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11. 发明授权

US08246569B1 Implantable intraocular pressure drain 有权
标题翻译：植入式眼内压排水
公开(公告)号：US08246569B1
公开(公告)日：2012-08-21
申请号：US11205757
申请日：2005-08-16
申请人： Ellis Fan-chuin Meng , Po-Jui Chen , Damien Rodger , Yu-Chong Tai , Mark Humayun
发明人： Ellis Fan-chuin Meng , Po-Jui Chen , Damien Rodger , Yu-Chong Tai , Mark Humayun
IPC分类号： A61M5/00
CPC分类号： A61F9/00781 , A61B3/16 , A61B5/4836 , A61B5/6821 , A61B2562/0247 , A61B2562/028 , A61B2562/12 , F16K99/0009 , F16K99/0057 , F16K2099/0086
摘要： An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube out of the eye. In one embodiment, only a first end of the tube implanted into the anterior chamber of the eye is open. Intra-ocular pressure (IOP) is then monitored, for example utilizing an implanted sensor. When IOP exceeds a critical value, a practitioner intervenes, puncturing with a laser a thinned region of the tube lying outside the eye, thereby initiating drainage of fluid and relieving pressure. In accordance with alternative embodiments, the both ends of the tube are open, and the tube includes a one-way valve configured to permit drainage where IOP exceeds the critical value. The tube may include projecting barbs to anchor the tube in the eye without the need for sutures.
摘要翻译：植入的聚对二甲苯管分流器可减轻眼内压力。该装置在眼睛的前房中植入开放端，允许多余的液体通过管排出眼睛。在一个实施例中，仅植入眼睛前房的管的第一端是开放的。然后监测眼内压（IOP），例如利用植入的传感器。当眼压超过临界值时，从业人员介入，用激光穿刺位于眼睛外部的管的薄化区域，从而引起流体排出并释放压力。根据替代实施例，管的两端是开放的，并且管包括被配置为允许IOP超过临界值的排水的单向阀。管可以包括突出的倒钩以将管锚定在眼睛中而不需要缝线。

12. 发明申请

US20120289883A1 Implantable Intraocular Pressure Drain 失效
标题翻译：植入式眼内压排水
公开(公告)号：US20120289883A1
公开(公告)日：2012-11-15
申请号：US13555329
申请日：2012-07-23
申请人： Ellis Fan-chuin Meng , Po-Jui Chen , Damien Rodger , Yu-Chong Tai , Mark Humayun
发明人： Ellis Fan-chuin Meng , Po-Jui Chen , Damien Rodger , Yu-Chong Tai , Mark Humayun
IPC分类号： A61F9/00 , A61M1/00
CPC分类号： A61F9/00781 , A61B3/16 , A61B5/4836 , A61B5/6821 , A61B2562/0247 , A61B2562/028 , A61B2562/12 , F16K99/0009 , F16K99/0057 , F16K2099/0086
摘要： An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube out of the eye. In one embodiment, only a first end of the tube implanted into the anterior chamber of the eye is open. Intra-ocular pressure (IOP) is then monitored, for example utilizing an implanted sensor. When IOP exceeds a critical valve, a practitioner intervenes, puncturing with a laser a thinned region of the tube lying outside the eye, thereby initiating drainage of fluid and relieving pressure. In accordance with alternative embodiments, the both ends of the tube are open, and the tube includes a one-way valve configured to permit drainage where IOP exceeds the critical value. The tube may include projecting barbs to anchor the tube in the eye without the need for sutures.
摘要翻译：植入的聚对二甲苯管分流器可减轻眼内压力。该装置在眼睛的前房中植入开放端，允许多余的液体通过管排出眼睛。在一个实施例中，仅植入眼睛前房的管的第一端是开放的。然后监测眼内压（IOP），例如利用植入的传感器。当IOP超过临界阀时，从业者介入，用激光穿刺位于眼睛外部的管的薄的区域，从而引起流体排出并释放压力。根据替代实施例，管的两端是开放的，并且管包括被配置为允许IOP超过临界值的排水的单向阀。管可以包括突出的倒钩以将管锚定在眼睛中而不需要缝线。

