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11. 发明申请

US20100137217A1 FIBROSIS INHIBITOR FOR IMPLANTED ORGAN 有权
标题翻译：用于植入有机体的纤维蛋白酶抑制剂
公开(公告)号：US20100137217A1
公开(公告)日：2010-06-03
申请号：US12695532
申请日：2010-01-28
申请人： Jun Amano , Ken-ichi Ito , Kazuhiro Yamaura , Kunio Matsumoto , Toshikazu Nakamura
发明人： Jun Amano , Ken-ichi Ito , Kazuhiro Yamaura , Kunio Matsumoto , Toshikazu Nakamura
IPC分类号： A61K38/18 , A61P43/00
CPC分类号： C07K14/4753 , A61K38/1833 , A61K48/00
摘要： A pharmaceutical preparation comprising a hepatocyte growth factor or a DNA molecule encoding the same and the like according to the present invention can suppress the fibrosis of a transplanted organ after organ transplantation. The present invention is useful in the fields of organ transplantation and regeneration therapy.
摘要翻译：包含肝细胞生长因子或编码本发明的DNA分子的药物制剂能够抑制器官移植后的移植器官的纤维化。本发明可用于器官移植和再生治疗领域。

12. 发明授权

US07577054B2 Memory with word-line driver circuit having leakage prevention transistor 有权
标题翻译：具有防漏晶体管的字线驱动电路的存储器
公开(公告)号：US07577054B2
公开(公告)日：2009-08-18
申请号：US11979237
申请日：2007-10-31
申请人： Toshikazu Nakamura
发明人： Toshikazu Nakamura
IPC分类号： G11C8/00
CPC分类号： G11C8/08 , G11C11/4085 , G11C11/4087 , G11C29/02 , G11C29/021 , G11C29/028 , G11C2029/1202
摘要： In a semiconductor memory having a plurality of word lines and bit lines and memory cells arranged at the positions of intersection thereof, a word driver circuit that drives the word line has a drive PMOS transistor and drive NMOS transistor which are connected in series between a first node and a second node and each of which has a gate connected to a third node, the word line being connected to a connection node of the two transistors. A first voltage or a second voltage lower than the first voltage is then applied to the third node, and the first voltage or second voltage is applied to the first node. In addition, between the third node and the gate of the drive PMOS transistor, there is provided a leakage prevention NMOS transistor having a gate applied with the first voltage or a voltage in the vicinity thereof.
摘要翻译：在具有布置在其相交位置处的多个字线和位线和存储单元的半导体存储器中，驱动字线的字驱动电路具有驱动PMOS晶体管和驱动NMOS晶体管，其串联连接在第一节点和第二节点，并且每个节点具有连接到第三节点的栅极，所述字线连接到所述两个晶体管的连接节点。然后将第一电压或低于第一电压的第二电压施加到第三节点，并且将第一电压或第二电压施加到第一节点。此外，在驱动PMOS晶体管的第三节点和栅极之间，提供了具有施加有第一电压的栅极或其附近的电压的防漏NMOS晶体管。

13. 发明申请

US20080194473A1 Hydrocephalus Treatment 失效
标题翻译：脑积水治疗
公开(公告)号：US20080194473A1
公开(公告)日：2008-08-14
申请号：US10579297
申请日：2004-11-19
申请人： Tsuyoshi Tada , Toshikazu Nakamura
发明人： Tsuyoshi Tada , Toshikazu Nakamura
IPC分类号： A61K38/18 , A61P43/00
CPC分类号： A61K38/1833
摘要： A method and compound for treatment of hydrocephalus is presented. Hepatocyte growth factor (HGF) is administered intraventricularly.
摘要翻译：提出了治疗脑积水的方法和化合物。肝细胞生长因子（HGF）在心室内施用。

