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11. 发明授权

US5300861A Method in a pulsed accelerator for accelerating a magnetized rotating plasma 失效
标题翻译：用于加速磁化旋转等离子体的脉冲加速器中的方法
公开(公告)号：US5300861A
公开(公告)日：1994-04-05
申请号：US32721
申请日：1993-03-16
申请人： Herman Helgesen , Sonja R. Helgesen , Alfred Sillesen , Jan Bergstrom , Vladimir M. Kouznetsov
发明人： Herman Helgesen , Sonja R. Helgesen , Alfred Sillesen , Jan Bergstrom , Vladimir M. Kouznetsov
IPC分类号： H05H1/54 , H05H1/24 , H01J7/24
CPC分类号： H05H1/52
摘要： The invention provides in an accelerator for accelerating a magnetized rotating plasma comprising a magnetic system arrange symmetrically around an axis, two electrodes (10, 11) extending symmetrically along said axis inside the magnetic system, said electrodes being spaced from each other in the transverse direction of said axis, two pulsed power sources connected to the magnetic system and the electrodes, respectively, and openings (18) in the inner electrode in a cross-section perpendicular to said axis for the supply of a neutral gas to the space defined by said electrodes, a method for controlling the operation of the accelerator wherein the magnetic field is confined to form a layer which comprises a first cylindrical portion (12) with a minor diameter and a second cylindrical portion (14) with a major diameter and a transition portion (13) interconnecting said first and second cylindrical portions being arranged axis-symmetrically around a common axis.
摘要翻译：本发明提供一种用于加速磁化旋转等离子体的加速器，该磁化旋转等离子体包括围绕轴线对称布置的磁体系统，在磁性系统内部沿所述轴对称延伸的两个电极（10,11），所述电极在横向彼此间隔开的两个脉冲电源分别连接到磁系统和电极，以及垂直于所述轴线的横截面中的内电极中的开口（18），用于向由所述轴线限定的空间供应中性气体电极，用于控制加速器的操作的方法，其中磁场被限制以形成包括具有小直径的第一圆柱形部分（12）和具有大直径和过渡部分的第二圆柱形部分（14）的层将所述第一和第二圆柱形部分互相连接的连接件（13）围绕公共轴线对称布置。

12. 发明授权

US10562007B2 Separation matrix 有权
公开(公告)号：US10562007B2
公开(公告)日：2020-02-18
申请号：US12667873
申请日：2008-07-22
申请人： Andreas Axen , Jan Bergstrom , Gunnar Glad , Bo-Lennart Johansson , Nils Norrman
发明人： Andreas Axen , Jan Bergstrom , Gunnar Glad , Bo-Lennart Johansson , Nils Norrman
IPC分类号： B01D15/36 , B01J20/289 , B01J20/32
摘要： The present invention relates to a separation matrix, which comprises a support; extenders coupled to an outer part of said support; and ligands coupled to said extenders, wherein the part of the support to which the extenders are coupled constitutes less than 50% of the volume of the separation matrix. The invention also embraces a method of preparing such a separation matrix, as well as a process wherein the separation media is used.

13. 发明授权

US09278297B2 Method for ion-exchange chromatography and media used thereof 有权
标题翻译：离子交换色谱法及其使用的介质
公开(公告)号：US09278297B2
公开(公告)日：2016-03-08
申请号：US13809179
申请日：2011-06-28
申请人： Jan Bergstrom , Bo-Lennart Johansson
发明人： Jan Bergstrom , Bo-Lennart Johansson
IPC分类号： G01N30/02 , B01D15/36 , C07K1/18
CPC分类号： B01D15/361 , C07K1/18
摘要： The present invention relates to a method for running ion exchange chromatography on a media comprising shell beads having an inner porous core and an outer shell, wherein the inner core is provided with ligands whose charge changes with pH and the shell is provided with charged ion exchange ligands, the method comprising the following steps: a) adsorbing sample molecules on the shell ligands at a first pH; b) causing a discharge of the inner core ligands at a second pH by addition of a buffer substance that is able to increase its charge having the same sign/type as that of the core ligands, which at the same time causes release of ions from the inner core ligands and thereby an increase in ionic strength that displaces the sample molecules from the shell ligands i.e. causes an elution.
摘要翻译：本发明涉及一种用于在包含具有内多孔芯和外壳的壳珠的介质上运行离子交换色谱的方法，其中内核具有其电荷随pH变化并且壳被带有带电离子交换的配体配体，该方法包括以下步骤：a）在第一pH下将样品分子吸附在壳配体上; b）通过添加能够增加其与核配体相同符号/类型的电荷的缓冲物质，在第二pH下引起内核配体的排出，同时使离子从内部核心配体，从而使离子强度的增加从壳体配体取代样品分子即引起洗脱。

