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1. 发明申请

US20070172531A1 Chinese traditional medicine composition for treatment of avian influenza, method for preparation, and application thereof 审中-公开
标题翻译：用于治疗禽流感的中药组合物，制备方法及其应用
公开(公告)号：US20070172531A1
公开(公告)日：2007-07-26
申请号：US11655563
申请日：2007-01-19
申请人： Desheng Tao , Yongqing Zeng , Hui Cao , Yi Guan
发明人： Desheng Tao , Yongqing Zeng , Hui Cao , Yi Guan
IPC分类号： A61K36/537 , A61K36/282 , A61K36/48 , A61K36/28
CPC分类号： A61K36/11 , A61K36/232 , A61K36/282 , A61K36/315 , A61K36/355 , A61K36/489 , A61K36/78 , A61K36/896 , A61K2300/00
摘要： A Chinese traditional medicine composition for prevention and treatment of avian influenza is provided. Its activated ingredients are consisted of: herba houttuyniae 21.4 wt. %, Caulis lonicerae japonicae 17.9 wt. %, radix isatidis 14.3 wt. %, male fern rhizome 10.7 wt. %, radix et rhizoma sophorae tonkinensis 7.1 wt. %, radix angelicae dahuricae 7.1 wt. %, rhizoma paridis 7.l wt. %, herba artemisiae annuae 7.2 wt. %, and rhizoma iridis tectoris 7.2 wt. %. This Chinese traditional medicine composition could be made into any regular medicinal types, for example, oral solutions, tablets, capsules, pellets and injection solution, etc. Modified preparation methods for this Chinese traditional medicine composition, as well as the use of the same in preparation of medicines and health foods for prevention or treatment of avian influenza were also provided in present invention. This Chinese traditional medicine composition could effectively prevent and treat avian influenza. It was a safer, more easily-obtained, and inexpensive anti-avian influenza drug.
摘要翻译：提供了一种预防和治疗禽流感的中药组合物。其活性成分由以下组成：her e 21.4重量％％，金银花17.9重量％％，丹参14.3重量％％，雄蕨根茎10.7wt。％，radix et rhizoma sophorae tonkinensis 7.1 wt。％，当归丹参7.1重量％％，百日草％，峨眉草7.2重量％％，和根瘤菌7.2重量％％。这种中药组合物可以制成任何常规药物类型，例如口服溶液，片剂，胶囊，丸剂和注射液等。这种中药组合物的改良制剂方法以及其用途本发明还提供了预防或治疗禽流感的药物和保健食品的制备。这种中药组合物可以有效预防和治疗禽流感。这是一种更安全，更容易获得和便宜的抗禽流感药物。

2. 发明授权

US09265805B2 Chinese traditional medicine composition for treatment of avian influenza, method for preparation and application thereof 有权
标题翻译：用于治疗禽流感的中药组合物，其制备方法及应用
公开(公告)号：US09265805B2
公开(公告)日：2016-02-23
申请号：US12030997
申请日：2008-02-14
申请人： Desheng Tao , Yongqing Zeng , Hui Cao , Yi Guan
发明人： Desheng Tao , Yongqing Zeng , Hui Cao , Yi Guan
IPC分类号： A61K36/489 , A61K36/11 , A61K36/232 , A61K36/282 , A61K36/315 , A61K36/355 , A61K36/78 , A61K36/896
CPC分类号： A61K36/11 , A61K36/232 , A61K36/282 , A61K36/315 , A61K36/355 , A61K36/489 , A61K36/78 , A61K36/896 , A61K2300/00
摘要： A Chinese traditional medicine composition for prevention and treatment of avian influenza is provided. Its active ingredients are consisted of: herba houttuyniae 21.4 wt. %, Caulis lonicerae japonicae 17.9 wt. %, radix isatidis 14.3 wt. %, male fern rhizome 10.7 wt. %, radix et rhizoma sophorae tonkinensis 7.1 wt. %, radix angelicae dahuricae 7.1 wt. %, rhizoma paridis 7.1 wt. %, herba artemisiae annuae 7.2 wt. %, and rhizoma iridis tectoris 7.2 wt. %. This Chinese traditional medicine composition could be made into any regular medicinal types, for example, oral solutions, tablets, capsules, pellets and injection solution, etc. Modified preparation methods for this Chinese traditional medicine composition, as well as the use of the same in preparation of medicines and health foods for prevention or treatment of avian influenza were also provided in present invention. This Chinese traditional medicine composition could effectively prevent and treat avian influenza. It was a safer, more easily-obtained, and inexpensive anti-avian influenza drug.
摘要翻译：提供了一种预防和治疗禽流感的中药组合物。其活性成分包括：her e 21.4重量％％，金银花17.9重量％％，丹参14.3重量％％，雄蕨根茎10.7wt。％，radix et rhizoma sophorae tonkinensis 7.1 wt。％，当归丹参7.1重量％％，百草枯7.1重量％％，峨眉草7.2重量％％，和根瘤菌7.2重量％％。这种中药组合物可以制成任何常规药物类型，例如口服溶液，片剂，胶囊，丸剂和注射液等。这种中药组合物的改良制剂方法以及其用途本发明还提供了预防或治疗禽流感的药物和保健食品的制备。这种中药组合物可以有效预防和治疗禽流感。这是一种更安全，更容易获得和便宜的抗禽流感药物。

