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11. 发明申请

US20100252223A1 METHOD AND DEVICE FOR MANUFACTURING A STRIP OF METAL 有权
标题翻译：用于制造金属条的方法和装置
公开(公告)号：US20100252223A1
公开(公告)日：2010-10-07
申请号：US12734778
申请日：2008-11-13
申请人： Rolf Franz , Olaf Norman Jepsen , Christian Mengel , Michael Breuer
发明人： Rolf Franz , Olaf Norman Jepsen , Christian Mengel , Michael Breuer
IPC分类号： B22D29/00 , B22D45/00
CPC分类号： B21B1/463 , B22D11/0631 , B22D11/1284
摘要： The invention pertains to a method for manufacturing a strip (1) of metal, particularly of steel, wherein liquid metal is delivered to a solidification section (3) from a delivery vessel (2), and wherein the cast metal solidifies along the solidification section (3). In order to achieve an optimal strip quality without damages, the inventive method proposes that liquid metal is delivered to a first location (4) of the solidification section (3) that is realized in the form of a horizontally extending conveyor element, and in that the solidified metal departs the conveyor element (3) at a second location (5) that is spaced apart from the first location in the transport direction (F), wherein means (6, 7) for maintaining the mass flow of the strip departing the solidification section (3) and/or the tension in the strip at a desired value are provided at or downstream of the second location (5) referred to the transport direction (F). The invention furthermore pertains to a device for manufacturing a strip of metal.
摘要翻译：本发明涉及一种用于制造特别是钢的金属带材（1）的方法，其中液态金属从输送容器（2）输送到固化部分（3），并且其中铸造金属沿固化部分固化（3）。为了实现最佳条带质量而不损坏，本发明的方法提出将液态金属输送到以水平延伸的输送机元件形式实现的凝固段（3）的第一位置（4），并且在该位置固化金属在与输送方向（F）上的第一位置间隔开的第二位置（5）处离开输送机元件（3），其中用于保持条带质量流动的装置（6,7）固化部分（3）和/或在期望值下的条带中的张力设置在涉及输送方向（F）的第二位置（5）的下游。本发明还涉及一种用于制造金属条的装置。

12. 发明授权

US07785847B2 Method for producing optically active alcohols from alkanones using a dehydrogenase of azoarcus 有权
标题翻译：使用azoarcus脱氢酶从链烷醇生产光学活性醇的方法
公开(公告)号：US07785847B2
公开(公告)日：2010-08-31
申请号：US11579292
申请日：2005-05-04
申请人： Rainer Stürmer , Maria Keβeler , Bernhard Haur , Thomas Friedrich , Michael Breuer , Hartwig Schröder
发明人： Rainer Stürmer , Maria Keβeler , Bernhard Haur , Thomas Friedrich , Michael Breuer , Hartwig Schröder
IPC分类号： C12P7/22 , C12P7/04 , C12P17/00 , C12N9/04 , C12N9/14 , C12N1/20 , C07H21/04
CPC分类号： C07D333/22 , C07D333/16 , C12P17/00
摘要： The invention relates to a method for producing the optically active alkanols of formula (I), wherein n is an integer of from 0 to 5; Cyc represents an optionally substituted, mononuclear or polynuclear, saturated or unsaturated, carbocylic or heterocyclic ring, and R1 represents halogen, SH, OH, NO2, NR2R3 or NR2R3R4+X−, wherein R2, R3 and R4 independently represent H or a lower alkyl or lower alkoxy group and X− represents a counterion. According to the invention, an enzyme (E) selected from the groups of dehydrogenases, aldehyde reductases and carbonyl reductases is incubated in a medium containing the alkanone of formula (II), wherein n, Cyc and R1 are defined as above, in the presence of reduction equivalents. The compound of formula (II) is enzymatically reduced to the compound of formula (I) and the reduction equivalents consumed during reaction are regenerated by reacting a sacrificial alcohol to the corresponding sacrificial ketone using enzyme (E) and at least partially removing the sacrificial ketone from the reaction medium, and then isolating the product (I) so produced.
摘要翻译：本发明涉及一种制备式（I）的光学活性链烷醇的方法，其中n为0-5的整数; Cyc表示任选取代的单核或多核，饱和或不饱和的碳环或杂环，并且R 1表示卤素，SH，OH，NO 2，NR 2 R 3或NR 2 R 3 R 4 + X - ，其中R 2，R 3和R 4独立地表示H或低级烷基或低级烷氧基，X-表示抗衡离子。根据本发明，在含有式（II）的烷酮的培养基中温育选自脱氢酶，醛还原酶和羰基还原酶的酶的酶（E），其中n，R 1和R 1如上定义，在存在下的还原当量。将式（II）化合物酶还原成式（I）化合物，并且通过使用酶（E）使牺牲醇与相应的牺牲酮反应，并且至少部分除去牺牲酮来再生反应期间消耗的还原当量从反应介质中分离出如此制备的产物（I）。

