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1. 发明申请

US20120196789A1 PEPTIDE BASED PEROXIDASE INHIBITORS AND METHODS OF USING SAME 有权
标题翻译：基于肽的过氧化物酶抑制剂及其使用方法
公开(公告)号：US20120196789A1
公开(公告)日：2012-08-02
申请号：US13500040
申请日：2010-10-05
申请人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, JR.
发明人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, JR.
IPC分类号： A61K38/06 , A61P9/12 , A61P25/28 , A61P35/00 , A61P9/10 , A61P11/06 , A61P9/04 , A61P17/06 , A61P11/00 , A61P29/00 , A61P19/02 , A61P1/00 , A61P43/00 , A61P9/00 , A61P37/06 , A61P31/00 , A61P37/08 , A61P21/00 , A61P7/00 , A61P25/16 , C07K4/00 , C07K5/09 , A61P25/00
CPC分类号： A61K38/06 , A61K38/02
摘要： The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
摘要翻译：本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂，其中AA1为带正电荷的带负电荷或中性氨基酸，AA2为氧化还原活性氨基酸，AA3为具有还原电位的氨基酸使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。这种组合的结果是高度有效的过氧化物酶活性抑制剂，其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。示例性三肽有效抑制过氧化物酶介导的LDL氧化，增加SCD小鼠的血管舒张，抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积，抑制急性肺损伤，减少心脏缺血性损伤。

2. 发明授权

US08937039B2 Peptide-based peroxidase inhibitors and methods of using same 有权
标题翻译：基于肽的过氧化物酶抑制剂及其使用方法
公开(公告)号：US08937039B2
公开(公告)日：2015-01-20
申请号：US14081695
申请日：2013-11-15
申请人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, Jr.
发明人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, Jr.
IPC分类号： A61K38/06 , A61P9/12 , A61P19/02 , C07K5/09
CPC分类号： C07K5/0815 , A61K38/00 , C07K5/0821
摘要： The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
摘要翻译：本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂，其中AA1为带正电荷的带负电荷或中性氨基酸，AA2为氧化还原活性氨基酸，AA3为具有还原电位的氨基酸使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。这种组合的结果是高度有效的过氧化物酶活性抑制剂，其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。示例性三肽有效抑制过氧化物酶介导的LDL氧化，增加SCD小鼠的血管舒张，抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积，抑制急性肺损伤，减少心脏缺血性损伤。

3. 发明申请

US20140194342A1 Peptide-Based Peroxidase Inhibitors and Methods of Using Same 有权
标题翻译：基于肽的过氧化物酶抑制剂及其使用方法
公开(公告)号：US20140194342A1
公开(公告)日：2014-07-10
申请号：US14081695
申请日：2013-11-15
申请人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, JR.
发明人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, JR.
IPC分类号： C07K5/09
CPC分类号： C07K5/0815 , A61K38/00 , C07K5/0821
摘要： The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
摘要翻译：本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂，其中AA1为带正电荷的带负电荷或中性氨基酸，AA2为氧化还原活性氨基酸，AA3为具有还原电位的氨基酸使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。这种组合的结果是高度有效的过氧化物酶活性抑制剂，其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。示例性三肽有效抑制过氧化物酶介导的LDL氧化，增加SCD小鼠的血管舒张，抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积，抑制急性肺损伤，减少心脏缺血性损伤。

4. 发明授权

US08673847B2 Peptide based peroxidase inhibitors and methods of using same 有权
标题翻译：基于肽的过氧化物酶抑制剂及其使用方法
公开(公告)号：US08673847B2
公开(公告)日：2014-03-18
申请号：US13500040
申请日：2010-10-05
申请人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, Jr.
发明人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, Jr.
IPC分类号： A61P9/12 , A61P19/02 , A61K38/06
CPC分类号： A61K38/06 , A61K38/02
摘要： The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
摘要翻译：本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂，其中AA1为带正电荷的带负电荷或中性氨基酸，AA2为氧化还原活性氨基酸，AA3为具有还原电位的氨基酸使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。这种组合的结果是高度有效的过氧化物酶活性抑制剂，其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。示例性三肽有效抑制过氧化物酶介导的LDL氧化，增加SCD小鼠的血管舒张，抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积，抑制急性肺损伤，减少心脏缺血性损伤。

