专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US07151182B2 Intermediates for N-substituted carbamoyloxyalkyl-azolium derivatives 有权
标题翻译： N-取代氨基甲酰氧基烷基 - 唑鎓衍生物的中间体
公开(公告)号：US07151182B2
公开(公告)日：2006-12-19
申请号：US10934551
申请日：2004-09-03
申请人： Hiroshi Fukuda , Tadakatsu Hayase , Eisaku Mizuguchi , Nobuo Shimma , Jun Ohwada , Nobuhiro Oikawa , Masahiro Sakaitani , Masao Tsukazaki , Isao Umeda
发明人： Hiroshi Fukuda , Tadakatsu Hayase , Eisaku Mizuguchi , Nobuo Shimma , Jun Ohwada , Nobuhiro Oikawa , Masahiro Sakaitani , Masao Tsukazaki , Isao Umeda
IPC分类号： C07D213/75 , C07D213/60 , C07D213/61
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D417/06 , C07D417/14
摘要： N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.
摘要翻译：具有抗真菌活性并可用于治疗真菌疾病的N-取代氨基甲酰氧基烷基 - 唑鎓衍生物。

12. 发明授权

US4803292A Process for producing statin and related compounds 失效
标题翻译：他汀类药物及相关化合物的制备方法
公开(公告)号：US4803292A
公开(公告)日：1989-02-07
申请号：US093271
申请日：1987-09-04
申请人： Yasufumi Ohfune , Masahiro Sakaitani
发明人： Yasufumi Ohfune , Masahiro Sakaitani
IPC分类号： B01J27/185 , B01J31/04 , B01J31/24 , C07B61/00 , C07C67/00 , C07C239/00 , C07C269/00 , C07C271/22 , C07C271/54 , C07D263/22 , C07F7/18 , C07C125/065
CPC分类号： C07D263/22 , Y02P20/55 , Y10S530/86
摘要： This invention relates to a process for producing statin having the general formula (I): ##STR1## and related compounds thereof; (wherein R is a C1 to C6 alkyl group, a phenyl group or a C7 to C8 phenylalkyl group and B is a protective group for an amino group).Recently, the anti-hyproperties of statin, namely the renin inhibitive properties, are attracting general attention.
摘要翻译：本发明涉及具有通式（I）的他汀类药物的制备方法：其中：（I）化合物及其相关化合物; （其中R为C1至C6烷基，苯基或C7至C8苯基烷基，B为氨基保护基）。最近，他汀类药物的抗降血糖药物，即肾素抑制性能受到广泛关注。

13. 发明授权

US07897792B2 Coumarin derivative having antitumor activity 有权
标题翻译：具有抗肿瘤活性的香豆素衍生物
公开(公告)号：US07897792B2
公开(公告)日：2011-03-01
申请号：US12161256
申请日：2007-02-09
申请人： Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
发明人： Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
IPC分类号： C07D311/00
CPC分类号： C07D311/18 , C07D405/12 , C07D417/12
摘要： The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from —N═ etc., Y3 and Y4 are selected from —CH═ etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.
摘要翻译：本发明提供下述通式（1）表示的化合物或其药学上可接受的盐：其中：X选自杂芳基等，Y1和Y2选自-N =等，Y 3和Y 4选自 - CH等等，A选自磺酰胺等，R1选自氢等，R2选自C1-6烷基等。该化合物或盐具有足够高的抗肿瘤活性，可用于细胞的治疗增殖性疾病，特别是癌症。本发明还提供含有作为活性成分的化合物或盐的药物组合物。

