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11. 发明授权

US07198890B2 Method for quantitatively determining homocysteine and a reagent for quantitative determination of homocysteine 有权
标题翻译：用于定量测定同型半胱氨酸的方法和用于定量测定同型半胱氨酸的试剂
公开(公告)号：US07198890B2
公开(公告)日：2007-04-03
申请号：US10755236
申请日：2004-01-13
申请人： Hiroyuki Ebinuma , Takami Sarashina , Takuji Matsumoto , Masahiro Sekiguchi , Koji Ushizawa
发明人： Hiroyuki Ebinuma , Takami Sarashina , Takuji Matsumoto , Masahiro Sekiguchi , Koji Ushizawa
IPC分类号： C12Q1/00 , C12N9/00 , C07K1/00
CPC分类号： G01N33/6812 , G01N2333/90241
摘要： The present invention provides a method for quantitatively determining homocysteine in a biological specimen containing homocysteine and cysteine by use of an enzyme which is capable of forming hydrogen sulfide both from homocysteine and from cysteine, which comprises (a) reacting the biological specimen with cysteine dioxygenase in the absence of a reducing agent, (b) subsequently reacting the resultant specimen of (a) with a reducing agent and the enzyme which is capable of forming hydrogen sulfide both from homocysteine and from cysteine, and (c) measuring the concentration of the hydrogen sulfide thus obtained to determine the homocysteine concentration in the biological specimen; and a reagent for such a quantitative determination of homocysteine.
摘要翻译：本发明提供了一种通过使用能够从高半胱氨酸和半胱氨酸形成硫化氢的酶来定量测定含有同型半胱氨酸和半胱氨酸的生物样品中的同型半胱氨酸的方法，其包括（a）使生物样品与半胱氨酸双加氧酶在不存在还原剂，（b）随后使（a）的所得样品与还原剂和能够从高半胱氨酸和半胱氨酸形成硫化氢的酶反应，和（c）测量氢的浓度硫化物，以确定生物样品中的同型半胱氨酸浓度; 和用于定量测定同型半胱氨酸的试剂。

12. 发明申请

US20070054344A1 Novel fructosyl peptide oxidase and utilization thereof 有权
标题翻译：新型果糖基肽氧化酶及其利用
公开(公告)号：US20070054344A1
公开(公告)日：2007-03-08
申请号：US10531305
申请日：2003-10-23
申请人： Hiroyuki Ebinuma
发明人： Hiroyuki Ebinuma
IPC分类号： C12Q1/37 , C12P21/06 , C12N9/24
CPC分类号： C07K14/805 , C12N9/0022 , C12N9/2402 , C12P21/00 , C12P21/005 , C12Q1/26 , C12Q1/34 , G01N33/68 , G01N33/725 , G01N2400/00
摘要： The present invention is directed to a defructosylation enzyme originating from a plant, a method of defructosylating a fructosylated peptide or protein through use of the enzyme, and a method of measuring a fructosylated peptide or protein.
摘要翻译：本发明涉及来自植物的脱甲硅烷基化酶，通过使用酶使果糖基化肽或蛋白质去结构化的方法，以及测量果糖基化肽或蛋白质的方法。

13. 发明申请

US20050153385A1 Method for quantitatively determining homocysteine and a reagent for quantitative determination of homocysteine 有权
标题翻译：用于定量测定同型半胱氨酸的方法和用于定量测定同型半胱氨酸的试剂
公开(公告)号：US20050153385A1
公开(公告)日：2005-07-14
申请号：US10755236
申请日：2004-01-13
申请人： Hiroyuki Ebinuma , Takami Sarashina , Takuji Matsumoto , Masahiro Sekiguchi , Koji Ushizawa
发明人： Hiroyuki Ebinuma , Takami Sarashina , Takuji Matsumoto , Masahiro Sekiguchi , Koji Ushizawa
IPC分类号： C12Q1/26 , C12Q1/527 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6812 , G01N2333/90241
摘要： The present invention provides a method for quantitatively determining homocysteine in a biological specimen containing homocysteine and cysteine by use of an enzyme which is capable of forming hydrogen sulfide both from homocysteine and from cysteine, which comprises (a) reacting the biological specimen with cysteine dioxygenase in the absence of a reducing agent, (b) subsequently reacting the resultant specimen of (a) with a reducing agent and the enzyme which is capable of forming hydrogen sulfide both from homocysteine and from cysteine, and (c) measuring the concentration of the hydrogen sulfide thus obtained to determine the homocysteine concentration in the biological specimen; and a reagent for such a quantitative determination of homocysteine.
摘要翻译：本发明提供了一种通过使用能够从高半胱氨酸和半胱氨酸形成硫化氢的酶来定量测定含有同型半胱氨酸和半胱氨酸的生物样品中的同型半胱氨酸的方法，其包括（a）使生物样品与半胱氨酸双加氧酶在不存在还原剂，（b）随后使（a）的所得样品与还原剂和能够从高半胱氨酸和半胱氨酸形成硫化氢的酶反应，和（c）测量氢的浓度硫化物，以确定生物样品中的同型半胱氨酸浓度; 和用于定量测定同型半胱氨酸的试剂。

