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11. 发明授权

US08653070B2 Hepatitis C virus inhibitors 有权
公开(公告)号：US08653070B2
公开(公告)日：2014-02-18
申请号：US12967486
申请日：2010-12-14
申请人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Hui Cao , Lu Ying , Yat Sun Or
发明人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Hui Cao , Lu Ying , Yat Sun Or
IPC分类号： A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/496 , A61K31/439 , C07D403/14 , C07D401/14 , C07D413/14
CPC分类号： C07D401/14 , A61K38/00 , C07D403/14 , C07D413/14
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

12. 发明申请

US20100286074A1 PHARMACEUTICAL USE OF GINSENOSIDE OR MIXTURE THEREOF AND PHARMACEUTICAL COMPOSITION OF GINSENOSIDE AND USE THEREOF 审中-公开
标题翻译：药物或其混合物及其药物组合物的药理学用途及其用途
公开(公告)号：US20100286074A1
公开(公告)日：2010-11-11
申请号：US12746737
申请日：2008-05-12
申请人： Yitao Wang , Shaoping Li , Hui Cao , Zhaohua Peng , Juhua Hu
发明人： Yitao Wang , Shaoping Li , Hui Cao , Zhaohua Peng , Juhua Hu
IPC分类号： A61K31/704 , C07J17/00 , A61P7/02
CPC分类号： A61K36/258 , A61K31/704 , C07J9/00 , C07J17/005
摘要： The present invention provides a use of ginsenosides represented by formula I or mixtures thereof for manufacturing a medicament for anti-platelet aggregation, wherein R1 and R2 are H or glucosyl, and when R1 is glucosyl, R2 is H; when R1 is H, R2 is glucosyl. The present invention further provides a pharmaceutical composition for anti-platelet aggregation, which is capable to be used to prevent and treat thrombosis. The present invention also provides a method for generating the effect of anti-platelet aggregation in patients in vivo.
摘要翻译：本发明提供式I所示的人参皂苷或其混合物用于制备用于抗血小板聚集的药物的用途，其中R 1和R 2为H或葡糖基，当R 1为葡糖基时，R 2为H; 当R1为H时，R2为葡糖基。本发明还提供了能够用于预防和治疗血栓形成的抗血小板聚集用药物组合物。本发明还提供了一种在体内产生抗血小板聚集作用的方法。

13. 发明申请

US20070172531A1 Chinese traditional medicine composition for treatment of avian influenza, method for preparation, and application thereof 审中-公开
标题翻译：用于治疗禽流感的中药组合物，制备方法及其应用
公开(公告)号：US20070172531A1
公开(公告)日：2007-07-26
申请号：US11655563
申请日：2007-01-19
申请人： Desheng Tao , Yongqing Zeng , Hui Cao , Yi Guan
发明人： Desheng Tao , Yongqing Zeng , Hui Cao , Yi Guan
IPC分类号： A61K36/537 , A61K36/282 , A61K36/48 , A61K36/28
CPC分类号： A61K36/11 , A61K36/232 , A61K36/282 , A61K36/315 , A61K36/355 , A61K36/489 , A61K36/78 , A61K36/896 , A61K2300/00
摘要： A Chinese traditional medicine composition for prevention and treatment of avian influenza is provided. Its activated ingredients are consisted of: herba houttuyniae 21.4 wt. %, Caulis lonicerae japonicae 17.9 wt. %, radix isatidis 14.3 wt. %, male fern rhizome 10.7 wt. %, radix et rhizoma sophorae tonkinensis 7.1 wt. %, radix angelicae dahuricae 7.1 wt. %, rhizoma paridis 7.l wt. %, herba artemisiae annuae 7.2 wt. %, and rhizoma iridis tectoris 7.2 wt. %. This Chinese traditional medicine composition could be made into any regular medicinal types, for example, oral solutions, tablets, capsules, pellets and injection solution, etc. Modified preparation methods for this Chinese traditional medicine composition, as well as the use of the same in preparation of medicines and health foods for prevention or treatment of avian influenza were also provided in present invention. This Chinese traditional medicine composition could effectively prevent and treat avian influenza. It was a safer, more easily-obtained, and inexpensive anti-avian influenza drug.
摘要翻译：提供了一种预防和治疗禽流感的中药组合物。其活性成分由以下组成：her e 21.4重量％％，金银花17.9重量％％，丹参14.3重量％％，雄蕨根茎10.7wt。％，radix et rhizoma sophorae tonkinensis 7.1 wt。％，当归丹参7.1重量％％，百日草％，峨眉草7.2重量％％，和根瘤菌7.2重量％％。这种中药组合物可以制成任何常规药物类型，例如口服溶液，片剂，胶囊，丸剂和注射液等。这种中药组合物的改良制剂方法以及其用途本发明还提供了预防或治疗禽流感的药物和保健食品的制备。这种中药组合物可以有效预防和治疗禽流感。这是一种更安全，更容易获得和便宜的抗禽流感药物。