14. 发明申请

US20070197433A1 Differentiation- Or Regeneration-Inducing Agent For Alveoli 有权
标题翻译：分化 - 或再生 - 肺泡诱导剂
公开(公告)号：US20070197433A1
公开(公告)日：2007-08-23
申请号：US10592087
申请日：2005-03-07
申请人： Hiroshi Kubo , Kota Ishizawa , Hidetada Sasaki , Toshikazu Nakamura
发明人： Hiroshi Kubo , Kota Ishizawa , Hidetada Sasaki , Toshikazu Nakamura
IPC分类号： A61K38/18
CPC分类号： A61K38/1833
摘要： The present invention provides an agent comprising HGF for inducing differentiation of bone marrow cells into alveolar cells. The present invention also provides an HGF-containing agent for alveolar formation in pulmonary emphysema and the like in which alveoli are destroyed.
摘要翻译：本发明提供了包含用于诱导骨髓细胞分化成肺泡细胞的HGF的药剂。本发明还提供了肺泡被破坏的肺气肿等肺泡形成用HGF试剂。

15. 发明授权

US07250201B2 Production method of cellulose film, cellulose film, protective film for polarizing plate, optical functional film, polarizing plate, and liquid crystal display 失效
标题翻译：纤维素膜，纤维素膜，偏光板用保护膜，光学功能膜，偏光板，液晶显示器的制造方法
公开(公告)号：US07250201B2
公开(公告)日：2007-07-31
申请号：US11102821
申请日：2005-04-11
申请人： Hidekazu Yamazaki , Toshikazu Nakamura , Hiroshi Miyachi
发明人： Hidekazu Yamazaki , Toshikazu Nakamura , Hiroshi Miyachi
IPC分类号： B29D7/00
CPC分类号： C08J5/18 , B01D67/0011 , B01D67/0013 , B01D67/0016 , B01D71/10 , B01D2323/16 , B29C41/26 , B29C41/28 , B29C41/32 , B29D7/01 , B29K2001/00 , B29K2001/12 , C08J2301/00 , G02B5/3033 , Y10T428/1041 , Y10T428/105
摘要： A production method of cellulose film wherein cellulose film is produced by preparing a polymer solution through dissolving cellulose ester in a solvent containing a prescribed organic solvent as the main component, forming a filmy object from the prepared polymer solution, and evaporating the solvent in the filmy object; the residual amount of the organic solvent is reduced while the film quality is not degraded, and the production efficiency is degraded to a least possible extent; a poor solvent, highest in boiling point among the materials contained in the solvent, is added in the content ranging from 0.1 wt % to 1.0 wt %, taking the total amount of the solvent in the prepared polymer solution to be 100 wt %; and the solubility of cellulose ester in the poor solvent is inferior to the solubility of the cellulose ester in the organic solvent which is the main component of the solvent.
摘要翻译：纤维素膜的制造方法，其中通过将纤维素酯溶解在含有规定的有机溶剂的溶剂作为主要成分的溶剂中制备聚合物溶液，从制备的聚合物溶液中形成膜状物质并使膜中的溶剂蒸发而制备纤维素膜目的; 有机溶剂的残留量降低，膜质量不降低，生产效率降低到最小程度; 以制备的聚合物溶液中的溶剂的总量为100重量％，添加溶剂中所含的材料中沸点最高的不良溶剂的含量为0.1重量％〜1.0重量％并且纤维素酯在不良溶剂中的溶解度不如纤维素酯在作为溶剂的主要成分的有机溶剂中的溶解度。

16. 发明申请

US20070135957A1 Model generating apparatus, model generating system, and fault detecting apparatus 审中-公开
标题翻译：模型生成装置，模型生成系统和故障检测装置
公开(公告)号：US20070135957A1
公开(公告)日：2007-06-14
申请号：US11606383
申请日：2006-11-30
申请人： Makoto Ogawa , Toshikazu Nakamura , Yoshikazu Aikawa , Shigeru Obayashi
发明人： Makoto Ogawa , Toshikazu Nakamura , Yoshikazu Aikawa , Shigeru Obayashi
IPC分类号： G06F19/00
CPC分类号： G05B19/41875 , G05B17/02 , G05B23/0243 , G05B2219/31357 , Y02P90/22
摘要： A model generating apparatus includes: a first input device for inputting process state information; a second input device for inputting test result information; a characteristic quantity extracting device for extracting a process characteristic quantity from the process state information in each of the areas; and an analyzing device for generating a process-quality model by executing an analysis of data mining using the process characteristic quantity and the test result information associated with each other. The model generating apparatus further includes: a third input device for inputting process position information so that the process position information can be associated with the process state information; and a fourth input device for inputting test position information so that the test position information can be associated with test result information.
摘要翻译：模型生成装置包括：用于输入处理状态信息的第一输入装置; 用于输入测试结果信息的第二输入设备; 特征量提取装置，用于从每个区域中的处理状态信息中提取处理特征量; 以及分析装置，用于通过使用相关联的处理特征量和测试结果信息执行数据挖掘的分析来生成过程质量模型。模型生成装置还包括：第三输入装置，用于输入处理位置信息，使得处理位置信息可以与处理状态信息相关联; 以及第四输入装置，用于输入测试位置信息，使得测试位置信息可以与测试结果信息相关联。

