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1. 发明授权

US07198905B2 Method of screening methods prediabetic state and screening reagent 有权
标题翻译：筛选方法前驱糖尿病状态和筛选试剂方法
公开(公告)号：US07198905B2
公开(公告)日：2007-04-03
申请号：US10471823
申请日：2002-03-01
申请人： Hiroyuki Ebinuma , Kazunori Saito , Hirohito Sone , Nobuhiro Yamada
发明人： Hiroyuki Ebinuma , Kazunori Saito , Hirohito Sone , Nobuhiro Yamada
IPC分类号： C12Q1/32
CPC分类号： G01N33/66
摘要： The present invention provides a screening method by which a prediabetic state can be more accurately determined and many test samples can be treated without physical burden on patients, and a diagnostic reagent used for it. By measuring a D-mannose concentration, preferably a D-mannose concentration and a glucose concentration, in a body fluid collected from a subject, and comparing them with their respective standard values, a patient in a prediabetic state can be detected. Further, the measurement of the mannose concentration is conducted by allowing an enzyme having an oxidizing activity on mannose by dehydrogenation to react on the mannose in a sample in the presence of an electron acceptor, and quantitatively determining the formed reductant of the electron acceptor.
摘要翻译：本发明提供了一种筛选方法，通过该方法能够更准确地确定前列腺状态，并且可以对患者进行治疗而不会对身体造成负担的许多测试样品以及用于其的诊断试剂。通过在从受试者收集的体液中测量D-甘露糖浓度，优选D-甘露糖浓度和葡萄糖浓度，并将其与它们各自的标准值进行比较，可以检测患有糖尿病状态的患者。此外，甘露糖浓度的测定是通过在电子受体的存在下，使通过脱氢使对甘露糖具有氧化活性的酶在样品中与甘露糖反应，并定量测定形成的电子受体的还原剂来进行的。

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