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11. 发明授权

US08224457B2 Medical implantable lead 有权
标题翻译：医用植入式铅
公开(公告)号：US08224457B2
公开(公告)日：2012-07-17
申请号：US12447984
申请日：2006-10-31
申请人： Hans Strandberg , Anna Norlin-Weissenrieder , Leda Henriquez , Eva Harström , Mikael Sjögren , Annika Naeslund , Susanne Nilsson , Olof Stegfeldt
发明人： Hans Strandberg , Anna Norlin-Weissenrieder , Leda Henriquez , Eva Harström , Mikael Sjögren , Annika Naeslund , Susanne Nilsson , Olof Stegfeldt
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/056 , H01B7/0823
摘要： A medical implantable lead has a proximal end and a distal end, and a flexible flat elongate body. The elongate body includes a layer of strip conductors extending along the length of the flat elongate body, a top insulating layer, and a bottom insulating layer. The layer of strip conductors is sealingly enclosed between the top and bottom insulating layers, and at least a major portion of the flat elongate body is twisted into an elongate helical portion having a central cavity extending longitudinally of the helical portion.
摘要翻译：医用可植入引线具有近端和远端，以及柔性扁平细长体。细长主体包括沿扁平细长体的长度延伸的条形导体层，顶部绝缘层和底部绝缘层。带状导体层被密封地封闭在顶部和底部绝缘层之间，并且扁平细长体的至少大部分被扭转成具有沿螺旋部分纵向延伸的中心空腔的细长螺旋部分。

12. 发明申请

US20100280563A1 DEVICE AND METHOD FOR DETECTING AND TREATING A MYOCARDIAL INFARCTION USING PHOTOBIOMODULATION 审中-公开
标题翻译：检测和治疗使用光合作用的心肌梗塞的装置和方法
公开(公告)号：US20100280563A1
公开(公告)日：2010-11-04
申请号：US12528363
申请日：2007-02-28
申请人： Anne Norlin-Weissenrieder , Leda Henriquez , Hans Strandberg , Eva Hartström , Mikael Sjögren , Annika Naeslund , Johan Eckerdal
发明人： Anne Norlin-Weissenrieder , Leda Henriquez , Hans Strandberg , Eva Hartström , Mikael Sjögren , Annika Naeslund , Johan Eckerdal
IPC分类号： A61N1/362
CPC分类号： A61N1/36521 , A61B5/0422 , A61B5/0452 , A61B5/053 , A61B5/6846 , A61B5/7239 , A61N1/36557 , A61N1/3702 , A61N5/0601 , A61N2005/063 , A61N2005/0652 , A61N2005/0659 , A61N2005/067
摘要： In an implantable medical device and a method for treating cardiac tissue of a heart of a patient with therapeutic light, a myocardial infarction is detected and a location the myocardial infarction is identified. A therapy session is initiated by selectively activating one or more of a number of light emitting units arranged in at least one medical lead connectable to the implantable medical device, to emit therapeutic light toward the detected location of the myocardial infarction upon detection of an occurrence of the myocardial infarction.
摘要翻译：在可植入医疗装置和用治疗光治疗患者心脏的心脏组织的方法中，检测到心肌梗塞并确定心肌梗塞的位置。通过选择性地激活布置在可连接到可植入医疗装置的至少一个医疗引线中的多个发光单元中的一个或多个来发起治疗会话，以便在检测到发生心肌梗死的发生时向被检测的心肌梗死位置发射治疗光心肌梗塞。

