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    • 17. 发明授权
    • Heterocyclic NF-κB inhibitors
    • 杂环NF-κB抑制剂
    • US08106048B2
    • 2012-01-31
    • US11575647
    • 2005-07-29
    • Johann LebanHarald SchmittKristina WolfStefano PegoraroAndreas Wuzík
    • Johann LebanHarald SchmittKristina WolfStefano PegoraroAndreas Wuzík
    • A61K31/535A61K31/53A61K31/497A61K31/4965A61K31/445A61K31/425C07D403/10C07D401/10
    • C07D263/48C07D277/56C07D401/14C07D413/06C07D413/12C07D413/14C07D417/04C07D417/06C07D417/12C07D417/14C07D487/04C07D491/04C07D495/04
    • The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, (I) wherein R1 is independently hydrogen, alkyl, cycloalkyl, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl or substituted arylalkyl; R2 is independently —NR3R4, (II) or (III) R3 is independently alkyl, cycloalkyl, alkoxy, alkylamine, —OH, —SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl, R4 is independently alkyl, cycloalkyl, alkoxy, alkylamine, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; R5 is independently H, COR6, CO2R6, SOR6, SO2R6, SO3R6, alkyl, cycloalkyl, alkoxy, —NH2, alkylamine, —NR7COR6, halogen, —OH, —SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; R6 is independently H, alkyl, cycloalkyl, —NH2, alkylamine, aryl or heteroaryl; R7 is independently H, alkyl, cycloalkyl, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, aryl, or heteroaryl; p is 0, or 1; q is 0, or 1; X is CO, or SO2.
    • 本发明涉及通式(I)的化合物及其盐和生理功能衍生物,其中R 1独立地为氢,烷基,环烷基,羟基烷基,卤代烷基,卤代烷氧基,芳基,取代的芳基,杂芳基,取代的杂芳基, 芳基烷基或取代的芳基烷基; R 2独立地是-NR 3 R 4,(II)或(III)R 3独立地是烷基,环烷基,烷氧基,烷基胺,-OH,-SH,烷硫基,羟基烷基,卤代烷基,卤代烷氧基,芳基或杂芳基,R 4独立地是烷基,环烷基,烷氧基 烷基胺,烷硫基,羟基烷基,卤代烷基,卤代烷氧基,芳基或杂芳基; R5独立地是H,COR6,CO2R6,SOR6,SO2R6,SO3R6,烷基,环烷基,烷氧基,-NH2,烷基胺,-NR7COR6,卤素,-OH,-SH,烷硫基,羟基烷基,卤代烷基,卤代烷氧基,芳基或杂芳基; R6独立地为H,烷基,环烷基,-NH2,烷基胺,芳基或杂芳基; R 7独立地是H,烷基,环烷基,烷氧基,-OH,-SH,烷硫基,羟基烷基,芳基或杂芳基; p为0或1; q为0或1; X是CO或SO2。
    • 19. 发明申请
    • SHUT-OFF DEVICE
    • 关闭装置
    • US20090294718A1
    • 2009-12-03
    • US12306231
    • 2007-06-25
    • Simon SchwarzAlexander RothermelFabian MaierDirk ElsasserHeiko GehrWolfgang SichlerHarald SchmittMichael SchneiderRalph Schmich
    • Simon SchwarzAlexander RothermelFabian MaierDirk ElsasserHeiko GehrWolfgang SichlerHarald SchmittMichael SchneiderRalph Schmich
    • F16K1/22
    • F16K1/165F16K31/502F16K31/521Y10T137/87981
    • The invention relates to a shut-off device comprising a housing which is to be connected to an adjacent conduit in a pressure-tight manner A tubular passage is defined in the housing for a medium flowing through the conduit. Said device also comprises at least one sealing body which can be displaced by an articulated mechanism, by means of an adjusting drive that can be moved vertically in relation to the direction of flow, from an open position into a closed position in which the sealing contour of the at least one sealing body comes into contact with the tubular passage in a radially sealing manner. The articulated mechanism is guided parallel to the direction of displacement of the adjusting drive and comprises a bearing body to which the at least one sealing body is pivotably applied. The inventive shut-off device is characterized in that the bearing body comprises two diametrically opposed ribs and two corresponding grooves are formed in the wall of the housing or in an insert at least partially lining the housing, the ribs forming a span extending transversally to the direction of flow of the medium.
    • 本发明涉及一种切断装置,其包括以压力方式连接到相邻管道的壳体。在壳体中限定了用于流过导管的介质的管状通道。 所述装置还包括至少一个密封体,所述至少一个密封体可以借助于相对于流动方向垂直移动的调节驱动器从打开位置移动到关闭位置,所述密封体可以通过铰接机构移动,在该位置中密封轮廓 的至少一个密封体以径向密封的方式与管状通道接触。 铰接机构平行于调节驱动器的移动方向被引导,并且包括轴承体,所述至少一个密封体可枢转地施加到所述轴承体。 本发明的切断装置的特征在于,所述轴承体包括两个直径相对的肋,并且在所述壳体的壁中或在至少部分地衬套所述壳体的插入件中形成两个相应的凹槽,所述肋形成横向延伸到 介质的流动方向。
    • 20. 发明申请
    • Method for enlarging the bandwidth of a group call
    • 扩大群组呼叫带宽的方法
    • US20090233615A1
    • 2009-09-17
    • US11921218
    • 2006-05-30
    • Harald Schmitt
    • Harald Schmitt
    • H04W72/04H04J3/00
    • H04W72/005H04W68/00H04W72/0446
    • The present invention relates to a method of enlarging a bandwidth available for a group call in a GSM network, in which, within a telephony channel (1) of the GSM network subdivided into a plurality of timeslots (TN0, . . . , TN7), a first (TN2) and at least one second (TN1, TN3) timeslot is allocated to the group call (VGC), the first timeslot (TN2) being provided for transmitting useful data of the group call (VGC) and the at least one second timeslot (TN1, TN3) being provided in order to supply additional bandwidth. Moreover, the present invention relates to a corresponding computer program and a computer program product.
    • 本发明涉及一种在GSM网络中扩大可用于群组呼叫的带宽的方法,其中在被划分成多个时隙(TN0,...,TN7)的GSM网络的电话信道(1)内, ,向组呼(VGC)分配第一(TN2)和至少一个第二(TN1,TN3)时隙,第一时隙(TN2)被提供用于发送组呼(VGC)的有用数据,并且至少 提供一个第二时隙(TN1,TN3)以便提供额外的带宽。 此外,本发明涉及相应的计算机程序和计算机程序产品。