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11. 发明授权

US08670123B2 Optical biosensor with focusing optics 有权
标题翻译：带聚焦光学的光学生物传感器
公开(公告)号：US08670123B2
公开(公告)日：2014-03-11
申请号：US13379721
申请日：2010-06-21
申请人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls
发明人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls
IPC分类号： G01N21/55 , G02B3/00
CPC分类号： G02B3/0068 , G01N21/552 , G01N21/648 , G01N2201/0638 , G02B27/1066 , G02B27/126
摘要： The invention relates to focusing optics (100) for a biosensor (10) which allow with simple means to accurately image an extended investigation region (13) onto a detector plane (P). To this end, the focusing optics (100) comprises at least two focusing lenslets (LL) that are arranged adjacent to each other such that they image an incident parallel light beam (L2) that is directed along a main optical axis (MOA) onto a common plane (P). The output light beam (L2) that is received by the focusing optics (100) may preferably originate from total internal reflection of a parallel input light beam (L1) at the investigation region (13) of a transparent carrier.
摘要翻译：本发明涉及用于生物传感器（10）的聚焦光学器件（100），其允许以简单的方式将扩展的检测区域（13）精确地成像到检测器平面（P）上。为此，聚焦光学器件（100）包括彼此相邻布置的至少两个聚焦小透镜（LL），使得它们将沿着主光轴（MOA）定向的入射平行光束（L2）成像到一个共同的平面（P）。由聚焦光学器件（100）接收的输出光束（L2）可以优选地源于透明载体的调查区域（13）处的平行输入光束（L1）的全内反射。

12. 发明申请

US20120147377A1 OPTICAL BIOSENSOR WITH FOCUSING OPTICS 有权
标题翻译：光学生物传感器与聚焦光学
公开(公告)号：US20120147377A1
公开(公告)日：2012-06-14
申请号：US13379721
申请日：2010-06-21
申请人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls
发明人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls
IPC分类号： G01N21/55 , G02B3/00
CPC分类号： G02B3/0068 , G01N21/552 , G01N21/648 , G01N2201/0638 , G02B27/1066 , G02B27/126
摘要： The invention relates to focusing optics (100) for a biosensor (10) which allow with simple means to accurately image an extended investigation region (13) onto a detector plane (P). To this end, the focusing optics (100) comprises at least two focusing lenslets (LL) that are arranged adjacent to each other such that they image an incident parallel light beam (L2) that is directed along a main optical axis (MOA) onto a common plane (P). The output light beam (L2) that is received by the focusing optics (100) may preferably originate from total internal reflection of a parallel input light beam (L1) at the investigation region (13) of a transparent carrier.
摘要翻译：本发明涉及用于生物传感器（10）的聚焦光学器件（100），其允许以简单的方式将扩展的检测区域（13）精确地成像到检测器平面（P）上。为此，聚焦光学器件（100）包括彼此相邻布置的至少两个聚焦小透镜（LL），使得它们将沿着主光轴（MOA）定向的入射平行光束（L2）成像到一个共同的平面（P）。由聚焦光学器件（100）接收的输出光束（L2）可以优选地源于透明载体的调查区域（13）处的平行输入光束（L1）的全内反射。

13. 发明申请

US20100165345A1 MICROELECTRONIC SENSOR DEVICE WITH A MODULATED LIGHT SOURCE 有权
标题翻译：具有调制光源的微电子传感器装置
公开(公告)号：US20100165345A1
公开(公告)日：2010-07-01
申请号：US12670148
申请日：2008-07-17
申请人： Dominique Maria Bruls , Johannes Joseph Hubertina Barbara Schleipen
发明人： Dominique Maria Bruls , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N21/59
CPC分类号： G01N21/552 , G01N21/648 , G01N27/745 , G01N2201/064 , G01N2201/0691 , G01N2201/0696
摘要： The invention relates to a microelectronic sensor device and a method for making optical examinations at a carrier (11), e.g. for the detection of magnetic particles (1) at a contact surface (12) of the carrier (11) by frustrated total internal reflection (FTIR). A light source (21), particularly a laser light source, with a laser modulator (22) are used for emitting an input light beam (L1) into the carrier (11) which is modulated such that optical interferences with reflections (L1′) of the input light beam (L1) from the entrance window (14) or other components of the carrier (11) are reduced/minimized. This can for example be achieved by a pulsed on/off modulation in which the first relaxation minimum of a currently emitted pulse (PN) coincides in the light source (21) with the first relaxation maximum of a reflected pulse (PN-1′). By reducing the effect of interferences, the setup is less prone to disturbances from dimensional variations that are e.g. induced by thermal extension.
摘要翻译：本发明涉及一种微电子传感器装置和一种用于在载体（11）上进行光学检查的方法。用于通过沮丧的全内反射（FTIR）检测载体（11）的接触表面（12）处的磁性颗粒（1）。使用具有激光调制器（22）的光源（21），特别是具有激光光源的光源（21）将输入光束（L1）发射到被调制的载波（11）中，使得与反射（L1'）的光学干涉（14）的输入光束（L1）或载体（11）的其他部件的距离减小/最小化。这可以例如通过脉冲开/关调制实现，其中当前发射的脉冲（PN）的第一弛豫最小值与光源（21）中的第一弛豫最小值与反射脉冲（PN-1'）的第一弛豫最大值一致，。通过减少干扰的影响，该装置不容易受到尺寸变化的干扰。由热延伸引起。

