in a horizontal direction by a motor 13, wherein an air supply device 21 for supplying drying air 22 to an upper surface side of the rotating disk 5 is provided above the rotating disk 5. The air supply device 21 has a cylindrical straight tube portion 25, and an air supply port 23 formed in a cone shape, and is disposed in a centrifugal tumbling chamber 6 to be movable in an up-and-down direction. During a granulating step, the air supply device 21 stops to supply the dry air 22 and waits at an upper position H. After the granulation processing, the air supply device is lowered at a lower position L and supplies the dry air 22 onto the rotating disk 5 to dry granulated substances. As a result, the granulating apparatus capable of efficiently obtaining, in a single apparatus, spherical particles of which each particle size is small and which exist within a narrow range of particle size distribution and of which deviation from spherical form is small is provided.
摘要翻译：离心式翻滚造粒装置1包括固定壁7，该固定壁7具有与粉末颗粒2接触并且水平部分形成为圆形的颗粒接触部分7a，以及设置有远离固定壁7的内侧并通过马达13在水平方向上旋转，其中，在旋转盘5的上方设置有用于将干燥空气22供给到旋转盘5的上表面侧的供气装置21。装置21具有圆柱形直管部分25和形成为锥形的空气供给口23，并且设置在离心翻转室6中以能够沿上下方向移动。在制粒步骤期间，空气供给装置21停止供给干燥空气22并在上部位置H等待。在造粒处理之后，供气装置在下部位置L下降，并将干燥空气22供给到旋转盘5干燥造粒物质。结果，能够在单个装置中有效地获得颗粒尺寸小的并且存在于窄的粒度分布范围内并且与球形的偏离小的球形颗粒的造粒装置。

12. 发明授权

US06346402B1 (S)-&agr;-phenethylamine: pyruvate transaminase 失效
标题翻译：（S）-α-苯乙胺：丙酮酸转氨酶
公开(公告)号：US06346402B1
公开(公告)日：2002-02-12
申请号：US09582764
申请日：2000-06-30
申请人： Akira Iwasaki , Yukio Yamada , Yasuhiro Ikenaka , Yoshihiko Yasohara , Junzo Hasegawa
发明人： Akira Iwasaki , Yukio Yamada , Yasuhiro Ikenaka , Yoshihiko Yasohara , Junzo Hasegawa
IPC分类号： C12P1304
CPC分类号： C12N9/1096 , C12P41/006
摘要： Relating to an enzyme capable of efficiently converting a ketone compound to an optically active amino compound by transamination, and a process for preparing an optically active amino compound using the enzyme. An (S)-&agr;-phenethylamine:pyruvate transaminase, which acts on (S)-&agr;-phenethylamine and a ketone compound, thereby catalyzing transamination for forming acetophenone and an amino compound corresponding to the ketone compound; a process for preparing an optically active amino compound using the transaminase; and a method for culturing a microorganism for producing the above transaminase, comprising adding to a medium one or more compounds selected from the group consisting of propylamine, 1-butylamine, 2-butylamine, 2-pentylamine, isopropylamine and isobutylamine as an inducer for the enzyme when a microorganism for producing (S)-&agr;-phenethylamine:pyruvate transaminase is cultured.
摘要翻译：关于能够通过转氨酶有效地将酮化合物转化为光学活性氨基化合物的酶，以及使用该酶制备光学活性氨基化合物的方法。（S）-α-苯乙胺：丙酮酸转氨酶，其作用于（S）-α-苯乙胺和酮化合物，从而催化转氨酶形成苯乙酮和对应于酮化合物的氨基化合物; 使用转氨酶制备光学活性氨基化合物的方法; 以及培养用于制备上述转氨酶的微生物的方法，包括向培养基中加入一种或多种选自丙胺，1-丁胺，2-丁胺，2-戊胺，异丙胺和异丁胺的化合物作为诱导剂用于生产（S）-α-苯乙胺：丙酮酸转氨酶的微生物培养时的酶。

