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11. 发明申请

US20050261162A1 Pharmaceutical composition for preventing and treating cancer and treating an inflammation 审中-公开
标题翻译：用于预防和治疗癌症并治疗炎症的药物组合物
公开(公告)号：US20050261162A1
公开(公告)日：2005-11-24
申请号：US10472780
申请日：2002-03-22
申请人： Kwang-Kyun Park , Jae-Kwan Hwang , Sang-Kook Lee , Won-Yoon Chung
发明人： Kwang-Kyun Park , Jae-Kwan Hwang , Sang-Kook Lee , Won-Yoon Chung
IPC分类号： A61K36/18 , A61K31/045 , A61K31/05 , A61P29/00 , A61P35/00 , A61K31/00
CPC分类号： A61K31/045
摘要： The present invention relates to a pharmaceutical composition preventing cancer and treating cancer and inflammation, which is characterized in that including xanthorrhizol as an active principle. Xanthorrhizol not only inhibits mutagenesis and tumor formation, and enhances the activity of detoxification enzyme of carcinogen, induces apoptosis of cancer cell, and suppresses the activity of COX-2 and iNOS which are related to tumor promotion and inflammatory reaction. Thus, a pharmaceutical composition including xanthorrhizol can be utilized for prevention of cancer and treatment of cancer and inflammation.
摘要翻译：本发明涉及一种预防癌症和治疗癌症和炎症的药物组合物，其特征在于包括作为活性成分的黄嘌呤。 Xanthorrhizol不仅抑制诱变和肿瘤形成，增强致癌物解毒酶的活性，诱导癌细胞凋亡，抑制与肿瘤促进和炎症反应相关的COX-2和iNOS的活性。因此，包含黄原酸的药物组合物可以用于预防癌症和治疗癌症和炎症。

12. 发明申请

US20100048885A1 Immunostimulating Polysaccharides Isolated From Curcuma Xanthorrhiza and Manufacturing Method Thereof 审中-公开
标题翻译：免疫刺激从姜黄素分离的多糖及其制备方法
公开(公告)号：US20100048885A1
公开(公告)日：2010-02-25
申请号：US11922107
申请日：2006-06-14
申请人： Jae-Kwan Hwang , Ah-Jin Kim , Jong-Hee Sohn , Kyu-Lee Han , Sun-Hee Lee , Jeong-Han Choo
发明人： Jae-Kwan Hwang , Ah-Jin Kim , Jong-Hee Sohn , Kyu-Lee Han , Sun-Hee Lee , Jeong-Han Choo
IPC分类号： C07H1/00 , C07H3/00
CPC分类号： C08B37/006 , C12P19/04
摘要： The present invention provides a method for manufacturing polysaccharides isolated from Curcuma xanthorrhiza, including steps of: (S1) preparing a powder of Curcuma xanthorrhiza Roxb.; (S2) extracting the powder with an organic solvent, and then filtering or centrifuging to obtain a residue; (S3) extracting the residue to prepare a solution containing polysaccharides; (S4) removing starch by adding starch-hydrolyzing enzyme to the polysaccharides-containing solution; (S5) precipitating the polysaccharides after the step (S4); and (S6) purifying the polysaccharides after the step (S5), polysaccharides obtained according to the manufacturing method, and a pharmaceutical composition in eluding the polysaccharides as effective component. The polysaccharides according to the present invention may be very effectively used in drugs and functional foods for stimulating macrophage activity, preventing and treating immunological diseases including cancer, and enhancing immunity after the treatment of the immunological diseases.
摘要翻译：本发明提供了从姜黄分离得到的多糖的制造方法，包括以下步骤：（S1）制备姜黄黄酮粉末; （S2）用有机溶剂萃取粉末，然后过滤或离心得到残留物; （S3）提取残渣以制备含有多糖的溶液; （S4）通过向含多糖溶液中加入淀粉水解酶除去淀粉; （S5）在步骤（S4）后沉淀多糖; 和（S6）步骤（S5）后的多糖的纯化，根据制造方法得到的多糖，以及除了多糖作为有效成分的药物组合物。本发明的多糖可以非常有效地用于药物和功能性食品中，用于刺激巨噬细胞活性，预防和治疗免疫疾病，包括癌症，以及增强免疫疾病治疗后的免疫力。