17. 发明申请

US20060293275A1 Hgf production accelerator containing heparin-like oligosaccharide 审中-公开
标题翻译：含有肝素寡糖的Hgf生产促进剂
公开(公告)号：US20060293275A1
公开(公告)日：2006-12-28
申请号：US10565301
申请日：2005-03-28
申请人： Toshikazu Nakamura , Kunio Matsumoto , Kazuhiro Fukuta
发明人： Toshikazu Nakamura , Kunio Matsumoto , Kazuhiro Fukuta
IPC分类号： A61K31/727
CPC分类号： C08B37/0075 , A61K31/7016 , A61K31/702 , A61K31/715 , C07H11/00 , C08B37/0078 , C08L5/10 , C12P19/04
摘要： The present invention aims to provide an agent for promoting HGF production comprising, as an effective ingredient, a disaccharide comprised of an uronic acid residue (wherein an uronic acid means an iduronic acid or a glucuronic acid, and has the same meaning hereinafter) and a glucosamine residue that are connected by α1,4-glycosidic linkage or β1,4-glycosidic linkage, or an oligosaccharide of tri- to hexadeca-saccharides having a structure in which uronic acid residues and glucosamine residues are alternately and repeatedly connected by α1,4-glycosidic linkage or β1,4-glycosidic linkage, wherein at least one hydroxy group of the uronic acid residues and/or the glucosamine residues may be sulfated, alkylated, acylated or aminated, and/or the amino group at position 2 of at least one of the glucosamine residue(s) may be sulfated, alkylated or acylated, or a salt thereof. The agent of the present invention for promoting HGF production is useful to promote healing of damaged tissues or organs of a living body.
摘要翻译：本发明的目的在于提供一种促进HGF生产的试剂，其包含由糖醛酸残基（其中糖醛酸表示艾杜糖醛酸或葡糖醛酸，并且具有下述相同含义）的二糖作为有效成分，和通过α1,4-糖苷键或β1,4-糖苷键连接的葡糖胺残基或具有其中糖醛酸残基和葡糖胺残基被α1,44交替并重复连接的结构的三十六碳糖的寡糖 - 糖苷键或β1,4-糖苷键，其中所述糖醛酸残基和/或所述葡糖胺残基的至少一个羟基可以被硫酸化，烷基化，酰化或胺化，和/或至少在第2位的氨基一种或多种葡糖胺残基可被硫酸化，烷基化或酰化，或其盐。用于促进HGF产生的本发明的药剂可用于促进活体损伤的组织或器官的愈合。

