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11. 发明授权

US07118730B2 Quinoline derivative as diagnostic probe for disease with tau protein accumulation 失效
标题翻译：喹啉衍生物作为具有tau蛋白积聚的疾病的诊断探针
公开(公告)号：US07118730B2
公开(公告)日：2006-10-10
申请号：US10494314
申请日：2003-11-28
申请人： Yukitsuka Kudo , Masako Suzuki , Takahiro Suemoto , Nobuyuki Okamura , Tsuyoshi Shiomitsu , Hiroshi Shimazu
发明人： Yukitsuka Kudo , Masako Suzuki , Takahiro Suemoto , Nobuyuki Okamura , Tsuyoshi Shiomitsu , Hiroshi Shimazu
IPC分类号： A61K49/00
CPC分类号： C07D215/52 , A61K31/47 , A61K31/473 , A61K51/0455 , A61K2123/00 , C07D215/12 , C07D221/10
摘要： The present invention provides compounds, or salts or solvates thereof, which can be used as probes for the imaging diagnosis of diseases in which tau protein accumulates, and compositions and kits comprising such compounds, or salts or solvates thereof. The present invention also provides a method for staining neurofibrillary tangles in brain samples, and a pharmaceutical composition for the treatment and/or prophylaxis of a disease in which β-sheet structure is the cause or possible cause.
摘要翻译：本发明提供可用作成像诊断tau蛋白积聚的疾病的探针的化合物或其盐或溶剂合物，以及包含这些化合物的组合物和试剂盒，或其盐或溶剂化物。本发明还提供了脑样本中神经原纤维缠结染色的方法，以及用于治疗和/或预防其中β-折叠结构是原因或可能的原因的疾病的药物组合物。

12. 发明授权

US6130277A Rubber composition improved in anti-static property and pneumatic tire using the same 失效
标题翻译：橡胶组合物的抗静电性能得到改善和使用其的充气轮胎
公开(公告)号：US6130277A
公开(公告)日：2000-10-10
申请号：US46589
申请日：1998-03-24
申请人： Nobuyuki Okamura , Masaaki Tsuchihashi , Isao Nishi
发明人： Nobuyuki Okamura , Masaaki Tsuchihashi , Isao Nishi
IPC分类号： C08K5/00 , C08K5/06 , C08K5/41 , C08L21/00 , C08K5/09
CPC分类号： C08K5/06 , C08K5/0075 , C08K5/41 , C08L21/00 , C08L9/06
摘要： Provided are a rubber composition improved in an anti-static property and a pneumatic tire using the same for its tread part, wherein the rubber composition comprises natural rubber and/or diene base synthetic rubber and a white filler as a filler, and further comprises an anionic anti-static agent or a polyoxyalkylene glycol compound represented by the flowing formulas (I), (II) or (III): ##STR1## wherein R.sup.1 and R.sup.3 each represent a linear or branched, saturated or unsaturated aliphatic hydrocarbon group having 1 to 21 carbon atoms, or an aryl group; R.sup.4 and R.sup.5 each represent a hydrogen atom, a linear or branched, saturated or unsaturated aliphatic hydrocarbon group having 1 to 21 carbon atoms, or an aryl group; R.sup.1 and R.sup.3 in the above formula (I), R.sup.4 and R.sup.3 in the above formula (II) and R.sup.4 and R.sup.5 in the above formula (III) in one same molecule may be the same as or different from each other; R.sup.2 is a methylene, ethylene, propylene or tetramethylene group, and all R.sup.2 's may be the same or different; and n is an integer of 100 or less.
摘要翻译：提供一种抗静电性提高的橡胶组合物和使用该橡胶组合物的胎面部分的充气轮胎，其中橡胶组合物包含天然橡胶和/或二烯基合成橡胶和作为填料的白色填料，并且还包含阴离子抗静电剂或由流化式（I），（II）或（III）表示的聚氧亚烷基二醇化合物：其中R 1和R 3各自表示具有1至21个碳原子的直链或支链，饱和或不饱和的脂族烃基，或芳基; R4和R5各自表示氢原子，具有1至21个碳原子的直链或支链，饱和或不饱和的脂族烃基或芳基; 上述式（I）中的R 1和R 3，上述式（II）中的R 4和R 3以及上述式（III）中的R 4和R 5在一个相同的分子中可以彼此相同或不同; R2是亚甲基，亚乙基，亚丙基或四亚甲基，所有的R 2可以相同或不同; n为100以下的整数。

