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11. 发明授权

US07643155B2 Partially coherent illumination for inverse scattering full-field interferometric synthetic aperture microscopy 有权
标题翻译：反向散射全场干涉合成孔径显微镜的部分相干照明
公开(公告)号：US07643155B2
公开(公告)日：2010-01-05
申请号：US12131390
申请日：2008-06-02
申请人： Daniel L. Marks , Brynmor J. Davis , Stephen A. Boppart , Paul Scott Carney
发明人： Daniel L. Marks , Brynmor J. Davis , Stephen A. Boppart , Paul Scott Carney
IPC分类号： G01B11/02
CPC分类号： G02B21/0056 , G01N21/4795 , G02B21/0064 , G02B27/58
摘要： Methods and apparatus for three-dimensional imaging of a sample. A source is provided of a beam of light characterized by partial spatial coherence. The beam is focused onto a sample and scattered light from the sample is superposed with a reference beam derived from the source onto a focal plane detector array to provide an interference signal. A forward scattering model is derived relating measurement data to structure of an object to allow solutions of an inverse scattering problem, based upon the interference signal so that a three-dimensional structure of the same may be inferred. The partial spatial coherence of the source, which may be fixed or variable, may advantageously provide for rejection of multiple scattering artifacts and thus improve image quality.
摘要翻译：样品三维成像的方法和装置。提供了源于以部分空间相干为特征的光束的源。光束被聚焦到样本上，并且来自样本的散射光与从光源导出的参考光束叠加到焦平面检测器阵列上以提供干涉信号。导出将测量数据与对象的结构相关联的前向散射模型，以便基于干扰信号来反演散射问题的解，从而可以推断出该三维结构。可以是固定的或可变的源的部分空间相干性可以有利地提供多个散射假象的抑制，从而提高图像质量。

12. 发明授权

US07602501B2 Interferometric synthetic aperture microscopy 有权
标题翻译：干涉合成孔径显微镜
公开(公告)号：US07602501B2
公开(公告)日：2009-10-13
申请号：US11775572
申请日：2007-07-10
申请人： Tyler S. Ralston , Daniel L. Marks , Paul Scott Carney , Stephen A. Boppart
发明人： Tyler S. Ralston , Daniel L. Marks , Paul Scott Carney , Stephen A. Boppart
IPC分类号： G01B11/02
CPC分类号： G02B21/0056 , G01N21/4795 , G02B21/0064 , G02B27/58
摘要： Methods and apparatus for three-dimensional imaging of a sample. A source is provided of a beam of substantially collimated light characterized by a temporally dependent spectrum. The beam is focused in a plane characterized by a fixed displacement along the propagation axis of the beam, and scattered light from the sample is superposed with a reference beam derived from the substantially collimated source onto a focal plane detector array to provide an interference signal. A forward scattering model is derived relating measured data to structure of an object to allow solution of an inverse scattering problem based upon the interference signal so that a three-dimensional structure of the sample may be inferred in near real time.
摘要翻译：样品三维成像的方法和装置。提供源于由时间依赖光谱表征的基本上准直的光束的光束。光束聚焦在特征为沿着光束的传播轴的固定位移的平面中，并且来自样本的散射光与从基本上准直的光源导出的参考光束叠加到焦平面检测器阵列上以提供干涉信号。派生前向散射模型将测量数据与对象的结构相关联，以允许基于干扰信号解决反散射问题，从而可以近似实时推断样本的三维结构。

