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11. 发明授权

US4774350A Phosphoric ester 失效
标题翻译：磷酸酯
公开(公告)号：US4774350A
公开(公告)日：1988-09-27
申请号：US896100
申请日：1986-08-13
申请人： Junya Wakatsuki , Tohru Katoh , Tomihiro Kurosaki
发明人： Junya Wakatsuki , Tohru Katoh , Tomihiro Kurosaki
IPC分类号： A61K8/00 , A61K8/06 , A61K8/55 , A61Q19/00 , A61Q19/10 , B01F17/18 , B01F17/38 , B01F17/42 , C07F9/09 , C09K3/16 , C11D1/34 , C11D1/88
CPC分类号： A61Q19/10 , A61K8/06 , A61K8/55 , A61Q19/00 , C07F9/091 , C11D1/886
摘要： Novel phosphoric esters represented by the following general formula (I) ##STR1## wherein R.sub.1 represents a linear or branched alkyl or alkenyl group having 1 to 36 carbon atoms, or a phenyl group substituted with a linear or branched alkyl group having 1 to 15 carbon atoms, R.sub.2 represents an alkylene group having 2 to 3 carbon atoms, R.sub.3, R.sub.4 and R.sub.5 individually represent a hydrogen atom or a linear or branched alkyl group having 1 to 36 carbon atoms providing that any one of R.sub.3, R.sub.4 and R.sub.5 has 5 or more carbon atoms, and n is a number from 0 to 30 are obtained by reacting phosphoric esters of the following formula ##STR2## with amines at a high purity and in a high yield. The phosphoric esters (I) are excellent in the surface tension and foaming property, and give extremely low stimulus to the skin, so that they can be utilized in detergent compositions, cosmetic compositions, emulsifiers, dispersants, anti-static agents and the like.
摘要翻译：由下列通式（I）表示的新型磷酸酯其中R 1表示具有1至36个碳原子的直链或支链烷基或烯基，或被具有1个直链或支链烷基取代的苯基至15个碳原子，R 2表示具有2至3个碳原子的亚烷基，R 3，R 4和R 5各自表示氢原子或具有1至36个碳原子的直链或支链烷基，条件是R3，R4和R5中的任一个具有5个或更多个碳原子，并且n为0至30的数是通过以下方式使磷酸酯与胺以高纯度和高收率反应得到的。磷酸酯（I）的表面张力和起泡性优异，对皮肤的刺激性极低，可以用于洗涤剂组合物，化妆品组合物，乳化剂，分散剂，防静电剂等。

12. 发明授权

US5543310A Immobilized phosphorylase 失效
标题翻译：固定磷酸化酶
公开(公告)号：US5543310A
公开(公告)日：1996-08-06
申请号：US113743
申请日：1993-08-31
申请人： Shigeto Kayane , Takashi Kawai , Masaru Sakata , Takashi Imamura , Masanobu Tanigaki , Tomihiro Kurosaki
发明人： Shigeto Kayane , Takashi Kawai , Masaru Sakata , Takashi Imamura , Masanobu Tanigaki , Tomihiro Kurosaki
IPC分类号： C07H11/04 , C07H1/02 , C12N11/08 , C12P19/02 , C12N9/10
CPC分类号： C12N11/08 , C12P19/02
摘要： A process for preparing glucose-1-phosphate from an .alpha.-glucan and orthophosphate using a phosphorylase immobilized onto an anion-exchange resin is disclosed. The anion-exchange resin used is a synthetic polymer resin into which an anion exchange group; a primary to quarternary ammonium group, a phosphonium group, or a sulfonium group, is introduced. This type of immobilized phosphorylase ensures (i) an effective utilization of phosphorylase, (ii) a higher reactivity of a higher absorbance of the phosphorylase to the resin, (iii) an excellent phosphorylase activity retention performance, and (iv) a higher physical strength of the resin.
摘要翻译：公开了使用固定在阴离子交换树脂上的磷酸化酶从α-葡聚糖和正磷酸盐制备葡萄糖-1-磷酸的方法。使用的阴离子交换树脂是合成聚合物树脂，其中阴离子交换基团; 引入了主要到季铵基，鏻基或锍基。这种固定的磷酸化酶可确保（i）磷酸化酶的有效利用，（ii）磷酸化酶对树脂的较高吸光度的较高反应性，（iii）优异的磷酸化酶活性保持性能，和（iv）较高的物理强度的树脂。