13. 发明授权

US07252006B2 Implantable mechanical pressure sensor and method of manufacturing the same 有权
标题翻译：可植入式机械压力传感器及其制造方法
公开(公告)号：US07252006B2
公开(公告)日：2007-08-07
申请号：US11148124
申请日：2005-06-07
申请人： Yu-Chong Tai , Ellis Meng , Po-Jui Chen , Damien C. Rodger , Mark Humayun
发明人： Yu-Chong Tai , Ellis Meng , Po-Jui Chen , Damien C. Rodger , Mark Humayun
IPC分类号： G01L9/00
CPC分类号： A61B3/16 , A61B2562/02 , A61B2562/028 , G01L7/045
摘要： A biocompatible, mechanical, micromachined pressure sensor and methods of manufacturing such a pressure sensor are provided. The pressure sensor of the current invention includes a high-aspect-ratio curved-tube structure fabricated through a one-layer parylene process. The pressure sensor of the current invention requires zero power consumption and indicates the pressure variation by changes of the in situ in-plane motion of the sensor, which can be gauged externally by a direct and convenient optical observation. In one embodiment, the pressure sensor of the current invention has been shown to work as an IOP sensor for eye implantation where the intraocular in-plane motion of the sensor can be recorded from outside of the eye, such that the intraocular pressure in glaucoma patients can be constantly monitored.
摘要翻译：提供生物相容的，机械的，微加工的压力传感器以及制造这种压力传感器的方法。本发明的压力传感器包括通过一层聚对二甲苯工艺制造的高纵横比弯曲管结构。本发明的压力传感器需要零功率消耗，并且通过传感器的原位面内运动的变化来指示压力变化，其可以通过直接和方便的光学观察在外部测量。在一个实施例中，本发明的压力传感器已经被证明可用作眼睛植入的IOP传感器，其中可以从眼睛外部记录传感器的眼内平面内运动，使得青光眼患者的眼内压可以不断监控。

14. 发明申请

US20110144617A1 MEMS DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：用于输送治疗剂的MEMS装置和方法
公开(公告)号：US20110144617A1
公开(公告)日：2011-06-16
申请号：US13026136
申请日：2011-02-11
申请人： Ellis MENG , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo Monterey Park , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
发明人： Ellis MENG , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo Monterey Park , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
IPC分类号： A61M5/152 , A61M5/14
CPC分类号： A61F9/0017 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M5/16881 , A61M37/00 , A61M2005/14204 , A61M2205/0244 , A61M2205/3507 , A61M2207/00 , A61M2210/0612 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F04B43/043 , F16K99/0001 , F16K99/0005 , F16K99/0034 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , Y10T29/49236
摘要： Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, a cannula in fluid communication with the reservoir, and means for forcing fluid from the reservoir into the cannula. Circuitry for controlling the means for forcing fluid from the reservoir into the cannula may be included.
摘要翻译：用于将治疗剂递送到患者的可植入装置的实施例包括：储存器，其构造成容纳包含治疗剂的液体，与储存器流体连通的套管，以及用于迫使流体从储存器进入套管的装置。可以包括用于控制用于将流体从储存器迫使进入套管的装置的电路。

15. 发明申请

US20100305550A1 MEMS DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS 有权
标题翻译：用于输送治疗剂的MEMS装置和方法
公开(公告)号：US20100305550A1
公开(公告)日：2010-12-02
申请号：US12790240
申请日：2010-05-28
申请人： Ellis Meng , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
发明人： Ellis Meng , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
IPC分类号： A61M35/00
CPC分类号： A61F9/0017 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M5/16881 , A61M37/00 , A61M2005/14204 , A61M2205/0244 , A61M2205/3507 , A61M2207/00 , A61M2210/0612 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F04B43/043 , F16K99/0001 , F16K99/0005 , F16K99/0034 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , Y10T29/49236
摘要： Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient's eyeball.
摘要翻译：用于将治疗剂递送到患者的可植入装置的实施例包括构造成容纳包含治疗剂的液体的储存器和与储存器流体连通的套管。套管被成形为便于将其插入患者眼球。

16. 发明申请

US20110144619A1 MEMS DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：用于输送治疗剂的MEMS装置和方法
公开(公告)号：US20110144619A1
公开(公告)日：2011-06-16
申请号：US13026121
申请日：2011-02-11
申请人： Ellis MENG , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
发明人： Ellis MENG , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
IPC分类号： A61M5/152 , A61M5/14
CPC分类号： A61F9/0017 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M5/16881 , A61M37/00 , A61M2005/14204 , A61M2205/0244 , A61M2205/3507 , A61M2207/00 , A61M2210/0612 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F04B43/043 , F16K99/0001 , F16K99/0005 , F16K99/0034 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , Y10T29/49236
摘要： Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. A valve for maintaining a constant flow rate through the cannula independent of the pressure applied to the device may be included.
摘要翻译：用于将治疗剂递送到患者的可植入装置的实施例包括构造成容纳包含治疗剂的液体的储存器和与储存器流体连通的套管。可以包括不依赖于施加到装置的压力来保持通过套管的恒定流速的阀。