14. 发明申请

US20100092996A1 MICROELECTRONIC SENSOR DEVICE FOR DETECTING LABEL PARTICLES 有权
标题翻译：用于检测标签颗粒的微电子传感器装置
公开(公告)号：US20100092996A1
公开(公告)日：2010-04-15
申请号：US12518164
申请日：2007-12-10
申请人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
发明人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/543 , G01N21/552 , G01N21/553 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N27/745 , G01N33/54306 , G01N33/54386 , Y10S436/00
摘要： The invention relates to a microelectronic sensor device for the detection of target components that comprise label particles, for example magnetic particles (1). The sensor device comprises a carrier (11) with a binding surface (12) at which target components can collect and optionally bind to specific capture elements. An input light beam (L1) is transmitted into the carrier and totally internally reflected at the binding surface (12). The amount of light in the output light beam (L2) and optionally also of fluorescence light emitted by target components at the binding surface is then detected by a light detector (31). Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles (1) at the binding surface (12) and will therefore be missing in the output light beam (L2). This can be used to determine the amount of target components at the binding surface (12) from the amount of light in the output light beam (L2, L2a, L2b). A magnetic field generator (41) is optionally used to generate a magnetic field (B) at the binding surface (12) by which magnetic label particles (1) can be manipulated, for example 15 attracted or repelled.
摘要翻译：本发明涉及用于检测包含标签颗粒（例如磁性颗粒（1））的目标组分的微电子传感器装置。传感器装置包括具有结合表面（12）的载体（11），靶组分可以收集并任选地结合到特定的捕获元件。输入光束（L1）被传输到载体中并在结合表面（12）处全反射。由光检测器（31）检测输出光束（L2）中的光量以及可选地由结合表面上的目标成分发出的荧光。在全内反射期间产生的渐消光在目标部件和/或粘合表面（12）处的标签颗粒（1）受到影响（吸收，散射），因此在输出光束（L2）中将被丢失。这可以用于根据输出光束（L2，L2a，L2b）中的光量来确定结合表面（12）处的目标成分的量。可选地使用磁场发生器（41）来在绑定表面（12）处产生磁场（B），通过该磁场可以操纵磁性标签颗粒（1），例如15被吸引或排斥。

15. 发明申请

US20080232208A1 High Frequency Central Aperture Tracking 审中-公开
标题翻译：高频中心光圈跟踪
公开(公告)号：US20080232208A1
公开(公告)日：2008-09-25
申请号：US12064085
申请日：2006-08-16
申请人： Alexander Marc Van Der Lee , Dominique Maria Bruls
发明人： Alexander Marc Van Der Lee , Dominique Maria Bruls
IPC分类号： G11B7/09
CPC分类号： G11B7/0903
摘要： The present invention relates to an optical system for performing radial tracking on an associated optical record carrier. The optical system contains at least one radiation-emitting device capable of emitting at least three beams: a first beam for reading and/or recording information, and at least a second beam and a third beam for tracking. The optical system is adapted for radial tracking of the first spot from a tracking error signal generated based on the high-frequency component of the central-aperture signal of the second and third beams. The tracking error signal may be generated based on a difference signal of a DC-level of the power of the high-frequency components of the central-aperture signal.
摘要翻译：本发明涉及一种用于在相关联的光学记录载体上进行径向跟踪的光学系统。该光学系统包含至少一个能够发射至少三个光束的辐射发射装置：用于读取和/或记录信息的第一光束，以及用于跟踪的至少第二光束和第三光束。光学系统适于从基于第二和第三光束的中心孔径信号的高频分量产生的跟踪误差信号中径向跟踪第一光点。可以基于中心孔径信号的高频分量的功率的直流电平的差信号来生成跟踪误差信号。