5. 发明授权

US12077787B2 Diacylglycerol acyltransferase 1 and application thereof in production of triacylglycerol 有权
公开(公告)号：US12077787B2
公开(公告)日：2024-09-03
申请号：US17469899
申请日：2021-09-09
申请人： Haiqin Chen , Wei Chen , Xin Tang , Jun Cao , Jianxin Zhao , Yongquan Chen , Hao Zhang
发明人： Haiqin Chen , Wei Chen , Xin Tang , Jun Cao , Jianxin Zhao , Yongquan Chen , Hao Zhang
IPC分类号： C12N9/10 , C12P7/6445
CPC分类号： C12N9/1029 , C12P7/6445 , C12Y203/0102
摘要： Disclosed is a diacylglycerol acyltransferase 1, a recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1, and application thereof in production of triacylglycerol. The diacylglycerol acyltransferase 1 of the invention has a function of catalyzing synthesis of triacylglycerol. After the recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1 of the invention is subjected to induction culture for 48 h, the content of total fatty acid and triacylglycerol in the recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1 can be respectively increased by 1.94 folds and 12.09 folds as compared with those of Saccharomyces cerevisiae without the recombinant diacylglycerol acyltransferase 1. The instant invention provides a method for improving the ability of microorganisms to produce polyunsaturated fatty acids (PUFAs) by means of genetic engineering.

6. 发明授权

US11756160B2 ML-based methods for pseudo-CT and HR MR image estimation 有权
公开(公告)号：US11756160B2
公开(公告)日：2023-09-12
申请号：US16525562
申请日：2019-07-29
申请人： Chunjoo (Justin) Park , Sasa Mutic , Hao Zhang , Olga Green
发明人： Chunjoo (Justin) Park , Sasa Mutic , Hao Zhang , Olga Green
IPC分类号： G06T3/40 , G06T5/00 , G06N3/08 , G06N3/04 , G06F17/18 , A61B6/00 , A61N5/10 , G06N20/20 , G06N3/045
CPC分类号： G06T3/4053 , A61B6/5258 , A61N5/1039 , G06F17/18 , G06N3/045 , G06N3/08 , G06N20/20 , G06T5/002 , G06T2207/10088
摘要： The present disclosure describes a computer-implemented method of transforming a low-resolution MR image to a high-resolution MR image using a deep CNN-based MRI SR network and a computer-implemented method of transforming an MR image to a pseudo-CT (sCT) image using a deep CNN-based sCT network. The present disclosure further describes a MR image-guided radiation treatment system that includes a computing device to implement the MRI SR and CT networks and to produce a radiation plan based in the resulting high resolution MR images and sCT images.

7. 发明授权

US10761231B2 Generating a high-resolution lithology model for subsurface formation evaluation 有权
公开(公告)号：US10761231B2
公开(公告)日：2020-09-01
申请号：US15883817
申请日：2018-01-30
申请人： Hao Zhang , Alberto Mezzatesta
发明人： Hao Zhang , Alberto Mezzatesta
IPC分类号： G06F11/30 , G01V1/30 , E21B7/06 , G01V1/50 , C09K8/62 , E21B49/00 , G01V99/00 , G01V1/28 , G01V5/10 , G01V3/08 , E21B43/00 , E21B44/00
摘要： Examples of techniques for generating a high-resolution lithology model for subsurface formation evaluation are disclosed. In one example implementation according to aspects of the present disclosure, a computer-implemented method includes determining, by a processing device, a low-resolution lithology volumetric model. The method further includes comparing, by the processing device, the low-resolution lithology volumetric model to a high-resolution imaging log. The method further includes calculating, by the processing device, a dynamic boundary curve for each of a plurality of moving windows. The method further includes generating, by the processing device, the high-resolution lithology model based at least in part on the calculated dynamic boundary curve for each of the plurality of moving windows. The method further includes controlling a drilling operation based at least in part on the high-resolution lithology model.