13. 发明授权

US4724714A Rack-and-pinion steering gear device 失效
标题翻译：机架式小齿轮转向装置
公开(公告)号：US4724714A
公开(公告)日：1988-02-16
申请号：US922735
申请日：1986-10-24
申请人： Akira Iwasaki , Takeomi Miyoshi
发明人： Akira Iwasaki , Takeomi Miyoshi
IPC分类号： B62D3/12 , F16H19/00 , F16H55/18 , F16H55/28 , F16H35/06
CPC分类号： F16H19/04 , B62D3/12 , F16H55/28 , F16H55/18 , Y10T74/19565 , Y10T74/1967 , Y10T74/19898
摘要： A rack-and-pinion steering gear device has a mechanism for adjusting backlash and eliminating lost motion or play between a rack and a pinion. The pinion is formed on a pinion shaft angularly movably supported by a pinion holder, the pinion shaft having an axis out of alignment with the central axis of the pinion holder. The pinion holder is angularly movably supported in a housing such that the relative positions of these components with respect to each other are adjustable. A subpinion is supported on the pinion shaft for angular movement with respect to the pinion, the pinion and the subpinion being held in mesh with the rack. The subpinion is normally urged by a resilient member in a direction to turn with respect to the pinion. By adjustably turning the pinion holder with respect to the housing, the backlash between the rack and the pinion is adjusted and the lost motion or play between the rack and the pinion is eliminated by the subpinion.
摘要翻译：齿条齿轮转向装置具有用于调节齿隙并消除齿条和小齿轮之间的运动或游隙的机构。小齿轮形成在由小齿轮保持器成角度地移动地支撑的小齿轮轴上，小齿轮轴具有与小齿轮保持器的中心轴线不对准的轴线。小齿轮保持器角度地可移动地支撑在壳体中，使得这些部件相对于彼此的相对位置是可调节的。副棘爪支撑在小齿轮轴上，用于相对于小齿轮角度运动，小齿轮和副压力保持与齿条啮合。副角通常由相对于小齿轮转动的方向由弹性构件推动。通过相对于壳体可调节地转动小齿轮保持器，调节齿条和小齿轮之间的间隙，并且齿条和小齿轮之间的空动或播放通过副压头消除。

14. 发明授权

US09315782B2 Isolated DNA encoding protein having improved stability 有权
标题翻译：编码具有改善的稳定性的蛋白质的分离的DNA
公开(公告)号：US09315782B2
公开(公告)日：2016-04-19
申请号：US13574458
申请日：2011-01-19
申请人： Shinichi Yoshida , Akira Iwasaki , Motohisa Washida , Tozo Nishiyama , Daisuke Moriyama , Naoaki Taoka
发明人： Shinichi Yoshida , Akira Iwasaki , Motohisa Washida , Tozo Nishiyama , Daisuke Moriyama , Naoaki Taoka
IPC分类号： C07H21/00 , C12N15/00 , C12N15/53 , C12N1/21 , C12N5/10 , C12N1/15 , C12N9/08 , C12N9/02 , C12P19/36 , C12P7/02 , C12P7/18 , C12P7/42 , C12P13/04
CPC分类号： C12N9/0036 , C12N9/0065 , C12P7/02 , C12P7/18 , C12P7/42 , C12P13/04 , C12P19/36 , C12Y106/03 , C12Y106/03001 , C12Y111/01001
摘要： Water-forming NADH oxidase derived from Streptococcus mutans should be further improved in terms of stability for practical use in industrial production. An object of the present invention is to provide an enzyme that is obtained through modification of a water-forming NADH oxidase, which is useful as an NAD+ regeneration system for stereoselective oxidation catalyzed by an oxidoreductase, by protein engineering techniques so that the enzyme can withstand long-term use without exhibiting a reduction of its activity for the regeneration of NAD+, that is, an enzyme having improved stability, and to provide a method for efficiently producing a useful substance such as an optically active alcohol or amino acid. The present invention relates to an enzyme modification method that can improve the stability of water-forming NADH oxidase derived from Streptococcus mutans by appropriately introducing mutation.
摘要翻译：来自变形链球菌的成水NADH氧化酶在工业生产实际使用的稳定性方面应进一步提高。本发明的目的是提供通过蛋白质工程技术，通过改性水合NADH氧化酶获得的酶，其可用作由氧化还原酶催化的用于立体选择性氧化的NAD +再生系统，使得酶能够承受长期使用而不显示其NAD +再生活性的活性降低，即稳定性提高的酶，以及提供有效生产光学活性醇或氨基酸等有用物质的方法。本发明涉及通过适当地引入突变来提高来自变形链球菌的水形成NADH氧化酶的稳定性的酶修饰方法。

15. 发明授权

US07315625B2 Sound apparatus, method of changing sound characteristics, and data recording medium on which a sound correction program 失效
标题翻译：声音设备，改变声音特性的方法以及声音校正程序的数据记录介质
公开(公告)号：US07315625B2
公开(公告)日：2008-01-01
申请号：US10743025
申请日：2003-12-23
申请人： Akira Iwasaki , Momotoshi Furunobu
发明人： Akira Iwasaki , Momotoshi Furunobu
IPC分类号： G06F17/00 , H04R29/00 , H03G3/00
CPC分类号： H04S7/30 , H04R5/04 , H04R29/00 , H04R29/001
摘要： This invention is a sound apparatus having a plurality of different kinds of speakers and that independently performs correction of the sound signal for each speaker to obtain optimum sound and sound field. This sound apparatus has an output device that receives audio signals and outputs sound, and comprises: a correction device for correcting the audio signals that are input to each of the output devices; and a correction-characteristic-setting device which sets correction characteristic for each of the output devices; and where the correction device correct the audio signals based on the set correction characteristic.
摘要翻译：本发明是具有多种不同种类的扬声器的声音设备，并且独立地对每个扬声器进行声音信号的校正以获得最佳的声音和声场。该声音设备具有接收音频信号并输出声音的输出设备，包括：用于校正输入到每个输出设备的音频信号的校正设备; 以及校正特性设定装置，其对每个输出装置设定校正特性; 并且其中校正装置基于所设置的校正特性校正音频信号。