16. 发明申请

US20080314407A1 Method of Cleaning an Optical Face of a Refractive Element for a Near Field Optical Scanning Apparatus and a Cleaning Device for Cleaning an Optical Face of a Refractive Element for a Near Field Optical Scanning Apparatus 审中-公开
$Method of Cleaning an Optical Face of a Refractive Element for a Near Field Optical Scanning Apparatus and a Cleaning Device for Cleaning an Optical Face of a Refractive Element for a Near Field Optical Scanning Apparatus$
标题翻译：清洁近场光扫描装置的折射元件的光学面的方法和用于清洁近场光学扫描装置的折射元件的光学面的清洁装置
公开(公告)号：US20080314407A1
公开(公告)日：2008-12-25
申请号：US12097557
申请日：2006-12-06
申请人： Dominique Maria Bruls , Jacobus Maria Antonius Van Den Eerenbeemd , Franciscus Marinus Andrea Maria Van Gaal
发明人： Dominique Maria Bruls , Jacobus Maria Antonius Van Den Eerenbeemd , Franciscus Marinus Andrea Maria Van Gaal
IPC分类号： B08B1/00 , B08B13/00
CPC分类号： G11B7/1387
摘要： The invention provides a method and a device for cleaning of the optical face of a refractive element for a near field optical scanning apparatus. A magnetically susceptible cleaning material is used to facilitate effective cleaning of the refractive element without damage to the element. The method according to the invention can be combined with known cleaning methods if desired.
摘要翻译：本发明提供一种用于清洁近场光学扫描装置的折射元件的光学面的方法和装置。使用磁敏感的清洁材料来促进折射元件的有效清洁而不损坏元件。如果需要，根据本发明的方法可以与已知的清洁方法组合。

17. 发明授权

US09134201B2 Fluid providing apparatus 有权
标题翻译：流体提供装置
公开(公告)号：US09134201B2
公开(公告)日：2015-09-15
申请号：US13000031
申请日：2009-06-22
申请人： Petrus Johannes Wilhelmus Van Lankvelt , Dominique Maria Bruls , Albert Hendrik Jan Immink
发明人： Petrus Johannes Wilhelmus Van Lankvelt , Dominique Maria Bruls , Albert Hendrik Jan Immink
IPC分类号： G01N35/10 , G01N1/02 , G01N35/00
CPC分类号： G01N1/02 , G01N35/00584 , G01N35/10 , G01N2001/028
摘要： The invention relates to a fluid providing apparatus (5; 34) for providing a fluid to an analyzing apparatus (17; 33) for analyzing the fluid and to the analyzing apparatus (17; 33). The fluid providing apparatus (34) comprises a casing (35), which has an introduction opening (7), through which a fluid transferring element (1) is introducible into the casing (35) for transferring the fluid to the fluid providing apparatus (34). The casing (35) comprises further a fluid releasing section (8) for releasing the fluid from the fluid transferring element (1) and a fluid transferring element detection section (36) for detecting whether the fluid transferring element (1) is introduced into the casing (35) by interacting with a fluid transferring element detection unit of the analyzing apparatus (17; 33).
摘要翻译：本发明涉及一种用于向用于分析流体和分析装置（17; 33）的分析装置（17; 33）提供流体的流体提供装置（5; 34）。流体提供装置（34）包括具有引入开口（7）的壳体（35），流体转移元件（1）可以通过该导入开口引入到壳体（35）中，用于将流体传送到流体提供装置 34）。壳体（35）还包括用于从流体传送元件（1）释放流体的流体释放部分（8）和用于检测流体传递元件（1）是否被引入到流体传输元件壳体（35）通过与分析装置（17; 33）的流体转移元件检测单元相互作用。

18. 发明申请

US20110206560A1 BIOSENSOR WITH MULTI-CHAMBER CARTRIDGE 审中-公开
标题翻译：生物传感器与多个盒子
公开(公告)号：US20110206560A1
公开(公告)日：2011-08-25
申请号：US13126000
申请日：2009-10-27
申请人： Jacobus Hermanus Maria Neijzen , Reinhold Wimberger-Friedl , Joost Hubert Maas , Jeroen Hans Nieuwenhuis , Dominique Maria Bruls , Albert Hendrik Jan Immink , Mikhail M. Ovsyanko
发明人： Jacobus Hermanus Maria Neijzen , Reinhold Wimberger-Friedl , Joost Hubert Maas , Jeroen Hans Nieuwenhuis , Dominique Maria Bruls , Albert Hendrik Jan Immink , Mikhail M. Ovsyanko
IPC分类号： G01N30/00
CPC分类号： G01N33/54326 , B01L3/502761 , B82Y25/00 , G01N27/745 , G01R33/093 , G01R33/1269
摘要： The present invention provides a biosensor comprising a cartridge for accommodating a fluid sample, the cartridge comprising at least two chambers, wherein each chamber comprises a sensor surface with one or more binding sites. The biosensor further comprises means for generating a magnetic field at the binding sites of the sensor surfaces of the at least two chambers. The biosensor also comprises means for detecting particles accumulated at/and or proximate the binding sites of the sensor surfaces of the at least two chambers. Therein, the magnetic field at the binding sites has a sufficiently large gradient to actuate magnetic label particles towards the binding sites.
摘要翻译：本发明提供了一种生物传感器，其包括用于容纳流体样品的盒，所述盒包括至少两个室，其中每个室包括具有一个或多个结合位点的传感器表面。生物传感器还包括用于在至少两个室的传感器表面的结合位置处产生磁场的装置。生物传感器还包括用于检测在至少两个室的传感器表面的结合位点处和/或附近堆积的颗粒的装置。其中，结合位点处的磁场具有足够大的梯度以朝向结合位点致动磁性标记颗粒。

