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1. 发明授权

US09778812B2 Screen transition diagram creator 有权
公开(公告)号：US09778812B2
公开(公告)日：2017-10-03
申请号：US14428429
申请日：2012-10-12
申请人： Kunio Matsumoto , Koichi Nakagawa
发明人： Kunio Matsumoto , Koichi Nakagawa
IPC分类号： G06F3/0481 , G06F9/44 , G06F17/21
CPC分类号： G06F3/0481 , G06F3/04817 , G06F8/38 , G06F17/212
摘要： A screen transition diagram creator that creates a screen transition diagram illustrating complicated transition relations in an easy-to-understand manner, including: a screen transition diagram editor providing the screen transition diagram in which transition relations among plural screens are illustrated by plural screen nodes and arrows between the screen nodes; a screen transition pattern applying unit applying a predetermined screen transition pattern to a target screen node group that includes at least part of the screen nodes illustrated in the screen transition diagram to provide a pattern-applied screen node group; and a screen transition structure diagram creator creating a screen transition structure diagram by abridgement processing on the pattern-applied screen node group according to a display layout corresponding to the screen transition pattern. In the abridgement processing, arrows are deleted and an icon that simplistically illustrates a transition pattern between the screen nodes displayed in the display layout is added.

2. 发明授权

US08927493B2 Promoter for regeneration of tendon-bone junction tissue or ligament-bone junction tissue 有权
标题翻译：肌腱 - 骨连接组织或韧带 - 骨连接组织再生的启动子
公开(公告)号：US08927493B2
公开(公告)日：2015-01-06
申请号：US13123091
申请日：2009-10-08
申请人： Katsuro Tomita , Hiroyuki Tsuchiya , Katsuhiko Kitaoka , Junsuke Nakase , Keigo Hanada , Kunio Matsumoto
发明人： Katsuro Tomita , Hiroyuki Tsuchiya , Katsuhiko Kitaoka , Junsuke Nakase , Keigo Hanada , Kunio Matsumoto
IPC分类号： A61K38/18 , C07K14/475 , A61P19/00 , A61P19/04 , A61K48/00
CPC分类号： A61K38/1833 , A61K48/00 , C07K14/4753
摘要： An object of the present invention is to provide a drug for promoting the regeneration of tendon-bone junction tissue or ligament-bone junction tissue. The present invention relates to a promoter for regeneration of tendon-bone junction tissue or ligament-bone junction tissue including the following (1) or (2) as an active ingredient: (1) the following (1-a), (1-b), or (1-c) (1-a) HGF protein, (1-b) a partial peptide of HGF protein, the peptide having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue, (1-c) a salt of (1-a) or (1-b); (2) DNA including the following (2-a), (2-b), or (2-c), (2-a) DNA encoding HGF protein, (2-b) DNA encoding a partial peptide of HGF protein, the peptide having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue, (2-c) DNA encoding a protein or a peptide, the protein or the peptide having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue, and the DNA hybridizing with DNA comprising a base sequence complementary to (2-a) or (2-b) under a stringent condition.
摘要翻译：本发明的目的是提供一种用于促进腱 - 骨连接组织或韧带 - 骨连接组织的再生的药物。本发明涉及包含以下（1）或（2）作为活性成分的腱 - 骨连接组织或韧带 - 骨连接组织再生促进剂：（1）以下（1-a），（1- b）或（1-c）（1-a）HGF蛋白，（1-b）HGF蛋白的部分肽，所述肽具有促进腱 - 骨连接组织或韧带 - 骨连接组织再生的作用，（1-c）（1-a）或（1-b）的盐; （2）包含以下（2-a），（2-b）或（2-c），（2-a）编码HGF蛋白的DNA的DNA，（2-b）编码HGF蛋白的部分肽的DNA，该肽具有促进腱 - 骨连接组织或韧带 - 骨连接组织再生的作用，（2-c）编码蛋白质或肽的DNA，所述蛋白质或肽具有促进腱 - 骨连接再生的作用组织或韧带 - 骨连接组织，以及在严格条件下与包含与（2-a）或（2-b）互补的碱基序列的DNA杂交的DNA。