13. 发明授权

US5814086A Perex respiratory system stimulation upon tachycardia detection 失效
标题翻译：佩雷克斯呼吸系统刺激对心动过速检测
公开(公告)号：US5814086A
公开(公告)日：1998-09-29
申请号：US950138
申请日：1997-10-14
申请人： Jakub Hirschberg , Hans Strandberg
发明人： Jakub Hirschberg , Hans Strandberg
IPC分类号： A61N1/365 , A61N1/36 , A61N1/372 , A61N1/38
CPC分类号： A61N1/3601
摘要： A tachycardia eliminating apparatus includes a heartbeat detector which detects heartbeats in an input heart activity signal which delivers an output heartbeat signal indicating each detected heartbeat, a tachycardia detector coupled to the output of the heartbeat detector which generates a tachycardia indication signal in response to a detected tachycardia status of a heart as reflected in the heartbeat signal, and a respiratory system stimulator coupled to the output of the tachycardia detector and generating an output respiratory system stimulation signal for stimulating a respiratory system to achieve a stimulated breathing rate, with the ratio of the detected heartbeat rate to the stimulated breathing rate corresponding to a predetermined value.
摘要翻译：心动过速消除装置包括心跳检测器，该心跳检测器检测输入心跳活动信号中的心跳，该信号传送指示每个检测到的心跳的输出心跳信号，耦合到心跳检测器的输出的心动过速检测器，其响应于检测到的心跳过程指示信号而产生心动过速指示信号在心跳信号中反映的心脏的心动过速状态，以及耦合到心动过速检测器的输出的呼吸系统刺激器，并且产生用于刺激呼吸系统以产生刺激呼吸频率的输出呼吸系统刺激信号，检测到对应于预定值的刺激呼吸频率的心跳速率。

14. 发明授权

US5697957A Adaptive method and apparatus for extracting an evoked response component from a sensed cardiac signal by suppressing electrode polarization components 失效
标题翻译：用于通过抑制电极偏振分量从感测的心脏信号中提取诱发反应分量的自适应方法和装置
公开(公告)号：US5697957A
公开(公告)日：1997-12-16
申请号：US705272
申请日：1996-08-29
申请人： Kjell Noren , Hans Strandberg
发明人： Kjell Noren , Hans Strandberg
IPC分类号： A61B5/0452 , A61N1/365 , A61N1/37
CPC分类号： A61N1/3704 , A61N1/3712 , A61N1/3716 , Y10S128/901
摘要： In a method and apparatus for suppressing electrode polarization components in a sensed cardiac signal, the sensed cardiac signal is added to either a differentiated or autocorrelated sensed cardiac signal and a difference is formed between the original sensed cardiac signal and the autocorrelated or differentiated signal, thereby extracting an evoked response component from the sensed cardiac signal, the evoked response component otherwise being overshadowed by the much higher-amplitude polarization component.
摘要翻译：在用于抑制检测到的心脏信号中的电极极化分量的方法和装置中，感测到的心脏信号被加到差分或自相关感测的心脏信号中，并且在原始感测心脏信号与自相关或微分信号之间形成差异，由此从所感测到的心脏信号中提取诱发反应分量，否则被高得多的振幅偏振分量遮蔽的诱发响应分量。

15. 发明授权

US5683428A Atrial tachycardia-detecting heart stimulator comparing a plurality of P-P intervals with a threshold 失效
标题翻译：房性心动过速检测心脏刺激器将多个P-P间隔与阈值进行比较
公开(公告)号：US5683428A
公开(公告)日：1997-11-04
申请号：US571190
申请日：1995-12-12
申请人： Per Franberg , Anders Lindgren , Hans Strandberg
发明人： Per Franberg , Anders Lindgren , Hans Strandberg
IPC分类号： A61B5/0402 , A61B5/0452 , A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/3682
摘要： A heart stimulator for detecting atrial tachycardia, contains a control device to which are connected an atrial detector, having a blanking period, for detecting atrial events, a ventricular stimulation unit for delivering stimulation pulses in the ventricle, a counter for generating a variable PV interval between a detected atrial event and a stimulation pulse delivered in the ventricle, a time measurement unit for measuring time between two consecutive, detected atrial events and a calculation unit which, in a test mode for determining of whether atrial tachycardia is present, is arranged to cause the counter to generate a PV interval so the PV interval plus the atrial detector's blanking period is equal to half or less than half of an adjustable threshold level PP tachycardia. The time measurement unit sends a detection signal to the control device when a defined number of measured, consecutive PP intervals is less than a defined threshold value PP for the PP interval (threshold value PP tachycardia).
摘要翻译：用于检测房性心动过速的心脏刺激器包含控制装置，其连接有心房检测器，具有用于检测心房事件的消隐期，用于在心室中传送刺激脉冲的心室刺激单元，用于产生可变PV间隔的计数器在检测到的心房事件和在心室中传送的刺激脉冲之间的时间测量单元，用于测量两个连续的检测到的心房事件之间的时间的时间测量单元和在用于确定是否存在心房性心动过速的测试模式中的计算单元被布置为导致计数器产生PV间隔，因此PV间隔加上心房检测器的消隐周期等于可调节阈值水平PP心动过速的一半或者更少的一半。当定义数量的测量的连续PP间隔小于PP间隔（阈值PP心动过速）的定义阈值PP时，时间测量单元向控制装置发送检测信号。