13. 发明授权

US4845239A Phosphoric esters and process for preparing the same 失效
标题翻译：磷酸酯及其制备方法
公开(公告)号：US4845239A
公开(公告)日：1989-07-04
申请号：US32627
申请日：1987-04-01
申请人： Junya Wakatsuki , Tohru Katoh , Akira Matsunaga , Tomihiro Kurosaki
发明人： Junya Wakatsuki , Tohru Katoh , Akira Matsunaga , Tomihiro Kurosaki
IPC分类号： C07F9/09 , C07F9/655
CPC分类号： C07F9/65502
摘要： A novel phosphoric ester of the following formula (I) ##STR1## is prepared by reacting a phosphoric ester of the following formula (II) ##STR2## with a basic compound. By reacting the phosphoric ester (I) with various types of amine compounds or other acidic hydrogen-bearing compounds, various phospholipid analogue compounds or phosphoric esters can be derived.
摘要翻译：下式（I）的新型磷酸酯通过将下式（Ⅱ）的磷酸酯与碱性化合物反应来制备。通过使磷酸酯（I）与各种胺化合物或其它酸性含氢化合物反应，可以得到各种磷脂类似物或磷酸酯。

14. 发明授权

US4650862A Sugar phosphates 失效
标题翻译：糖磷酸盐
公开(公告)号：US4650862A
公开(公告)日：1987-03-17
申请号：US753058
申请日：1985-07-09
申请人： Takashi Imamura , Shigeto Kayane , Tomihiro Kurosaki
发明人： Takashi Imamura , Shigeto Kayane , Tomihiro Kurosaki
IPC分类号： A61K8/00 , A61K8/60 , A61Q5/00 , A61Q5/02 , C07H11/04
CPC分类号： A61Q5/02 , A61K8/60 , C07H11/04
摘要： Sugar phosphate of the following general formula (I): ##STR1## is prepared by reaction between a phosphoric monoester and a glycidyltriammonium salt.The sugar phosphate according to the invention has good moisture retention and good adsorptivity on hair, and can be used in shampoos, rinses and cosmetics.
摘要翻译：以下通式（I）的磷酸盐：通过磷酸单酯和缩水甘油基三铵盐之间的反应制备。根据本发明的糖磷酸盐具有良好的保湿性和对头发的良好的吸附性，并且可用于洗发剂，漂洗剂和化妆品中。

15. 发明授权

US4350645A Method for producing a phosphoric monoester 失效
标题翻译：磷酸单酯的制备方法
公开(公告)号：US4350645A
公开(公告)日：1982-09-21
申请号：US210352
申请日：1980-11-25
申请人： Tomihiro Kurosaki , Akio Manba
发明人： Tomihiro Kurosaki , Akio Manba
IPC分类号： C07F9/11 , C07F9/09 , C07F9/141
CPC分类号： C07F9/09
摘要： A phosphoric monoester of an organic hydroxy compound can be produced in a high concentration in accordance with a two-step reaction. In a first step, the organic hydroxy compound is esterified in the presence of an excess amount of one or more phosphorylating agents selected from the group consisting of phosphorus pentoxide, phosphoric acid and polyphosphoric acids. A further portion of the same organic hydroxy compound is added, in a second step, to the reaction mixture of the first step to make the overall quantity of the organic hydroxy compound equivalent to its stoichiometric quantity.
摘要翻译：根据两步反应，可以以高浓度制备有机羟基化合物的磷酸单酯。在第一步中，有机羟基化合物在过量的一种或多种选自五氧化二磷，磷酸和多磷酸的磷酸化剂存在下酯化。在第二步骤中，将另一部分相同的有机羟基化合物加入到第一步的反应混合物中，使有机羟基化合物的总量等于其化学计量量。