14. 发明授权

US07879887B2 α-amino acid derivatives and medicaments containing the same as an active ingredient 有权
标题翻译： α-氨基酸衍生物和含有活性成分的药物
公开(公告)号：US07879887B2
公开(公告)日：2011-02-01
申请号：US12306901
申请日：2007-06-29
申请人： Kazuhiko Ohrai , Michiaki Adachi , Koji Toyama , Takanori Shimizu , Keishi Hayashi , Masataka Minami , Yoshiyuki Suzuki , Masakazu Sugiyama , Masateru Ohta , Shojiro Kadono , Takuya Shiraishi , Haruhiko Sato , Yoshiaki Watanabe , Nobuya Ishii , Masahiro Sakaitani , Masami Hasegawa
发明人： Kazuhiko Ohrai , Michiaki Adachi , Koji Toyama , Takanori Shimizu , Keishi Hayashi , Masataka Minami , Yoshiyuki Suzuki , Masakazu Sugiyama , Masateru Ohta , Shojiro Kadono , Takuya Shiraishi , Haruhiko Sato , Yoshiaki Watanabe , Nobuya Ishii , Masahiro Sakaitani , Masami Hasegawa
IPC分类号： C07D513/04 , A61K31/429
CPC分类号： C07D513/04
摘要： The present invention provides novel α-amino acid derivatives of formula (1): (wherein, R1, R2, R3, R4, X and Y are as defined in the claims) or pharmaceutically acceptable salts, prodrugs or solvates thereof. The derivatives of formula (1) have βARK1 inhibitory activity and are useful for preventing or treating heart failure. Moreover, the derivatives of formula (1) also have antitumor activity, particularly dual inhibitory activity on Aurora kinase and CDK, and are useful for cell proliferative diseases such as cancer.
摘要翻译：本发明提供新的式（1）的α-氨基酸衍生物：其中R1，R2，R3，R4，X和Y如权利要求中所定义）或其药学上可接受的盐，前药或溶剂合物。式（1）的衍生物具有ARK1抑制活性，可用于预防或治疗心力衰竭。此外，式（1）的衍生物还具有抗肿瘤活性，特别是对极光激酶和CDK的双重抑制活性，并且可用于细胞增殖性疾病如癌症。

15. 发明授权

US06812238B1 N-substituted carbamoyloxyalkyl-azolium derivatives 有权
标题翻译： N-取代氨基甲酰氧基烷基 - 唑鎓衍生物
公开(公告)号：US06812238B1
公开(公告)日：2004-11-02
申请号：US09702944
申请日：2000-10-31
申请人： Hiroshi Fukuda , Tadakatsu Hayase , Eisaku Mizuguchi , Nobuo Shimma , Jun Ohwada , Nobuhiro Oikawa , Masahiro Sakaitani , Masao Tsukazaki , Isao Umeda
发明人： Hiroshi Fukuda , Tadakatsu Hayase , Eisaku Mizuguchi , Nobuo Shimma , Jun Ohwada , Nobuhiro Oikawa , Masahiro Sakaitani , Masao Tsukazaki , Isao Umeda
IPC分类号： A61K314439
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D417/06 , C07D417/14
摘要： N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.
摘要翻译：具有抗真菌活性并可用于治疗真菌疾病的N-取代氨基甲酰氧基烷基 - 唑鎓衍生物。

