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    • 18. 发明申请
    • Pharmaceutical Composition for Prevention or Treatment of Disease Associated with Tear Reduction
    • 用于预防或治疗与撕裂相关的疾病的药物组合物
    • US20110092509A1
    • 2011-04-21
    • US12526298
    • 2009-08-07
    • Mamoru KobayashiTetsuya AsariMariko Tadachi
    • Mamoru KobayashiTetsuya AsariMariko Tadachi
    • A61K31/5377A61K31/165A61K31/4453A61P27/02
    • A61K31/165A61K31/4453A61K31/5375
    • The present invention provides pharmaceutical compositions for the prevention or treatment of diseases associated with decrease in tear.The present invention provides pharmaceutical compositions for the prevention or treatment of diseases associated with decrease in tear such as dry eye, dry disorders of cornea and conjunctiva, disorders of the keratoconjunctival epithelium, syndrome with decrease in tear secretion, xerophthalmia, dry eye due to aging, ophthalmopathy in Stevens-Johnson syndrome, ophthalmopathy in Sjögren's syndrome, keratoconjunctival ulcer, dryness in wearing of contact lens or the like, which comprises as an active ingredient a phenylethanolaminotetralin-carboxamide derivative represented by the general formula (I) wherein A represents a lower alkylene group, B represents an amino group, a di(lower alkyl)amino group or a 3 to 7-membered alicyclic amino group which may have an oxygen atom in the ring, a carbon atom with the mark “*” represents a carbon atom of S-configuration or R-configuration, or a mixture thereof and a carbon atom with (S) represents a carbon atom of S-configuration, or a pharmaceutically acceptable salt thereof.
    • 本发明提供了用于预防或治疗与泪液减少相关的疾病的药物组合物。 本发明提供了用于预防或治疗与泪液减少相关的疾病的药物组合物,例如干眼症,角膜和结膜的干性失调,角膜结膜上皮的病症,泪液分泌减少的综合征,干眼症,老化造成的干眼症 ,史蒂文森 - 约翰逊综合征中的眼病,西格伦综合征的眼病,角膜结膜溃疡,隐形眼镜等的磨损,其包含作为活性成分的由通式(I)表示的苯基乙酰氨基四氢化萘 - 甲酰胺衍生物,其中A表示低级 亚烷基,B表示氨基,二(低级烷基)氨基或在环中可具有氧原子的3〜7元脂环族氨基,具有标记“*”的碳原子表示碳原子 的S-构型或R构型,或其混合物和碳原子与(S)表示S-构型的碳原子,或者是Phar 其药学上可接受的盐。