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11. 发明授权

US09365635B2 Intravenous immunoglobulin composition 有权
标题翻译：静脉内免疫球蛋白组成
公开(公告)号：US09365635B2
公开(公告)日：2016-06-14
申请号：US13619011
申请日：2012-09-14
申请人： Israel Nur , Liliana Bar , Orgad Laub
发明人： Israel Nur , Liliana Bar , Orgad Laub
IPC分类号： A61K38/00 , C07K16/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/081 , A61K38/00 , A61K39/39591 , A61K2039/505 , C07K2319/00
摘要： A concentrated, immunoglobulin composition for treating subjects vaccinated against or infected with a pathogenic microorganism, is made by (a) selecting a population of individuals previously vaccinated against antigens associated with the pathogenic microorganism; (b) identifying very high titer individuals by determining the level of specific antibodies immunoreactive with the pathogenic microorganism in the blood of the individuals; (c) combining blood from the very high titer individuals; and (d) purifying and/or concentrating the product of step (c). A concentrated immunoglobulin composition can include specific antibodies immunoreactive with a pathogenic microorganism, wherein the titer of specific antibodies is at least 5 times higher than the average titer of specific antibodies of a population of individuals previously vaccinated against antigens associated with the pathogenic microorganism. The composition has a relatively high protein concentration and a low percentage of protein aggregates. The pathogenic microorganism is preferably smallpox virus or vaccinia virus.
摘要翻译：用于治疗接种疫苗或感染致病微生物的受试者的浓缩的免疫球蛋白组合物是通过（a）选择先前针对与病原微生物相关的抗原进行接种的个体群体; （b）通过确定与个体血液中的病原微生物免疫反应的特异性抗体的水平来鉴定非常高的滴度个体; （c）结合来自极高滴度个体的血液; 和（d）纯化和/或浓缩步骤（c）的产物。浓缩的免疫球蛋白组合物可以包括与病原微生物免疫反应的特异性抗体，其中特异性抗体的滴度比先前接种抗原与病原微生物相关抗原的个体群体的特异性抗体的平均滴度高至少5倍。该组合物具有相对高的蛋白质浓度和低百分比的蛋白质聚集体。病原微生物优选为天花病毒或痘苗病毒。

12. 发明申请

US20130011388A1 INTRAVENOUS IMMUNOGLOBULIN COMPOSITION 有权
标题翻译：内脏免疫组织化学
公开(公告)号：US20130011388A1
公开(公告)日：2013-01-10
申请号：US13619011
申请日：2012-09-14
申请人： Israel Nur , Liliana Bar , Orgad Laub
发明人： Israel Nur , Liliana Bar , Orgad Laub
IPC分类号： A61K39/395 , C07K16/08 , A61P31/20 , C07K16/00
CPC分类号： C07K16/081 , A61K38/00 , A61K39/39591 , A61K2039/505 , C07K2319/00
摘要： A concentrated, immunoglobulin composition for treating subjects vaccinated against or infected with a pathogenic microorganism, is made by (a) selecting a population of individuals previously vaccinated against antigens associated with the pathogenic microorganism; (b) identifying very high titre individuals by determining the level of specific antibodies immunoreactive with the pathogenic microorganism in the blood of the individuals; (c) combining blood from the very high titre individuals; and (d) purifying and/or concentrating the product of step (c). A concentrated immunoglobulin composition can include specific antibodies immunoreactive with a pathogenic microorganism, wherein the titre of specific antibodies is at least 5 times higher than the average titre of specific antibodies of a population of individuals previously vaccinated against antigens associated with the pathogenic microorganism. The composition has a relatively high protein concentration and a low percentage of protein aggregates. The pathogenic microorganism is preferably smallpox virus or vaccinia virus.
摘要翻译：用于治疗接种疫苗或感染致病微生物的受试者的浓缩的免疫球蛋白组合物是通过（a）选择先前针对与病原微生物相关的抗原进行接种的个体群体; （b）通过确定与个体血液中的病原微生物免疫反应的特异性抗体的水平来鉴定非常高的滴度个体; （c）结合极高滴度个体的血液; 和（d）纯化和/或浓缩步骤（c）的产物。浓缩的免疫球蛋白组合物可以包括与病原微生物免疫反应的特异性抗体，其中特异性抗体的滴度比先前接种抗原与病原微生物相关抗原的个体群体的特异性抗体的平均滴度高至少5倍。该组合物具有相对高的蛋白质浓度和低百分比的蛋白质聚集体。病原微生物优选为天花病毒或痘苗病毒。