3. 发明授权

US08795742B2 Chinese traditional medicine composition for treatment of avian influenza, method for preparation and application thereof 有权
标题翻译：用于治疗禽流感的中药组合物，其制备方法及应用
公开(公告)号：US08795742B2
公开(公告)日：2014-08-05
申请号：US12030977
申请日：2008-02-14
申请人： Desheng Tao , Yongqing Zeng , Hui Cao , Yi Guan
发明人： Desheng Tao , Yongqing Zeng , Hui Cao , Yi Guan
IPC分类号： A61K36/00 , A61K36/355 , A61K36/489 , A61K36/232
CPC分类号： A61K36/11 , A61K36/232 , A61K36/282 , A61K36/315 , A61K36/355 , A61K36/489 , A61K36/78 , A61K36/896 , A61K2300/00
摘要： A Chinese traditional medicine composition for prevention and treatment of avian influenza is provided. Its active ingredients are consisted of: herba houttuyniae 21.4 wt. %, Caulis lonicerae japonicae 17.9 wt. %, radix isatidis 14.3 wt. %, male fern rhizome 10.7 wt. %, radix et rhizoma sophorae tonkinensis 7.1 wt. %, radix angelicae dahuricae 7.1 wt. %, rhizoma paridis 7.1 wt. %, herba artemisiae annuae 7.2 wt. %, and rhizoma iridis tectoris 7.2 wt. %. This Chinese traditional medicine composition could be made into any regular medicinal types, for example, oral solutions, tablets, capsules, pellets and injection solution, etc. Modified preparation methods for this Chinese traditional medicine composition, as well as the use of the same in preparation of medicines and health foods for prevention or treatment of avian influenza were also provided in present invention. This Chinese traditional medicine composition could effectively prevent and treat avian influenza. It was a safer, more easily-obtained, and inexpensive anti-avian influenza drug.
摘要翻译：提供了一种预防和治疗禽流感的中药组合物。其活性成分包括：her e 21.4重量％％，金银花17.9重量％％，丹参14.3重量％％，雄蕨根茎10.7wt。％，radix et rhizoma sophorae tonkinensis 7.1 wt。％，当归丹参7.1重量％％，百草枯7.1重量％％，峨眉草7.2重量％％，和根瘤菌7.2重量％％。这种中药组合物可以制成任何常规药物类型，例如口服溶液，片剂，胶囊，丸剂和注射液等。这种中药组合物的改良制剂方法以及其用途本发明还提供了预防或治疗禽流感的药物和保健食品的制备。这种中药组合物可以有效预防和治疗禽流感。这是一种更安全，更容易获得和便宜的抗禽流感药物。