16. 发明申请

US20070292923A1 Process For Production Of Enantiomer-Enriched Compounds 审中-公开
标题翻译：富含对映异构体的化合物的制备方法
公开(公告)号：US20070292923A1
公开(公告)日：2007-12-20
申请号：US11659473
申请日：2005-08-01
申请人： Akira Iwasaki , Motohisa Washida , Junzou Hasegawa
发明人： Akira Iwasaki , Motohisa Washida , Junzou Hasegawa
IPC分类号： C12P19/36 , C12N1/20 , C12N15/00 , C12N9/02 , C12N9/14
CPC分类号： C12P41/002 , C12P7/16 , C12P7/22 , Y02E50/10
摘要： The present invention relates to a production method of an enantiomer-enriched compound, which includes the following (1) and (2): (1) contacting an enantiomer mixture with a stereoselective dehydrogenase, for which NAD+ (nicotinamide adenine dinucleotide) is a coenzyme, thereby preferentially oxidizing one enantiomer and leaving the other enantiomer to form NADH, and (2) contacting the NADH formed by the oxidation reaction in (1) with a water-forming NADH oxidase stable under oxidative conditions to convert the NADH to NAD+. According to the present invention, in the production of an enantiomer-enriched compound from an enantiomer mixture, which uses a dehydrogenase, NAD+ can be regenerated even without addition of a stabilizer and an enantiomer-enriched compound can be obtained efficiently.
摘要翻译：本发明涉及富含对映异构体的化合物的制备方法，其包括以下（1）和（2）：（1）使对映异构体混合物与立体选择性脱氢酶接触，其中NAD +（烟酰胺腺嘌呤二核苷酸）是辅酶，从而优先氧化一种对映异构体并使另一种对映异构体形成NADH，和（2）使（1）中的氧化反应形成的NADH与在氧化条件下稳定的水形式的NADH氧化酶接触以将NADH转化为NAD +。根据本发明，在使用脱氢酶的对映异构体混合物的富含对映体的化合物的制造中，即使不添加稳定剂也能够再生NAD +，能够有效地获得富含对映体的化合物。

17. 发明申请

US20070026510A1 Process for biochemical production of glyoxylic acid 审中-公开
标题翻译：乙醛酸生化生产工艺
公开(公告)号：US20070026510A1
公开(公告)日：2007-02-01
申请号：US10544618
申请日：2004-02-13
申请人： Akira Iwasaki , Takehiro Matsumoto , Motohisa Washida , Hiroshi Watanabe , Junzou Hasegawa , Sakayu Shimizu
发明人： Akira Iwasaki , Takehiro Matsumoto , Motohisa Washida , Hiroshi Watanabe , Junzou Hasegawa , Sakayu Shimizu
IPC分类号： C12P7/50 , C12N1/20
CPC分类号： C12P7/40
摘要： The present invention provides an industrially advantageous process for biochemical production of glyoxylic acid from glyoxal. More specifically, the present invention provides a process for production of glyoxylic acid, which is characterized in that the process comprises allowing oxidoreductase that can convert glyoxal into glyoxylic acid, such as oxidase and dehydrogenase, to act on glyoxal, so as to convert glyoxal into glyoxylic acid.
摘要翻译：本发明提供了从乙二醛生物化生产乙醛酸的工业上有利的方法。更具体地说，本发明提供了一种生产乙醛酸的方法，其特征在于该方法包括允许将乙二醛转化为乙醛酸（如氧化酶和脱氢酶）的氧化还原酶作用于乙二醛，从而将乙二醛转化为乙醛酸。