13. 发明申请

US20100310524A1 Compositions Suitable for Treatment of Spinal Disease, Disorder or Condition 有权
标题翻译：适用于治疗脊髓疾病，疾病或病症的组合物
公开(公告)号：US20100310524A1
公开(公告)日：2010-12-09
申请号：US12675234
申请日：2008-08-29
申请人： Edna Bechor , Liliana Bar , Israel Nur
发明人： Edna Bechor , Liliana Bar , Israel Nur
IPC分类号： A61K35/16 , C12N5/02 , A61K38/43 , A61P19/00
CPC分类号： A61K35/16 , A61K35/545 , A61K38/1709 , A61K38/363 , A61L27/3616 , A61L27/3804 , A61L27/3856 , A61L27/3878 , A61L2430/38 , C12N5/0655 , C12N2500/84 , A61K2300/00
摘要： The invention relates to the use of viral inactivated-plasma cryoprecipitate concentrate (VIPCC) comprising a suitable fibronectin/fibrinogen ratio for treating a spine disease, disorder or condition such as intervertebral disc degeneration.
摘要翻译：本发明涉及包含适当的纤连蛋白/纤维蛋白原比例的病毒灭活血浆冷沉淀物浓缩物（VIPCC）用于治疗脊椎疾病，病症或病症如椎间盘退变的用途。

14. 发明申请

US20100203033A1 Kits, formulations and solutions having enzymatically- permissive amounts of visualization agents and uses thereof 审中-公开
标题翻译：具有酶允许量的可视化试剂的试剂盒，制剂和溶液及其用途
公开(公告)号：US20100203033A1
公开(公告)日：2010-08-12
申请号：US12665810
申请日：2008-07-01
申请人： Israel Nur , Roberto Meidler , Liliana Bar
发明人： Israel Nur , Roberto Meidler , Liliana Bar
IPC分类号： A61L24/10
CPC分类号： A61L24/106 , A61L24/043 , A61L24/108 , A61L31/046 , C08L89/00
摘要： The invention relates to a proteolytic enzyme which is capable of forming fibrin when it reacts with fibrinogen, a fibrin-glue kit and a fibrin-glue formulation comprising an enzymatically-permissive concentration of a visualization agent and to their use in methods for prevention and/or reduction of adhesions and/or methods for promotion of blood coagulation sealing or filling body surfaces.
摘要翻译：本发明涉及当与纤维蛋白原反应时能够形成纤维蛋白的蛋白水解酶，纤维蛋白胶试剂盒和包含酶允许浓度的可视化试剂的纤维蛋白胶制剂，以及它们在预防和/ 或减少用于促进血液凝固密封或填充体表面的粘合和/或方法。

15. 发明申请

US20060257458A1 Reinforced absorbable multilayered hemostatis wound dressing 有权
标题翻译：增强吸收性多层切割伤口敷料
公开(公告)号：US20060257458A1
公开(公告)日：2006-11-16
申请号：US11400849
申请日：2006-04-10
申请人： Anne Gorman , Sanyog Pendharkar , Guanghui Zhang , Liliana Bar , Israel Nur , Roberto Meidler
发明人： Anne Gorman , Sanyog Pendharkar , Guanghui Zhang , Liliana Bar , Israel Nur , Roberto Meidler
IPC分类号： A61L15/00
CPC分类号： A61L15/26 , A61F13/00029 , A61L15/28 , A61L15/32 , A61L15/44 , A61L15/64 , A61L2300/418 , A61L2300/608 , A61L2400/04 , B32B5/022 , B32B5/024 , B32B5/026 , B32B5/26 , B32B23/02 , B32B23/10 , B32B27/36 , B32B2250/20 , B32B2262/0276 , B32B2262/04 , B32B2262/06 , B32B2262/062 , B32B2307/726 , B32B2556/00 , Y10T442/2525 , C08L67/04
摘要： The present invention is directed to a reinforced absorbable multilayered hemostatic wound dressing comprising a first absorbable nonwoven fabric, a second absorbable woven or knitted fabric, thrombin and/or fibrinogen.
摘要翻译：本发明涉及包含第一可吸收无纺布，第二可吸收编织物或针织物，凝血酶和/或纤维蛋白原的增强可吸收多层止血伤口敷料。