13. 发明申请

US20100068760A1 PROTEINS WITH ESTERASE ACTIVITY 有权
标题翻译：蛋白质与蛋白酶活性
公开(公告)号：US20100068760A1
公开(公告)日：2010-03-18
申请号：US12306703
申请日：2007-06-26
申请人： Michael Breuer , Bernhard Hauer , Ulrich Schwaneberg , Tuck Seng Wong
发明人： Michael Breuer , Bernhard Hauer , Ulrich Schwaneberg , Tuck Seng Wong
IPC分类号： C12P21/00 , C12N9/16 , C07H21/00 , C12N15/63 , C12N1/00 , C12P7/62
CPC分类号： C12N9/16 , C12P7/62 , C12P41/003
摘要： The invention relates to novel proteins having esterase activity, to mutants thereof, to nucleic acid sequences coding therefor, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.
摘要翻译：本发明涉及具有酯酶活性的新型蛋白质，其突变体与其编码的核酸序列，表达盒，载体和重组微生物; 涉及用于制备所述蛋白质的方法及其用于酶，特别是对映选择性酶，酯水解或酯交换有机酯的用途。

14. 发明申请

US20080319208A1 Method for Production of Optically Active (1S)-3-Chloro-1-(2-Thienyl)-Propan-1-Ol 有权
标题翻译：光活性（1S）-3-氯-1-（2-噻吩基） - 丙-1-醇的制备方法
公开(公告)号：US20080319208A1
公开(公告)日：2008-12-25
申请号：US12158526
申请日：2006-12-13
申请人： Michael Breuer
发明人： Michael Breuer
IPC分类号： C07D333/06
CPC分类号： C12P17/00 , C12P41/002
摘要： A process for preparing optically active (1S)-3-chloro-1-(2-thienyl)propan-1-ol of the formula I by, in a medium comprising 3-chloro-1-(2-thienyl)propan-1-one of the formula II reducing this compound to the compound of the formula I by means of an alcohol dehydrogenase from the Thermoanaerobacter genus, and isolating the product formed in substantially enantiomerically pure form.
摘要翻译：在包含3-氯-1-（2-噻吩基）丙-1-酮的介质中制备式I的光学活性（1S）-3-氯-1-（2-噻吩基）丙-1-醇的方法，式II的一种通过来自热厌氧杆菌属的醇脱氢酶将该化合物还原成式I的化合物，并分离基本上对映体纯的形式形成的产物。

15. 发明申请

US20080108835A1 Method For Purifying (1S)-3-Methylamino-1-(2-Thienyl)-1-Propanol 审中-公开
标题翻译：纯化（1S）-3-甲基氨基-1-（2-噻吩基）-1-丙醇的方法
公开(公告)号：US20080108835A1
公开(公告)日：2008-05-08
申请号：US11814253
申请日：2005-12-31
申请人： Rainer Sturmer , Jurgen Dauwel , Maria Kesseler , Brigitte Achatz , Michael Breuer
发明人： Rainer Sturmer , Jurgen Dauwel , Maria Kesseler , Brigitte Achatz , Michael Breuer
IPC分类号： C07D333/20
CPC分类号： B01D3/12 , C07D333/20
摘要： The present invention relates to a method for purifying (1S)-3-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL by distilling a reaction mixture which comprises between 25 and 99% by weight of (IS)-3-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL.
摘要翻译：本发明涉及一种通过蒸馏反应混合物来纯化（1S）-3-甲基氨基-1-（2-噻吩基）-1-丙醇的方法，所述反应混合物包含25至99重量％的（1S）-3-甲基氨基 -1-（2-噻吩基）-1-丙醇。