13. 发明授权

US07586618B2 Distinguishing non-resonant four-wave-mixing noise in coherent stokes and anti-stokes Raman scattering 有权
标题翻译：在相干斯托克斯和反斯托克斯拉曼散射中区分非谐振四波混频噪声
公开(公告)号：US07586618B2
公开(公告)日：2009-09-08
申请号：US11068739
申请日：2005-02-28
申请人： Daniel L. Marks , Stephen A. Boppart
发明人： Daniel L. Marks , Stephen A. Boppart
IPC分类号： G01J3/45
CPC分类号： G01N21/65 , B33Y80/00 , G01J3/4412 , G01N2021/653 , G01N2021/656
摘要： A method of examining a sample comprises exposing the sample to a pump pulse of electromagnetic radiation for a first period of time, exposing the sample to a stimulant pulse of electromagnetic radiation for a second period of time which overlaps in time with at least a portion of the first exposing, to produce a signal pulse of electromagnetic radiation for a third period of time, and interfering the signal pulse with a reference pulse of electromagnetic radiation, to determine which portions of the signal pulse were produced during the exposing of the sample to the stimulant pulse. The first and third periods of time are each greater than the second period of time.
摘要翻译：检查样品的方法包括将样品暴露于第一时间段的电磁辐射的泵脉冲，将样品暴露于电磁辐射的刺激脉冲持续第二时间段，时间上与至少一部分时间重叠第一次曝光，以产生第三时间段的电磁辐射的信号脉冲，并用电磁辐射的参考脉冲干扰信号脉冲，以确定信号脉冲的哪些部分在样品暴露于兴奋脉冲。第一和第三个时间段都大于第二个时间段。

14. 发明申请

US20090185191A1 DEVICE AND METHOD FOR IMAGING THE EAR USING OPTICAL COHERENCE TOMOGRAPHY 有权
标题翻译：用于使用光学相干图像成像的装置和方法
公开(公告)号：US20090185191A1
公开(公告)日：2009-07-23
申请号：US12040539
申请日：2008-02-29
申请人： Stephen A. Boppart , Chuanwu Xi
发明人： Stephen A. Boppart , Chuanwu Xi
IPC分类号： G01B9/02
CPC分类号： G01B9/02014 , A61B1/227 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/6852 , A61B5/7257 , G01B9/02004 , G01B9/02044 , G01B9/0205 , G01B9/02083 , G01B9/02091 , G01B2290/65
摘要： A method of forming an image of tissue. The method includes non-invasively inserting a fiber-based device into a patient's ear canal and acquiring OCT data from ear tissue while the fiber-based device is in the ear canal. The method also includes converting the OCT data into at least one image.
摘要翻译：一种形成组织图像的方法。该方法包括将基于纤维的装置非侵入性地插入到患者的耳道中，并且当基于纤维的装置在耳道中时从耳朵组织获取OCT数据。该方法还包括将OCT数据转换成至少一个图像。

15. 发明申请

US20090185166A1 MAGNETOMOTIVE OPTICAL COHERENCE TOMOGRAPHY 有权
标题翻译：磁共振光学相干图
公开(公告)号：US20090185166A1
公开(公告)日：2009-07-23
申请号：US12041366
申请日：2008-03-03
申请人： Amy L. Oldenburg , Stephen A. Boppart , Vasilica Crecea , Xing Liang
发明人： Amy L. Oldenburg , Stephen A. Boppart , Vasilica Crecea , Xing Liang
IPC分类号： G01N21/00
CPC分类号： G01N21/4795 , A61B5/0051 , A61B5/0066 , A61B5/0073 , A61B5/415 , A61B5/416 , A61B5/418
摘要： A spectral-domain magnetomotive optical coherence tomography apparatus, includes (a) a spectral-domain optical coherence tomography device, and (b) a magnet. The magnet is coupled with the optical coherence tomography device so that changes in the magnetic field are coordinated with collection of data by the optical coherence tomography device. This device may be used to examine a sample by spectral-domain magnetomotive optical coherence tomography, which includes examining the sample with a spectral-domain optical coherence tomography device, to collect optical coherence tomography data. The sample contains magnetic particles, and the magnetic particles are subjected to a changing magnetic field during the examining.
摘要翻译：一种光谱域磁动势光学相干断层摄影装置，包括（a）光谱域光学相干断层摄影装置，（b）磁体。磁体与光学相干断层摄影装置耦合，使得磁场的变化与光学相干断层摄影装置的数据采集协调。该装置可以用于通过光谱域动力学光学相干断层扫描来检查样本，其包括用光谱域光学相干断层摄影装置检查样本，以收集光学相干断层扫描数据。样品含有磁性颗粒，磁性颗粒在检查过程中经历变化的磁场。