8. 发明申请

US20180318603A1 RADIATION MODULATOR AND METHODS OF USE AND PRODUCTION THEREOF 审中-公开
公开(公告)号：US20180318603A1
公开(公告)日：2018-11-08
申请号：US15972907
申请日：2018-05-07
申请人： Chunjoo Park , Sasa Mutic , Hao Zhang
发明人： Chunjoo Park , Sasa Mutic , Hao Zhang
IPC分类号： A61N5/10
CPC分类号： A61N5/1016 , A61N5/1007 , A61N5/1027 , A61N5/1039 , A61N2005/1003
摘要： The present disclosure is directed to a computer-implemented method for designing a patient-specific brachytherapy (BT) tandem applicator. The method is implemented using at least one processor in communication with at least one memory. The method includes receiving a radiation treatment plan for treating a region of interest. The radiation treatment plan includes a prescribed radiation dosage and patient anatomical data of the region of interested to be treated. The method also includes applying an inverse planning optimization model to determine an optimal thickness of an interior surface of the tandem applicator at a plurality of dwell positions within the region of interest. The method also includes generating a schedule of dwell times for the tandem applicator based on the generated position-dependent thickness profile. The method also includes transmitting design instructions to a 3D printer for fabrication of the tandem applicator.

9. 发明授权

US09888030B2 Detection of stealthy malware activities with traffic causality and scalable triggering relation discovery 有权
公开(公告)号：US09888030B2
公开(公告)日：2018-02-06
申请号：US14267422
申请日：2014-05-01
申请人： Danfeng Yao , Hao Zhang
发明人： Danfeng Yao , Hao Zhang
IPC分类号： H04L29/06 , G06F21/31 , G06F21/32 , G06F21/56
CPC分类号： H04L63/145 , G06F21/316 , G06F21/32 , G06F21/566 , G06F2221/2133
摘要： A computer system for distinguishing user-initiated network traffic from malware-initiated network traffic comprising at least one central processing unit (CPU) and a memory communicatively coupled to the CPU. The memory includes a program code executable by the CPU to monitor individual network events to determine for an individual network event whether the event has a legitimate root-trigger. Malware-initiated traffic is identified as an individual network event that does not have a legitimate root-trigger.

10. 发明授权

US09643124B2 Gas separation membranes based on fluorinated and perfluorinated polymers 有权
公开(公告)号：US09643124B2
公开(公告)日：2017-05-09
申请号：US14921382
申请日：2015-10-23
申请人： Hao Zhang , Zhenjie He , Timothy C Merkel , Yoshiyuki Okamoto , Yasuhiro Koike
发明人： Hao Zhang , Zhenjie He , Timothy C Merkel , Yoshiyuki Okamoto , Yasuhiro Koike
IPC分类号： B01D53/22 , B01D71/32
CPC分类号： B01D53/228 , B01D71/32 , B01D2256/245 , B01D2257/102 , B01D2257/108 , B01D2257/11 , B01D2257/504 , Y02C10/10
摘要： A process for separating components of a gas mixture using gas-separation copolymer membranes. These membranes use a selective layer made from copolymers of partially fluorinated or perfluorinated dioxolane monomers and a second monomer, such as dioxane or a partially fluorinated dioxolane. The resulting membranes have superior selectivity performance for gas pairs of interest while maintaining fast gas permeance compared to membranes prepared using conventional perfluoropolymers, such as Teflon® AF, Hyflon® AD, and Cytop®.

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