18. 发明申请

US20060098523A1 Semiconductor memory device capable of driving non-selected word lines to first and second potentials 失效
标题翻译：能够将未选择的字线驱动到第一和第二电位的半导体存储器件
公开(公告)号：US20060098523A1
公开(公告)日：2006-05-11
申请号：US11313963
申请日：2005-12-22
申请人： Masato Takita , Masato Matsumiya , Satoshi Eto , Toshikazu Nakamura , Masatomo Hasegawa , Ayako Kitamoto , Kuninori Kawabata , Hideki Kanou , Toru Koga , Yuki Ishii , Shinichi Yamada , Kaoru Mori
发明人： Masato Takita , Masato Matsumiya , Satoshi Eto , Toshikazu Nakamura , Masatomo Hasegawa , Ayako Kitamoto , Kuninori Kawabata , Hideki Kanou , Toru Koga , Yuki Ishii , Shinichi Yamada , Kaoru Mori
IPC分类号： G11C8/00
CPC分类号： G11C5/147 , G11C8/08 , G11C8/12 , G11C11/4074 , G11C11/4085 , G11C2207/2227
摘要： A semiconductor device includes a word line drive circuit for resetting the word line by driving the word line connected to a memory cell and is constituted so as to switch a reset level of the word line drive circuit, which is set at the time of the reset operation of the word line, between a first potential such as a ground potential and a second potential such as a negative potential. Further, a semiconductor device including a memory cell array formed by arranging a plurality of memory cells and a word line reset level generating circuit for generating a negative potential makes it possible to vary the amount of a current supply of the word line reset level generating circuit when non-selected word lines are set to a negative potential by applying the output of the word line reset level generating circuit to the non-selected word lines, and varies the amount of the current supply of the negative potential in accordance with the operation of the memory cell array. Furthermore, in a semiconductor device including a plurality of power source circuits each having an oscillation circuit and a capacitor, for driving the capacitor by the oscillation signal outputted by the oscillation circuit, at least a part of these power source circuits shares in common the oscillation circuit, and different capacitors are driven by the oscillation signal outputted from the common oscillation circuit.
摘要翻译：半导体器件包括字线驱动电路，用于通过驱动连接到存储单元的字线来重置字线，并且被构造成切换在复位时设置的字线驱动电路的复位电平在诸如地电位的第一电位和诸如负电位的第二电位之间的字线的操作。此外，包括通过布置多个存储单元形成的存储单元阵列和用于产生负电位的字线复位电平发生电路的半导体器件使得可以改变字线复位电平产生电路的电流供应量当通过将字线复位电平产生电路的输出施加到未被选择的字线而将未被选择的字线设置为负电位时，根据操作来改变负电位的电流供给量存储单元阵列。此外，在具有振荡电路和电容器的多个电源电路的半导体装置中，通过由振荡电路输出的振荡信号来驱动电容器，这些电源电路的至少一部分共享振荡电路，不同的电容器由共同的振荡电路输出的振荡信号驱动。

19. 发明申请

US20060030517A1 Anti-cancer agent 失效
公开(公告)号：US20060030517A1
公开(公告)日：2006-02-09
申请号：US11019360
申请日：2004-12-23
申请人： Toshikazu Nakamura
发明人： Toshikazu Nakamura
IPC分类号： A61K38/18
CPC分类号： A61K38/1833
摘要： The invention relates to an anti-cancer agent containing α-chain protein (α-fragment) of HGF (hepatocyte growth factor) as an active ingredient. The active ingredient of α-fragment has a specific suppressing effect on invasion and metastasis of cancer cells such as gallbladder cancer, lung cancer and other, which are highly metastatic and result in a high mortality. Therefore, the agent of the invention is used in treatment and prevention of cancer as an anti-cancer agent, and is extremely useful clinically.

20. 发明申请

US20050221441A1 Segment of glycosylation-deficient HGF alpha-chain 审中-公开
标题翻译：糖基化缺陷型HGFα链的区段
公开(公告)号：US20050221441A1
公开(公告)日：2005-10-06
申请号：US11041363
申请日：2005-01-25
申请人： Toshikazu Nakamura , Kunio Matsumoto , Kazuhiro Fukuta
发明人： Toshikazu Nakamura , Kunio Matsumoto , Kazuhiro Fukuta
IPC分类号： A61K38/00 , C07K14/475 , C07H21/04 , C12N15/09
CPC分类号： C07K14/4753
摘要： The present invention provides a segment of glycosylation-deficient HGF having mutation(s) introduced into an amino acid sequence so as to prevent glycosylation at least one glycosylation site of a hepatocyte growth factor (HGF), and a method of producing the same. The segment of glycosylation-deficient HGF of the present invention has the same activity as that of a segment of glycosylated HGF, therefore, it is useful as an alternate for a segment of glycosylated HGF.
摘要翻译：本发明提供具有引入氨基酸序列的突变的糖基化缺陷型HGF片段，以防止肝细胞生长因子（HGF）的至少一个糖基化位点的糖基化及其制备方法。本发明的糖基化缺陷型HGF片段具有与糖基化HGF片段相同的活性，因此，作为糖基化HGF片段的替代物是有用的。

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