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    • 11. 发明授权
    • Signal processing for media type identification
    • 媒体类型识别的信号处理
    • US08291001B2
    • 2012-10-16
    • US12037970
    • 2008-02-27
    • Greg M. BurkeYang Shi
    • Greg M. BurkeYang Shi
    • G06F7/00G06F15/00B41J2/01B41J29/393
    • B41J2/1753B41J11/009B41J29/393
    • A method for identifying a type of recording medium using a time-varying output signal from a photosensor includes amplifying the time-varying output signal of the photosensor; converting the amplified time-varying output signal of the photosensor to digitized data points using an analog to digital converter thereby creating a first set of digitized data; filtering the first set of digitized data to provide a low pass data set; filtering the first set of digitized data to provide a high pass data set; computing the standard deviation of the low pass data set; computing the standard deviation of the high pass data set; and identifying the recording medium type using values from both the standard deviation of the low pass data set and the standard deviation of the high pass data set.
    • 使用来自光传感器的时变输出信号来识别记录介质的类型的方法包括放大光传感器的时变输出信号; 使用模数转换器将放大的光电传感器的时变输出信号转换为数字化数据点,从而产生第一组数字化数据; 过滤第一组数字化数据以提供低通数据集; 过滤第一组数字化数据以提供高通数据集; 计算低通数据集的标准偏差; 计算高通数据集的标准偏差; 以及使用来自低通数据集的标准偏差和高通数据集的标准偏差的值来识别记录介质类型。
    • 15. 发明申请
    • SIGNAL PROCESSING OF RECORDING MEDIUM INDICIA
    • 记录媒体信号处理
    • US20090213158A1
    • 2009-08-27
    • US12037963
    • 2008-02-27
    • Yang ShiGreg M. Burke
    • Yang ShiGreg M. Burke
    • B41J29/38
    • B41J29/393B41J2/1753
    • A method of processing a time-varying output signal from a photosensor is provided. The time-varying output signal corresponds to a plurality of marks or indicia on a recording medium moving into and out of a field of view of the photosensor with the marks having been printed on the recording medium by a printing system. The method includes amplifying the time-varying output signal from the photosensor; converting the amplified time-varying output signal from the photosensor to digitized data points using an analog to digital converter; and averaging a plurality of the digitized data points.
    • 提供了一种处理来自光电传感器的时变输出信号的方法。 时变输出信号对应于记录介质上移动和移出光传感器的视场中的多个标记或标记,其中标记已由打印系统打印在记录介质上。 该方法包括放大来自光电传感器的时变输出信号; 使用模数转换器将来自光电传感器的放大的时变输出信号转换成数字化数据点; 以及对多个数字化数据点进行平均。
    • 16. 发明申请
    • PRINTER CONTROL SYSTEM AND METHOD FOR ARTIFACT FREE AND BORDERLESS PRINTING
    • 打印机控制系统和无法打印无边打印的方法
    • US20090033694A1
    • 2009-02-05
    • US11831081
    • 2007-07-31
    • Yang ShiRichard A. DibiaseChristopher RuebyYu Chen
    • Yang ShiRichard A. DibiaseChristopher RuebyYu Chen
    • B41J29/38
    • B41J2/2139B41J11/0065
    • A system and a method for improving the quality of prints using a print mask for a printer having at least one printhead with a plurality of dot forming elements arranged in complementary dot forming element groups by section to prevent artifacts by compensating for bad dot forming elements on a print head. The method including the steps of identifying each bad dot forming element, identifying and setting up a threshold for each complementary dot forming element group corresponding to one or more bad dot forming elements, and creating a compensation print mask having one or more intermediate print sections by reassigning printing duty cycle from the bad dot forming elements to their respective complementary dot forming elements before printing using the compensation print mask.
