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11. 发明授权

US06664281B1 Carboxylic acid derivatives and drugs containing the same as the active ingredient 失效
标题翻译：羧酸衍生物和含有与活性成分相同的药物
公开(公告)号：US06664281B1
公开(公告)日：2003-12-16
申请号：US09763575
申请日：2001-02-26
申请人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
发明人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
IPC分类号： C07D26332
CPC分类号： C07D413/04 , C07D263/32 , C07D493/08
摘要： A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.
摘要翻译：含有式（I）的羧酸衍生物（其中所有符号如本说明书中所定义），其无毒性酸或其水合物作为活性成分的过氧化物酶体增殖物激活受体调节剂。由于具有调节PPAR的作用，式（I）化合物可用作降血糖药，降血脂药，与代谢紊乱相关疾病（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症等），高脂血症，动脉粥样硬化的预防和/或补救措施高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂以及用于缓解糖尿病或综合征X危险因素的药物。

12. 发明申请

US20060251651A1 Antagonist and agonist which bind to a strong binding site of chemokine receptor 审中-公开
标题翻译：拮抗剂和激动剂，其结合趋化因子受体的强结合位点
公开(公告)号：US20060251651A1
公开(公告)日：2006-11-09
申请号：US10538364
申请日：2003-12-12
申请人： Shiro Shibayama , Kenji Sagawa , Noriki Watanabe , Kazuhiko Takeda , Hideaki Tada , Daikichi Fukushima
发明人： Shiro Shibayama , Kenji Sagawa , Noriki Watanabe , Kazuhiko Takeda , Hideaki Tada , Daikichi Fukushima
IPC分类号： A61K39/395 , G01N33/567 , C07K16/28
CPC分类号： A61K31/49 , A61K31/00 , A61K31/503 , A61K31/5377 , G01N2333/715 , G01N2500/04
摘要： An antagonist or an agonist which binds to a strong binding site of CCR5; a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the same; a method for screening a compound which binds to a strong binding site of CCR5; a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the antagonist or the agonist selected by the screening method; an antagonist or an agonist which binds to a strong binding site of a chemokine receptor; a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the same; a method for screening a compound which binds to a strong binding site of a chemokine receptor; and a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the antagonist or the agonist selected by the screening method. The antagonist or the agonist of the present invention is useful as a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer.
摘要翻译：结合CCR5的强结合位点的拮抗剂或激动剂; 用于过敏性疾病，炎性疾病，免疫疾病和/或包含该疾病的癌症的预防和/或治疗剂; 用于筛选结合CCR5的强结合位点的化合物的方法; 包含通过筛选方法选择的拮抗剂或激动剂的过敏性疾病，炎性疾病，免疫疾病和/或癌症的预防和/或治疗剂; 结合趋化因子受体的强结合位点的拮抗剂或激动剂; 用于过敏性疾病，炎性疾病，免疫疾病和/或包含该疾病的癌症的预防和/或治疗剂; 用于筛选结合趋化因子受体的强结合位点的化合物的方法; 以及包含通过筛选方法选择的拮抗剂或激动剂的过敏性疾病，炎性疾病，免疫疾病和/或癌症的预防和/或治疗剂。本发明的拮抗剂或激动剂可用作过敏性疾病，炎性疾病，免疫疾病和/或癌症的预防和/或治疗剂。

13. 发明授权

US08008451B2 Antibodies to TNF (tumor necrosis factor) receptor family members 有权
标题翻译： TNF（肿瘤坏死因子）受体家族成员的抗体
公开(公告)号：US08008451B2
公开(公告)日：2011-08-30
申请号：US12697676
申请日：2010-02-01
申请人： Hideaki Tada , Mikio Konishi , Daikichi Fukushima
发明人： Hideaki Tada , Mikio Konishi , Daikichi Fukushima
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： C07K14/70578 , A61K38/00
摘要： Polypeptide produced from human stromal cell line, the process for the preparation of the polypeptide, DNA encoding the polypeptide, vector carrying the DNA, host cell transformed by the vector, antibody of the polypeptide, and pharmaceutical composition containing the polypeptide or the antibody.
摘要翻译：由人类基质细胞系产生的多肽，制备多肽的方法，编码多肽的DNA，携带DNA的载体，载体转化的宿主细胞，多肽的抗体和含多肽或抗体的药物组合物。