16. 发明授权

US4837349A Tertiary-butyldimethylsilyl carbamate derivative and process for producing the same 失效
标题翻译：叔丁基二甲基甲硅烷基氨基甲酸酯衍生物及其制备方法
公开(公告)号：US4837349A
公开(公告)日：1989-06-06
申请号：US909397
申请日：1986-09-19
申请人： Yasufumi Ohfune , Masahiro Sakaitani
发明人： Yasufumi Ohfune , Masahiro Sakaitani
IPC分类号： C07F7/18
CPC分类号： C07F7/1896
摘要： A t-butyldimethylsilyl carbamate derivative and a process for producing the same are disclosed. Tertiary-butyldimethylsilyl carbamate derivatives having the following general formula (1) are intermediates for the production of a variety of carbamate esters that can be extensively used as drugs acting on the central nervous system or circulatory organs, as agrichemicals (e.g. insecticides and herbicides), or as antimicrobial agents; a process capable of economical and efficient production of such intermediates is also disclosed: ##STR1## where R.sup.1 is an alkyl group having 1-3 carbon atoms or a hydrogen atom; R.sup.2 is ##STR2## (where R.sup.3 is a hydrogen atom, an alkyl, alkenyl or aralkyl group having 1-10 carbon atoms, each of which groups may be substituted by a hydroxyl group, a t-butyldimethylsilyloxy group, a methylthio group, a lower alkoxycarbonyl group, a lower alkoxy group, an indolyl group or an imidazolyl group; R.sup.4 is a lower alkoxycarbonyl group, an N-alkylamido group having 2-6 carbon atoms, an O-tetrahydropyranylthr eonine methyl ester amido residue, an O-t-butyldimethylsilylthreonine methyl ester amido residue, a threonine methyl ester amido residue or --(CH.sub.2).sub.n --COOR.sup.5 (where n is an integer of 1-3 and R.sup.5 is a lower alkyl group), provided that R.sup.3 combines with R.sup.4 to form a cyclopentyl group, a cyclohexyl group, a tetrahydrofuranyl group or a dioxanyl group, these rings being optionally substituted by a lower alkyl group, a lower alkenyl group, a lower alkoxycarbonyl group or a lower alkoxycarbonylmethyl group); and R.sup.1 and R.sup.2, when taken together, form a 4- or 5-membered carbon ring, which may be substituted by a lower alkoxycarbonyl group or a t-butyldimethylsilyloxycarbonyl group.
摘要翻译：公开了一种叔丁基二甲基甲硅烷基氨基甲酸酯衍生物及其制备方法。具有以下通式（1）的叔丁基二甲基甲硅烷基氨基甲酸酯衍生物是用于生产可广泛用作作为农药（例如杀虫剂和除草剂）作为中枢神经系统或循环器官的药物的各种氨基甲酸酯的中间体，或作为抗微生物剂; 还公开了能够经济有效地生产这样的中间体的方法：其中R1是具有1-3个碳原子的烷基或氢原子的（1） R2是（其中R3是氢原子，具有1-10个碳原子的烷基，烯基或芳烷基，它们各自可以被羟基取代，叔丁基二甲基甲硅烷氧基，甲硫基，低级烷氧基羰基，低级烷氧基，吲哚基或咪唑基; R4为低级烷氧基羰基，具有2-6个碳原子的N-烷基酰氨基，O-四氢吡喃基硫代氨基甲酸酯酰胺残基，二叔丁基二甲基甲硅烷基苏氨酸甲基酯酰氨基残基，苏氨酸甲酯酰氨基残基或 - （CH 2）n -COOR 5（其中n为1-3的整数，R 5为低级烷基），条件是R 3与R 4结合形成环戊基，环己基，四氢呋喃基或二恶烷基，这些环任选被低级烷基，低级烯基，低级烷氧基羰基或低级烷氧基羰基甲基取代）。当R 1和R 2一起形成可被低级烷氧基羰基或叔丁基二甲基甲硅烷氧基羰基取代的4-或5-元碳环时，

17. 发明授权

US08278465B2 Coumarin derivative having antitumor activity 有权
标题翻译：具有抗肿瘤活性的香豆素衍生物
公开(公告)号：US08278465B2
公开(公告)日：2012-10-02
申请号：US12960134
申请日：2010-12-03
申请人： Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
发明人： Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
IPC分类号： C07D311/00
CPC分类号： C07D311/18 , C07D405/12 , C07D417/12
摘要： The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from —N═ etc., Y3 and Y4 are selected from —CH═ etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.
摘要翻译：本发明提供下述通式（1）表示的化合物或其药学上可接受的盐：其中：X选自杂芳基等，Y1和Y2选自-N =等，Y 3和Y 4选自 - CH等等，A选自磺酰胺等，R1选自氢等，R2选自C1-6烷基等。该化合物或盐具有足够高的抗肿瘤活性，可用于细胞的治疗增殖性疾病，特别是癌症。本发明还提供含有作为活性成分的化合物或盐的药物组合物。