18. 发明授权

US4838576A Impact energy absorbing mechanism for a steering device of a motor vehicle 失效
标题翻译：机动车转向装置的冲击能量吸收机构
公开(公告)号：US4838576A
公开(公告)日：1989-06-13
申请号：US227928
申请日：1988-08-03
申请人： Yoshito Hamasaki , Akira Iwasaki , Hiroaki Sue
发明人： Yoshito Hamasaki , Akira Iwasaki , Hiroaki Sue
IPC分类号： B62D1/19
CPC分类号： B62D1/195
摘要： An impact energy absorbing mechanism for a steering device of a motor vehicle includes guides each having a generally U-shaped guide surface. Each guide is mounted to a steering column which is movable in the axial direction when the operator's body is thrown out onto a steering wheel due a collision of the vehicle. A retaining portion is provided integrally with the guide and at a predetermined distance from the guide surface. An absorbing plate is fixed at one end to the vehicle body and left free at the other end. The free end of the absorbing plate is inserted and retained in a gap defined between the guide surface and retaining portion of the guide, so that the absorbing plate is held in a generally U-shaped bent position along the guide surface. When the guide is moved together with the steering column, the bent portion of the absorbing plate is sequentially shifted while maintaining the shape which is defined by the guide, thereby absorbing impact energy.
摘要翻译：用于机动车辆的转向装置的冲击能量吸收机构包括各自具有大致U形的引导表面的引导件。每个引导件安装到转向柱上，当转向柱由于车辆的碰撞而将操作者的身体甩出方向盘时，可以沿轴向移动。保持部分与引导件一体地设置并且与引导表面预定距离。吸收板一端固定在车体上，另一端固定。吸收板的自由端被插入并保持在限定在引导件的引导表面和保持部分之间的间隙中，使得吸收板沿着引导表面保持在大致U形的弯曲位置。当引导件与转向柱一起移动时，吸收板的弯曲部分依次移动，同时保持由引导件限定的形状，从而吸收冲击能量。

19. 发明授权

US4310108A Aerosol sprayer with pressure reservoir 失效
标题翻译：气压喷雾器带压力贮存器
公开(公告)号：US4310108A
公开(公告)日：1982-01-12
申请号：US176448
申请日：1980-08-08
申请人： Shimesu Motoyama , Shuri Yamada , Kaoru Kurita , Akira Iwasaki
发明人： Shimesu Motoyama , Shuri Yamada , Kaoru Kurita , Akira Iwasaki
IPC分类号： B65D83/14 , G05D16/06 , B65D83/00
CPC分类号： B65D83/663 , G05D16/0655 , Y10T137/7808
摘要： An aerosol sprayer, which comprises a can for accommodating an aerosol material which is provided with a spray nozzle and connected with a pressure regulator, and a small-sized bomb which is charged with a highly compressed gas and connected with said pressure regulator.
摘要翻译：一种气溶胶喷雾器，其包括用于容纳设置有喷嘴并与压力调节器连接的气溶胶材料的罐，以及装有高压缩气体并与所述压力调节器连接的小型炸弹。

20. 发明授权

US07169592B2 Producing optically active amino compounds 有权
标题翻译：生产光学活性氨基化合物
公开(公告)号：US07169592B2
公开(公告)日：2007-01-30
申请号：US10112706
申请日：2002-04-02
申请人： Yukio Yamada , Akira Iwasaki , Noriyuki Kizaki , Keiji Matsumoto , Yasuhiro Ikenaka , Masahiro Ogura , Junzo Hasegawa
发明人： Yukio Yamada , Akira Iwasaki , Noriyuki Kizaki , Keiji Matsumoto , Yasuhiro Ikenaka , Masahiro Ogura , Junzo Hasegawa
IPC分类号： C12N9/10 , C12N1/21 , C12N15/54 , C12N15/63 , C12N15/82 , C12N15/85 , C07H21/04
CPC分类号： C12P13/001 , C12N9/1096
摘要： To provide a method for preparing optically active compounds, which mainly contain (R)-amino compounds, by microbial enzymes efficiently and inexpensively; a polypeptide having stereoselective transaminase activity which can be suitably used for the above preparation method; and a DNA encoding the polypeptide. A method for preparing an optically active amino compound, characterized in stereoselectively transaminating by acting a transaminase on an amino group acceptor, a ketone compound in the presence of an amino group donor, a primary amine; a DNA comprising a nucleotide sequence encoding a polypeptide having stereoselective transaminase activity; and a polypeptide having stereoselective transaminase activity obtainable from a culture of a microorganism belonging to the genus Arthrobacter.
摘要翻译：提供通过微生物酶有效且廉价地制备主要含有（R） - 氨基化合物的光学活性化合物的方法; 具有立体选择性转氨酶活性的多肽，可适用于上述制备方法; 和编码该多肽的DNA。一种制备光学活性氨基化合物的方法，其特征在于通过在氨基受体上起转氨酶的作用，在氨基供体存在下的酮化合物，伯胺，立体选择性转氨酶; 包含编码具有立体选择性转氨酶活性的多肽的核苷酸序列的DNA; 和具有立体选择性转氨酶活性的多肽，其可从属于节杆菌属的微生物的培养物获得。

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