14. 发明授权

US08212925B2 Sync separation circuit 有权
标题翻译：同步分离电路
公开(公告)号：US08212925B2
公开(公告)日：2012-07-03
申请号：US12249515
申请日：2008-10-10
申请人： Toru Okada , Hiroyuki Ebinuma
发明人： Toru Okada , Hiroyuki Ebinuma
IPC分类号： H04N5/08 , H04N5/10
CPC分类号： H04N5/08
摘要： A sync separation circuit separates a synchronizing signal from a video signal containing the synchronizing signal. A minimum level detecting section detects a minimum level of a video signal. A sync tip level detecting section detects a sync tip level in the video signal. A pedestal level detecting section detects a pedestal level in the video signal. Based on both the sync tip level detected by the sync tip level detecting section and the pedestal level control by the pedestal level detecting section, a slice level setting section sets a slice level corresponding to an intermediate value between the sync tip level and the pedestal level. The slice level control section sets the slice level based on the minimum level detected by the minimum level detecting section if the slice level set based on the sync tip level and the pedestal level is inappropriate.
摘要翻译：同步分离电路从包含同步信号的视频信号中分离同步信号。最小电平检测部分检测视频信号的最小电平。同步尖端电平检测部分检测视频信号中的同步尖端电平。基座电平检测部分检测视频信号中的基座电平。基于由同步尖端电平检测部检测到的同步尖端电平和基准电平检测部分的基座电平控制，限幅电平设定部分设定与同步电位电平和基准电平之间的中间值相对应的限幅电平。如果基于同步尖端级别和基座级别设置的限幅电平不合适，则限幅电平控制部分基于由最小电平检测部分检测到的最小电平来设置限幅电平。

15. 发明授权

US08039223B2 Method of selectively assaying adiponectin multimers 有权
标题翻译：选择性测定脂连蛋白多聚体的方法
公开(公告)号：US08039223B2
公开(公告)日：2011-10-18
申请号：US12468440
申请日：2009-05-19
申请人： Hiroyuki Ebinuma , Hirokazu Yago , Yuka Akimoto , Osamu Miyazaki , Takashi Kadowaki , Toshimasa Yamauchi , Kazuo Hara
发明人： Hiroyuki Ebinuma , Hirokazu Yago , Yuka Akimoto , Osamu Miyazaki , Takashi Kadowaki , Toshimasa Yamauchi , Kazuo Hara
IPC分类号： G01N33/53
CPC分类号： G01N33/74 , G01N2800/042 , G01N2800/32
摘要： Kits and methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of adiponectin multimers and provide information that cannot be obtained through measurement of the total amount of adiponectin alone. A method for selectively assaying a target adiponectin multimer in a biological sample comprising distinguishing target adiponectin multimer from the other adiponectin multimers by using a protease and/or an antibody.
摘要翻译：用于选择性测定生物样品中目标脂联素多聚体的试剂盒和方法。这种方法通过脂联素多聚体的选择性测定来准确地评估疾病与脂联素之间的关系，并提供通过单独测量脂连蛋白的总量不能获得的信息。一种用于选择性测定生物样品中的目标脂联素多聚体的方法，包括通过使用蛋白酶和/或抗体将目标脂连蛋白多聚体与其它脂联素多聚体区分开。