16. 发明授权

US09439997B2 Reinforced absorbable multilayered hemostatis wound dressing 有权
公开(公告)号：US09439997B2
公开(公告)日：2016-09-13
申请号：US11400849
申请日：2006-04-10
申请人： Anne Jessica Gorman , Sanyog Manohar Pendharkar , Guanghui Zhang , Liliana Bar , Israel Nur , Roberto Meidler
发明人： Anne Jessica Gorman , Sanyog Manohar Pendharkar , Guanghui Zhang , Liliana Bar , Israel Nur , Roberto Meidler
IPC分类号： A61L15/00 , A61L15/26 , A61L15/28 , A61L15/32 , A61L15/44 , A61L15/64 , B32B5/02 , B32B5/26 , B32B23/02 , B32B23/10 , B32B27/36
CPC分类号： A61L15/26 , A61F13/00029 , A61L15/28 , A61L15/32 , A61L15/44 , A61L15/64 , A61L2300/418 , A61L2300/608 , A61L2400/04 , B32B5/022 , B32B5/024 , B32B5/026 , B32B5/26 , B32B23/02 , B32B23/10 , B32B27/36 , B32B2250/20 , B32B2262/0276 , B32B2262/04 , B32B2262/06 , B32B2262/062 , B32B2307/726 , B32B2556/00 , Y10T442/2525 , C08L67/04
摘要： The present invention is directed to a reinforced absorbable multilayered hemostatic wound dressing comprising a first absorbable nonwoven fabric, a second absorbable woven or knitted fabric, thrombin and/or fibrinogen.

17. 发明授权

US09125906B2 Treatment of peripheral vascular disease using umbilical cord tissue-derived cells 有权
标题翻译：使用脐带组织来源的细胞治疗外周血管疾病
公开(公告)号：US09125906B2
公开(公告)日：2015-09-08
申请号：US13206913
申请日：2011-08-10
申请人： Charito S. Buensuceso , Anthony J. Kihm , Sridevi Dhanaraj , Roee Atlas , Israel Nur , Roberto Meidler , Liliana Bar
发明人： Charito S. Buensuceso , Anthony J. Kihm , Sridevi Dhanaraj , Roee Atlas , Israel Nur , Roberto Meidler , Liliana Bar
IPC分类号： A61K35/51 , A61K45/00 , A61K38/48 , A61K45/06 , A61L27/38 , C12N5/073 , A61K38/36
CPC分类号： A61K35/51 , A61K35/34 , A61K35/44 , A61K35/545 , A61K38/363 , A61K38/4833 , A61K45/06 , A61L27/3834 , A61L27/3839 , A61L27/3886 , A61L27/3895 , C12N5/0605 , C12N2510/00 , A61K2300/00 , A61K35/15
摘要： Compositions and methods of using cells derived from umbilical cord tissue, to stimulate and support angiogenesis, to improve blood flow, to regenerate, repair, and improve skeletal muscle damaged by a peripheral ischemic event, and to protect skeletal muscle from ischemic damage in peripheral vascular disease patients are disclosed. In particular, methods of treating a patient having a peripheral vascular disease with umbilical derived cells and fibrin glue are disclosed.
摘要翻译：使用衍生自脐带组织的细胞刺激和支持血管生成，改善血流量，再生，修复和改善由外周缺血事件损伤的骨骼肌的组合物和方法，以及保护骨骼肌免受外周血管中的缺血性损伤疾病患者被披露。特别地，公开了用脐带血细胞和纤维蛋白胶治疗患有外周血管疾病的患者的方法。