14. 发明申请

US20110045574A1 CHROMATOGRAPHY MEDIUM 审中-公开
标题翻译：色谱介质
公开(公告)号：US20110045574A1
公开(公告)日：2011-02-24
申请号：US12988707
申请日：2009-04-21
申请人： Jan Bergstrom , Gunnar Glad , Bo-Lennart Johansson , Jean-Luc Maloisel , Nils Norrman , Tobias E. Soderman
发明人： Jan Bergstrom , Gunnar Glad , Bo-Lennart Johansson , Jean-Luc Maloisel , Nils Norrman , Tobias E. Soderman
IPC分类号： C12N7/02 , H01F1/00 , C12N1/20 , C12N15/63 , B01J20/00 , B01J20/26 , C07K16/00 , C07K1/14 , C07H21/00 , C11B3/00
CPC分类号： B01D15/327 , B01J20/28009 , B01J20/285 , B01J20/287 , B01J20/3212 , B01J20/3293 , B01J39/26 , C07K1/20 , C07K16/00 , C12N7/00 , C12N2760/16151 , G01N1/405
摘要： The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.
摘要翻译：本发明在色谱领域内。更准确地说，它涉及一种新颖的色谱介质，即由于疏水介质的孔隙率和/或盖的孔隙度，提供了不同盖子的疏水介质，其中排除了一定尺寸的分子。本发明还涉及用于纯化不分离介质的大分子的分离介质以及进入分离介质并从其中洗脱的小分子的用途。

15. 发明申请

US20100320149A1 SEPARATION MATRIX 审中-公开
标题翻译：分离矩阵
公开(公告)号：US20100320149A1
公开(公告)日：2010-12-23
申请号：US12667873
申请日：2008-07-22
申请人： Andreas Axen , Jan Bergstrom , Gunnar Glad , Bo-Lennart Johansson , Nils Norrman
发明人： Andreas Axen , Jan Bergstrom , Gunnar Glad , Bo-Lennart Johansson , Nils Norrman
IPC分类号： B01D15/38 , B01D15/36
摘要： The present invention relates to a separation matrix, which comprises a support; extenders coupled to an outer part of said support; and ligands coupled to said extenders, wherein the part of the support to which the extenders are coupled constitutes less than 50% of the volume of the separation matrix. The invention also embraces a method of preparing such a separation matrix, as well as a process wherein the separation media is used.
摘要翻译：本发明涉及一种分离基质，其包括载体; 联接到所述支撑件的外部的延伸器; 和与所述增量剂偶联的配体，其中与所述增量剂偶联的载体的部分构成小于分离基质体积的50％。本发明还包括制备这种分离基质的方法，以及其中使用分离介质的方法。