16. 发明授权

US07829294B2 Anti-human soluble fibrin monoclonal antibody and immunological assay method using the antibody 有权
标题翻译：抗人溶性纤维蛋白单克隆抗体和免疫测定法使用抗体
公开(公告)号：US07829294B2
公开(公告)日：2010-11-09
申请号：US11722998
申请日：2005-12-27
申请人： Masanao Matsuo , Hiroyuki Ebinuma , Osamu Miyazaki , Kyoko Tanaka , Akiko Suzuki
发明人： Masanao Matsuo , Hiroyuki Ebinuma , Osamu Miyazaki , Kyoko Tanaka , Akiko Suzuki
IPC分类号： G01N33/543 , G01N33/573 , G01N33/577 , C07K16/36 , C12N5/20 , C12P21/08
CPC分类号： C07K16/18 , C07K14/745 , C07K14/75 , G01N33/86 , G01N2333/75 , G01N2800/224
摘要： The present invention is directed to a monoclonal antibody against a soluble fibrin, which specifically recognizes a conformation-changed site newly occurred in a C-terminal region of an Aα-chain of the soluble fibrin formed through thrombin digestion of fibrinogen. The present invention is also directed to a hybridoma which produces the antibody, an immunological assay method employing the antibody, and a method for evaluating hypercoagulability in a test sample by measuring the soluble fibrin level in the sample with the assay method. Through employment of the monoclonal antibody of the present invention, soluble fibrin on which plasmin has not acted, which reflects exclusively initial hypercoagulability, can be specifically detected.
摘要翻译：本发明涉及针对可溶性纤维蛋白的单克隆抗体，其特异性识别通过纤维蛋白原凝血酶消化形成的可溶性纤维蛋白的Aα链的C末端区域中新发生的构象改变部位。本发明还涉及产生抗体的杂交瘤，使用抗体的免疫测定方法，以及通过使用测定方法测量样品中的可溶性纤维蛋白水平来评估测试样品中的高凝状态的方法。通过使用本发明的单克隆抗体，可以特异性检测仅反映初始高凝状态的纤维蛋白溶酶未起作用的可溶性纤维蛋白。

17. 发明申请

US20090096926A1 AUTOMATIC GAIN CONTROL CIRCUIT IN VIDEO SIGNAL PROCESSING DEVICE 有权
标题翻译：视频信号处理装置中的自动增益控制电路
公开(公告)号：US20090096926A1
公开(公告)日：2009-04-16
申请号：US12249528
申请日：2008-10-10
申请人： Hirotoshi Mori , Hiroyuki Ebinuma
发明人： Hirotoshi Mori , Hiroyuki Ebinuma
IPC分类号： H03M1/12 , H04N5/52
CPC分类号： H04N5/52 , H04N5/08
摘要： In an automatic gain control circuit comprising a black level detecting unit which detects a black level from a video signal, a white level detecting unit which detects a white level from the video signal, and an analog-to-digital converter which adjusts a dynamic range of the video signal based on a difference value between the black level and the white level, a video signal for adjustment including a black level which indicates a minimum brightness of a video image and a white level which indicates a maximum brightness of the video image is input and the dynamic range is adjusted.
摘要翻译：在包括从视频信号检测黑电平的黑电平检测单元的自动增益控制电路中，从视频信号中检测白电平的白电平检测单元和调整动态范围的模数转换器基于黑电平和白电平之间的差值的视频信号，包括指示视频图像的最小亮度的黑电平的调整用视频信号和表示视频图像的最大亮度的白电平是输入和动态范围进行调整。