18. 发明申请

US20070037170A1 Intravenous immunoglobulin composition 有权
标题翻译：静脉内免疫球蛋白组成
公开(公告)号：US20070037170A1
公开(公告)日：2007-02-15
申请号：US11201282
申请日：2005-08-11
申请人： Israel Nur , Liliana Bar , Orgad Laub
发明人： Israel Nur , Liliana Bar , Orgad Laub
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C07K16/081 , A61K38/00 , A61K39/39591 , A61K2039/505 , C07K2319/00
摘要： A method for preparing a concentrated, immunoglobulin composition for treating subjects vaccinated against or infected with a pathogenic microorganism, comprising: (a) selecting a population of individuals previously vaccinated against one or more antigens associated with the pathogenic microorganism; (b) determining the level of specific antibodies immunoreactive with the pathogenic microorganism in a blood or blood component of the individuals to identify very high titre individuals having a very high titre of the specific antibodies; (c) combining blood or blood components comprising immunoglobulins from the very high titre individuals; and (d) purifying and/or concentrating the product of step (c), thereby obtaining a concentrated immunoglobulin composition. Also disclosed is a concentrated immunoglobulin composition comprising specific antibodies immunoreactive with a pathogenic microorganism, characterized in that the titre of specific antibodies of the composition is at least 5 times higher than the average titre of specific antibodies of a population of individuals previously vaccinated against one or more antigens associated with the pathogenic microorganism. The composition has a relatively high protein concentration and a low percentage of protein aggregates, and is therefore suitable for both iv and im administration. In a preferred embodiment, the pathogenic microorganism is smallpox virus or vaccinia virus.
摘要翻译：一种制备用于治疗接种疫苗或感染病原微生物的受试者的浓缩免疫球蛋白组合物的方法，包括：（a）选择先前针对与病原微生物相关的一种或多种抗原接种的个体群体; （b）确定在个体的血液或血液成分中与病原微生物免疫反应的特异性抗体的水平，以鉴定具有非常高的特异性抗体滴度的极高滴度的个体; （c）从非常高的滴度个体组合包含免疫球蛋白的血液或血液成分; 和（d）纯化和/或浓缩步骤（c）的产物，由此获得浓缩的免疫球蛋白组合物。还公开了包含与病原微生物免疫反应性的特异性抗体的浓缩免疫球蛋白组合物，其特征在于组合物的特异性抗体滴度比先前接种于一种或多种疫苗的个体群体的特异性抗体的平均滴度高至少5倍更多与病原微生物相关的抗原。该组合物具有相对高的蛋白质浓度和低百分比的蛋白质聚集体，因此适用于iv和im施用。在优选的实施方案中，致病微生物是天花病毒或痘苗病毒。

19. 发明授权

US06468733B2 Method of the inactivation of viruses by a solvent-detergent combination and nanofiltration 有权
标题翻译：通过溶剂 - 洗涤剂组合和纳滤法灭活病毒的方法
公开(公告)号：US06468733B2
公开(公告)日：2002-10-22
申请号：US09843153
申请日：2001-04-27
申请人： Israel Nur , Liliana Bar
发明人： Israel Nur , Liliana Bar
IPC分类号： A01N102
CPC分类号： A61L2/0017 , A61L2/0005 , Y10S977/906
摘要： The invention concerns a method for elimination of viruses from a biological preparation wherein initially enveloped viruses are eliminated by a solvent-detergent step, then the solvent-detergents are removed by a resin composed of silicon beads and finally the preparation is nanofiltered.
摘要翻译：本发明涉及从生物制剂中消除病毒的方法，其中通过溶剂 - 洗涤步骤消除初始包膜的病毒，然后通过由硅珠组成的树脂除去溶剂 - 去污剂，最后制备纳米过滤。

20. 发明授权

US09328338B2 Method for removing a lytic enzyme from a heterogeneous mixture 有权
标题翻译：从异质混合物中除去裂解酶的方法
公开(公告)号：US09328338B2
公开(公告)日：2016-05-03
申请号：US13532997
申请日：2012-06-26
申请人： Roberto Meidler , Nina Raver-Shapira , Liliana Bar , Oleg Belyaev , Israel Nur
发明人： Roberto Meidler , Nina Raver-Shapira , Liliana Bar , Oleg Belyaev , Israel Nur
IPC分类号： C12N9/50 , C07K14/81 , C12N9/68 , C07K1/22
CPC分类号： C12N9/50 , C07K1/22 , C07K14/81 , C07K14/811 , C12N9/6435 , C12Y304/21007
摘要： The invention relates to purification of an intact, non-degraded macromolecule from a biological mixture comprising the macromolecule in the presence of its lytic enzyme. The method comprises providing the biological mixture as a heterogeneous mixture comprising the lytic enzyme, at least partially, in soluble form and the macromolecule, at least partially, in non-soluble form; batch-wise contacting the heterogeneous mixture with an immobilized inhibitor of the lytic enzyme; increasing the solubility of the macromolecule in the mixture; and removing the immobilized inhibitor from the mixture.
摘要翻译：本发明涉及在其溶解酶存在下从包含大分子的生物混合物中纯化完整的未降解的大分子。该方法包括提供生物混合物作为非均质混合物，其包含溶解酶，至少部分可溶形式和大分子，至少部分为非溶解形式; 将非均相混合物与溶解酶的固定化抑制剂分批接触; 增加大分子在混合物中的溶解度; 并从混合物中除去固定化的抑制剂。

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