17. 发明授权

US07887508B2 MEMS device and method for delivery of therapeutic agents 有权
标题翻译：用于递送治疗剂的MEMS装置和方法
公开(公告)号：US07887508B2
公开(公告)日：2011-02-15
申请号：US11686310
申请日：2007-03-14
申请人： Ellis Meng , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
发明人： Ellis Meng , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
IPC分类号： A61F7/12
CPC分类号： A61F9/0017 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M5/16881 , A61M37/00 , A61M2005/14204 , A61M2205/0244 , A61M2205/3507 , A61M2207/00 , A61M2210/0612 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F04B43/043 , F16K99/0001 , F16K99/0005 , F16K99/0034 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , Y10T29/49236
摘要： Embodiments of an implantable device for delivering a therapeutic agent to a patient includes a reservoir configured to contain a liquid comprising the therapeutic agent and a cannula in fluid communication with the reservoir. The device and related methods may provide such features as constant-flow operation, an electrolytic mode of pumping, and/or wireless communication.
摘要翻译：用于将治疗剂递送到患者的可植入装置的实施例包括构造成容纳包含治疗剂的液体和与储存器流体连通的插管的储存器。该装置和相关方法可以提供诸如恒流操作，电解抽吸模式和/或无线通信之类的特征。

18. 发明授权

US06672629B2 Micromachined fluidic coupler and method of making the same 失效
标题翻译：微加工流体耦合器及其制造方法
公开(公告)号：US06672629B2
公开(公告)日：2004-01-06
申请号：US10198013
申请日：2002-07-18
申请人： Yu-Chong Tai , Shuyun Wu , Ellis Fan-chuin Meng
发明人： Yu-Chong Tai , Shuyun Wu , Ellis Fan-chuin Meng
IPC分类号： F16L1700
CPC分类号： B81B1/00 , B81B2201/13
摘要： A micromachined coupler for coupling a capillary having a first size to an orifice having a shape and a second size, has a body which has a shape conforming the shape of the cavity into which the body must fit. A through hole is defined through the body. The through hole has a size conforming to the first size of the capillary. The capillary is disposable into the through hole so that the capillary is communicated to the orifice without the first and second sizes necessarily being the same. The cavity and the body have conforming slanting surfaces, and in particular the cavity and the body define truncated pyramidal shapes. The cavity and the body each have a truncated pyramidal shape. The pyramidal shape may be square, triangular, or conical. A method of fabricating the micromachined coupler is achieved either by micromaching or micromolding.
摘要翻译：用于将具有第一尺寸的毛细管耦合到具有形状和第二尺寸的孔口的微机械加工器具有具有与主体必须配合的空腔形状一致的形状的主体。通孔穿过身体。通孔的尺寸符合毛细管的第一尺寸。毛细管一次性进入通孔，使得毛细管连通到孔口，而第一和第二尺寸必须相同。空腔和主体具有一致的倾斜表面，特别是空腔和主体限定截锥形的形状。空腔和身体各具有截头锥形。锥体形状可以是正方形，三角形或圆锥形。微加工耦合器的制造方法可以通过微机械加工或微型成型来实现。