16. 发明授权

US5602342A Method and device for measuring the flow of an electrolytic fluid 失效
标题翻译：用于测量电解液流动的方法和装置
公开(公告)号：US5602342A
公开(公告)日：1997-02-11
申请号：US677910
申请日：1996-07-10
申请人： Hans Strandberg
发明人： Hans Strandberg
IPC分类号： A61N1/365 , G01F1/64 , G01P5/00 , G01P5/08 , A61B5/00
CPC分类号： A61N1/36514 , G01F1/64 , G01P5/008 , G01P5/083
摘要： In a method for measuring the flow of an electrolytic fluid, the voltage or current is measured between two stationary electrodes immersed in the electrolytic fluid. A device for measuring the flow has at least two electrodes intended for immersion in the electrolyte. The electrodes are stationary, and a measurement unit is arranged to measure the voltage or current between the electrodes.
摘要翻译：在测量电解液流量的方法中，在浸入电解液中的两个固定电极之间测量电压或电流。用于测量流动的装置具有至少两个用于浸入电解质中的电极。电极是静止的，并且布置测量单元以测量电极之间的电压或电流。

17. 发明授权

US5476496A Implantable medical electrode system having an indifferent electrode formed as a part of the electrode insulator sleeve 失效
标题翻译：具有形成为电极绝缘体套筒的一部分的无差异电极的植入式医用电极系统
公开(公告)号：US5476496A
公开(公告)日：1995-12-19
申请号：US241397
申请日：1994-05-11
申请人： Hans Strandberg , Jakub Hirschberg
发明人： Hans Strandberg , Jakub Hirschberg
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： An implantable electrode system includes a connector for connecting a proximal end of the electrode to an implantable medical apparatus, such as for stimulating living tissue, and a distal end at which a tip electrode is located. The proximal end and the distal end are connected by a conductor which electrically connects the medical apparatus to the electrode tip, and which is surrounded by a flexible insulating sleeve. In order to provide an indifferent electrode having a large surface area relative to the size of the tip electrode, the insulating sleeve is provided with a section formed by an electrically conductive, flexible material, which serves as the indifferent electrode. The flexibility of the electrode system is retained, while providing an indifferent electrode of optional size.
摘要翻译：可植入电极系统包括用于将电极的近端连接到可植入医疗装置的连接器，例如用于刺激生物体组织和尖端电极所在的远端。近端和远端通过将医疗设备电连接到电极尖端并由柔性绝缘套管包围的导体连接。为了提供相对于尖端电极的尺寸具有大的表面积的无关电极，绝缘套管设置有由用作无差异电极的导电柔性材料形成的部分。保持电极系统的灵活性，同时提供任选尺寸的无关电极。

18. 发明授权

US5314452A Protective arrangement for an implantable defibrillator 失效
标题翻译：可植入除颤器的保护装置
公开(公告)号：US5314452A
公开(公告)日：1994-05-24
申请号：US946599
申请日：1992-09-18
申请人： Jakub Hirschberg , Hans Strandberg
发明人： Jakub Hirschberg , Hans Strandberg
IPC分类号： A61N1/37 , A61N1/39 , A61N1/08
CPC分类号： A61N1/3931 , A61N1/37 , A61N1/3718 , Y10S128/908
摘要： In order to prevent a person handling a defibrillator during manufacture and in conjunction with implantation of the defibrillator from receiving an electrical shock due to a fault, a protective arrangement is provided for the defibrillator. This protective arrangement is in the form of a plug part detachably connectable to the defibrillator housing and having terminal pins engaging into the connecting sockets of the defibrillator which is present for receiving the electrode leads. The terminal pins produce an electrically conductive connection in the sockets and are directly connected to one another inside the plug part via an electrical resistor. In case of a fault, the high-voltage energy generated between the connecting sockets is harmlessly absorbed in the resistor.
摘要翻译：为了防止在制造过程中处理除颤器的人员以及除颤器的植入不会因故障而引起的电击，为除颤器提供保护装置。该保护装置是可拆卸地连接到去纤颤器壳体并且具有接合到用于接收电极引线的除颤器的连接插座中的端子销的插头部件的形式。端子引脚在插座中产生导电连接，并通过电阻器直接连接在插头部分内部。在发生故障的情况下，连接插座之间产生的高电压能量在电阻器中无害化吸收。