19. 发明申请

US20080112304A1 Spot Alignment For Parrallel Read-Out Of Two-Dimensional Encoded Optical Storage Media 审中-公开
标题翻译：用于二维编码光存储介质的Parrallel读出的点对齐
公开(公告)号：US20080112304A1
公开(公告)日：2008-05-15
申请号：US11568116
申请日：2005-04-14
申请人： Alexander Marc Van Der Lee , Christopher Busch , Dominique Maria Bruls
发明人： Alexander Marc Van Der Lee , Christopher Busch , Dominique Maria Bruls
IPC分类号： G11B7/00 , G11B7/24
CPC分类号： G11B7/0938 , G11B7/14 , G11B7/24085
摘要： The present invention provides a two-dimensional encoded optical storage medium (12) comprising at least one alignment pattern (14) for aligning a spot array (16) intended to read out the optical storage medium (12). Furthermore, the present invention is directed to a method and a device for reading out a two-dimensional encoded optical storage medium (12) having at least one alignment pattern (14) comprising a plurality of bit rows (R1, R2, R3, R4, R5, R6, R7, R8), wherein at least one bit row (R2, R3, R4, R6, R7, R8) of said alignment pattern (14) is empty.
摘要翻译：本发明提供了一种二维编码光学存储介质（12），其包括用于对准用于读出光学存储介质（12）的光点阵列（16）的至少一个对准图案（14）。此外，本发明涉及一种用于读出具有至少一个对齐图案（14）的二维编码光学存储介质（12）的方法和装置，所述对准图案包括多个位行（R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8），其中所述对准图案（14）的至少一个位列（R 2，R 3，R 4，R 6，R 7，R 8）是空的。

20. 发明申请

US20110093213A1 FLUID PROVIDING APPARATUS 有权
标题翻译：流体提供装置
公开(公告)号：US20110093213A1
公开(公告)日：2011-04-21
申请号：US13000031
申请日：2009-06-22
申请人： Petrus Johannes Wilhelmus Van Lankvelt , Dominique Maria Bruls , Albert Hendrik Jan Immink
发明人： Petrus Johannes Wilhelmus Van Lankvelt , Dominique Maria Bruls , Albert Hendrik Jan Immink
IPC分类号： G06F19/00 , G01N21/59 , G01N21/55
CPC分类号： G01N1/02 , G01N35/00584 , G01N35/10 , G01N2001/028
摘要： The invention relates to a fluid providing apparatus (5; 34) for providing a fluid to an analyzing apparatus (17; 33) for analyzing the fluid and to the analyzing apparatus (17; 33). The fluid providing apparatus (34) comprises a casing (35), which has an introduction opening (7), through which a fluid transferring element (1) is introducible into the casing (35) for transferring the fluid to the fluid providing apparatus (34). The casing (35) comprises further a fluid releasing section (8) for releasing the fluid from the fluid transferring element (1) and a fluid transferring element detection section (36) for detecting whether the fluid transferring element (1) is introduced into the casing (35) by interacting with a fluid transferring element detection unit of the analyzing apparatus (17; 33).
摘要翻译：本发明涉及一种用于向用于分析流体和分析装置（17; 33）的分析装置（17; 33）提供流体的流体提供装置（5; 34）。流体提供装置（34）包括具有引入开口（7）的壳体（35），流体转移元件（1）可以通过该导入开口引入到壳体（35）中，用于将流体传送到流体提供装置 34）。壳体（35）还包括用于从流体传送元件（1）释放流体的流体释放部分（8）和用于检测流体传递元件（1）是否被引入到流体传输元件壳体（35）通过与分析装置（17; 33）的流体转移元件检测单元相互作用。

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