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11. 发明申请

US20050288490A1 Modified bio-related substance, process for producing the same, and intermediate 有权
标题翻译：改性生物相关物质，其生产方法和中间体
公开(公告)号：US20050288490A1
公开(公告)日：2005-12-29
申请号：US11142255
申请日：2005-06-02
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： A61K47/48 , A61P43/00 , C07C43/13 , C07C43/164 , C07K14/47 , C08G65/26 , C08G65/28 , C08G65/329 , C08G85/00 , A61K35/14
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
摘要翻译：一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA 1 和/或O 2各自为具有2〜4个碳原子的氧化烯基，由R表示的基团在一个分子中彼此相同或不同， SUP> 2个在一个分子中彼此相同或不同，n和m各自是加成的氧化烯基的平均摩尔数，n表示0〜1000，m表示10〜1000。

12. 发明申请

US20050058620A1 Modified bio-related substance, process for producing the same, and intermediate 审中-公开
标题翻译：改性生物相关物质，其生产方法和中间体
公开(公告)号：US20050058620A1
公开(公告)日：2005-03-17
申请号：US10716432
申请日：2003-11-20
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： A61K47/48 , A61P43/00 , C07C43/13 , C07C43/164 , C07K14/47 , C08G65/26 , C08G65/28 , C08G65/329 , C08G85/00 , A61K31/765 , C08G59/14
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, R and OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
摘要翻译：一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA 1和 OA 2各自为具有2〜4个碳原子的氧化烯基，R 1和OA 2在一个分子中相同或不同，n和m各自是加入的氧化烯基的平均摩尔数，n 表示0〜1000，m表示10〜1000。

13. 发明授权

US10040761B2 Branched hetero polyethylene glycol and intermediate 有权
公开(公告)号：US10040761B2
公开(公告)日：2018-08-07
申请号：US13167777
申请日：2011-06-24
申请人： Yuji Yamamoto , Hiroki Yoshioka , Fumiaki Manabe
发明人： Yuji Yamamoto , Hiroki Yoshioka , Fumiaki Manabe
IPC分类号： C07D207/452 , C07D209/48 , C08G65/26 , C08G65/331 , C08G65/333 , C08G65/334 , G01N33/543
摘要： A branched hetero polyethylene glycol according to the present invention is represented by the formula [1]: wherein X and Y represent each an atomic group containing at least a functional group which reacts with a functional group present in a bio-functional molecule to form a covalent bond and the functional group contained in the atomic group X and the functional group contained in the atomic group Y are different from each other; s is an integer of 2 to 8, which represents the number of polyethylene glycol chains; n is the number of average added moles for the polyethylene glycol chain and 20≤n≤2000; and E is a branching linker moiety having s-valent bonding valency for the polyethylene glycol chains and having monovalent bonding valency for the functional group Y.

14. 发明申请

US20100292515A1 Purification method of high-molecular-weight polyethylene glycol compound 审中-公开
标题翻译：高分子量聚乙二醇化合物的纯化方法
公开(公告)号：US20100292515A1
公开(公告)日：2010-11-18
申请号：US12751195
申请日：2010-03-31
申请人： Yuji Yamamoto , Hiroki Yoshioka
发明人： Yuji Yamamoto , Hiroki Yoshioka
IPC分类号： C07C43/178 , C07C43/11
CPC分类号： C08G65/30
摘要： An impurity derived from a high-molecular-weight polyethylene glycol compound is removed from a high-molecular-weight polyethylene glycol compound whose total average number of moles of ethylene oxide units added in the molecule is 220 to 4500. In a state where the high-molecular-weight polyethylene glycol compound is dissolved in at least one of water and an organic solvent selected from aromatic hydrocarbon solvents having 8 or less carbon atoms in total and ester compound solvents having 5 or less carbon atoms in total, the water and the organic solvent are mixed. The resulting mixture was separated into an organic layer and an aqueous layer, and the organic layer is separated from the aqueous layer.
摘要翻译：从分子中加入的环氧乙烷单元的总平均摩尔数为220〜4500的高分子量聚乙二醇化合物除去来自高分子量聚乙二醇化合物的杂质。在高分子量聚乙二醇化合物分子量的聚乙二醇化合物溶解在选自总共具有8个或更少碳原子的芳族烃溶剂和总共具有5个或更少碳原子的酯化合物溶剂的水和有机溶剂中的至少一种中，水和有机物溶剂混合。将所得混合物分离成有机层和水层，并将有机层与水层分离。