16. 发明申请

US20070143930A1 METHOD FOR REMOVING HORN SUBSTANCES FROM ANIMAL SKIN 审中-公开
标题翻译：从动物皮肤中去除牛皮质的方法
公开(公告)号：US20070143930A1
公开(公告)日：2007-06-28
申请号：US11682924
申请日：2007-03-07
申请人： Hans-Georg LEMAIRE , Tilman Taeger , Gunther Pabst , Philippe Lamalle , Michael Breuer , Burkhard Kroger , Thomas Subkowski
发明人： Hans-Georg LEMAIRE , Tilman Taeger , Gunther Pabst , Philippe Lamalle , Michael Breuer , Burkhard Kroger , Thomas Subkowski
IPC分类号： C14C1/06
CPC分类号： C14C1/065
摘要： Horny substances are removed from animal hides by a process wherein animal hides are treated in a liquor comprising from 0.05 to 5% by weight, based on the salted weight, of one or more compounds of the formula I or the corresponding alkali metal or alkaline earth metal or ammonium or phosphonium salts thereof, the variables being defined as follows: R1 is selected from hydrogen and C1-C12-alkyl, unsubstituted or substituted by one or more S—H or O—H groups; X1 to X4 are identical or different and are selected from hydrogen, C1-C4-alkyl, O—H, S—H and N—HR2, R2 is hydrogen or C1-C12-alkyl or a C1-C4-alkyl-C═O group, at least one of the radicals X1 to X4 being S—H, and, if R1 contains neither O—H nor S—H, at least one further radical from among X1 to X4 is selected from S—H, OH and NH—R2, and furthermore with at least one compound which catalyzes the hydrolysis of peptide bonds.
摘要翻译：通过一种方法将动物皮肤从动物皮革中去除，其中动物皮由含有0.05至5重量％（以盐重计）的一种或多种式I化合物或相应的碱金属或碱土金属金属或铵或鏻盐，变量定义如下：R 1选自氢和C 1 -C 12 - 烷基未取代或被一个或多个SH或OH基取代; X 1至X 4相同或不同，并且选自氢，C 1 -C 4 - C 4 - 烷基，OH，SH和N-HR 2，R 2是氢或C 1 -C 12 - C 12 - 烷基或C 1 -C 4 - 烷基-CO基团，基团X 1至X 4中的至少一个， SUP>为SH，并且如果R 1不包含OH或SH，则X 1至X 4中的至少一个其它基团为选自SH，OH和NH-R 2，以及至少一种催化肽键水解的化合物。

17. 发明申请

US20060037148A1 Method for removing horn substances from animal skin 失效
标题翻译：从动物皮肤去除角质物质的方法
公开(公告)号：US20060037148A1
公开(公告)日：2006-02-23
申请号：US10531167
申请日：2003-10-14
申请人： Hans-George Lemaire , Tilman Taeger , Gunther Pabst , Philippe Lamalle , Michael Breuer , Burkhard Kroger , Thomas Subkowski
发明人： Hans-George Lemaire , Tilman Taeger , Gunther Pabst , Philippe Lamalle , Michael Breuer , Burkhard Kroger , Thomas Subkowski
IPC分类号： C14C1/00
CPC分类号： C14C1/065
摘要： The invention relates to a method for removing horn substances from animal skin. Said method is characterised in that animal skins are treated in an aqueous bath containing between 0.05 and 5 wt. %—in relation to the weight of the salt—of at least one compound of general formula I or the corresponding alkali metallic salts or alkaline-earth metallic salts thereof or ammonium or phosphonium salts, the variables having the following definitions: R1 is selected from hydrogen or C1-C12 alkyl, unsubstituted or substituted by at least one S—H group or one O—H group; X1 to X4 are the same or different and selected from hydrogen, C1-C4 alkyl, O—H, S—H or N—HR2; and R2 represents hydrogen or C1-C12 alkyl or a C1-C4-alkyl-C═O group, at least one X1 to X4 representing S—H. If R1 contains neither O—H nor S—H, at least one other X1 to X4 is selected from S—H, OH or NH—R2. Said aqueous bath also comprises at least one compound which catalyses the hydrolysis of peptide compounds.
摘要翻译：本发明涉及从动物皮肤去除角质物质的方法。所述方法的特征在于动物皮肤在含有0.05至5wt。％ - 与至少一种通式I化合物或其相应的碱金属盐或碱土金属盐或铵盐或鏻盐的盐的重量相关，所述变量具有以下定义：R 1选自氢或C1-C12烷基，未被取代或被至少一个SH基团或一个OH基团取代; X 1〜X 4相同或不同，选自氢，C 1 -C 4烷基，O-H，S-H或N-HR 2; 并且R 2表示氢或C 1 -C 12烷基或C 1 -C 4烷基-C 0基团，至少一个表示S-H的X 1至X 4。如果R 1既不含O-H也不包含S-H，则至少一个其它的X 1至X 4选自S-H，OH或NH-R 2。所述水浴还包含至少一种催化肽化合物水解的化合物。