13. 发明申请

US20090156688A1 SUPPRESSANT OF TOXICITY INDUCED BY CANCER CHEMOTHERAPEUTIC AGENT AND COMPOSITION OF CANCER CHEMOTHERAPEUTIC AGENT CONTAINING THE SAME 审中-公开
标题翻译：癌症化疗药物引起的毒性抑制剂和含有其的癌症化学治疗剂的组合物
公开(公告)号：US20090156688A1
公开(公告)日：2009-06-18
申请号：US12338912
申请日：2008-12-18
申请人： Kwang-Kyun Park , Won-Yoon Chung , Gyoung-Ok Hong , Jae-Kwan Hwang
发明人： Kwang-Kyun Park , Won-Yoon Chung , Gyoung-Ok Hong , Jae-Kwan Hwang
IPC分类号： A61K31/05
CPC分类号： A61K31/045 , A61K31/05 , A61K31/28 , A61K31/555 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： Disclosed are a suppressant of toxicity such as hepatotoxicity and nephrotoxicity, induced by cancer chemotherapeutic agent, and a composition of cancer chemotherapeutic agent containing the suppressant. The suppressant of toxicity induced by a cancer chemotherapeutic agent contains xanthorrhizol as an active ingredient. Xanthorrhizol shows an excellent ability in suppressing ill effects generated by dosage of cancer chemotherapeutic agent, such as hepatotoxicity and nephrotoxicity.
摘要翻译：公开了由癌症化学治疗剂诱导的毒性抑制剂如肝毒性和肾毒性，以及含有抑制剂的癌症化学治疗剂的组合物。癌症化学治疗剂诱导的毒性抑制剂含有作为活性成分的黄嘌呤。 Xanthorrhizol具有优异的抑制癌症化疗药物剂量引起的不良反应的能力，如肝毒性和肾毒性。

14. 发明申请

US20140186473A1 COMPOSITION FOR TREATING OBESITY AND DIABETES AND FOR INCREASING MUSCLE MASS AND IMPROVING CAPACITY FOR EXERCISE, COMPRISING EXTRACTS OF PIPER RETROFRACTUM VAHL. FRUITS AS ACTIVE INGREDIENTS 审中-公开
标题翻译：用于治疗肥胖和糖尿病并用于增加肌肉质量并改善运动能力的组合物，包括管状回流VAHL的提取物。水果作为主要成分
公开(公告)号：US20140186473A1
公开(公告)日：2014-07-03
申请号：US14122752
申请日：2012-05-31
申请人： Kyung-Jin Kim , Min-Sun Kim , Jae-Kwan Hwang
发明人： Kyung-Jin Kim , Min-Sun Kim , Jae-Kwan Hwang
IPC分类号： A61K36/67 , A23L1/30
CPC分类号： A61K36/67 , A23L33/105 , A23V2002/00 , A61K2236/37 , A61K2236/51
摘要： The present invention relates to a food composition, and to a pharmaceutical composition, which exhibit anti-obesity effects by means of a thermogenesis produced by an activity of a UCP of fat cells, which exhibit anti-diabetes effects by means of an improved insulin resistance, increase muscle mass, and improve capacity for exercise. More particularly, the present invention relates to a novel use of a composition containing extracts of piper retrofractum, and to the food composition or pharmaceutical composition which exhibit anti-obesity effects by means of decreased body weight and body fat, exhibit anti-diabetes effects by means of ameliorated insulin resistance through the reduction of blood glucose and blood insulin, increase muscle mass by increasing an energy source being supplied to the muscles, and improve the capacity for exercise including increased endurance.
摘要翻译：本发明涉及一种食品组合物和药物组合物，其通过由脂肪细胞的UCP的活性产生的产生嗜酸性的表现出抗肥胖作用，其通过改善的胰岛素抵抗显示抗糖尿病作用增加肌肉量，提高运动能力。更具体地说，本发明涉及一种含有枸杞子提取物的组合物的新用途，以及通过降低体重和体脂肪显示出抗肥胖作用的食品组合物或药物组合物，具有抗糖尿病作用通过减少血糖和血液胰岛素来改善胰岛素抵抗的手段，通过增加供应给肌肉的能量来增加肌肉质量，并提高运动能力，包括增加耐力。