13. 发明授权

US6021831A Pneumatic tire having foamed rubber 失效
标题翻译：具有发泡橡胶的气动轮胎
公开(公告)号：US6021831A
公开(公告)日：2000-02-08
申请号：US49980
申请日：1998-03-30
申请人： Koji Yamauchi , Nobuyuki Okamura , Kojiro Yamaguchi , Kazunori Shinohara
发明人： Koji Yamauchi , Nobuyuki Okamura , Kojiro Yamaguchi , Kazunori Shinohara
IPC分类号： B60C1/00 , B60C11/00 , B60C11/14 , C08K3/00 , C08K3/04 , C08K3/36 , C08L9/00 , C08L21/00
CPC分类号： B60C11/14 , B60C1/0016 , B60C11/00 , C08K3/36 , B60C2011/147
摘要： A pneumatic tire in which a foamed rubber layer having closed cells is provided at a surface of a tire tread which substantially contacts at least a road surface, wherein the foamed rubber layer has closed cells whose average diameter is about 1 .mu.m to about 120 .mu.m and has an expansion ratio of about 1% to about 100%, a solid-phase rubber portion of the foamed rubber layer has a rubber composition in which at least both of a diene-type rubber and silica are mixed, and an amount of the silica is about 10 to about 80 parts by weight based on 100 parts by weight of the diene-type rubber. The pneumatic tire exhibits excellent traction and braking abilities and controllability on snowy, icy and wet road surfaces.
摘要翻译：一种充气轮胎，其中具有闭孔的发泡橡胶层设置在至少基本上接触路面的轮胎胎面的表面，其中，发泡橡胶层具有平均直径为约1μm至约120μm的闭孔 m，膨胀率为1％〜100％左右，发泡橡胶层的固相橡胶部分为橡胶组合物，其中二烯类橡胶和二氧化硅中的至少两者混合，基于100重量份的二烯类橡胶，二氧化硅为约10至约80重量份。充气轮胎在雪，冰冷和潮湿的路面表现出优异的牵引力和制动能力和可控性。

14. 发明授权

US5478609A Substrate heating mechanism 失效
标题翻译：基板加热机构
公开(公告)号：US5478609A
公开(公告)日：1995-12-26
申请号：US95184
申请日：1993-07-23
申请人： Nobuyuki Okamura
发明人： Nobuyuki Okamura
IPC分类号： C23C14/50 , C23C14/00
CPC分类号： C23C14/50
摘要： A substrate-heating mechanism has a heat source for heating a substrate for heating a substrate face side reverse to a film formation face in a film deposition on the film formation surface of the substrate held on a substrate holder in a vacuum chamber, the mechanism comprises a second vacuum chamber for maintaining vacuum the substrate face reverse to the film formation face.
摘要翻译：基板加热机构具有热源，用于在保持在真空室中的基板保持器上的基板的成膜表面上的膜沉积中加热与基板正面相反的基板的基板，该机构包括第二真空室，用于将基板面保持与成膜面相反的真空。

15. 发明申请

US20050009865A1 Quinoline derivative as diagnostic probe for disease with tau protein accumulation 失效
标题翻译：喹啉衍生物作为具有tau蛋白积聚的疾病的诊断探针
公开(公告)号：US20050009865A1
公开(公告)日：2005-01-13
申请号：US10494314
申请日：2003-11-28
申请人： Yukitsuka Kudo , Masako Suzuki , Takahiro Suemoto , Nobuyuki Okamura , Tsuyoshi Shiomitsu , Hiroshi Shimazu
发明人： Yukitsuka Kudo , Masako Suzuki , Takahiro Suemoto , Nobuyuki Okamura , Tsuyoshi Shiomitsu , Hiroshi Shimazu
IPC分类号： A61K31/47 , A61K31/473 , A61K51/04 , A61P25/00 , A61P25/28 , C07D215/12 , C07D215/52 , C07D221/10 , C07D215/16 , C07D215/20
CPC分类号： C07D215/52 , A61K31/47 , A61K31/473 , A61K51/0455 , A61K2123/00 , C07D215/12 , C07D221/10
摘要： The present invention provides compounds, or salts or solvates thereof, which can be used as probes for the imaging diagnosis of diseases in which tau protein accumulates, and compositions and kits comprising such compounds, or salts or solvates thereof. The present invention also provides a method for staining neurofibrillary tangles in brain samples, and a pharmaceutical composition for the treatment and/or prophylaxis of a disease in which β-sheet structure is the cause or possible cause.
摘要翻译：本发明提供可用作成像诊断tau蛋白积聚的疾病的探针的化合物或其盐或溶剂合物，以及包含这些化合物的组合物和试剂盒，或其盐或溶剂化物。本发明还提供了脑样本中神经原纤维缠结染色的方法，以及用于治疗和/或预防其中β-折叠结构是原因或可能的原因的疾病的药物组合物。