16. 发明授权

US6090288A Process for chromatographic separation of peptides and nucleic acid, and new high affinity ion exchange matrix 有权
标题翻译：肽和核酸的色谱分离方法，以及新的高亲和力离子交换矩阵
公开(公告)号：US6090288A
公开(公告)日：2000-07-18
申请号：US117678
申请日：1998-12-29
申请人： Rolf Berglund , Jan Bergstrom , Makonnen Belew , Lennart Soderberg
发明人： Rolf Berglund , Jan Bergstrom , Makonnen Belew , Lennart Soderberg
IPC分类号： B01D15/08 , B01D15/36 , B01J41/20 , C07K1/18
CPC分类号： G01N30/482 , B01D15/363 , B01J41/20 , C07K1/18 , B01J2220/54
摘要： Process for separating off a peptide or a nucleic acid by an anion exchanger (I) characterized in that a) the anion exchanger (I) exhibits ligands, which (i) contain a primary, secondary or tertiary amino group and (ii) are covalently bound to an organic polymer (matrix), b) there on a carbon atom at a distance of 2 or 3 atoms away from an amino nitrogen in the ligands is a hydroxyl group or a primary, secondary or tertiary amino group, and c) the maximum elution ionic strength in the pH range 2-14 for at least one of the proteins transferrin, ovalbumin 1, ovalbumin 2, .beta.-lactoglobulin 1 and .beta.-lactoglobulin 2 on the anion exchanger is higher than the elution ionic strength required for a quaternary comparative ion exchanger.
摘要翻译： PCT No.PCT / SE97 / 00237 Sec。 371 1998年12月29日第 102（e）日期1998年12月29日PCT 1997年2月14日提交PCT公布。第WO97 / 29825号公报日期1997年8月21日阴离子交换剂（I）分离肽或核酸的方法，其特征在于a）阴离子交换剂（I）表现出配体，其中（i）含有伯，仲或叔氨基，（ii）与有机聚合物（基体）共价结合，b）在配位体中与氨基氮离开2或3个原子的碳原子处是羟基或伯，仲或叔氨基，和c）阴离子交换剂上至少一种蛋白质转运蛋白，卵白蛋白1，卵白蛋白2，β-乳球蛋白1和β-乳球蛋白2在pH范围2-14中的最大洗脱离子强度高于洗脱离子四级比较离子交换器所需的强度。

17. 发明授权

US5766460A Liquid chromatographic system 失效
标题翻译：液相色谱系统
公开(公告)号：US5766460A
公开(公告)日：1998-06-16
申请号：US779059
申请日：1997-01-06
申请人： Jan Bergstrom , Lennart Soderberg
发明人： Jan Bergstrom , Lennart Soderberg
IPC分类号： B01D15/08 , G01N30/60 , G01N30/88
CPC分类号： B01D15/08 , G01N30/6004 , G01N2030/8881 , G01N30/6034 , G01N30/6047
摘要： A liquid chromatographic system comprises at least two modules, at least one fluid flow line, and at least two connector devices provided along the flow line and respectively connecting the modules to the flow line. One of the two modules comprises a separation module and the other of the two modules comprises an ancillary module having a non-separation function. Each of the two modules includes at least one end connector fit into the respective connector device, and each end connector is adapted to interchangeably fit into either connector device.
摘要翻译：液相色谱系统包括至少两个模块，至少一个流体流动线，以及沿着流动管线设置并分别将模块连接到流动管线的至少两个连接器装置。两个模块之一包括分离模块，并且两个模块中的另一个模块包括具有非分离功能的辅助模块。两个模块中的每一个包括配合到相应连接器装置中的至少一个端部连接器，并且每个端部连接器适于可互换地装配到任一连接器装置中。

18. 发明授权

US09259729B2 Method for production of chromatography media 有权
标题翻译：色谱介质的制备方法
公开(公告)号：US09259729B2
公开(公告)日：2016-02-16
申请号：US13642937
申请日：2011-04-20
申请人： Jan Bergstrom , Bo-Lennart Johansson
发明人： Jan Bergstrom , Bo-Lennart Johansson
IPC分类号： B01J39/16 , B01J47/00 , B01J20/286 , B01J20/32 , B01J20/28
CPC分类号： B01J39/165 , B01J20/28004 , B01J20/286 , B01J20/3242 , B01J20/3293 , B01J39/17 , B01J47/018
摘要： The present invention relates to a method and means to produce chromatography media having improved pressure-flow properties. More closely, the invention relates to bimodal particle size distribution and the use of layer functionalization as means to change pressure-flow properties of chromatography media. The invention relates to a method for production of chromatography media having improved pressure-flow properties, comprising mixing large beads/particles, comprising an inner core and an outer functionalized shell/lid, with smaller beads/particles, wherein the ratio of the particle size of large and small beads: [D50V for large particles/D50V for small particles]>1.2, and wherein the volume ratio of large and small beads in the column: [Total volume of large beads/Total volume beads] is in the range 0.05-0.9.
摘要翻译：本发明涉及产生具有改进的压力 - 流动性质的色谱介质的方法和方法。更具体地说，本发明涉及双峰粒径分布和层官能化作为改变色谱介质压力流动性质的手段。本发明涉及一种用于制备具有改进的压力 - 流动性质的色谱介质的方法，包括将具有较小珠粒/颗粒的包含内核和外部功能化壳/盖的大珠粒/颗粒混合，其中颗粒尺寸大珠粒：[D50V为大颗粒/ D50V为小颗粒]> 1.2，其中柱中大小珠的体积比为[大珠/总体积珠的总体积]在0.05 -0.9。