16. 发明授权

US5153000A Phosphate, liposome comprising the phosphate as membrane constituent, and cosmetic and liposome preparation comprising the liposome 失效
标题翻译：磷酸盐，包含磷酸盐作为膜组织的脂质体，以及包含脂质体的化妆和脂质体制备
公开(公告)号：US5153000A
公开(公告)日：1992-10-06
申请号：US437099
申请日：1989-11-16
申请人： Yoshiko Chikawa , Katsumi Kita , Mitsuharu Masuda , Tomihiro Kurosaki , Takashi Itoh , Noriko Inoue , Haruya Kato , Takashi Imamura , Yasuo Ishii , Yoshitaka Kokusho , Akira Tsunoda , Shigeaki Kato
发明人： Yoshiko Chikawa , Katsumi Kita , Mitsuharu Masuda , Tomihiro Kurosaki , Takashi Itoh , Noriko Inoue , Haruya Kato , Takashi Imamura , Yasuo Ishii , Yoshitaka Kokusho , Akira Tsunoda , Shigeaki Kato
IPC分类号： A61K8/14 , A61K8/55 , A61K9/127 , A61Q19/00 , C07F9/10 , C07H11/04
CPC分类号： C07H11/04 , A61K8/14 , A61K8/556 , A61K9/1271 , A61K9/1272 , A61Q19/00 , C07F9/10 , Y10S977/797 , Y10S977/904 , Y10S977/915 , Y10S977/926
摘要： A novel monophosphate and a novel diphosphate prepared by a phosphatidyl transfer reaction of a phospholipid and an alcohol in the presence of phospholipase D are disclosed. The phosphates can independently or together form small and stable liposomes which can include active components therein. Cosmetic compositions comprising these phosphates or liposomes penetrate well into the hair and the skin, and exhibit long-lasting excellent moisture-retaining, beauty, skin-activation effects.

17. 发明授权

US5071585A Phosphoric acid ester, process for preparing the same, and detergent composition containing the same 失效
标题翻译：磷酸酯，其制备方法和含有它的洗涤剂组合物
公开(公告)号：US5071585A
公开(公告)日：1991-12-10
申请号：US604172
申请日：1990-10-29
申请人： Akira Matsunaga , Junya Wakatsuki , Nobutaka Horinishi , Takashi Imamura , Tomihiro Kurosaki
发明人： Akira Matsunaga , Junya Wakatsuki , Nobutaka Horinishi , Takashi Imamura , Tomihiro Kurosaki
IPC分类号： A61K8/06 , A61K8/00 , A61K8/55 , A61K8/58 , A61Q5/02 , A61Q19/10 , C07F9/09 , C08G65/32 , C11D1/78 , C11D1/88 , C11D3/36
CPC分类号： A61Q19/10 , A61K8/55 , A61K8/553 , A61Q5/02 , C07F9/091 , C11D1/886
摘要： Phosphoric acid esters represented by the following formulae (I) and (IX) as well as processes for preparing them are disclosed. ##STR1## wherein R.sub.1 represents a linear or branched, alkyl or alkenyl group having a C.sub.1-36 carbon atom content, with or without the hydrogen atom(s) being substituted with fluorine atom(s), or a phenyl group with substituted linear or branched alkyl group(s) having a C.sub.1-15 carbon atom content, R.sub.2 represents an alkylene group having a C.sub.2-3 carbon atom content, R.sub.3 and R.sub.4 independently denote a hydrogen atom or an alkyl group having a C.sub.1-3 carbon atom content, R.sub.5 and R.sub.6 independently denote a hydrogen atom, or an alkyl, alkenyl, or phenyl group with or without the hydrogen atom(s) being substituted with group(s) containing hetero atom(s), excepting for a mercapto group, R.sub.7 and R.sub.8 independently denote a hydrogen atom, or an alkyl, or alkenyl group, m is an integer of 0-30, n is an integer of 0-5, l is an integer of 0-3, M is a hydrogen atom, an alkali metal, an alkali earth metal, an ammonium group, an alkyl amine group, or an alkanol amine group. The phosphoric acid esters have outstanding surface activity and good foaming capability, and imparts only extremely low irritation to the skin. The detergent composition into which they are formulated is particularly useful as, shampoo, baby shampoo, body shampoo.