14. 发明申请

US20060244451A1 Shimmed magnetic resonance imaging apparatus and shimming method therefor 有权
标题翻译： Shimmed磁共振成像装置及其调整方法
公开(公告)号：US20060244451A1
公开(公告)日：2006-11-02
申请号：US11394629
申请日：2006-03-31
申请人： Cheng Ni , Hui Cao , Jin Chen , Zhong Ren
发明人： Cheng Ni , Hui Cao , Jin Chen , Zhong Ren
IPC分类号： G01V3/00
CPC分类号： G01R33/3873 , G01R33/3875
摘要： In a shimming method for an irregular object to be examined by magnetic resonant equipment magnetic field parameters are measured at measurement points located on the surface of an irregular object to be examined. Based on the measured magnetic field parameters, the positions and number of shims for adjusting magnetic field homogeneity are calculated when a passive shimming is to be performed, or the current value in a shimming coil are calculated when an active shimming is to be performed, or at the same time both the positions and number of shims and current value in the shimming coil are calculated when active shimming and passive shimming are to be performed at the same time. Shimming is then performed according to the calculated results. These above steps are repeated until achieving required magnetic field homogeneity. Since the homogeneous region is designed to have an irregular shape, it can provide a better coverage of the irregular object to be examined, and at the same time it reduces the shimming constraints to the unnecessary regions outside the irregular object to be examined, therefore avoiding shimming in those unnecessary regions.
摘要翻译：在通过磁共振设备检查的不规则物体的匀场方法中，在位于待检查的不规则物体的表面上的测量点处测量磁场参数。基于测量的磁场参数，当要执行被动匀场调整时计算用于调整磁场均匀性的垫片的位置和数量，或者当要执行活动匀场时计算匀场线圈中的当前值，或同时，当同时进行有效匀场和被动匀场时，同时计算匀场线圈的位置和数量以及匀场线圈中的当前值。然后根据计算结果执行匀场。重复上述步骤，直到达到所需的磁场均匀性。由于均匀区域被设计成具有不规则形状，所以可以提供对待检查的不规则物体的更好的覆盖，并且同时将匀场限制减小到待检查的不规则物体之外的不需要的区域，因此避免在这些不必要的地区。

15. 发明申请

US20050119302A1 Methods for the prevention or treament of bacterial and fungal infections 审中-公开
标题翻译：预防或治疗细菌和真菌感染的方法
公开(公告)号：US20050119302A1
公开(公告)日：2005-06-02
申请号：US10493989
申请日：2002-10-30
申请人： Laurence Rahme , Hui Cao , Francois Lepine , Eric Deziel , Ronald Tompkins
发明人： Laurence Rahme , Hui Cao , Francois Lepine , Eric Deziel , Ronald Tompkins
IPC分类号： A61K31/365 , A61K31/47
CPC分类号： A61K31/365 , A61K31/47
摘要： The present invention features improved methods for treating, stabilizing, or preventing a bacterial or a fungal infection in a plant or an animal, such as a mammal. In particular, these methods involve the use of a compound, that is controlled by MvfR, and that affects the expression of an MvfR protein or that promotes its modification or inactivation, or a compound produced by P. aeruginosa strain PA14, but not by P. aeruginosa containing an mvfR mutation, in late stationary phase culture.
摘要翻译：本发明的特征在于在植物或动物如哺乳动物中治疗，稳定或预防细菌或真菌感染的改进方法。特别地，这些方法涉及使用由MvfR控制并影响MvfR蛋白的表达或促进其修饰或失活的化合物或由铜绿假单胞菌菌株PA14产生的化合物而不是由P 在晚期固定期培养中含有mvfR突变的铜绿假单胞菌。