4. 发明申请

US20140023732A1 USE OF A TRADITIONAL CHINESE MEDICINE COMBINATION IN PREPARATION OF ANTI-ENTEROVIRUS 71 DRUG 审中-公开
标题翻译：传统中医药组合在制备抗肠毒素71药物中的应用
公开(公告)号：US20140023732A1
公开(公告)日：2014-01-23
申请号：US13990920
申请日：2011-12-28
申请人： Hui Cao , Yi Guan , Yongqing Zeng , Desheng Tao
发明人： Hui Cao , Yi Guan , Yongqing Zeng , Desheng Tao
IPC分类号： A61K36/67 , A61K36/282 , A61K36/484 , A61K36/315
CPC分类号： A61K36/67 , A61K9/1623 , A61K36/11 , A61K36/19 , A61K36/232 , A61K36/282 , A61K36/315 , A61K36/355 , A61K36/484 , A61K36/489 , A61K36/78 , A61K36/88 , A61K36/896 , A61K2300/00
摘要： Disclosed is a use of a pharmaceutical composition in preparation of anti-enterovirus 71 agents.
摘要翻译：公开了药物组合物在制备抗肠道病毒71剂中的用途。

5. 发明申请

US20120093951A1 TRADITIONAL CHINESE MEDICINE COMPOSITION FOR TREATING SWINE INFLUENZA, PREPARATION METHOD AND USE THEREOF 审中-公开
标题翻译：传统中医药组合物，用于治疗肝炎流行性感冒，其制备方法及其用途
公开(公告)号：US20120093951A1
公开(公告)日：2012-04-19
申请号：US13377862
申请日：2010-06-17
申请人： Desheng Tao , Yongging Zeng , Hui Cao , Yi Guan
发明人： Desheng Tao , Yongging Zeng , Hui Cao , Yi Guan
IPC分类号： A61K36/78 , A61K36/315 , A61K36/489 , A61K36/232 , A61K36/19 , A61P31/16 , A61K36/282 , A61K36/80 , A61K36/534 , A61K36/346 , A61K36/484 , A61K36/355 , A61K36/906
CPC分类号： A61K36/78 , A61K31/12 , A61K36/11 , A61K36/185 , A61K36/19 , A61K36/232 , A61K36/282 , A61K36/288 , A61K36/315 , A61K36/34 , A61K36/355 , A61K36/484 , A61K36/489 , A61K36/534 , A61K36/70 , A61K36/88 , A61K36/896 , A61K2300/00
摘要： The present invention relates to a traditional Chinese medicine composition for preventing and treating swine influenza, preparation method and use thereof. The said traditional Chinese medicine composition is made from Herba Houttuyniae 21.4 wt. %, Caulis Lonicerae Japonicae 17.9 wt. %, Radix Isatidis 14.3 wt. %, Rhizoma Dryopteris Crassirhizomatis 10.7%, Radix et Rhizoma Sophorae Tonkinensis 7.1 wt. %, Radix Angelicae Dahuricae 7.1 wt. %, Rhizoma Paridis 7.1 wt. %, Herba Artemisiae Annuae 7.1 wt. %, and Rhizoma Iridis Tectori 7.1 wt. %.
摘要翻译：本发明涉及一种预防和治疗猪流感的中药组合物及其制备方法及用途。所述中药组合物由鱼腥草21.4重量％％，金银花金银花17.9重量％％，石斛兰14.3重量％％，Rhizoma Dryopteris Crassirhizomatis 10.7％，Radix et Rhizoma Sophorae Tonkinensis 7.1 wt。％，当归甘草7.1重量％％，百日草7.1重量％％，蒿蒿7.1重量％％，枸杞子（Rhizoma Iridis Tectori）7.1重量％％。

