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1. 发明授权

US06821994B2 Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient 失效
标题翻译：羧酸衍生物和含有该衍生物作为活性成分的药物组合物
公开(公告)号：US06821994B2
公开(公告)日：2004-11-23
申请号：US10428096
申请日：2003-05-02
申请人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
发明人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
IPC分类号： A61K314427
CPC分类号： C07D413/06 , C07D413/14 , C07D417/06
摘要： A peroxisome proliferator activated receptor regulator containing a compound of formula (I) (wherein all symbols are as defined in the specification), or a salt thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.
摘要翻译：含有式（I）化合物（其中所有符号如说明书中所定义）或其盐作为活性成分的过氧化物酶体增殖物激活受体调节剂。由于具有调节PPAR的作用，式（I）化合物可用作降血糖药物，降血脂药物，与代谢紊乱（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症等）相关疾病，高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食的疾病的预防和/或补救措施，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂和用于缓解糖尿病或综合征X的危险因素的药物。

2. 发明授权

US07037914B2 Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient 失效
公开(公告)号：US07037914B2
公开(公告)日：2006-05-02
申请号：US10251805
申请日：2002-09-23
申请人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
发明人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
IPC分类号： C07C69/612 , C07C69/614 , C07C69/618 , A61K31/216
CPC分类号： C07D213/30 , A61K31/00 , C07C59/66 , C07C59/68 , C07C59/72 , C07C323/52 , C07D213/65 , C07D263/32 , C07D263/34 , C07D263/48 , C07D277/24 , C07D317/54 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/10
摘要： A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diseases or syndrome X.

3. 发明授权

US06506757B1 Carboxylic acid derivatives and drugs containing the same as the active ingredient 失效
标题翻译：羧酸衍生物和含有与活性成分相同的药物
公开(公告)号：US06506757B1
公开(公告)日：2003-01-14
申请号：US09623913
申请日：2000-09-11
申请人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
发明人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
IPC分类号： C07D21330
CPC分类号： C07D213/30 , A61K31/00 , C07C59/66 , C07C59/68 , C07C59/72 , C07C323/52 , C07D213/65 , C07D263/32 , C07D263/34 , C07D263/48 , C07D277/24 , C07D317/54 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/10
摘要： A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diseases or syndrome X.
摘要翻译：含有式（I）的羧酸衍生物（其中所有符号如说明书中所定义），其无毒性酸或其水合物作为活性成分的过氧化物酶体增殖物激活受体调节剂。由于具有调节PPAR的作用，式（I）化合物可用作降血糖剂，降血脂药，用于代谢紊乱（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症）的疾病的预防和/或补救措施等），高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂和用于缓解危险因素的药物疾病或综合征X.

4. 发明授权

US07211591B2 Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient 失效
标题翻译：羧酸衍生物和含有该衍生物作为活性成分的药物组合物
公开(公告)号：US07211591B2
公开(公告)日：2007-05-01
申请号：US11178639
申请日：2005-07-12
申请人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
发明人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
IPC分类号： C07D413/12 , C07D417/02 , A61K31/4427
CPC分类号： C07D213/30 , A61K31/00 , C07C59/66 , C07C59/68 , C07C59/72 , C07C323/52 , C07D213/65 , C07D263/32 , C07D263/34 , C07D263/48 , C07D277/24 , C07D317/54 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/10
摘要： A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diseases or syndrome X.
摘要翻译：含有式（I）的羧酸衍生物（其中所有符号如说明书中所定义），其无毒性酸或其水合物作为活性成分的过氧化物酶体增殖物激活受体调节剂。由于具有调节PPAR的作用，式（I）化合物可用作降血糖剂，降血脂药，用于代谢紊乱（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症）的疾病的预防和/或补救措施等），高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂和用于缓解危险因素的药物疾病或综合征X.

5. 发明申请

US20060287304A1 Dihydronaphthalene derivative compounds and agent comprising the derivative as active ingredient 审中-公开
标题翻译：二氢萘衍生物化合物和包含该衍生物作为活性成分的试剂
公开(公告)号：US20060287304A1
公开(公告)日：2006-12-21
申请号：US11505359
申请日：2006-08-17
申请人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
发明人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/497 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/421 , C07D417/02 , C07D413/02
CPC分类号： C07D407/04 , C07D263/32 , C07D277/40 , C07D277/42 , C07D413/04 , C07D413/12 , C07D417/04
摘要： A compound of formula (I) (wherein all symbols are as defined in the specification) and salt thereof, and peroxisome proliferator activated receptor regulator comprising thereof as active ingredient. Because a compound of formula (I) have an activity of regulating peroxisome proliferator activated receptor regulator, the compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or treatment agent for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.
摘要翻译：式（I）的化合物（其中所有符号如说明书中所定义）及其盐，以及其包含作为活性成分的过氧化物酶体增殖物激活受体调节剂。由于式（I）化合物具有调节过氧化物酶体增殖物激活受体调节剂的活性，式（I）化合物可用作降血糖剂，降血脂剂，与代谢紊乱相关的疾病的预防和/或治疗剂（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症等），高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低药物和缓解糖尿病或综合征X危险因素的药物。

6. 发明授权

US07241784B2 Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient 失效
标题翻译：羧酸衍生物和含有该衍生物作为活性成分的药物组合物
公开(公告)号：US07241784B2
公开(公告)日：2007-07-10
申请号：US10464459
申请日：2003-06-19
申请人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
发明人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
IPC分类号： A61K31/422 , C07D413/10
CPC分类号： C07D413/04 , C07D263/32 , C07D493/08
摘要： A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from, risk factors of diabetes or syndrome X.
摘要翻译：含有式（I）的羧酸衍生物（其中所有符号如说明书中所定义），其无毒性酸或其水合物作为活性成分的过氧化物酶体增殖物激活受体调节剂。由于具有调节PPAR的作用，式（I）化合物可用作降血糖剂，降血脂药，用于代谢紊乱（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症）的疾病的预防和/或补救措施等），高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂和用于缓解危险因素的药物的糖尿病或综合症。