16. 发明授权

US5840638A Phosphate glasses for radioactive, hazardous and mixed waste immobilization 失效
标题翻译：磷酸盐玻璃用于放射性，危险和混合废物固定
公开(公告)号：US5840638A
公开(公告)日：1998-11-24
申请号：US772982
申请日：1996-12-23
申请人： Hui Cao , Jay W. Adams , Paul D. Kalb
发明人： Hui Cao , Jay W. Adams , Paul D. Kalb
IPC分类号： C03C1/00 , C03C3/17 , C03C10/00 , C03C14/00
CPC分类号： C03C10/0054 , C03C1/002 , C03C14/00 , C03C3/17 , C03C2214/14 , Y10S106/01
摘要： Lead-free phosphate glass compositions are provided which can be used to immobilize low level and/or high level radioactive wastes in monolithic waste forms. The glass composition may also be used without waste contained therein. Lead-free phosphate glass compositions prepared at about 900.degree. C. include mixtures from about 1 mole % to about 6 mole % iron (III) oxide, from about 1 mole % to about 6 mole % aluminum oxide, from about 15 mole % to about 20 mole % sodium oxide or potassium oxide, and from about 30 mole % to about 60 mole % phosphate. The invention also provides phosphate, lead-free glass ceramic glass compositions which are prepared from about 400.degree. C. to about 450.degree. C. and which includes from about 3 mole % to about 6 mole % sodium oxide, from about 20 mole % to about 50 mole % tin oxide, from about 30 mole % to about 70 mole % phosphate, from about 3 mole % to about 6 mole % aluminum oxide, from about 3 mole % to about 8 mole % silicon oxide, from about 0.5 mole % to about 2 mole % iron (III) oxide and from about 3 mole % to about 6 mole % potassium oxide. Method of making lead-free phosphate glasses are also provided.
摘要翻译：提供了无铅磷酸盐玻璃组合物，其可用于将低水平和/或高放射性废物固定在整体废物形式中。也可以使用玻璃组合物而不含有废物。在约900℃制备的无铅磷酸盐玻璃组合物包括约1摩尔％至约6摩尔％的氧化铁（III），约1摩尔％至约6摩尔％的氧化铝，约15摩尔％至约20摩尔％的氧化钠或氧化钾，以及约30摩尔％至约60摩尔％的磷酸盐。本发明还提供磷酸盐，无铅玻璃陶瓷玻璃组合物，其由约400℃至约450℃制备，并且包括约3摩尔％至约6摩尔％的氧化钠，约20摩尔％至约20摩尔％约50摩尔％的氧化锡，约30摩尔％至约70摩尔％的磷酸盐，约3摩尔％至约6摩尔％的氧化铝，约3摩尔％至约8摩尔％的氧化硅，约0.5摩尔％至约2摩尔％的氧化铁（III）和约3摩尔％至约6摩尔％的氧化钾。还提供了制造无铅磷酸盐玻璃的方法。

17. 外观设计

USD839583S1 Power box with wireless earphone 有权
公开(公告)号：USD839583S1
公开(公告)日：2019-02-05
申请号：US29618807
申请日：2017-09-25
申请人： Hui Cao
设计人： Hui Cao

