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11. 发明申请

US20090275033A1 Uses of BNIPXL-Beta in premature canities 失效
标题翻译： BNIPXL-Beta在早产儿中的应用
公开(公告)号：US20090275033A1
公开(公告)日：2009-11-05
申请号：US12387138
申请日：2009-04-28
申请人： Bruno Bernard , Stephane Commo , Olivier De Lacharriere
发明人： Bruno Bernard , Stephane Commo , Olivier De Lacharriere
IPC分类号： C12Q1/68 , C07K14/00 , C07H21/02 , C12Q1/00 , G01N33/68 , G01N33/566
CPC分类号： C07K14/4747 , A61K8/64 , A61Q5/00
摘要： The present invention concerns the use of a polypeptide comprising a sequence having at least 90% identity with all or part of BNIPXLβ, for cosmetic or therapeutic applications, in the treatment or prevention of premature canities in humans, said portion comprising at least 30 amino acids, as well as the use, for the same purpose, of a molecule comprising a RNAi sequence having at least 90% identity with all or part of the cDNA sequence of BNIPXLβ, said part comprising at least 18 nucleotides.The invention also concerns methods for screening molecules modulating the expression of a gene coding for BNIPXL-beta and molecules modulating the activity of the BNIPXL-beta polypeptide, in order to identify an agent for use for cosmetic or therapeutic purposes in the field of pigmentation. The invention also encompasses various uses of molecules which may be identified by these methods.
摘要翻译：本发明涉及包含与全部或部分BNIPXLβ具有至少90％同一性的序列用于化妆品或治疗应用的多肽在治疗或预防人类早衰症中的用途，所述部分包含至少30个氨基酸以及用于相同目的的包含与BNIPXLβ的全部或部分cDNA序列具有至少90％同一性的RNAi序列的分子，所述部分包含至少18个核苷酸。本发明还涉及用于筛选调节编码BNIPXL-β的基因的表达的调节分子和调节BNIPXL-β多肽的活性的分子的方法，以鉴定在色素沉着领域中用于化妆品或治疗目的的药剂。本发明还包括可以通过这些方法鉴定的分子的各种用途。

12. 发明申请

US20090118203A1 Administration of agents inducing dopachrome tautomerase (TRP-2) expression for protecting hair follicle melanocytes 审中-公开
标题翻译：施用诱导多巴肼互变异构酶（TRP-2）表达以保护毛囊黑素细胞的药剂
公开(公告)号：US20090118203A1
公开(公告)日：2009-05-07
申请号：US12076753
申请日：2008-03-21
申请人： Stephane Commo , Bruno Bernard
发明人： Stephane Commo , Bruno Bernard
IPC分类号： A61K31/704 , A61K31/7088 , A61K31/352 , C12Q1/48
CPC分类号： A61Q5/065 , A61K8/34 , A61K8/42 , A61K8/63 , A61K8/64 , A61K31/7048 , A61K2800/70 , A61Q5/00 , A61Q5/10 , A61Q7/00
摘要： Agents inducing the expression of DOPAchrome tautomerase are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译：诱导诱导DOPAchrome互变异构酶表达的药剂，特别是局部施用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止并保持灰色或白色头发和/或身体毛发的天然色素沉着。

13. 发明申请

US20080026019A1 Administration of ellagic acid for the treatment of canities 有权
标题翻译：管理鞣花酸治疗犬只
公开(公告)号：US20080026019A1
公开(公告)日：2008-01-31
申请号：US11812572
申请日：2007-06-20
申请人： Stephane Commo
发明人： Stephane Commo
IPC分类号： A61K31/352 , A61K31/454 , A61K33/04 , A61K8/11 , A61Q5/00
CPC分类号： A61K8/498 , A61Q5/065
摘要： At least one compound selected from among ellagic acid, its salts, its metal complexes, its monoether or polyether, monoacylated or polyacylated derivatives and its carbonate or carbamate derivatives deriving from hydroxyl groups and mixtures thereof, and admixtures thereof with other active agents selected from among active agents for combating desquamative conditions of the scalp, plant extracts having propigmenting activity and active agents that slow hair loss and/or promote hair regrowth, are useful for preventing and/or limiting and/or stopping the development of canities.
摘要翻译：选自鞣花酸，其盐，其金属络合物，其单醚或聚醚，单酰化或多酰化衍生物及其衍生自羟基的碳酸酯或氨基甲酸酯衍生物及其混合物的至少一种化合物，及其与其它活性剂的混合物，所述活性剂选自用于防治头皮脱屑条件的活性剂，具有促进作用的植物提取物和缓慢脱发和/或促进头发再生的活性剂，可用于预防和/或限制和/或阻止发酵。