15. 发明申请

US20120088840A1 NOVEL USE OF PANDURATIN DERIVATIVE OR BOESENBERGIA PANDURATA EXTRACT 有权
标题翻译：使用潘多林衍生物或槟榔酚提取物
公开(公告)号：US20120088840A1
公开(公告)日：2012-04-12
申请号：US13123519
申请日：2009-10-09
申请人： Jae-Kwan Hwang , Do Un Kim
发明人： Jae-Kwan Hwang , Do Un Kim
IPC分类号： A61K31/12 , C07C49/835 , A61P3/10 , A61P3/04 , A61P3/06 , A61P7/00 , C07C49/84 , A61P3/00
CPC分类号： A23C9/152 , A23L2/02 , A23L2/52 , A23L13/67 , A23L23/00 , A23L33/105 , A23L33/30 , A61K31/121 , A61K36/906
摘要： The present invention relates to a novel use of a panduratin derivative or a Boesenbergia pandurata extract. More specifically, the invention relates to a composition for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, containing a panduratin derivative represented by Chemical Formula 1, 2 or 3 or a Boesenbergia pandurata extract as an active ingredient, a method for treating a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, by administering an effective amount of the panduratin derivative or the Boesenbergia pandurata extract to a subject in need thereof, and a use of the panduratin derivative or the Boesenbergia pandurata extract to prepare a reagent for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes. As can be seen foregoing, the present invention provides a novel use of a panduratin derivative or a Boesenbergia pandurata extract. A panduratin derivative or a Boesenbergia pandurata extract of the present invention shows excellent effects on a metabolic disease such as obesity, hyperlipidemia, hypercholesterolemia and diabetes by decreasing highly related causes of metabolic diseases such as on weight, body fat and lipid-content. Since a composition of the present invention is originated from natural materials, it can be used without side effect and provides novel method for preventing and treating/relieving a metabolic disease through body weight loss and body fat loss and the like.
摘要翻译：本发明涉及一种潘多汀衍生物或蒲公英提取物的新用途。更具体地说，本发明涉及用于预防和治疗或减轻选自肥胖，高脂血症，高胆固醇血症和糖尿病的代谢疾病的组合物，其含有由化学式1,2或3表示的潘多肽衍生物或泛酸鲍氏菌提取物作为活性成分，可以通过向有需要的受试者施用有效量的潘多汀衍生物或泛黄柏提取物来治疗选自肥胖症，高脂血症，高胆固醇血症和糖尿病的代谢疾病的方法，以及使用的潘多汀衍生物或Boesenbergia pandurata提取物，以制备用于预防和治疗/减轻选自肥胖症，高脂血症，高胆固醇血症和糖尿病的代谢疾病的试剂。从前面可以看出，本发明提供了一种潘多汀衍生物或Boesenbergia pandurata提取物的新用途。本发明的潘多林衍生物或潘氏白僵菌提取物通过降低代谢性疾病如重量，体脂肪和脂质含量的高度相关原因，对肥胖症，高脂血症，高胆固醇血症和糖尿病等代谢疾病表现出优异的效果。由于本发明的组合物来自天然材料，所以可以无副作用地使用，并且通过体重减轻和身体脂肪减少等提供预防和治疗/减轻代谢疾病的新方法。