14. 发明授权

US07705140B2 DNAs encoding TNF receptor family members 失效
标题翻译：编码TNF受体家族成员的DNA
公开(公告)号：US07705140B2
公开(公告)日：2010-04-27
申请号：US11935305
申请日：2007-11-05
申请人： Hideaki Tada , Mikio Konishi , Daikichi Fukushima
发明人： Hideaki Tada , Mikio Konishi , Daikichi Fukushima
IPC分类号： C07H21/04 , C12P21/06 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/02 , C12N15/74
CPC分类号： C07K14/70578 , A61K38/00
摘要： Polypeptide produced from human stromal cell line, the process for the preparation of the polypeptide, DNA encoding the polypeptide, vector carrying the DNA, host cell transformed by the vector, antibody of the polypeptide, and pharmaceutical composition containing the polypeptide or the antibody.
摘要翻译：由人类基质细胞系产生的多肽，制备多肽的方法，编码多肽的DNA，携带DNA的载体，载体转化的宿主细胞，多肽的抗体和含多肽或抗体的药物组合物。

15. 发明申请

US20070054310A1 Novel polypeptide, cDNA encoding the same, and use thereof 审中-公开
标题翻译：新型多肽，编码其的cDNA及其用途
公开(公告)号：US20070054310A1
公开(公告)日：2007-03-08
申请号：US11593037
申请日：2006-11-06
申请人： Daikichi Fukushima , Shiro Shibayama , Hideaki Tada
发明人： Daikichi Fukushima , Shiro Shibayama , Hideaki Tada
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/705 , A61K38/00 , C07K14/4703
摘要： Novel polypeptides produced by a human adult brain tissue, a cell line derived therefrom, a cell line derived from human bone marrow and a human umbilical cord venous endothelial cell line; a process for producing these polypeptides; cDNAs encoding the polypeptides; fragments hybridizable selectively with the cDNA sequences; replication or expression plasmids having the cDNAs integrated thereinto; host cells transformed by the plasmids; antibodies against the above polypeptides; and medicinal compositions containing the peptides or the antibodies.
摘要翻译：由人成人脑组织产生的新型多肽，源自其的细胞系，源自人骨髓的细胞系和人脐带静脉内皮细胞系; 一种生产这些多肽的方法; 编码多肽的cDNA; 片段可与cDNA序列选择性杂交; 具有整合cDNA的复制或表达质粒; 由质粒转化的宿主细胞; 针对上述多肽的抗体; 以及含有肽或抗体的药物组合物。

16. 发明授权

US07638281B2 Polypeptide, cDNA encoding the same and use of them 失效
标题翻译：多肽，编码相同的cDNA并使用它们
公开(公告)号：US07638281B2
公开(公告)日：2009-12-29
申请号：US11703200
申请日：2007-02-07
申请人： Daikichi Fukushima , Shiro Shibayama , Hideaki Tada
发明人： Daikichi Fukushima , Shiro Shibayama , Hideaki Tada
IPC分类号： C07H21/04 , C12N15/00 , C12N5/06
CPC分类号： C07K14/47 , A61K38/00
摘要： A new polypeptide prepared from human library by the SST method and a process for preparation of it; a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the cDNA; a replication or expression plasmid containing the cDNA integrated thereinto; a host cell transformed with plasmid; an antibody against the polypeptide; and a pharmaceutical composition containing the polypeptide or the antibody.
摘要翻译：通过SST方法从人类文库制备的新多肽及其制备方法; 编码该多肽的cDNA; 选择性地与cDNA序列杂交的片段; 包含其中整合的cDNA的复制或表达质粒; 用质粒转化的宿主细胞; 抗多肽的抗体; 和含有多肽或抗体的药物组合物。

17. 发明申请

US20080175843A1 NOVEL POLYPEPTIDES, DNAS ENCODING THE SAME AND USE THEREOF 失效
标题翻译：新型多肽，编码它们的DNA和其使用
公开(公告)号：US20080175843A1
公开(公告)日：2008-07-24
申请号：US11935305
申请日：2007-11-05
申请人： Hideaki TADA , Mikio Konishi , Daikichi Fukushima
发明人： Hideaki TADA , Mikio Konishi , Daikichi Fukushima
IPC分类号： A61K39/395 , C12N15/11 , C12N15/00 , C12N5/06 , A61P43/00 , C12P21/04 , A61K38/00
CPC分类号： C07K14/70578 , A61K38/00
摘要： Polypeptide produced from human stromal cell line, the process for the preparation of the polypeptide, DNA encoding the polypeptide, vector carrying the DNA, host cell transformed by the vector, antibody of the polypeptide, and pharmaceutical composition containing the polypeptide or the antibody.
摘要翻译：由人类基质细胞系产生的多肽，制备多肽的方法，编码多肽的DNA，携带DNA的载体，载体转化的宿主细胞，多肽的抗体和含多肽或抗体的药物组合物。