7. 发明授权

US06924295B2 Tetrahydroquinoline derivative compound and drug containing the compound as active ingredient 失效
标题翻译：四氢喹啉衍生物化合物和含有该化合物作为活性成分的药物
公开(公告)号：US06924295B2
公开(公告)日：2005-08-02
申请号：US10481103
申请日：2002-06-17
申请人： Hisao Tajima , Yoshisuke Nakayama , Tadashi Tatsumi , Daikichi Fukushima
发明人： Hisao Tajima , Yoshisuke Nakayama , Tadashi Tatsumi , Daikichi Fukushima
IPC分类号： A61K31/47 , A61K31/4709 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P43/00 , C07D215/20 , C07D215/36 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D215/02 , C07D401/02
CPC分类号： C07D215/20 , A61K31/47 , A61K31/4709 , C07D215/36 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： A compound of formula (I) (wherein all symbols are as defined in the specification) and salt thereof, and peroxisome proliferator activated receptor regulator comprising thereof as active ingredient. Because a compound of formula (I) have an activity of regulating peroxisome proliferator activated receptor regulator, the compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or treatment agent for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.
摘要翻译：式（I）的化合物（其中所有符号如说明书中所定义）及其盐，以及其包含作为活性成分的过氧化物酶体增殖物激活受体调节剂。由于式（I）化合物具有调节过氧化物酶体增殖物激活受体调节剂的活性，式（I）化合物可用作降血糖剂，降血脂剂，与代谢紊乱相关的疾病的预防和/或治疗剂（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症等），高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低药物和缓解糖尿病或综合征X危险因素的药物。

8. 发明授权

US06589969B1 Carboxylic acid derivatives and drugs containing the same as the active ingredient 失效
标题翻译：羧酸衍生物和含有与活性成分相同的药物
公开(公告)号：US06589969B1
公开(公告)日：2003-07-08
申请号：US09807305
申请日：2001-04-11
申请人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
发明人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
IPC分类号： C07D41314
CPC分类号： C07D413/06 , C07D413/14 , C07D417/06
摘要： A peroxisome proliferator activated receptor regulator containing a compound of formula (I) (wherein all symbols are as defined in the specification), or a salt thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.
摘要翻译：含有式（I）化合物（其中所有符号如说明书中所定义）或其盐作为活性成分的过氧化物酶体增殖物激活受体调节剂。由于具有调节PPAR的作用，式（I）化合物可用作降血糖药物，降血脂药物，与代谢紊乱（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症等）相关疾病，高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食的疾病的预防和/或补救措施，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂和用于缓解糖尿病或综合征X的危险因素的药物。

9. 发明授权

US07220864B2 Dihydronaphthalene derivative compounds and agent comprising the derivative as active ingredient 失效
标题翻译：二氢萘衍生物化合物和包含该衍生物作为活性成分的试剂
公开(公告)号：US07220864B2
公开(公告)日：2007-05-22
申请号：US10451679
申请日：2001-12-21
申请人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
发明人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
IPC分类号： C07D263/32
CPC分类号： C07D407/04 , C07D263/32 , C07D277/40 , C07D277/42 , C07D413/04 , C07D413/12 , C07D417/04
摘要： The compound 3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalene-1-yl)propanoic acid or a nontoxic salt thereof. Because this compound has activity of regulating peroxisome proliferators activated receptor regulator, it is useful as a hyperglycemic agent, a hypolipidemic agent, a preventative and/or treatment agent for diseases associated with metabolic disorders etc.
摘要翻译：化合物3-（5-（2-（2-（4-甲基苯基）-5-甲基恶唑-4-基）乙氧基）-3,4-二氢萘-1-基）丙酸或其无毒盐。因为这种化合物具有调节过氧化物酶体增殖物激活受体调节剂的活性，所以它可用作高血糖剂，降血脂剂，与代谢紊乱相关疾病的预防和/或治疗剂。

10. 发明申请

US20050250824A1 Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient 失效
标题翻译：羧酸衍生物和含有该衍生物作为活性成分的药物组合物
公开(公告)号：US20050250824A1
公开(公告)日：2005-11-10
申请号：US11178639
申请日：2005-07-12
申请人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
发明人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
IPC分类号： A61K31/00 , A61K31/421 , C07C59/66 , C07C59/68 , C07C59/72 , C07C323/52 , C07D213/30 , C07D213/65 , C07D263/32 , C07D263/34 , C07D263/48 , C07D277/24 , C07D317/54 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/10
CPC分类号： C07D213/30 , A61K31/00 , C07C59/66 , C07C59/68 , C07C59/72 , C07C323/52 , C07D213/65 , C07D263/32 , C07D263/34 , C07D263/48 , C07D277/24 , C07D317/54 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/10
摘要： A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diseases or syndrome X.
摘要翻译：含有式（I）的羧酸衍生物（其中所有符号如说明书中所定义），其无毒性酸或其水合物作为活性成分的过氧化物酶体增殖物激活受体调节剂。由于具有调节PPAR的作用，式（I）化合物可用作降血糖剂，降血脂药，用于代谢紊乱（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症）的疾病的预防和/或补救措施等），高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂和用于缓解危险因素的药物疾病或综合征X.

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