16. 发明授权

US06291029B1 Plasma processing method 有权
标题翻译：等离子体处理方法
公开(公告)号：US06291029B1
公开(公告)日：2001-09-18
申请号：US09368497
申请日：1999-08-05
申请人： Satoshi Takaki , Atsushi Yamagami , Nobuyuki Okamura
发明人： Satoshi Takaki , Atsushi Yamagami , Nobuyuki Okamura
IPC分类号： C23C1600
CPC分类号： H01J37/32082 , C23C16/24 , C23C16/509
摘要： To improve the processing rate and uniformity in a plasma processing for a substrate having a relatively large area, a plasma processing apparatus includes a reaction vessel which has a portion made of a dielectric member, which accommodates a film formation substrate, and which can be evacuated, an evacuating means and a gas supply means for supplying a predetermined gas into the reaction vessel, a cathode electrode arranged in a position outside the reaction vessel where the cathode electrode opposes the film formation substrate accommodated in the reaction vessel via the dielectric member, and a high frequency power supply means (a matching circuit and a high frequency power supply) for supplying high frequency power of 30 MHz to 300 MHz to the cathode electrode. The high frequency power of 30 MHz to 300 MHz is supplied to the cathode electrode to generate a plasma between the dielectric member and the film formation substrate.
摘要翻译：为了提高具有相对较大面积的基板的等离子体处理的加工速度和均匀性，等离子体处理装置包括反应容器，该反应容器具有由电介质部件构成的部分，其容纳成膜基板，并且能够被抽真空排气装置和用于将预定气体供应到反应容器中的气体供给装置，设置在反应容器外侧位置处的阴极，阴极电极经由电介质构件与容纳在反应容器中的成膜基板相对，并且用于将30MHz至300MHz的高频功率提供给阴极的高频电源装置（匹配电路和高频电源）。将30MHz至300MHz的高频功率提供给阴极，以在电介质构件和成膜衬底之间产生等离子体。

17. 发明授权

US5970907A Plasma processing apparatus 失效
标题翻译：等离子体处理装置
公开(公告)号：US5970907A
公开(公告)日：1999-10-26
申请号：US791460
申请日：1997-01-27
申请人： Satoshi Takai , Atsushi Yamagami , Nobuyuki Okamura
发明人： Satoshi Takai , Atsushi Yamagami , Nobuyuki Okamura
IPC分类号： C23C16/24 , C23C16/509 , H01J37/32 , C23C16/00
CPC分类号： H01J37/32082 , C23C16/24 , C23C16/509
摘要： To improve the processing rate and uniformity in a plasma processing for a substrate having a relatively large area, a plasma processing apparatus includes a reaction vessel which has a portion made of a dielectric member, which accommodates a film formation substrate, and which can be evacuated, an evacuating means and a gas supply means for supplying a predetermined gas into the reaction vessel, a cathode electrode arranged in a position outside the reaction vessel where the cathode electrode opposes the film formation substrate accommodated in the reaction vessel via the dielectric member, and a high frequency power supply means (a matching circuit and a high frequency power supply) for supplying high frequency power of 30 MHz to 300 MHz to the cathode electrode. The high frequency power of 30 MHz to 300 MHz is supplied to the cathode electrode to generate a plasma between the dielectric member and the film formation substrate.
摘要翻译：为了提高具有相对较大面积的基板的等离子体处理的加工速度和均匀性，等离子体处理装置包括反应容器，该反应容器具有由电介质部件构成的部分，其容纳成膜基板，并且能够被抽真空排气装置和用于将预定气体供应到反应容器中的气体供给装置，设置在反应容器外侧位置处的阴极，阴极电极经由电介质构件与容纳在反应容器中的成膜基板相对，并且用于将30MHz至300MHz的高频功率提供给阴极的高频电源装置（匹配电路和高频电源）。将30MHz至300MHz的高频功率提供给阴极，以在电介质构件和成膜衬底之间产生等离子体。