6. 发明授权

US07553944B2 Human virus causing respiratory tract infection and uses thereof 有权
标题翻译：引起呼吸道感染的人类病毒及其用途
公开(公告)号：US07553944B2
公开(公告)日：2009-06-30
申请号：US10895064
申请日：2004-07-21
申请人： Kwok Yung Yuen , Chiu Yat Patrick Woo , Kar Pui Susanna Lau , Kwok Hung Chan , Lit Man Poon , Joseph Sriyal Malik Peiris , Yi Guan
发明人： Kwok Yung Yuen , Chiu Yat Patrick Woo , Kar Pui Susanna Lau , Kwok Hung Chan , Lit Man Poon , Joseph Sriyal Malik Peiris , Yi Guan
IPC分类号： C07H21/02 , C12N15/00 , A61K39/00 , A61K39/12
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C12N7/00 , C12N2770/20021 , C12N2770/20022
摘要： The present invention provides the complete genomic sequence of a novel human coronavirus, coined as coronavirus-HKU1 (“CoV-HKU1”), isolated in Hong Kong from a patient who had a recent history of visit to Schenzhen, China. The virus belongs to the order Nidovirales of the family Coronaviridae, being a single-stranded RNA virus of positive polarity. The invention also provides the deduced amino acid sequences of the complete genome of the CoV-HKU1. The nucleotide sequences and deduced amino acid sequences of the CoV-HKU1 are useful in preventing, diagnosing and/or treating the infection by CoV-HKU1. Furthermore, the invention provides immunogenic and vaccine preparations using recombinant and chimeric forms as well as subunits of the CoV-HKU1 based on the nucleotide sequences and deduced amino acid sequences of the CoV-HKU1.
摘要翻译：本发明提供了一种新型人冠状病毒的完整基因组序列，其创造为冠状病毒HKU1（“CoV-HKU1”），在香港从最近访问中国的深圳的病人中分离出来。该病毒属于冠状病毒科家族的Nidovirales，是正极性的单链RNA病毒。本发明还提供了CoV-HKU1的完整基因组的推导的氨基酸序列。 CoV-HKU1的核苷酸序列和推导的氨基酸序列可用于预防，诊断和/或治疗CoV-HKU1感染。此外，本发明基于CoV-HKU1的核苷酸序列和推定的氨基酸序列，提供使用重组和嵌合形式以及CoV-HKU1的亚基的免疫原性和疫苗制剂。

7. 发明授权

US07491489B2 Synthetic peptide targeting critical sites on the SARS-associated coronavirus spike protein responsible for viral infection and method of use thereof 有权
标题翻译：针对负责病毒感染的SARS相关冠状病毒穗蛋白上的关键位点的合成肽及其使用方法
公开(公告)号：US07491489B2
公开(公告)日：2009-02-17
申请号：US11262044
申请日：2005-10-28
申请人： Bojian Zheng , Yi Guan , Jiandong Huang , Ming-Liang He
发明人： Bojian Zheng , Yi Guan , Jiandong Huang , Ming-Liang He
IPC分类号： C12Q1/00 , C12Q1/18 , C12Q1/70 , G01N33/53
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/20022 , C12Q1/701 , G01N33/56983 , G01N33/6878 , G01N2333/165
摘要： The present invention provides methods for locating critical portions or sites on the spike protein (S protein) of SARS-associated coronavirus (SARS-CoV) responsible for the viral infection that causes Severe Acute Respiratory Syndrome (SARS). The present invention also provides new synthetic peptides targeting such critical portions or sites of the S protein of SARS-CoV for preventing or treating of SARS-CoV infection in a subject. The present invention further provides methods of testing antiviral activity exerted by antiviral agents using real-time quantitative PCR.
摘要翻译：本发明提供了用于定位造成严重急性呼吸综合征（SARS）的病毒感染的SARS相关冠状病毒（SARS-CoV）的刺突蛋白（S蛋白）上的关键部位或位点的方法。本发明还提供靶向SARS-CoV的S蛋白的关键部分或位点的新的合成肽，用于预防或治疗受试者中的SARS-CoV感染。本发明还提供了使用实时定量PCR检测由抗病毒剂产生的抗病毒活性的方法。

8. 发明授权

US07267942B2 Diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS) 有权
标题翻译：导致严重急性呼吸综合征（SARS）的人类病毒的诊断测定
公开(公告)号：US07267942B2
公开(公告)日：2007-09-11
申请号：US10808187
申请日：2004-03-24
申请人： Joseph S. M. Peiris , Kwok Yung Yuen , Lit Man Poon , Yi Guan , Kwok Hung Chan , John M. Nicholls
发明人： Joseph S. M. Peiris , Kwok Yung Yuen , Lit Man Poon , Yi Guan , Kwok Hung Chan , John M. Nicholls
IPC分类号： C12Q1/70 , C12N15/50
CPC分类号： C12Q1/701 , C07H21/04 , C12Q1/6844
摘要： The present invention relates to a diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). In particular, the invention relates to a real-time quantitative PCR assay for the detection of hSARS virus using reverse transcription and polymerase chain reaction. Specifically, the quantitative assay is a TaqMan® assay using the primers and probes constructed based on the genome of the hSARS virus. The invention further relates to a diagnostic kit that comprises nucleic acid molecules for the detection of the hSARS virus.
摘要翻译：本发明涉及在人类中引起严重急性呼吸综合征（SARS）的病毒的诊断测定法（“hSARS病毒”）。特别地，本发明涉及使用逆转录和聚合酶链反应检测hSARS病毒的实时定量PCR测定。具体地，定量测定是使用基于hSARS病毒基因组构建的引物和探针的TaqMan测定法。本发明还涉及包含用于检测hSARS病毒的核酸分子的诊断试剂盒。