18. 发明授权

US5043424A Modification method for peptides and proteins by reacting with a phosphoric acid ester 失效
标题翻译：通过与磷酸酯反应来改变肽和蛋白质的方法
公开(公告)号：US5043424A
公开(公告)日：1991-08-27
申请号：US260709
申请日：1988-10-21
申请人： Akira Matsunaga , Nobutaka Horinishi , Junya Wakatsuki , Takashi Imamura , Tomihiro Kurosaki
发明人： Akira Matsunaga , Nobutaka Horinishi , Junya Wakatsuki , Takashi Imamura , Tomihiro Kurosaki
IPC分类号： C07K14/655 , C07K1/00 , C07K1/02 , C07K1/107 , C07K1/113 , C07K1/14 , C07K4/00 , C07K5/06 , C07K14/00 , C07K14/575 , C07K14/76 , C07K16/00 , C12N9/16 , C12N9/96
CPC分类号： C07K5/06191 , C07K1/1077
摘要： A peptide or protein is modified by reacting a phosphoric acid ester represented by the following general formula (I) with a peptide or protein: ##STR1## wherein R.sub.1 means a linear or branched, C.sub.1-36 alkyl or C.sub.2-36 alkenyl group whose hydrogen atom or atoms may be substituted by the corresponding number of fluorine atom(s) or a phenyl group substituted by at least one linear or branched C.sub.1-15 alkyl group, R.sub.2 denotes a C.sub.2-3 alkylene group, m stands for a number of 0-30, and M is a hydrogen atom, an alkali metal ion, an alkaline earth metal ion, an ammonium ion, an alkylamine residue or an alkanolamine residue.

19. 发明授权

US4787940A Method for purifying sugar phosphates or their salts 失效
标题翻译：糖精磷酸盐或其盐的净化方法
公开(公告)号：US4787940A
公开(公告)日：1988-11-29
申请号：US12496
申请日：1987-02-09
申请人： Shigeto Kayane , Mitsugu Morishita , Takashi Imamura , Masanobu Tanigaki , Tomihiro Kurosaki
发明人： Shigeto Kayane , Mitsugu Morishita , Takashi Imamura , Masanobu Tanigaki , Tomihiro Kurosaki
IPC分类号： C07H1/06 , C07H11/04 , C13D3/18 , B01D17/06
CPC分类号： C07H1/06 , C07H11/04
摘要： A novel method for purifying a sugar phosphate or its salt, in which a sugar-containing mixture of a sugar phosphate or its salt and phosphoric acid or its salt is subjected to electrodialysis to remove the phosphoric acid or its salt from the mixture.According to this method, the phosphoric acid or its salt can be readily obtained in a reusable form. The method is thus quite advantageous in view of the economy.
摘要翻译：一种纯化糖磷酸盐或其盐的新方法，其中糖磷酸盐或其盐的含糖混合物和磷酸或其盐进行电渗析以从混合物中除去磷酸或其盐。根据该方法，可以容易地以可重复使用的形式获得磷酸或其盐。鉴于经济，该方法是非常有利的。

20. 发明授权

US4751320A Phosphoric ester and process for producing same 失效
标题翻译：磷酸酯及其制备方法
公开(公告)号：US4751320A
公开(公告)日：1988-06-14
申请号：US925384
申请日：1986-10-31
申请人： Mitsuharu Masuda , Tomihiro Kurosaki
发明人： Mitsuharu Masuda , Tomihiro Kurosaki
IPC分类号： A61K8/55 , A61Q19/00 , B01F17/14 , C07F9/09
CPC分类号： A61Q19/00 , A61K8/55 , C07F9/091 , Y02P20/55
摘要： A novel phosphoric ester represented by the following formula (I): ##STR1## is produced by halogenating the hydroxyl group of a monoalkyl phosphoric acid, reacting the halogenated product with N-benzoyloxycarbonyl serine ester and then removing protecting groups for the carboxyl group and amino group.According to the present production process, the phosphoric ester can be obtained inexpensively at a high yield and high purity. Further, the phosphoric ester has a structure similar to that of the phospholipid and has nitrogen-containing polar groups such as amino group in one molecule, so that it has excellent emulsification ability and moisture keeping function. It is thus useful as emulsifiers, humectants and the like.
摘要翻译：由下式（I）表示的新型磷酸酯：通过卤化单烷基磷酸的羟基，使卤代物与N-苯甲酰氧基羰基丝氨酸酯反应，然后除去羧基的保护基来制备（I）组和氨基。根据本制造方法，可以高产率和高纯度廉价地获得磷酸酯。此外，磷酸酯具有与磷脂类似的结构，并且在一个分子中具有含氮极性基团如氨基，因此其具有优异的乳化能力和保湿功能。因此，作为乳化剂，保湿剂等是有用的。

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