15. 发明授权

US08952125B2 Polyoxyethylene derivative having plural hydroxyl groups at terminal end thereof 有权
标题翻译：在其末端具有多个羟基的聚氧乙烯衍生物
公开(公告)号：US08952125B2
公开(公告)日：2015-02-10
申请号：US13435556
申请日：2012-03-30
申请人： Hiroki Yoshioka , Takashi Matani , Yuji Yamamoto
发明人： Hiroki Yoshioka , Takashi Matani , Yuji Yamamoto
IPC分类号： C08G65/04 , C08G65/34 , A61K47/48 , C08G65/26 , C08G65/333 , C08G65/00
CPC分类号： A61K47/48215 , A61K47/60 , C08G65/2606 , C08G65/33337 , C08L2203/02
摘要： A polyoxyethylene derivative represented by the formula (1): wherein a whole molecular weight of the polyoxyethylene derivative is 500 to 160,000; n is 5 to 3650; L1, L2, and L3 each independently represent an alkylene group, a phenylene group, an ester bond, an amide bond, an ether bond, a urethane bond, a carbonate bond, a secondary amino group, or a combination thereof; X represents a functional group capable of reacting with a bio-related substance; Y represents a hydrophilic group having plural hydroxyl groups made from a residual group of xylitol or volemitol or a residual group of polyglycerin of trimer to 31-mer; Z represents a residual group of a compound having 2 to 5 active hydrogen atoms; b and c are as follows: 1≦b≦4, 1≦c≦4, and 2≦b+c≦5; and d and e each independently are 0 or 1.
摘要翻译：由式（1）表示的聚氧乙烯衍生物：其中聚氧乙烯衍生物的全部分子量为500〜160,000; n为5〜3650; L1，L2和L3各自独立地表示亚烷基，亚苯基，酯键，酰胺键，醚键，氨基甲酸酯键，碳酸酯键，仲氨基或其组合; X表示能够与生物相关物质反应的官能团; Y表示具有由残留的木糖醇或甘露醇混合物制成的多个羟基或三聚体的聚甘油的残基为31聚物的亲水基团; Z表示具有2〜5个活性氢原子的化合物的残基; b和c如下：1＆nlE; b＆nlE; 4,1＆nlE; c＆nlE; 4和2＆nlE; b + c＆nlE; 5; d和e各自独立地为0或1。

16. 发明申请

US20120322955A1 POLYOXYETHYLENE DERIVATIVE HAVING PLURAL HYDROXYL GROUPS AT TERMINAL END THEREOF 有权
标题翻译：在其末端具有多个羟基的聚氧乙烯衍生物
公开(公告)号：US20120322955A1
公开(公告)日：2012-12-20
申请号：US13435556
申请日：2012-03-30
申请人： Hiroki Yoshioka , Takashi Matani , Yuji Yamamoto
发明人： Hiroki Yoshioka , Takashi Matani , Yuji Yamamoto
IPC分类号： C08G59/14 , C08G59/16
CPC分类号： A61K47/48215 , A61K47/60 , C08G65/2606 , C08G65/33337 , C08L2203/02
摘要： A polyoxyethylene derivative represented by the formula (1): wherein a whole molecular weight of the polyoxyethylene derivative is 500 to 160,000; n is 5 to 3650; L1, L2, and L3 each independently represent an alkylene group, a phenylene group, an ester bond, an amide bond, an ether bond, a urethane bond, a carbonate bond, a secondary amino group, or a combination thereof; X represents a functional group capable of reacting with a bio-related substance; Y represents a hydrophilic group having plural hydroxyl groups made from a residual group of xylitol or volemitol or a residual group of polyglycerin of trimer to 31-mer; Z represents a residual group of a compound having 2 to 5 active hydrogen atoms; b and c are as follows: 1≦b≦4, 1≦c≦4, and 2≦b+c≦5; and d and e each independently are 0 or 1.
摘要翻译：由式（1）表示的聚氧乙烯衍生物：其中聚氧乙烯衍生物的全部分子量为500〜160,000; n为5〜3650; L1，L2和L3各自独立地表示亚烷基，亚苯基，酯键，酰胺键，醚键，氨基甲酸酯键，碳酸酯键，仲氨基或其组合; X表示能够与生物相关物质反应的官能团; Y表示具有由残留的木糖醇或甘露醇混合物制成的多个羟基或三聚体的聚甘油的残基为31聚物的亲水基团; Z表示具有2〜5个活性氢原子的化合物的残基; b和c如下：1＆nlE; b＆nlE; 4,1＆nlE; c＆nlE; 4和2＆nlE; b + c＆nlE; 5; d和e各自独立地为0或1。