14. 发明授权

US6113889A Screening of candidates for biological hair care activity 失效
标题翻译：筛选候选人的生物护发活动
公开(公告)号：US6113889A
公开(公告)日：2000-09-05
申请号：US233062
申请日：1999-01-20
申请人： Fran.cedilla.oise Jarrousse , Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Fran.cedilla.oise Jarrousse , Stephane Commo , Olivier Gaillard , Bruno Bernard
IPC分类号： A61K8/02 , A61Q7/00 , G01N33/50 , A61K7/06
CPC分类号： G01N33/5088 , Y10S514/88
摘要： The invention concerns a procedure for testing a potentially-active substance used in the hair-care field, this procedure being characterized by the fact that a fragment of at least one hair follicle without dermal papilla is isolated, this fragment being taken from beneath the point of attachment of the sebaceous gland and excluding the portion of the hair shaft located above the point of attachment of the sebaceous gland; that this fragment is incubated in a suitable culture medium for a sufficient period; that this fragment is placed in contact with a potentially-active hair-care substance; that a marker of the activity of said tested substance is quantitatively determined; and that the results of this determination are assessed as they compare to a control.
摘要翻译：本发明涉及一种用于测试头发护理领域中使用的潜在活性物质的方法，该方法的特征在于，至少一种没有真皮乳头的毛囊的片段被分离，该片段从点下面皮脂腺附着并排除位于皮脂腺附着点之上的毛发部分; 将该片段在合适的培养基中培养足够的时间; 该片段与潜在活性的护发物质接触; 定量测定所述被测物质的活性的标记物; 并且与其对照相比，评估该测定的结果。

15. 发明授权

US08969407B2 Administration of coumarin, butylated hydroxyanisole and ethoxyquine for the treatment of canities 有权
标题翻译：管理香豆素，丁基化羟基苯甲醚和乙氧基喹啉治疗阴茎
公开(公告)号：US08969407B2
公开(公告)日：2015-03-03
申请号：US13689947
申请日：2012-11-30
申请人： Stephane Commo
发明人： Stephane Commo
IPC分类号： A61K31/45 , A61K8/00 , A61K8/02 , A61Q5/00 , A61K31/47 , A61K31/05 , A61K31/075 , A61K8/49 , A61K8/34 , A61Q5/06
CPC分类号： A61K8/498 , A61K8/347 , A61K8/4926 , A61Q5/00 , A61Q5/065 , H01L2924/0002 , H01L2924/00
摘要： At least one compound selected from among coumarin and/or derivative thereof, butylated hydroxyanisole, ethoxyquine and mixtures thereof, and admixtures thereof with other active agents selected from among active agents for combating desquamative conditions of the scalp, plant extracts having propigmenting activity and active agents that slow hair loss and/or promote hair regrowth, are useful for preventing and/or limiting and/or stopping the development of canities.
摘要翻译：选自香豆素和/或其衍生物中的至少一种化合物，丁基化羟基茴香醚，乙氧基喹啉及其混合物，以及与其它活性剂的混合物，所述活性剂选自用于防治头皮脱屑条件的活性剂，具有辅助活性的植物提取物和活性剂减缓脱发和/或促进头发再生长，对于预防和/或限制和/或阻止发展神经系统是有用的。

16. 发明授权

US08895037B2 Administation of ellagic acid for the treatment of canities 有权
标题翻译：管理鞣花酸治疗病毒
公开(公告)号：US08895037B2
公开(公告)日：2014-11-25
申请号：US11812572
申请日：2007-06-20
申请人： Stephane Commo
发明人： Stephane Commo
IPC分类号： A61K8/02 , A61Q5/06 , A61K8/49
CPC分类号： A61K8/498 , A61Q5/065
摘要： At least one compound selected from among ellagic acid, its salts, its metal complexes, its monoether or polyether, monoacylated or polyacylated derivatives and its carbonate or carbamate derivatives deriving from hydroxyl groups and mixtures thereof, and admixtures thereof with other active agents selected from among active agents for combating desquamative conditions of the scalp, plant extracts having propigmenting activity and active agents that slow hair loss and/or promote hair regrowth, are useful for preventing and/or limiting and/or stopping the development of canities.
摘要翻译：选自鞣花酸，其盐，其金属络合物，其单醚或聚醚，单酰化或多酰化衍生物及其衍生自羟基的碳酸酯或氨基甲酸酯衍生物及其混合物的至少一种化合物，及其与其它活性剂的混合物，所述活性剂选自用于防治头皮脱屑条件的活性剂，具有促进作用的植物提取物和缓慢脱发和/或促进头发再生的活性剂，可用于预防和/或限制和/或阻止发酵。