18. 发明申请

US20070154879A1 METHOD FOR QUANTITATIVELY DETERMINING A SPECIFIC COMPONENT IN A BIOLOGICAL SPECIMEN, AND REAGENT FOR QUANTITATIVE DETERMINATION 有权
标题翻译：定量测定生物样本中特定成分的方法和定量测定试剂
公开(公告)号：US20070154879A1
公开(公告)日：2007-07-05
申请号：US11684827
申请日：2007-03-12
申请人： Hiroyuki Ebinuma , Kumiko Yuki
发明人： Hiroyuki Ebinuma , Kumiko Yuki
IPC分类号： C12Q1/00 , C12Q1/26
CPC分类号： C12Q1/32
摘要： A method for quantitatively determining a specific component in a biological specimen, which includes reacting a biological specimen, in the presence of an electron acceptor, with an enzyme which has an ability, by the dehydrogenation reaction, to oxidize the specific component or a substance derived from the specific component, and measuring the formed reductant of the electron acceptor, wherein the method avoids the influence of hemoglobin effectively if any contained in the specimen by using a measuring reagent containing albumin, thereby making an quantitative determination of the target component accurately; and a reagent for the quantitative determination.
摘要翻译：一种用于定量测定生物样本中的特定成分的方法，其包括使生物样品在电子受体存在下与通过脱氢反应具有能够氧化特定成分或衍生物质的酶反应的酶测定形成的电子受体的还原剂，其中，通过使用含有白蛋白的测定试剂，如果含有试样中的任何含量，则可有效地避免血红蛋白的影响，从而准确地定量确定目标成分; 和用于定量测定的试剂。

19. 发明授权

US07198905B2 Method of screening methods prediabetic state and screening reagent 有权
标题翻译：筛选方法前驱糖尿病状态和筛选试剂方法
公开(公告)号：US07198905B2
公开(公告)日：2007-04-03
申请号：US10471823
申请日：2002-03-01
申请人： Hiroyuki Ebinuma , Kazunori Saito , Hirohito Sone , Nobuhiro Yamada
发明人： Hiroyuki Ebinuma , Kazunori Saito , Hirohito Sone , Nobuhiro Yamada
IPC分类号： C12Q1/32
CPC分类号： G01N33/66
摘要： The present invention provides a screening method by which a prediabetic state can be more accurately determined and many test samples can be treated without physical burden on patients, and a diagnostic reagent used for it. By measuring a D-mannose concentration, preferably a D-mannose concentration and a glucose concentration, in a body fluid collected from a subject, and comparing them with their respective standard values, a patient in a prediabetic state can be detected. Further, the measurement of the mannose concentration is conducted by allowing an enzyme having an oxidizing activity on mannose by dehydrogenation to react on the mannose in a sample in the presence of an electron acceptor, and quantitatively determining the formed reductant of the electron acceptor.
摘要翻译：本发明提供了一种筛选方法，通过该方法能够更准确地确定前列腺状态，并且可以对患者进行治疗而不会对身体造成负担的许多测试样品以及用于其的诊断试剂。通过在从受试者收集的体液中测量D-甘露糖浓度，优选D-甘露糖浓度和葡萄糖浓度，并将其与它们各自的标准值进行比较，可以检测患有糖尿病状态的患者。此外，甘露糖浓度的测定是通过在电子受体的存在下，使通过脱氢使对甘露糖具有氧化活性的酶在样品中与甘露糖反应，并定量测定形成的电子受体的还原剂来进行的。

20. 发明申请

US20050164330A1 Method for quantitatively determining a specific component in a biological specimen, and reagent for quantitative determination 审中-公开
标题翻译：用于定量测定生物样本中特定组分的方法和用于定量测定的试剂
公开(公告)号：US20050164330A1
公开(公告)日：2005-07-28
申请号：US10764455
申请日：2004-01-27
申请人： Hiroyuki Ebinuma , Kumiko Yuki
发明人： Hiroyuki Ebinuma , Kumiko Yuki
IPC分类号： C12Q1/26 , C12Q1/32
CPC分类号： C12Q1/32
摘要： A method for quantitatively determining a specific component in a biological specimen, which includes reacting a biological specimen, in the presence of an electron acceptor, with an enzyme which has an ability, by the dehydrogenation reaction, to oxidize the specific component or a substance derived from the specific component, and measuring the formed reductant of the electron acceptor, wherein the method avoids the influence of hemoglobin effectively if any contained in the specimen by using a measuring reagent containing albumin, thereby making an quantitative determination of the target component accurately; and a reagent for the quantitative determination.
摘要翻译：一种用于定量测定生物样本中的特定成分的方法，其包括使生物样品在电子受体存在下与通过脱氢反应具有能够氧化特定成分或衍生物质的酶反应的酶测定形成的电子受体的还原剂，其中，通过使用含有白蛋白的测定试剂，如果含有试样中的任何含量，则可有效地避免血红蛋白的影响，从而准确地定量确定目标成分; 和用于定量测定的试剂。

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