18. 发明授权

US5510011A Method for forming a functional deposited film by bias sputtering process at a relatively low substrate temperature 失效
标题翻译：在相对低的基板温度下通过偏压溅射法形成功能沉积膜的方法
公开(公告)号：US5510011A
公开(公告)日：1996-04-23
申请号：US362750
申请日：1994-12-22
申请人： Nobuyuki Okamura , Atsushi Yamagami
发明人： Nobuyuki Okamura , Atsushi Yamagami
IPC分类号： C23C14/34 , H01J37/34 , H01L21/203 , H01L21/331
CPC分类号： C23C14/345 , C23C14/34 , H01J37/32706 , H01J37/3405 , H01J37/3473 , H01L21/02381 , H01L21/02532 , H01L21/02631 , H01L29/66287
摘要： In a bias sputtering method comprising generating a plasma of a sputtering gas between a target electrode having a target thereon and a substrate electrode having a substrate for film formation thereon in a vacuum vessel with the use of a high frequency energy from a high frequency power source and sputtering said target with said plasma while applying a direct current voltage from a direct current power source to at least one of said target electrode or said substrate electrode thereby causing the formation of a film on said substrate, the improvement which comprises alternately repeating a deposition step and a non-deposition step, said deposition step comprising sputtering said target with said plasma while irradiating said substrate with ions of said plasma while depositing a film on said substrate, and said non-deposition step comprising irradiating said substrate with ions of said plasma without sputtering said target, thereby forming a high quality functional deposited film on said substrate.
摘要翻译：在一种偏压溅射方法中，包括在真空容器内使用来自高频电源的高频能产生溅射气体的等离子体，所述溅射气体的等离子体在其上具有目标靶的目标电极和具有用于成膜的基板的基板电极之间并用所述等离子体溅射所述靶，同时从直流电源施加直流电压至所述目标电极或所述衬底电极中的至少一个，由此导致在所述衬底上形成膜，其改进包括交替地重复沉积步骤和非沉积步骤，所述沉积步骤包括用所述等离子体溅射所述靶，同时用所述等离子体的离子辐照所述衬底，同时在所述衬底上沉积膜，并且所述非沉积步骤包括用所述等离子体的离子照射所述衬底而不溅射所述靶，从而在s上形成高质量的功能沉积膜辅助底物。

19. 发明授权

US08709159B2 Vertical heat treatment apparatus 有权
标题翻译：立式热处理设备
公开(公告)号：US08709159B2
公开(公告)日：2014-04-29
申请号：US12170477
申请日：2008-07-10
申请人： Nobuyuki Okamura
发明人： Nobuyuki Okamura
IPC分类号： C23C16/00 , C23F1/00 , H01L21/306
CPC分类号： H01L21/67248
摘要： A vertical heat treatment apparatus enabling the insertion of a temperature sensor in the reaction tube without disassembling the apparatus is disclosed. The vertical heat treatment apparatus includes a reaction tube; a heating section; a wafer holding section; a supporting section movably provided in the vertical direction so as to seal the reaction tube while the wafer holding section is in the reaction tube; a temperature sensor insertion section provided in the supporting section and having a through hole for guiding a temperature sensor so that the temperature sensor can be inserted into the reaction tube; and a cap section for opening and closing the through hole of the temperature sensor insertion section while the wafer holding section is on the supporting section.
摘要翻译：公开了能够在不拆卸设备的情况下将温度传感器插入反应管的立式热处理装置。立式热处理装置包括反应管; 加热段; 晶片保持部; 支撑部分，其在所述晶片保持部位于所述反应管中的同时沿所述垂直方向可移动地设置以密封所述反应管; 温度传感器插入部，设置在所述支撑部中，并具有用于引导温度传感器的通孔，使得所述温度传感器能够插入所述反应管中; 以及盖部，用于在晶片保持部位在支撑部上的同时打开和关闭温度传感器插入部的通孔。

20. 发明授权

US07910579B2 Benzoxazole derivatives 失效
标题翻译：苯并恶唑衍生物
公开(公告)号：US07910579B2
公开(公告)日：2011-03-22
申请号：US12520752
申请日：2007-07-04
申请人： Yukitsuka Kudo , Syozo Furumoto , Nobuyuki Okamura
发明人： Yukitsuka Kudo , Syozo Furumoto , Nobuyuki Okamura
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/4523 , A61K31/427 , A61K31/423 , C07D417/14 , C07D413/14 , C07D277/20 , C07D263/30
CPC分类号： C07D417/06 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/0463 , A61K51/0465 , A61K51/0468 , C07D417/14 , G01N33/6893
摘要： It is intended to provide a benzoxazole derivative or a pharmaceutically acceptable salt or solvate thereof which is useful in the early diagnosis of a conformation disease; a composition or a kit containing the same for diagnosing a conformation disease; a medical composition for treating and/or preventing a conformation disease; and so on.
摘要翻译：本发明提供可用于构象疾病早期诊断的苯并恶唑衍生物或其药学上可接受的盐或溶剂合物; 用于诊断构象疾病的组合物或试剂盒; 用于治疗和/或预防构象疾病的医药组合物; 等等。

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