17. 发明授权

US08481762B2 Administration of compounds that increase glutathione levels in the melanocytes for the treatment of canities 有权
标题翻译：施用增加黑素细胞中谷胱甘肽水平治疗犬的化合物
公开(公告)号：US08481762B2
公开(公告)日：2013-07-09
申请号：US11812900
申请日：2007-06-22
申请人： Stephane Commo
发明人： Stephane Commo
IPC分类号： C07D307/77 , A61K9/50
CPC分类号： A61Q5/10 , A61K8/11 , A61K8/49 , A61K8/4986 , A61K8/63 , A61K2800/412 , A61K2800/413 , A61Q7/00
摘要： At least one compound that increases the level of glutathione (GSH) in the melanocytes of hair follicles, and admixtures thereof with other active agents selected from among active agents for combating desquamative conditions of the scalp, plant extracts having propigmenting activity and active agents that slow hair loss and/or promote hair regrowth, are useful for preventing and/or limiting and/or stopping the development of canities.
摘要翻译：至少一种增加毛囊黑素细胞中的谷胱甘肽（GSH）水平的化合物，以及与其它活性剂的混合物，所述其它活性剂选自用于防治头皮脱屑条件的活性剂，具有辅助活性的植物提取物和缓慢的活性剂脱发和/或促进头发再生长，对于预防和/或限制和/或阻止发展的发明是有用的。

18. 发明授权

US08445004B2 Administration of agents mimicking dopachrome tautomerase (TRP-2) activity for protecting hair follicle melanocytes 有权
标题翻译：给予模仿多巴肼互变异构酶（TRP-2）活性以保护毛囊黑素细胞的药剂
公开(公告)号：US08445004B2
公开(公告)日：2013-05-21
申请号：US12541398
申请日：2009-08-14
申请人： Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Stephane Commo , Olivier Gaillard , Bruno Bernard
IPC分类号： A61K8/02
CPC分类号： C12Q1/533 , A61K8/19 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/10
摘要： Agents mimicking DOPAchrome tautomerase activity are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译：施用模仿DOPAchrome互变异构酶活性的试剂，特别是局部应用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止囊泡的发育，并保持灰色或白色头发和/或身体毛发的天然色素沉着。

19. 发明申请

US20080027129A1 Administration of 3H-1, 2-dithiole-3-thione, anethole dithiolethione, sulforaphane, phenethyl isothiocyanate, 6-(methylsulfinyl)hexyl isothiocyanate and allyl isothiocyanate for the treatment of canities 审中-公开
标题翻译：施用3H-1,2-二硫杂环戊烯-3-硫酮，茴香脑二硫代硫酮，萝卜硫素，异硫氰酸苯乙酯，异硫氰酸6-（甲基亚磺酰基）己基酯，异硫氰酸烯丙酯
公开(公告)号：US20080027129A1
公开(公告)日：2008-01-31
申请号：US11812573
申请日：2007-06-20
申请人： Stephane Commo
发明人： Stephane Commo
IPC分类号： A61K31/26 , A61K31/385 , A61Q7/00
CPC分类号： A61K8/4986 , A61K8/11 , A61K8/46 , A61K2800/412 , A61K2800/413 , A61Q5/10
摘要： At least one compound selected from among 3H-1,2-dithiole-3-thione, anethole dithiolethione, sulforaphane, phenethyl isothiocyanate, 6-(methylsulfinyl)hexyl isothiocyanate and allyl isothiocyanate and derivatives and mixtures thereof, and admixtures thereof with other active agents selected from among active agents for combating desquamative conditions of the scalp, plant extracts having propigmenting activity and active agents that slow hair loss and/or promote hair regrowth, are useful for preventing and/or limiting and/or stopping the development of canities.
摘要翻译：至少一种选自3H-1,2-二硫杂环戊烯-3-硫酮，茴香脑二硫代硫醚，萝卜硫素，异硫氰酸苯乙酯，6-（甲基亚磺酰基）异硫氰酸己酯和异硫氰酸烯丙酯及其衍生物和混合物的化合物及其与其它活性剂选自用于防治头皮脱屑条件的活性剂，具有促进作用的植物提取物和缓慢脱发和/或促进头发再生的活性剂，可用于预防和/或限制和/或阻止发展。

20. 发明申请

US20080014229A1 Administration of compounds that increase glutathione levels in the melanocytes for the treatment of canities 有权
标题翻译：施用增加黑素细胞中谷胱甘肽水平治疗犬的化合物
公开(公告)号：US20080014229A1
公开(公告)日：2008-01-17
申请号：US11812900
申请日：2007-06-22
申请人： Stephane Commo
发明人： Stephane Commo
IPC分类号： A61K8/02 , A61K8/18 , A61Q5/00
CPC分类号： A61Q5/10 , A61K8/11 , A61K8/49 , A61K8/4986 , A61K8/63 , A61K2800/412 , A61K2800/413 , A61Q7/00
摘要： At least one compound that increases the level of glutathione (GSH) in the melanocytes of hair follicles, and admixtures thereof with other active agents selected from among active agents for combating desquamative conditions of the scalp, plant extracts having propigmenting activity and active agents that slow hair loss and/or promote hair regrowth, are useful for preventing and/or limiting and/or stopping the development of canities.
摘要翻译：至少一种增加毛囊黑素细胞中的谷胱甘肽（GSH）水平的化合物，以及与其它活性剂的混合物，所述其它活性剂选自用于防治头皮脱屑条件的活性剂，具有辅助活性的植物提取物和缓慢的活性剂脱发和/或促进头发再生长，对于预防和/或限制和/或阻止发展的发明是有用的。

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