16. 发明授权

US08731272B2 Computational adaptive optics for interferometric synthetic aperture microscopy and other interferometric imaging 有权
标题翻译：用于干涉合成孔径显微镜和其他干涉成像的计算自适应光学器件
公开(公告)号：US08731272B2
公开(公告)日：2014-05-20
申请号：US13996838
申请日：2012-01-16
申请人： Steven G. Adie , Paul Scott Carney , Stephen A. Boppart
发明人： Steven G. Adie , Paul Scott Carney , Stephen A. Boppart
IPC分类号： G06K9/00
CPC分类号： G06T11/008 , G02B21/0056
摘要： Methods for correcting for aberrations in the image or three-dimensional reconstruction of a sampled region obtained by broadband interferometry. The sampled region is illuminated with a broadband beam of light, and light returned from the sample is detected, along with a reference beam, in order to derive an interference signal for pixels of a volume spanned by wavenumber and axes transverse to the beam propagation direction. An optimization procedure is performed with respect to a specified criterion so as to obtain an aberration-corrected image of at least one plane of the sampled region, either in a plane-specific manner or in a space-invariant manner throughout the sampled region. A filter function, which may be derived from the interference signal attendant to irradiating a sparsely distributed plurality of point scatterers, or otherwise, corrects for a detected aberrated point spread function. Methods of the present invention may be used for aberration correction in reading information from an optical data storage medium.
摘要翻译：用于校正通过宽带干涉测量获得的采样区域的图像中的像差或三维重建的方法。用宽带光束照射采样区域，并且与参考光束一起检测从样本返回的光，以便导出由波数和横向于光束传播方向的轴的像素的干涉信号。针对特定标准执行优化过程，以便在整个采样区域以平面特定的方式或以空间不变的方式获得采样区域的至少一个平面的像差校正图像。可以从伴随照射稀疏分布的多个点散射体的干扰信号导出的滤波器功能，或以其他方式校正检测到的像差点扩展函数。本发明的方法可以用于从光学数据存储介质读取信息中的像差校正。

17. 发明授权

US08447373B2 Apparatus and method for measuring a characteristic of a composition reactive to a magnetic field 有权
标题翻译：用于测量与磁场无关的组合物的特性的装置和方法
公开(公告)号：US08447373B2
公开(公告)日：2013-05-21
申请号：US12464020
申请日：2009-05-11
申请人： Stephen A. Boppart
发明人： Stephen A. Boppart
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/05
摘要： A system that incorporates teachings of the present disclosure may include, for example, a sensor having a pulse oximeter sensor to measure an oxygen saturation level in a liquid, a magnetic source coupled to the pulse oximeter sensor, and a controller to control the pulse oximeter sensor and the magnetic source, and to measure a mechanical effect on the liquid responsive to the magnetic source applying a magnetic field to the liquid. Additional embodiments are disclosed.
摘要翻译：结合本公开的教导的系统可以包括例如具有用于测量液体中的氧饱和度水平的脉搏血氧计传感器的传感器，耦合到脉搏血氧计传感器的磁源，以及控制脉冲血氧计传感器和磁源，并且响应于向液体施加磁场的磁源来测量对液体的机械效应。公开了另外的实施例。

18. 发明申请

US20110063718A1 Optical frequency up-conversion of femtosecond pulses into targeted single bands in the visible and ultraviolet 有权
标题翻译：飞秒脉冲的光学频率上变换成可见光和紫外线的目标单波段
公开(公告)号：US20110063718A1
公开(公告)日：2011-03-17
申请号：US12807772
申请日：2010-09-14
申请人： Haohua Tu , Stephen A. Boppart
发明人： Haohua Tu , Stephen A. Boppart
IPC分类号： G02F1/365 , G02B6/10
CPC分类号： G02F1/353 , G02F1/3544 , G02F2202/32 , H01S3/1625 , H01S3/1636 , H01S3/235
摘要： An apparatus and methods for generating a substantially supercontinuum-free widely-tunable multimilliwatt source of radiation characterized by a narrowband line profile. The apparatus and methods employ nonlinear optical mechanisms in a nonlinear photonic crystal fiber (PCF) by detuning the wavelength of a pump laser to a significant extent relative to the zero-dispersion wavelength (ZDW) of the PCF. Optical phenomena employed for the selective up-conversion in the PCF include, but are not limited to, four-wave mixing and Cherenkov radiation. Tunability is achieved by varying pump wavelength and power and by substituting different types of PCFs characterized by specified dispersion properties.
摘要翻译：一种用于产生基本上不连续无菌的广泛可调谐的多元辐射辐射源的装置和方法，其特征在于窄带线轮廓。该装置和方法通过使泵浦激光器的波长相对于PCF的零色散波长（ZDW）有明显的失调，在非线性光子晶体光纤（PCF）中采用非线性光学机制。用于PCF选择性上转换的光学现象包括但不限于四波混合和切伦科夫辐射。通过改变泵浦波长和功率并通过用不同类型的以特定分散特性为特征的PCF来代替可调谐性。