9. 发明授权

US07129223B2 Inhibition of SARS-associated coronavirus (SCoV) infection and replication by RNA interference 有权
标题翻译：通过RNA干扰抑制SARS相关冠状病毒（SCoV）感染和复制
公开(公告)号：US07129223B2
公开(公告)日：2006-10-31
申请号：US10848737
申请日：2004-05-19
申请人： Hsiang-Fu Kung , Ming-Liang He , Bo-Jiang Zheng , Yi Guan , Marie Chia-Mi Lin , Ying Peng
发明人： Hsiang-Fu Kung , Ming-Liang He , Bo-Jiang Zheng , Yi Guan , Marie Chia-Mi Lin , Ying Peng
IPC分类号： A61K31/7088 , C07H21/04 , C12N5/10 , C12N15/50 , C12N15/63
CPC分类号： C12N15/1131 , A61K39/00 , A61K48/005 , A61K2039/53 , C07K14/005 , C12N2310/111 , C12N2310/14 , C12N2770/20022
摘要： The present invention relates to therapeutic agents useful for the treatment of Severe Acute Respiratory Syndrome (SARS) in humans. In particular, the present invention relates to RNA interference (RNAi) molecules useful for inhibiting the infection and replication of hSARS virus. Preferably, the RNAi molecules target the replicase region of the hSARS virus, or combinations of different sites of hSARS virus genes. The present invention further encompasses methods of using the RNAi molecules for preventing and/or treating SARS. Vaccines and kits comprising therapeutically effective amounts of the RNAi molecules are also encompassed.
摘要翻译：本发明涉及可用于治疗人类中严重急性呼吸综合征（SARS）的治疗剂。特别地，本发明涉及可用于抑制hSARS病毒的感染和复制的RNA干扰（RNAi）分子。优选地，RNAi分子靶向hSARS病毒的复制酶区域或hSARS病毒基因的不同位点的组合。本发明还包括使用RNAi分子来预防和/或治疗SARS的方法。还包括包含治疗有效量的RNAi分子的疫苗和试剂盒。

10. 发明授权

US06687689B1 System and methods for document retrieval using natural language-based queries 失效
标题翻译：使用自然语言查询的文档检索系统和方法
公开(公告)号：US06687689B1
公开(公告)日：2004-02-03
申请号：US09613849
申请日：2000-07-11
申请人： Pascale Fung , Chi Shun Cheung , Yi Guan , Yongsheng Yang
发明人： Pascale Fung , Chi Shun Cheung , Yi Guan , Yongsheng Yang
IPC分类号： G06F1730
CPC分类号： G06F17/30672 , Y10S707/99933 , Y10S707/99936
摘要： A system and associated methods identify documents relevant to an inputted natural-language user query. One associate method includes: selecting a set of keywords from the user query; determining at least one word, not necessarily found in the user query, that is semantically similar to a keyword of the set of keywords; using the set of keywords and the at least one word to determining a subset of word sets from a database of pre-stored word sets, wherein the pre-stored word sets are each pre-associated with at least one document; determining a plurality of word sets, from the subset of word sets, that is most semantically similar to the user query; and identifying documents that have been pre-associated with the plurality of word sets as being relevant to the natural-language user query.
摘要翻译：系统和相关方法识别与输入的自然语言用户查询相关的文档。一个关联方法包括：从用户查询中选择一组关键字; 确定语义上类似于该组关键字的关键词的在用户查询中不一定找到的至少一个单词; 使用所述一组关键字和所述至少一个单词来从预先存储的单词集的数据库中确定单词组的子集，其中所述预先存储的单词集每个都与至少一个文档预先关联; 从所述词集的子集中确定在语义上类似于所述用户查询的多个单词集合; 以及将已经与所述多个单词集预先相关联的文档识别为与所述自然语言用户查询相关。

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