16. 发明授权

US06696404B1 Antibacterial composition having xanthorrizol 有权
标题翻译：具有黄三唑的抗菌组合物
公开(公告)号：US06696404B1
公开(公告)日：2004-02-24
申请号：US10312134
申请日：2002-12-19
申请人： Jae-Kwan Hwang
发明人： Jae-Kwan Hwang
IPC分类号： C11D338
CPC分类号： A61Q17/005 , A61K8/347 , A61K8/97 , A61Q11/00 , A61Q19/00
摘要： An antibacterial composition having xanthorrizol is provided. The xanthorrizol is prepared by obtaining crude extract having antibacterial activity from Curcuma xanthorriza Roxb. lysate by the aid of solvent extraction, supercritical fluid extraction, microwave extraction or ultrasonic extraction; applying the crude extract to chromatography to obtain active fraction; acetylation of the active fraction to change its polarity and applying to chromatography to isolate an acetylated single compound; and, deacetylation of the acetylated single compound to give xanthorrizol having antibacterial activity. Since xanthorrizol has potential antibacterial activity over a broad spectrum of microorganisms under a wide range of temperature, it can be practically applied to antibacterial agent, tooth paste, oral cleanser, chewing gum, soap and cosmetics which require the antibacterial activity.
摘要翻译：提供了具有黄三唑的抗菌组合物。通过从姜黄中获得具有抗菌活性的粗提取物来制备黄嘌呤三唑。通过溶剂萃取，超临界流体萃取，微波提取或超声波提取的裂解液; 将粗提物进行色谱分离以获得活性级分; 活化级分的乙酰化以改变其极性并施加到色谱法以分离乙酰化的单一化合物; 和乙酰化单一化合物的脱乙酰化，得到具有抗菌活性的三唑盐。由于紫藤三唑在广泛的温度范围内对广泛的微生物具有潜在的抗菌活性，因此可以实际应用于需要抗菌活性的抗菌剂，牙膏，口腔清洁剂，口香糖，肥皂和化妆品。

17. 发明授权

US08653143B2 Use of panduratin derivative or Boesenbergia pandurata extract 有权
标题翻译：使用潘多汀衍生物或Boesenbergia pandurata提取物
公开(公告)号：US08653143B2
公开(公告)日：2014-02-18
申请号：US13123519
申请日：2009-10-09
申请人： Jae-Kwan Hwang , Do Un Kim
发明人： Jae-Kwan Hwang , Do Un Kim
IPC分类号： A61K31/12
CPC分类号： A23C9/152 , A23L2/02 , A23L2/52 , A23L13/67 , A23L23/00 , A23L33/105 , A23L33/30 , A61K31/121 , A61K36/906
摘要： The present invention relates to a novel use of a panduratin derivative or a Boesenbergia pandurata extract. More specifically, the invention relates to a composition for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, containing a panduratin derivative represented by Chemical Formula 1, 2 or 3 or a Boesenbergia pandurata extract as an active ingredient, a method for treating a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, by administering an effective amount of the panduratin derivative or the Boesenbergia pandurata extract to a subject in need thereof, and a use of the panduratin derivative or the Boesenbergia pandurata extract to prepare a reagent for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes.
摘要翻译：本发明涉及一种潘多汀衍生物或蒲公英提取物的新用途。更具体地说，本发明涉及用于预防和治疗或减轻选自肥胖，高脂血症，高胆固醇血症和糖尿病的代谢疾病的组合物，其含有由化学式1,2或3表示的潘多肽衍生物或泛酸鲍氏菌提取物作为活性成分，可以通过向有需要的受试者施用有效量的潘多汀衍生物或泛黄柏提取物来治疗选自肥胖症，高脂血症，高胆固醇血症和糖尿病的代谢疾病的方法，以及使用的潘多汀衍生物或Boesenbergia pandurata提取物，以制备用于预防和治疗/减轻选自肥胖症，高脂血症，高胆固醇血症和糖尿病的代谢疾病的试剂。

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