18. 发明申请

US20140230582A1 ACTUATING APPARATUS 审中-公开
标题翻译：执行装置
公开(公告)号：US20140230582A1
公开(公告)日：2014-08-21
申请号：US14348055
申请日：2012-07-17
申请人： Andres Toennesmann , Andreas Koester , Martin Nowak , Michael Schaefer , Michael Breuer
发明人： Andres Toennesmann , Andreas Koester , Martin Nowak , Michael Schaefer , Michael Breuer
IPC分类号： F16H19/02
CPC分类号： F16H19/02 , F02B37/186 , F02M26/27 , F02M26/48 , F02M26/67 , Y02T10/144 , Y10T74/18056
摘要： An actuating apparatus includes a housing, an actuating unit, a receiver element, and a transmitter element. The actuating unit comprises a first end with a circular arc-shaped contour whose circular arc central axis is configured to act as a first pivot axis. The actuating unit is configured to be moved via an actuator and to undertake a translational main movement and a pivoting movement. The translational main movement is superimposed by the pivoting movement. The receiver element is fixedly arranged in the housing. The transmitter element comprises a magnetic field. The transmitter element is configured to be translationally movable, to be biased so as to bear against the first end of the actuating unit, and to cooperate with the receiver element.
摘要翻译：致动装置包括壳体，致动单元，接收器元件和发射器元件。致动单元包括具有圆弧形轮廓的第一端，其圆弧中心轴构造成用作第一枢轴。致动单元构造成经由致动器移动并进行平移主运动和枢转运动。平移主运动由枢转运动叠加。接收器元件固定地布置在壳体中。发射机元件包括磁场。发射器元件构造成可平移移动，以被偏压以抵靠致动单元的第一端，并与接收器元件配合。

19. 发明授权

US08759043B2 Biocatalytic production of ambroxan 有权
标题翻译：生物催化生产氨溴索
公开(公告)号：US08759043B2
公开(公告)日：2014-06-24
申请号：US13375996
申请日：2010-06-02
申请人： Michael Breuer , Andrea Hörster , Bernhard Hauer
发明人： Michael Breuer , Andrea Hörster , Bernhard Hauer
IPC分类号： C12P17/04 , C12N1/15 , C12N1/19 , C12N1/21
CPC分类号： C12P17/04 , C12N9/90
摘要： The invention relates to a process for the biocatalytic production of ambroxan by means of a polypeptide with the activity of a homofarnesol-ambroxan cyclase, which are a novel class of enzymes.
摘要翻译：本发明涉及一种通过具有活性的同型异恶唑烷醇 - 氨溴环己烷酶的多肽生物催化生产氨溴辛的方法，该酶是新一类酶。

20. 发明授权

US08338146B2 Method for producing optically active alcohols using an Azoarcus sp. EbN1 dehydrogenase 有权
标题翻译：使用Azoarcus sp。制备光学活性醇的方法 EbN1脱氢酶
公开(公告)号：US08338146B2
公开(公告)日：2012-12-25
申请号：US12665383
申请日：2008-06-16
申请人： Michael Breuer , Ralf Rabus , Johann Heider
发明人： Michael Breuer , Ralf Rabus , Johann Heider
IPC分类号： C12P7/02
CPC分类号： C12P7/02
摘要： A process for preparing optically active alcohols of the formula Ia or Ib in which R1,R2 are alkyl, alkenyl, aryl, or alkylaryl groups which may in turn be substituted one or more times by alkyl, halogen, SH, SR2, OH, OR2, NO2, CN, CO, COOR2, NR2R3 or NR2R3R4+X, where R2, R3 and R4 are independently of one another H or a lower alkyl or lower alkoxy radical, and X−is a counter ion, with the proviso that R1 is not equal to R2, by reducing the corresponding ketone, where the reduction is carried out with a dehydrogenase having the polypeptide sequence of SEQ ID NO: 2 or NO: 4, or with a polypeptide sequence in which up to 25% of the amino acid residues are altered by comparison with SEQ ID NO: 2 or NO: 4 by deletion, insertion, substitution or a combination thereof.
摘要翻译：制备式Ia或Ib的光学活性醇的方法，其中R1，R2是烷基，烯基，芳基或烷基芳基，其又可以被烷基，卤素，SH，SR2，OH，OR2取代一次或多次，NO 2，CN，CO，COOR 2，NR 2 R 3或NR 2 R 3 R 4 + X，其中R 2，R 3和R 4彼此独立地为H或低级烷基或低级烷氧基，X为抗衡离子，条件是R 1为通过还原相应的酮，其中还原是用具有SEQ ID NO：2或NO：4的多肽序列的脱氢酶，或多肽序列，其中多达25％的氨基酸通过与SEQ ID NO：2或NO：4的比较，通过缺失，插入，取代或其组合来改变残基。

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