19. 发明授权

US07228172B2 Bi-ventricular pacer, system and method 有权
标题翻译：双心室起搏器，系统及方法
公开(公告)号：US07228172B2
公开(公告)日：2007-06-05
申请号：US10734767
申请日：2003-12-13
申请人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
发明人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3684 , A61N1/3712
摘要： An implantable bi-ventricular heart stimulating device and system, suitable for treating congestive heart failure, have a control circuit with first and second pacing circuits and first and second sensing circuits. The device operates with time cycles corresponding to normal heart cycles. The control circuit determines: (a) whether a signal typical of an evoked response to a pacing pulse delivered by the first pacing circuit is sensed within a first time interval and (b) whether a signal typical for an R-wave transferred from the second ventricle, or from some other part of the heart, to the first ventricle is detected within a first time window. The operation of the device depends on whether the conditions (a) and (b) are fulfilled.
摘要翻译：适用于治疗充血性心力衰竭的可植入式双心室心脏刺激装置和系统具有具有第一和第二起搏电路和第一和第二感测电路的控制电路。该装置以对应于正常心脏周期的时间周期运行。控制电路确定：（a）在第一时间间隔内是否感测到由第一起搏电路传送的起搏脉冲的典型诱发响应的信号，以及（b）是否从第二时间间隔传送的R波的典型信号在第一时间窗口内检测到心室或心脏的其他部分到第一脑室。设备的操作取决于条件（a）和（b）是否得到满足。

20. 发明授权

US6134472A Heart stimulation device 有权
标题翻译：心脏刺激装置
公开(公告)号：US6134472A
公开(公告)日：2000-10-17
申请号：US269347
申请日：1999-11-26
申请人： Hans Strandberg , Johan Lidman , Kjell Noren
发明人： Hans Strandberg , Johan Lidman , Kjell Noren
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/36521 , A61N1/3627
摘要： In the determination of an optimal rate for the delivery of stimulation pulses to a heart, the stroke volume (SV) of a heart ventricle is measured as a function of heart rate (HR), e.g. by determination of impedance in individual heart cycles whose duration is varied from the duration corresponding to the prevailing rate or the basic rate regarded as optimal for stimulation. The optimal rate should lie at the knee of this function. A corresponding knee is also found in the curve for cardiac output (CO). This rate is determined by calculation of an auxiliary function, e.g. HF=HR.times.CO, which displays a peak at the heart rate at which the knee is located, and the heart rate is determined which yields this maximum. The heart rate determined in this manner is subsequently employed as a basic rate.
摘要翻译： PCT No.PCT / SE97 / 01590 Sec。 371日期1999年11月26日 102（e）1999年11月26日PCT PCT 1997年9月22日PCT公布。公开号WO98 / 14240 日期1998年4月9日在确定将心脏刺激脉冲递送到最佳速率时，测量心室的搏动体积（SV）作为心率（HR）的函数，例如心率。通过确定其持续时间从对应于当前速率或被认为是刺激最佳的基本速率的持续时间变化的各个心脏周期中的阻抗的确定。最佳速率应该在这个功能的膝盖上。在心输出量（CO）曲线中也发现了相应的膝盖。该速率通过辅助功能的计算来确定，例如， HF = HRxCO，其以膝盖所处的心率显示峰值，并且确定产生该最大值的心率。以这种方式确定的心率随后用作基本速率。

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