3. 发明授权

US08420350B2 Glycosylation-deficient hepatocyte growth factor 有权
标题翻译：糖基化缺陷型肝细胞生长因子
公开(公告)号：US08420350B2
公开(公告)日：2013-04-16
申请号：US12722823
申请日：2010-03-12
申请人： Toshikazu Nakamura , Kunio Matsumoto , Kazuhiro Fukuta
发明人： Toshikazu Nakamura , Kunio Matsumoto , Kazuhiro Fukuta
IPC分类号： C12P21/06 , C12N1/00 , C12N5/00 , C12N15/12 , C07K14/475 , A61K38/18 , C07H21/02
CPC分类号： C07K14/4753 , A61K48/00
摘要： The invention provides a modified glycosylation-deficient HGF and a production method thereof. The glycosylation-deficient HGF is produced by introducing amino acid mutation(s) so that no glycosylation take place at at least one glycosylation site of hepatocyte growth factor.
摘要翻译：本发明提供了修饰的糖基化缺陷型HGF及其制备方法。通过引入氨基酸突变来产生糖基化缺陷型HGF，使得在肝细胞生长因子的至少一个糖基化位点处不发生糖基化。

4. 发明申请

US20120149642A1 FIBROSIS INHIBITOR FOR IMPLANTED ORGAN 有权
标题翻译：用于植入有机体的纤维蛋白酶抑制剂
公开(公告)号：US20120149642A1
公开(公告)日：2012-06-14
申请号：US13288392
申请日：2011-11-03
申请人： Jun AMANO , Ken-ichi Ito , Kazuhiro Yamaura , Kunio Matsumoto , Toshikazu Nakamura
发明人： Jun AMANO , Ken-ichi Ito , Kazuhiro Yamaura , Kunio Matsumoto , Toshikazu Nakamura
IPC分类号： A61K38/18 , A61P43/00 , A61P37/06
CPC分类号： C07K14/4753 , A61K38/1833 , A61K48/00
摘要： A pharmaceutical preparation comprising a hepatocyte growth factor or a DNA molecule encoding the same and the like according to the present invention can suppress the fibrosis of a transplanted organ after organ transplantation. The present invention is useful in the fields of organ transplantation and regeneration therapy.
摘要翻译：包含肝细胞生长因子或编码本发明的DNA分子的药物制剂能够抑制器官移植后的移植器官的纤维化。本发明可用于器官移植和再生治疗领域。

5. 发明申请

US20120064090A1 THERAPEUTIC AGENT FOR CANCER HAVING REDUCED SENSITIVITY TO MOLECULAR TARGET DRUG AND PHARMACEUTICAL COMPOSITION FOR ENHANCING SENSITIVITY TO MOLECULAR TARGET DRUG 审中-公开
标题翻译：具有降低灵敏度的分子靶向药物和药物组合物用于提高对分子靶向药物敏感性的癌症治疗药物
公开(公告)号：US20120064090A1
公开(公告)日：2012-03-15
申请号：US13258718
申请日：2009-10-09
申请人： Seiji Yano , Kunio Matsumoto
发明人： Seiji Yano , Kunio Matsumoto
IPC分类号： A61K39/395 , C07K14/47 , A61K31/496 , A61P35/00 , A61P35/02 , C07D403/14 , C07K16/22 , A61K38/17
CPC分类号： A61K39/39558 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K2317/76 , A61K2300/00
摘要： Provided are a pharmaceutical composition which enhances the sensitivity of a cancer to a molecular target drug, such as gefitinib and erlotinib, wherein the cancer has resistance to the molecular target drug, and a cancer therapeutic agent effective against a cancer having resistance to a molecular target drug, such as gefitinib and erlotinib. The pharmaceutical composition comprising an HGF-MET receptor pathway inhibitor enhances the sensitivity of a cancer to a molecular target drug, such as gefitinib and erlotinib, even though the cancer has resistance to the molecular target drug. The cancer therapeutic agent comprising a molecular target drug in combination with an HGF-MET receptor pathway inhibitor is effective against a cancer having resistance to the molecular target drug.
摘要翻译：提供了增强癌症对分子靶药物如吉非替尼和厄洛替尼的敏感性的药物组合物，其中癌症具有对分子靶药物的抗性，以及对抗分子靶抗性的癌症的癌症治疗剂药物，如吉非替尼和厄洛替尼。包含HGF-MET受体途径抑制剂的药物组合物增强癌症对分子靶药物如吉非替尼和埃罗替尼的敏感性，即使癌症对分子靶向药物具有抗性。包含与HGF-MET受体途径抑制剂组合的分子靶向药物的癌症治疗剂对于具有抗分子靶向药物的癌症是有效的。