18. 发明申请

US20110009398A1 p27 Protein Inducer 有权
标题翻译： p27蛋白诱导剂
公开(公告)号：US20110009398A1
公开(公告)日：2011-01-13
申请号：US12669944
申请日：2008-07-18
申请人： Toshiyuki Sakai , Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
发明人： Toshiyuki Sakai , Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
IPC分类号： A61K31/536 , A61K31/4965 , A61K31/506 , A61K31/436 , A61K31/427 , A61K31/366 , C07D413/02 , C07D405/02 , C07D405/14 , C07D471/02 , C07D417/12 , C07D311/06 , C07D417/14
CPC分类号： C07D405/14 , C07D407/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/052
摘要： The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G1, G2, G3 and G8 are each independently selected from —N═ etc., Ring G6 is selected from divalent aryl etc., A is selected from amino etc., G4 is selected from oxygen etc., G5 is selected from oxygen etc., G7 is selected from —CH2— etc., and R2 is selected from C1-6 alkyl etc.
摘要翻译：本发明提供一种p27蛋白诱导剂，其含有下述通式（11）表示的化合物或其药学上可接受的盐作为活性成分：其中，G1，G2，G3和G8各自独立地选自-N等。环 G6选自二价芳基等，A选自氨基等，G4选自氧等，G5选自氧等，G7选自-CH2-等，R2选自C1- 6烷基等

19. 发明申请

US20100004233A1 NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY 有权
标题翻译：具有抗肿瘤活性的新型香豆素衍生物
公开(公告)号：US20100004233A1
公开(公告)日：2010-01-07
申请号：US12161256
申请日：2007-02-09
申请人： Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
发明人： Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
IPC分类号： A61K31/536 , C07D311/06 , A61K31/352 , C07D405/12 , A61K31/506 , C07D413/12
CPC分类号： C07D311/18 , C07D405/12 , C07D417/12
摘要： The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from —N═ etc., Y3 and Y4 are selected from —CH═ etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.
摘要翻译：本发明提供下述通式（1）表示的化合物或其药学上可接受的盐：其中：X选自杂芳基等，Y1和Y2选自-N-等，Y3和Y4选自 - CH-等，A选自磺酰胺等，R1选自氢等，R2选自C1-6烷基等。化合物或盐具有足够高的抗肿瘤活性，可用于治疗细胞增殖性疾病，特别是癌症。本发明还提供含有作为活性成分的化合物或盐的药物组合物。

20. 发明申请

US20050038038A1 N-phenyl substituted carbamoyloxyalkyl-azolium derivatives 有权
标题翻译： N-苯基取代的氨基甲酰氧基烷基 - 唑鎓衍生物
公开(公告)号：US20050038038A1
公开(公告)日：2005-02-17
申请号：US10933577
申请日：2004-09-03
申请人： Hiroshi Fukuda , Tadakatsu Hayase , Eisaku Mizuguchi , Nobuo Shimma , Jun Ohwada , Nobuhiro Oikawa , Masahiro Sakaitani , Masao Tsukazaki , Isao Umeda
发明人： Hiroshi Fukuda , Tadakatsu Hayase , Eisaku Mizuguchi , Nobuo Shimma , Jun Ohwada , Nobuhiro Oikawa , Masahiro Sakaitani , Masao Tsukazaki , Isao Umeda
IPC分类号： C07D417/06 , C07D417/14 , C07D521/00 , A61K31/496 , A61K31/4178 , A61K31/4196 , A61K31/4439 , A61K31/454 , C07D43/02 , C07D45/14
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D417/06 , C07D417/14
摘要： N-substituted carbamoyloxyalkyl-azolium derivatives Which have antifungal activity and are useful for the treatment of fungal diseases.
摘要翻译： N-取代氨基甲酰氧基烷基 - 唑类衍生物具有抗真菌活性，可用于治疗真菌病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式