18. 发明授权

US07288558B2 Pharmaceutical composition for treatment for urinary diseases comprising LPA receptor regulator 失效
标题翻译：用于治疗包括LPA受体调节剂的尿液疾病的药物组合物
公开(公告)号：US07288558B2
公开(公告)日：2007-10-30
申请号：US10467359
申请日：2003-02-07
申请人： Shinji Nakade , Daikichi Fukushima
发明人： Shinji Nakade , Daikichi Fukushima
IPC分类号： A61K31/42
CPC分类号： C07D261/14 , A61K31/00 , A61K31/136 , A61K31/16 , A61K31/167 , A61K31/216 , A61K31/352 , A61K31/42 , A61K31/425 , A61K31/445 , A61K31/454 , A61K31/46 , A61K31/495 , A61K31/506 , A61K31/517 , A61K31/565 , A61K31/57 , A61K31/58 , A61K31/661 , A61K31/685
摘要： The present invention relates to a pharmaceutical composition for treatment and/or prevention for urinary diseases comprising a lysophosphatidic acid (LPA) receptor regulator.As LPA receptor regulators act on urethra and prostate, compounds acting on this receptor are useful in treating urinary diseases (urinary incontinence, dysuria, etc.). For example, an LPA receptor agonist useful for treatment of urinary incontinence, while an LPA receptor antagonist is useful for treatment of dysuria, ischuria, pollakiuria, nocturia, urodynia and benign prostatic hyperplasia.
摘要翻译：本发明涉及用于治疗和/或预防尿病的药物组合物，其包含溶血磷脂酸（LPA）受体调节剂。由于LPA受体调节剂作用于尿道和前列腺，作用于该受体的化合物可用于治疗尿路疾病（尿失禁，排尿困难等）。例如，可用于治疗尿失禁的LPA受体激动剂，而LPA受体拮抗剂可用于治疗排尿困难，败血症，尿频症，夜尿症，尿频症和良性前列腺增生。

19. 发明授权

US07189546B2 Polypeptide, cDNA encoding the same, and use of them 失效
标题翻译：多肽，编码相同的cDNA，并使用它们
公开(公告)号：US07189546B2
公开(公告)日：2007-03-13
申请号：US10414378
申请日：2003-04-16
申请人： Daikichi Fukushima , Shiro Shibayama , Hideaki Tada
发明人： Daikichi Fukushima , Shiro Shibayama , Hideaki Tada
IPC分类号： C07K14/47 , C12P21/02
CPC分类号： C07K14/47 , A61K38/00
摘要： A new polypeptide prepared from human library by the SST method and a process for preparation of it; a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the cDNA; a replication or expression plasmid containing the cDNA integrated thereinto; a host cell transformed with plasmid; an antibody against the polypeptide; and a pharmaceutical composition containing the polypeptide or the antibody.
摘要翻译：通过SST方法从人类文库制备的新多肽及其制备方法; 编码该多肽的cDNA; 选择性地与cDNA序列杂交的片段; 包含其中整合的cDNA的复制或表达质粒; 用质粒转化的宿主细胞; 抗多肽的抗体; 和含有多肽或抗体的药物组合物。

20. 发明申请

US20100298546A1 DNAS ENCODING TNF RECEPTOR FAMILY MEMBERS 有权
标题翻译： DNAS编码TNF受体家族成员
公开(公告)号：US20100298546A1
公开(公告)日：2010-11-25
申请号：US12697676
申请日：2010-02-01
申请人： Hideaki TADA , Mikio Konishi , Daikichi Fukushima
发明人： Hideaki TADA , Mikio Konishi , Daikichi Fukushima
IPC分类号： C07K16/28
CPC分类号： C07K14/70578 , A61K38/00
摘要： Polypeptide produced from human stromal cell line, the process for the preparation of the polypeptide, DNA encoding the polypeptide, vector carrying the DNA, host cell transformed by the vector, antibody of the polypeptide, and pharmaceutical composition containing the polypeptide or the antibody.
摘要翻译：由人类基质细胞系产生的多肽，制备多肽的方法，编码多肽的DNA，携带DNA的载体，载体转化的宿主细胞，多肽的抗体和含多肽或抗体的药物组合物。

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