6. 发明授权

US07807177B2 Segment of glycosylation-deficient HGFalpha-chain 有权
标题翻译：糖基化缺陷型HGFalpha链的区段
公开(公告)号：US07807177B2
公开(公告)日：2010-10-05
申请号：US10926088
申请日：2004-08-26
申请人： Toshikazu Nakamura , Kunio Matsumoto , Kazuhiro Fukuta
发明人： Toshikazu Nakamura , Kunio Matsumoto , Kazuhiro Fukuta
IPC分类号： C07K14/575 , A61K38/22 , C12N15/00
CPC分类号： C07K14/4753
摘要： The present invention provides a segment of glycosylation-deficient HGF having mutation(s) introduced into an amino acid sequence so as to prevent glycosylation at at least one glycosylation site of a hepatocyte growth factor (HGF), and a method of producing the same. The segment of glycosylation-deficient HGF of the present invention has the same activity as that of a segment of glycosylated HGF, therefore, it is useful as an alternate for a segment of glycosylated HGF.
摘要翻译：本发明提供了具有引入氨基酸序列的突变以防止肝细胞生长因子（HGF）的至少一个糖基化位点处的糖基化的糖基化缺陷型HGF的片段及其制备方法。本发明的糖基化缺陷型HGF片段具有与糖基化HGF片段相同的活性，因此，作为糖基化HGF片段的替代物是有用的。

7. 发明授权

US07741452B2 Glycosylation-deficient hepatocyte growth factor 有权
标题翻译：糖基化缺陷型肝细胞生长因子
公开(公告)号：US07741452B2
公开(公告)日：2010-06-22
申请号：US10582973
申请日：2004-12-15
申请人： Toshikazu Nakamura , Kunio Matsumoto , Kazuhiro Fukuta
发明人： Toshikazu Nakamura , Kunio Matsumoto , Kazuhiro Fukuta
IPC分类号： C07K14/175
CPC分类号： C07K14/4753 , A61K48/00
摘要： The invention provides a modified glycosylation-deficient HGF and a production method thereof. The glycosylation-deficient HGF is produced by introducing amino acid mutation(s) so that no glycosylation take place at at least one glycosylation site of hepatocyte growth factor.
摘要翻译：本发明提供了修饰的糖基化缺陷型HGF及其制备方法。通过引入氨基酸突变来产生糖基化缺陷型HGF，使得在肝细胞生长因子的至少一个糖基化位点处不发生糖基化。

8. 发明授权

US07675387B2 Surface acoustic wave device and communication terminal using the same 失效
标题翻译：表面声波装置和通信终端使用相同
公开(公告)号：US07675387B2
公开(公告)日：2010-03-09
申请号：US11514229
申请日：2006-09-01
申请人： Kazuyuki Sakiyama , Kengo Asai , Atsushi Isobe , Kunio Matsumoto , Shinichi Fujiwara
发明人： Kazuyuki Sakiyama , Kengo Asai , Atsushi Isobe , Kunio Matsumoto , Shinichi Fujiwara
IPC分类号： H01L41/00
CPC分类号： H03H9/02574 , H03H9/02834
摘要： A surface acoustic wave device in the present invention is provided with a piezoelectric substrate, a supporting substrate being jointed to the piezoelectric substrate and including a material different in expansion coefficient from the piezoelectric substrate and an interdigital electrode for exciting a surface acoustic wave, the electrode being arranged on the surface of the piezoelectric substrate. Either the interdigital electrode or the piezoelectric substrate is configured so that the interdigital electrode is 40% or more to 70% or less as long as the piezoelectric substrate in the direction to which a surface acoustic wave propagates.
摘要翻译：本发明的声表面波装置具有压电基板，支撑基板与压电基板连接，并且具有与压电基板不同的膨胀系数的材料和用于激励表面声波的叉指电极，所述电极布置在压电基板的表面上。叉指电极或压电基板之间的配置使得叉指电极与表面声波传播方向上的压电基片一样长度为40％以上至70％以下。