19. 发明授权

US07706887B2 Method for integrating pre-fabricated chip structures into functional electronic systems 有权
标题翻译：将预制芯片结构集成到功能电子系统中的方法
公开(公告)号：US07706887B2
公开(公告)日：2010-04-27
申请号：US11933222
申请日：2007-10-31
申请人： Yu-Chong Tai , Damien C. Rodger
发明人： Yu-Chong Tai , Damien C. Rodger
IPC分类号： A61N1/18
CPC分类号： H01L24/19 , B81C1/0023 , B81C1/00333 , H01L21/561 , H01L21/568 , H01L21/6835 , H01L23/5387 , H01L23/5389 , H01L24/97 , H01L2221/68345 , H01L2224/04105 , H01L2224/20 , H01L2224/211 , H01L2224/24137 , H01L2224/96 , H01L2224/97 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01023 , H01L2924/01029 , H01L2924/01033 , H01L2924/01047 , H01L2924/01057 , H01L2924/01061 , H01L2924/01074 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/12041 , H01L2924/12042 , H01L2924/12044 , H01L2924/14 , H01L2924/1433 , H01L2924/1461 , H01L2924/1815 , H01L2924/19043 , H01L2224/82 , H01L2924/00
摘要： A method (and resulting structure) for fabricating a sensing device. The method includes providing a substrate comprising a surface region and forming an insulating material overlying the surface region. The method also includes forming a film of carbon based material overlying the insulating material and treating to the film of carbon based material to pyrolyzed the carbon based material to cause formation of a film of substantially carbon based material having a resistivity ranging within a predetermined range. The method also provides at least a portion of the pyrolyzed carbon based material in a sensor application and uses the portion of the pyrolyzed carbon based material in the sensing application. In a specific embodiment, the sensing application is selected from chemical, humidity, piezoelectric, radiation, mechanical strain or temperature.
摘要翻译：一种用于制造感测装置的方法（和结果）。该方法包括提供包括表面区域并形成覆盖表面区域的绝缘材料的基板。该方法还包括形成覆盖绝缘材料的碳基材料薄膜，并处理碳基材料薄膜以热解碳基材料，以形成电阻率范围在预定范围内的基本上碳基材料的薄膜。该方法还在传感器应用中提供热解碳基材料的至少一部分，并且在感测应用中使用部分热解碳基材料。在具体实施例中，感测应用选自化学，湿度，压电，辐射，机械应变或温度。

20. 发明授权

US07338836B2 Method for integrating pre-fabricated chip structures into functional electronic systems 有权
标题翻译：将预制芯片结构集成到功能电子系统中的方法
公开(公告)号：US07338836B2
公开(公告)日：2008-03-04
申请号：US10974006
申请日：2004-10-25
申请人： Yu-Chong Tai , Damien C. Rodger
发明人： Yu-Chong Tai , Damien C. Rodger
IPC分类号： H01L21/44
CPC分类号： H01L24/19 , B81C1/0023 , B81C1/00333 , H01L21/561 , H01L21/568 , H01L21/6835 , H01L23/5387 , H01L23/5389 , H01L24/97 , H01L2221/68345 , H01L2224/04105 , H01L2224/20 , H01L2224/211 , H01L2224/24137 , H01L2224/96 , H01L2224/97 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01023 , H01L2924/01029 , H01L2924/01033 , H01L2924/01047 , H01L2924/01057 , H01L2924/01061 , H01L2924/01074 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/12041 , H01L2924/12042 , H01L2924/12044 , H01L2924/14 , H01L2924/1433 , H01L2924/1461 , H01L2924/1815 , H01L2924/19043 , H01L2224/82 , H01L2924/00
摘要： A method for manufacturing integrated objects, e.g., electronic devices, biological devices. The method includes providing a holder substrate, which has at least one recessed region, the recessed region having a predetermined shape. The holder substrate has a selected thickness and is characterized as being substantially rigid in shape. The method includes aligning a chip comprising a face and a backside into the predetermined shape of the recessed region and disposing the chip into the recessed region. The chip is secured into the recessed region. The method includes providing a first film of insulating material having a first thickness overlying the face and portions of the holder substrate to attach the chip to a portion of the first film of insulating material and patterning the first film of insulating material to form at least one opening through a portion of the first thickness to a contact region on the face of the chip. The method includes forming a metallization layer overlying the first film of insulating material to couple to the contact region through the one opening and forming a protective layer overlying the metallization layer. The method includes releasing the chip from the holder substrate while maintaining attachment of the chip to the first film of insulating material.
摘要翻译：一种用于制造诸如电子装置的生物装置的集成物体的方法。该方法包括提供具有至少一个凹陷区域的保持器基底，该凹陷区域具有预定形状。保持器基板具有选定的厚度，并且其特征在于其形状基本上是刚性的。该方法包括将包括面和背面的芯片对准到凹陷区域的预定形状，并将芯片设置在凹陷区域中。芯片固定在凹陷区域内。该方法包括提供绝缘材料的第一膜，其具有覆盖在保持器基板的表面和部分上的第一厚度，以将芯片附接到第一绝缘材料膜的一部分，并且使第一绝缘材料膜形成图案以形成至少一个通过第一厚度的一部分打开到芯片的表面上的接触区域。该方法包括形成覆盖绝缘材料的第一膜的金属化层，以通过一个开口耦合到接触区域并形成覆盖金属化层的保护层。该方法包括从保持器基板释放芯片，同时保持芯片与第一绝缘材料膜的连接。

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