18. 发明授权

US09007873B2 Clamp type ultrasonic processor and application thereof 有权
标题翻译：夹式超声波处理器及其应用
公开(公告)号：US09007873B2
公开(公告)日：2015-04-14
申请号：US13576398
申请日：2010-11-01
申请人： Zhuosheng Yan , Jinxuan Yan , Zhuoli Yan , Zhizhong Yang , Qiang Ye , Hui Cao , Yanmiao He
发明人： Zhuosheng Yan , Jinxuan Yan , Zhuoli Yan , Zhizhong Yang , Qiang Ye , Hui Cao , Yanmiao He
IPC分类号： H04B1/03 , B22D1/00 , B22D27/20
CPC分类号： B22D1/00 , B22D27/20
摘要： A clamp type ultrasonic processor comprises a transducer assembly and a functional gripper. The transducer assembly comprises a transducer (1) and an amplitude transforming shaft (2) attached thereto. At least one transducer assembly is connected to the functional gripper. The functional gripper comprises an irradiation front line shaft-approximal block (3) and an irradiation front line tube-supporting block (4), and a functional gripper chamber (8) is provided in the functional gripper for accommodating an ultrasonic irradiation receiver. The irradiation front line shaft-approximal block (3) and the irradiation front line tube-supporting block (4) are connected to grip tightly the ultrasonic irradiation receiver to be irradiated. Irradiation front line shaft-approximal block (3) and/or the irradiation front line tube-supporting block (4) are connected to the amplitude transforming shaft (2). An application of the clamp type ultrasonic processor and its application in metal production are also provided.
摘要翻译：夹式超声波处理器包括换能器组件和功能夹持器。换能器组件包括连接到其上的换能器（1）和振幅变换轴（2）。至少一个换能器组件连接到功能夹持器。功能夹持器包括照射前线轴近似块（3）和照射前线管支撑块（4），功能夹持器（8）设置在功能夹持器中，用于容纳超声波照射接收器。照射前线轴近似块（3）和照射前线管支撑块（4）连接以紧紧地夹紧要照射的超声波照射接收器。照射前线轴近似块（3）和/或照射前线管支撑块（4）与振幅变换轴（2）连接。还提供了夹式超声波处理器的应用及其在金属生产中的应用。

19. 发明申请

US20120076755A1 Hepatitis C Virus Inhibitors 有权
标题翻译：丙型肝炎病毒抑制剂
公开(公告)号：US20120076755A1
公开(公告)日：2012-03-29
申请号：US13252818
申请日：2011-10-04
申请人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Lu Ying , Hui Cao , Yat Sun Or
发明人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Lu Ying , Hui Cao , Yat Sun Or
IPC分类号： A61K31/4188 , A61K31/424 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61P31/14 , A61P37/02 , A61K38/21 , A61K39/12 , A61K31/4196 , A61K31/427 , A61P1/16 , A61P29/00 , A61P31/18 , C12N7/06 , C07D487/16
CPC分类号： A61K31/415 , A61K31/4188 , A61K31/4196 , A61K31/424 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D471/22 , C07D487/18 , C07D487/22 , C07D498/18 , C07D498/22 , C07D513/18 , Y02A50/463 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: Q-G-A-L-B-W (I), which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式（I）化合物及其药学上可接受的盐，酯或前药：抑制含RNA病毒，特别是丙型肝炎病毒（HCV）的Q-G-A-L-B-W（I）因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

20. 发明申请

US20110300104A1 HEPATITIS C VIRUS INHIBITORS 失效
标题翻译： HEPATITIS C病毒抑制剂
公开(公告)号：US20110300104A1
公开(公告)日：2011-12-08
申请号：US13152377
申请日：2011-06-03
申请人： Yao-Ling Qiu , Ce Wang , Hui Cao , Xiaowen Peng , Datong Tang , Yat Sun Or
发明人： Yao-Ling Qiu , Ce Wang , Hui Cao , Xiaowen Peng , Datong Tang , Yat Sun Or
IPC分类号： A61K31/4178 , A61K31/4439 , A61K31/5377 , A61K31/496 , A61K31/427 , C12N7/06 , A61P31/14 , A61K39/00 , A61K38/21 , A61K38/19 , A61K31/7056 , C07D491/107 , A61K31/422
CPC分类号： A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/7056 , A61K38/21 , A61K45/06 , C12N2770/24211 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the Hepatitis C Virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the Hepatitis C Virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

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