19. 发明申请

US20130115709A1 CHROMATOGRAPHY METHOD AND MEDIA USED THEREFORE 有权
标题翻译：使用的色谱方法和介质
公开(公告)号：US20130115709A1
公开(公告)日：2013-05-09
申请号：US13809179
申请日：2011-06-28
申请人： Jan Bergstrom , Bo-Lennart Johansson
发明人： Jan Bergstrom , Bo-Lennart Johansson
IPC分类号： G01N30/02
CPC分类号： B01D15/361 , C07K1/18
摘要： The present invention relates to a method for running ion exchange chromatography on a media comprising shell beads having an inner porous core and an outer shell, wherein the inner core is provided with ligands whose charge changes with pH and the shell is provided with charged ion exchange ligands, the method comprising the following steps: a) adsorbing sample molecules on the shell ligands at a first pH; b) causing a discharge of the inner core ligands at a second pH by addition of a buffer substance that is able to increase its charge having the same sign/type as that of the core ligands, which at the same time causes release of ions from the inner core ligands and thereby an increase in ionic strength that displaces the sample molecules from the shell ligands i.e. causes an elution.
摘要翻译：本发明涉及一种用于在包含具有内多孔芯和外壳的壳珠的介质上运行离子交换色谱的方法，其中内核具有其电荷随pH变化并且壳被带有带电离子交换的配体配体，该方法包括以下步骤：a）在第一pH下将样品分子吸附在壳配体上; b）通过添加能够增加其与核配体相同符号/类型的电荷的缓冲物质，在第二pH下引起内核配体的排出，同时使离子从内部核心配体，从而使离子强度的增加从壳体配体取代样品分子即引起洗脱。

20. 发明申请

US20130040809A1 METHOD FOR PRODUCTION OF CHROMATOGRAPHY MEDIA 有权
标题翻译：生产色谱介质的方法
公开(公告)号：US20130040809A1
公开(公告)日：2013-02-14
申请号：US13642937
申请日：2011-04-20
申请人： Jan Bergstrom , Bo-Lennart Johansson
发明人： Jan Bergstrom , Bo-Lennart Johansson
IPC分类号： B01J20/281 , B01J20/282 , B01J41/20 , B01J20/30 , B01J39/26
CPC分类号： B01J39/165 , B01J20/28004 , B01J20/286 , B01J20/3242 , B01J20/3293 , B01J39/17 , B01J47/018
摘要： The present invention relates to a method and means to produce chromatography media having improved pressure-flow properties. More closely, the invention relates to bimodal particle size distribution and the use of layer functionalisation as means to change pressure-flow properties of chromatography media. The invention relates to a method for production of chromatography media having improved pressure-flow properties, comprising mixing large beads/particles, comprising an inner core and an outer functionalized shell/lid, with smaller beads/particles, wherein the ratio of the particle size of large and small beads: [D50V for large particles/D50V for small particles]>1.2, and wherein the volume ratio of large and small beads in the column: [Total volume of large beds/Total volume beads] is in the range 0.05-0.9.
摘要翻译：本发明涉及产生具有改进的压力 - 流动性质的色谱介质的方法和方法。本发明更紧密地涉及双峰粒度分布和层官能化用作改变色谱介质压力流动性质的手段。本发明涉及一种用于制备具有改进的压力 - 流动性质的色谱介质的方法，包括将具有较小珠粒/颗粒的包含内核和外部功能化壳/盖的大珠粒/颗粒混合，其中颗粒尺寸大颗粒和小珠：[D50V为大颗粒/ D50V为小颗粒]> 1.2，其中柱中大小珠的体积比为[大床/总体积珠的总体积]在0.05 -0.9。

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