17. 发明申请

US20120077988A1 BRANCHED HETERO POLYETHYLENE GLYCOL AND INTERMEDIATE 审中-公开
标题翻译：分支异戊烯聚乙二醇和中间体
公开(公告)号：US20120077988A1
公开(公告)日：2012-03-29
申请号：US13167777
申请日：2011-06-24
申请人： Yuji Yamamoto , Hiroki Yoshioka , Fumiaki Manabe
发明人： Yuji Yamamoto , Hiroki Yoshioka , Fumiaki Manabe
IPC分类号： C07C43/178 , C07C43/13 , C07D403/12 , C07C217/28 , C07D207/452 , C07C43/164 , C07C309/68
CPC分类号： C07D207/452 , C07D209/48 , C08G65/2612 , C08G65/3312 , C08G65/33337 , C08G65/33396 , C08G65/3344 , C08L2203/02 , G01N33/54353
摘要： A branched hetero polyethylene glycol according to the present invention is represented by the formula [1]: wherein X and Y represent each an atomic group containing at least a functional group which reacts with a functional group present in a bio-functional molecule to form a covalent bond and the functional group contained in the atomic group X and the functional group contained in the atomic group Y are different from each other; s is an integer of 2 to 8, which represents the number of polyethylene glycol chains; n is the number of average added moles for the polyethylene glycol chain and 20≦n≦2000; and E is a branching linker moiety having s-valent bonding valency for the polyethylene glycol chains and having monovalent bonding valency for the functional group Y.
摘要翻译：根据本发明的支链杂聚乙二醇由式[1]表示：其中X和Y各自代表至少含有与生物功能分子中存在的官能团反应的官能团的原子团，形成共价键和包含在原子团X中的官能团和原子团Y中所含的官能团彼此不同; s为2〜8的整数，表示聚乙二醇链的数目; n是聚乙二醇链的平均加成摩尔数和20＆nlE; n＆nlE; 2000; 并且E是具有对于聚乙二醇链具有s价键合价并且具有官能团Y的单价键合价的支链连接部分。

18. 发明授权

US09400427B2 Method of manufacturing fine structure body and fine structure mold 有权
标题翻译：精细结构体精细结构模具的制造方法
公开(公告)号：US09400427B2
公开(公告)日：2016-07-26
申请号：US13821379
申请日：2012-04-26
申请人： Yuji Yamamoto , Toshihiko Wada , Yoshifumi Takasu , Akihisa Yamada
发明人： Yuji Yamamoto , Toshihiko Wada , Yoshifumi Takasu , Akihisa Yamada
IPC分类号： B29C59/02 , G03F7/00 , B82Y10/00 , B82Y40/00 , B29C33/42
CPC分类号： G03F7/0002 , B29C33/42 , B29C59/02 , B82Y10/00 , B82Y40/00
摘要： The present invention is a method of manufacturing a fine structure body which manufactures the fine structure body by repeating a basic fine structure body forming step that forms a basic fine structure body by pressing a fine structure mold against a curable resin (photocurable resin film) on a surface of a base material and a release and moving step that releases the fine structure mold from the base material and moves the fine structure mold, wherein the fine structure mold includes at least a first mold depression pattern which is disposed at center area of it, and a second mold depression pattern which is disposed in at least one side part in circumference area of it, and a size of the second mold depression pattern is smaller than a size of the first mold depression pattern.
摘要翻译：本发明是一种制造精细结构体的方法，该精细结构体通过重复通过将精细结构模具压在固化树脂（光固化树脂膜）上而形成基本精细结构体的基本细微结构体形成步骤基材的表面和释放和移动步骤，从基材释放精细结构模具并移动精细结构模具，其中精细结构模具至少包括设置在其中心区域的第一凹陷图案以及设置在其圆周区域中的至少一个侧部中的第二凹陷图案，并且第二凹陷图案的尺寸小于第一凹陷图案的尺寸。