9. 发明授权

US07548503B2 Recording medium, information recording apparatus, information recording method, information recording medium, and recording program 有权
公开(公告)号：US07548503B2
公开(公告)日：2009-06-16
申请号：US11321630
申请日：2005-12-30
申请人： Yoshio Sasaki , Satoshi Uchiumi , Hirohisa Tsudome , Kunio Matsumoto , Eiji Muramatsu , Shoji Taniguchi , Akiyoshi Inoue
发明人： Yoshio Sasaki , Satoshi Uchiumi , Hirohisa Tsudome , Kunio Matsumoto , Eiji Muramatsu , Shoji Taniguchi , Akiyoshi Inoue
IPC分类号： G11B7/125
CPC分类号： G11B20/00086 , G11B7/0045 , G11B7/00456 , G11B7/00736 , G11B7/1267 , G11B7/26 , G11B7/268 , G11B19/12 , G11B20/10481 , G11B20/1217 , G11B27/329 , G11B27/36 , G11B2020/1275 , G11B2220/218 , G11B2220/2562
摘要： In a DVD-R on which information is to be recorded by an information recording apparatus, prior to the recording of the information therein, there are recorded in advance at least identification information for identifying the information recording apparatus for recording the information onto the DVD-R, and recording parameter information containing optimization information for optimizing a recording state in the record processing executed by the information recording apparatus specified by the identification information. Furthermore, the information recording apparatus reads the recording parameter information at the execution of record processing to use it for the record processing.

10. 发明授权

US07385892B2 Recording medium, information recording apparatus, information recording method, information recording medium, and recording program 有权
标题翻译：记录介质，信息记录装置，信息记录方法，信息记录介质和记录程序
公开(公告)号：US07385892B2
公开(公告)日：2008-06-10
申请号：US10076602
申请日：2002-02-19
申请人： Yoshio Sasaki , Satoshi Uchiumi , Hirohisa Tsudome , Kunio Matsumoto , Eiji Muramatsu , Shoji Taniguchi , Akiyoshi Inoue
发明人： Yoshio Sasaki , Satoshi Uchiumi , Hirohisa Tsudome , Kunio Matsumoto , Eiji Muramatsu , Shoji Taniguchi , Akiyoshi Inoue
IPC分类号： G11B7/00 , G11B7/125
CPC分类号： G11B20/00086 , G11B7/0045 , G11B7/00456 , G11B7/00736 , G11B7/1267 , G11B7/26 , G11B7/268 , G11B19/12 , G11B20/10481 , G11B20/1217 , G11B27/329 , G11B27/36 , G11B2020/1275 , G11B2220/218 , G11B2220/2562
摘要： In a DVD-R on which information is to be recorded by an information recording apparatus, prior to the recording of the information therein, there are recorded in advance at least identification information for identifying the information recording apparatus for recording the information onto the DVD-R, and recording parameter information containing optimization information for optimizing a recording state in the record processing executed by the information recording apparatus specified by the identification information. Furthermore, the information recording apparatus reads the recording parameter information at the execution of record processing to use it for the record processing.
摘要翻译：在由信息记录装置记录信息的DVD-R中，在其中记录信息之前，至少记录有用于识别信息记录装置的识别信息，用于将信息记录在DVD- R，以及记录参数信息，其中包含用于优化由由识别信息指定的信息记录装置执行的记录处理中的记录状态的优化信息。此外，信息记录装置在执行记录处理时读取记录参数信息，以将其用于记录处理。

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