    • 一种用于使用具有至少一个打印头的打印头的打印掩模来提高打印质量的系统和方法,所述打印头具有多个点形成元件,所述多个点形成元件被逐个地排列成互补的点形成元件,以通过补偿不良点形成元件来防止伪影 打印头。 该方法包括以下步骤:识别每个坏点形成元件,识别并设置与一个或多个坏点形成元件相对应的每个互补点形成元素组的阈值,以及通过以下步骤创建具有一个或多个中间印刷部分的补偿打印掩模: 在使用补偿打印掩模进行打印之前,从坏点形成元件重新分配打印占空比到其各自的互补点形成元件。
    • 17. 发明授权
    • Peptide-based peroxidase inhibitors and methods of using same
    • 基于肽的过氧化物酶抑制剂及其使用方法
    • US08937039B2
    • 2015-01-20
    • US14081695
    • 2013-11-15
    • Hao ZhangYang ShiHao XuKirkwood A. Pritchard, Jr.
    • Hao ZhangYang ShiHao XuKirkwood A. Pritchard, Jr.
    • A61K38/06A61P9/12A61P19/02C07K5/09
    • C07K5/0815A61K38/00C07K5/0821
    • The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
    • 本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂,其中AA1为带正电荷的带负电荷或中性氨基酸,AA2为氧化还原活性氨基酸,AA3为具有还原电位的氨基酸 使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。 这种组合的结果是高度有效的过氧化物酶活性抑制剂,其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。 示例性三肽有效抑制过氧化物酶介导的LDL氧化,增加SCD小鼠的血管舒张,抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积,抑制急性肺损伤,减少心脏缺血性损伤。
    • 18. 发明申请
    • Peptide-Based Peroxidase Inhibitors and Methods of Using Same
    • 基于肽的过氧化物酶抑制剂及其使用方法
    • US20140194342A1
    • 2014-07-10
    • US14081695
    • 2013-11-15
    • Hao ZhangYang ShiHao XuKirkwood A. Pritchard, JR.
    • Hao ZhangYang ShiHao XuKirkwood A. Pritchard, JR.
    • C07K5/09
    • C07K5/0815A61K38/00C07K5/0821
    • The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
    • 本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂,其中AA1为带正电荷的带负电荷或中性氨基酸,AA2为氧化还原活性氨基酸,AA3为具有还原电位的氨基酸 使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。 这种组合的结果是高度有效的过氧化物酶活性抑制剂,其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。 示例性三肽有效抑制过氧化物酶介导的LDL氧化,增加SCD小鼠的血管舒张,抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积,抑制急性肺损伤,减少心脏缺血性损伤。
    • 20. 发明授权
    • Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    • 组胺脱甲基化由核胺氧化酶同源物LSD1介导
    • US08323941B2
    • 2012-12-04
    • US12754087
    • 2010-04-05
    • Yang ShiYujiang Shi
    • Yang ShiYujiang Shi
    • C12N9/00C12N15/09
    • C12Q1/26A61K31/713A61K45/06G01N2333/906G01N2500/02
    • LSD1, a homolog of nuclear amine oxidases, functions as a histone demethylase and transcriptional co-repressor. LSD1 specifically demethylates histone H3 lysine 4, which is linked to active transcription. Lysine demethylation occurs via an oxidation reaction that generates formaldehyde. Importantly, RNAi inhibition of LSD1 causes an increase in H3 lysine 4 methylation and concomitant de-repression of target genes, suggesting that LSD1 represses transcription via histone demethylation. The results thus identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histone methylases and demethylases.
    • LSD1是核胺氧化酶的同源物,用作组蛋白脱甲基酶和转录共抑制子。 LSD1特异性去甲基化组蛋白H3赖氨酸4,其与活性转录相关。 通过产生甲醛的氧化反应发生赖氨酸去甲基化。 重要的是,RNAi抑制LSD1导致H3赖氨酸4甲基化和伴随的靶基因去抑制的增加,这表明LSD1通过组蛋白去甲基化抑制转录。 因此,结果鉴定了从耻垢分枝杆菌保守的人组蛋白去甲基化酶,并揭示组蛋白甲基化和脱甲基酶的组蛋白甲基化的动态调节。