19. 发明授权

US08815241B2 Use of combination of anti-angiogenic substance and c-kit kinase inhibitor 有权
标题翻译：使用抗血管生成物质和c-kit激酶抑制剂的组合
公开(公告)号：US08815241B2
公开(公告)日：2014-08-26
申请号：US13205328
申请日：2011-08-08
申请人： Yuji Yamamoto
发明人： Yuji Yamamoto
IPC分类号： A61K39/395 , A61K31/506 , A61K31/47 , A61P35/00 , A61K31/4709 , A61K31/404 , A61K31/517 , A61K45/06 , A61K31/519 , A61K31/502 , A61K31/5377 , A61K31/4439 , A61K31/4409 , C07D215/48
CPC分类号： C07D215/48 , A61K31/404 , A61K31/4409 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K45/06
摘要： The object of the present invention is to find a pharmaceutical composition and a method for treating cancer that show an excellent antitumor effect. Combinational use of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide and analogues thereof can result in an excellent antitumor effect when combined with a substance having a c-kit kinase-inhibiting activity.
摘要翻译：本发明的目的是找到显示出优异的抗肿瘤效果的药物组合物和治疗癌症的方法。当与具有c-kit激酶抑制活性的物质组合时，组合使用4-（3-氯-4-（环丙基氨基羰基）氨基苯氧基）-7-甲氧基-6-喹啉甲酰胺及其类似物可以产生优异的抗肿瘤效果。

20. 发明申请

US20130139950A1 ROTATIONAL MISALIGNMENT MEASURING DEVICE OF BONDED SUBSTRATE, ROTATIONAL MISALIGNMENT MEASURING METHOD OF BONDED SUBSTRATE, AND METHOD OF MANUFACTURING BONDED SUBSTRATE 有权
标题翻译：粘结基板的旋转误差测量装置，结合基板的旋转缺陷测量方法和制造粘结基板的方法
公开(公告)号：US20130139950A1
公开(公告)日：2013-06-06
申请号：US13691491
申请日：2012-11-30
申请人： Masato KANNAKA , Masakazu Kajita , Eiji Takahashi , Yuji Yamamoto , Masaru Akamatsu , Kunio Iba , Kenji Imanishi
发明人： Masato KANNAKA , Masakazu Kajita , Eiji Takahashi , Yuji Yamamoto , Masaru Akamatsu , Kunio Iba , Kenji Imanishi
IPC分类号： G01B11/27
CPC分类号： G01B11/272
摘要： A rotational misalignment between semiconductor wafers constituting a bonded wafer is calculated. A light source is arranged at a position which is on a front side of an opening of a notch and which is separated from an outer edge portion of a bonded wafer by a predetermined interval, and outputs light to irradiate the outer edge portion of the bonded wafer including the notch. A camera receives and photoelectrically converts reflected light that is specularly-reflected by the outer edge portion of the bonded wafer including the notch among the light outputted by the light source in order to output a brightness distribution of the reflected light as an image. A computer analyzes positions of notches from the image outputted by the camera to obtain a notch position misalignment, and further calculates a rotational misalignment between semiconductor wafers using a center position misalignment between the semiconductor wafers.
摘要翻译：计算构成接合晶片的半导体晶片之间的旋转未对准。光源布置在位于凹口的开口的前侧上并且与键合晶片的外边缘部分隔开预定间隔的位置处，并输出光以照射粘合的晶片的外边缘部分晶圆包括凹口。照相机接收并光电转换由光源输出的光中包括凹口的键合晶片的外边缘部分被镜面反射的反射光，以输出作为图像的反射光的亮度分布。计算机分析由相机输出的图像的凹口的位置以获得切口位置未对准，并且还使用半导体晶片之间的中心位置未对准来计算半导体晶片之间的旋转未对准。

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