19. 发明授权

US07787129B2 Method and apparatus for measurement of optical properties in tissue 有权
标题翻译：用于测量组织中光学性质的方法和装置
公开(公告)号：US07787129B2
公开(公告)日：2010-08-31
申请号：US11669561
申请日：2007-01-31
申请人： Adam M. Zysk , Steven G. Adie , Matthew S. Leigh , Julian J. Armstrong , David D. Sampson , Stephen A. Boppart
发明人： Adam M. Zysk , Steven G. Adie , Matthew S. Leigh , Julian J. Armstrong , David D. Sampson , Stephen A. Boppart
IPC分类号： G01B9/02
CPC分类号： A61B5/0084 , A61B5/0066 , A61B5/0091 , A61B5/6848 , A61B10/0233
摘要： A method of analyzing tissue includes inserting a radiation source into tissue, impinging radiation upon the tissue, obtaining a sample signal of the radiation that impinges upon the tissue, and determining a refractive index of the tissue from the sample signal. The method may also include determining at least one other optical property of the tissue. The method may provide for identifying tissue as part of a biopsy method. A device for analyzing tissue may include a low-coherence interferometer and a probe optically coupled to the interferometer, where the probe includes a radiation source.
摘要翻译：分析组织的方法包括将辐射源插入到组织中，将辐射照射到组织上，获得撞击在组织上的辐射的样本信号，以及从样本信号确定组织的折射率。该方法还可以包括确定组织的至少一个其它光学性质。该方法可以提供识别组织作为活检方法的一部分。用于分析组织的装置可以包括低相干干涉仪和光学耦合到干涉仪的探针，其中探针包括辐射源。

20. 发明授权

US07751057B2 Magnetomotive optical coherence tomography 有权
标题翻译：磁光学相干断层扫描
公开(公告)号：US07751057B2
公开(公告)日：2010-07-06
申请号：US12041366
申请日：2008-03-03
申请人： Amy L. Oldenburg , Stephen A. Boppart , Vasilica Crecea , Xing Liang
发明人： Amy L. Oldenburg , Stephen A. Boppart , Vasilica Crecea , Xing Liang
IPC分类号： G01B11/02
CPC分类号： G01N21/4795 , A61B5/0051 , A61B5/0066 , A61B5/0073 , A61B5/415 , A61B5/416 , A61B5/418
摘要： A spectral-domain magnetomotive optical coherence tomography apparatus, includes (a) a spectral-domain optical coherence tomography device, and (b) a magnet. The magnet is coupled with the optical coherence tomography device so that changes in the magnetic field are coordinated with collection of data by the optical coherence tomography device. This device may be used to examine a sample by spectral-domain magnetomotive optical coherence tomography, which includes examining the sample with a spectral-domain optical coherence tomography device, to collect optical coherence tomography data. The sample contains magnetic particles, and the magnetic particles are subjected to a changing magnetic field during the examining.
摘要翻译：一种光谱域磁动势光学相干断层摄影装置，包括（a）光谱域光学相干断层摄影装置，（b）磁体。磁体与光学相干断层摄影装置耦合，使得磁场的变化与光学相干断层摄影装置的数据采集协调。该装置可以用于通过光谱域动力学光学相干断层扫描来检查样本，其包括用光谱域光学相干断层摄影装置检查样本，以收集光学相干断层扫描数据。样品含有磁性颗粒，磁性颗粒在检查过程中经历变化的磁场。

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