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11. 发明申请

US20070126982A1 Interpenetrating polymer network hydrogel contact lenses 有权
标题翻译：互穿聚合物网络水凝胶隐形眼镜
公开(公告)号：US20070126982A1
公开(公告)日：2007-06-07
申请号：US11636114
申请日：2006-12-07
申请人： David Myung , Jaan Noolandi , Christopher Ta , Curtis Frank
发明人： David Myung , Jaan Noolandi , Christopher Ta , Curtis Frank
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , C08L51/08
摘要： The present invention provides interpenetrating polymer network hydrogels that have high oxygen permeability, strength, water content, and resistance to protein adsorption. The hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. The telechelic macromonomer preferably has a molecular weight of between about 575 Da and about 20,000 Da. Mixtures of molecular weights may also be used. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. The material is designed to serve as a contact lens.
摘要翻译：本发明提供了具有高透氧性，强度，含水量和耐蛋白质吸附性的互穿聚合物网状水凝胶。水凝胶包括两个互穿聚合物网络。第一个聚合物网络是基于亲水的遥爪大分子单体。第二聚合物网络基于亲水性单体。在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。遥爪大分子单体的分子量优选为约575Da至约20,000Da。也可以使用分子量的混合物。在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。该材料被设计成用作隐形眼镜。

12. 发明申请

US20060287721A1 Artificial cornea 审中-公开
标题翻译：人造角膜
公开(公告)号：US20060287721A1
公开(公告)日：2006-12-21
申请号：US11409218
申请日：2006-04-20
申请人： David Myung , Christopher Ta , Nabeel Farooqui , Curtis Frank , Won-Gun Koh , Jungmin Ko , Jaan Noolandi , Michael Carrasco
发明人： David Myung , Christopher Ta , Nabeel Farooqui , Curtis Frank , Won-Gun Koh , Jungmin Ko , Jaan Noolandi , Michael Carrasco
IPC分类号： A61F2/14
CPC分类号： A61F2/142 , A61F2/15 , A61K35/12
摘要： The present invention provides an artificial corneal implant having an optically clear central core and a porous, hydrophilic, biocompatible skirt peripheral to the central core. In one embodiment, the central core is made of an interpenetrating double network hydrogel and the skirt is made of poly(2-hydroxyethyl acrylate) (PHEA). In another embodiment, both the central core and the skirt are made of interpenetrating double network hydrogels. The artificial corneal implant may also have an interdiffusion zone in which the skirt component is interpenetrated with the core component, or vice versa. In a preferred embodiment, biomolecules are linked to the skirt, central core or both. These biomolecules may be any type of biomolecule, but are preferably biomolecules that support epithelial and/or fibroblast cell survival and growth. Preferably, the biomolecules are linked in a spatially selective manner. The present invention also provides a method of making an artificial corneal implant using photolithography.
摘要翻译：本发明提供了一种人造角膜植入物，其具有光学透明的中心纤芯和围绕中心纤芯的多孔，亲水的，生物相容的裙部。在一个实施方案中，中心芯由互穿双网络水凝胶制成，裙部由聚（丙烯酸2-羟乙酯）（PHEA）制成。在另一个实施例中，中心芯和裙部均由互穿双网络水凝胶制成。人造角膜植入物也可以具有相互扩散区域，其中裙部组件与芯部件互穿，反之亦然。在优选的实施方案中，生物分子连接到裙部，中心芯或两者。这些生物分子可以是任何类型的生物分子，但优选支持上皮和/或成纤维细胞存活和生长的生物分子。优选地，生物分子以空间选择性方式连接。本发明还提供了使用光刻法制造人造角膜植入物的方法。

13. 发明授权

US06930668B2 Color-enabled electrophoretic display and medium 失效
标题翻译：支持彩色电泳显示和介质
公开(公告)号：US06930668B2
公开(公告)日：2005-08-16
申请号：US10345436
申请日：2003-01-15
申请人： Jaan Noolandi , James H. Sharp
发明人： Jaan Noolandi , James H. Sharp
IPC分类号： G02F1/167 , G09G3/34 , G02B26/00
CPC分类号： G09G3/344 , G02F1/167 , G09G2310/02
摘要： A display medium including a plurality of electrically photosensitive particles positioned within at least one ambipolar shell to form at least one first composite particle, and a plurality of white particles encapsulated in a plurality of insulating shells to form a plurality of second composite particles. A photoelectrophoretic display and method of photoelectrophoretic imaging are also disclosed.
摘要翻译：一种显示介质，包括位于至少一个双极壳内的多个电光敏颗粒以形成至少一个第一复合颗粒，以及多个白色颗粒，其被封装在多个绝缘壳中以形成多个第二复合颗粒。还公开了光电泳显示器和光电泳成像方法。

14. 发明申请

US20050118067A1 Device to print biofluids 审中-公开
标题翻译：打印生物流体的设备
公开(公告)号：US20050118067A1
公开(公告)日：2005-06-02
申请号：US10503693
申请日：2003-02-12
申请人： Jaan Noolandi
发明人： Jaan Noolandi
IPC分类号： B01L3/00 , B01L3/02 , C40B60/14
CPC分类号： B01L3/0268 , B01J2219/00315 , B01J2219/0036 , B01L3/50853 , B01L2300/04 , B01L2400/027 , C40B60/14 , Y10T436/2575
摘要： An apparatus and method of printing microarrays by ejecting droplets of electrically conducting liquids from wells (12) onto a substrate (21) on top of a charged plate (20) using electrodes (18) inserted into the wells (12).
摘要翻译：一种通过使用插入孔（12）中的电极（18）将来自阱（12）的液滴喷射到带电板（20）顶部上的衬底（21）上的打印微阵列的装置和方法。

15. 发明授权

US06861034B1 Priming mechanisms for drop ejection devices 有权
标题翻译：液滴喷射装置的启动机构
公开(公告)号：US06861034B1
公开(公告)日：2005-03-01
申请号：US09721388
申请日：2000-11-22
申请人： Scott A. Elrod , Joy Roy , Babur B. Hadimioglu , Richard H. Bruce , Jaan Noolandi , David A. Horine
发明人： Scott A. Elrod , Joy Roy , Babur B. Hadimioglu , Richard H. Bruce , Jaan Noolandi , David A. Horine
IPC分类号： C12M1/00 , B01L3/02 , B05B1/04 , B05B17/06 , B01L3/00 , B41J23/00 , B41J29/38
CPC分类号： B05B17/0607 , B01L3/0268
摘要： Provided is a priming mechanism for priming a biofluid drop ejection device having a drop ejection opening leading to an ejection reservoir. The priming mechanism includes a vacuum unit which generates a vacuum force, connected to a vacuum nozzle. The vacuum nozzle is located over the drop ejection opening. A disposable sleeve or tubing is attached to the vacuum nozzle and is placed in operational contact with the drop ejection opening. A fluid height detection sensor is positioned to sense a fluid height within at least one of the disposable tubing and the vacuum nozzle. Upon sensing a predetermined fluid height, by the fluid height detection sensor, the priming operation is completed, and the primer mechanism is removed from the operational contact with the drop ejection opening.
摘要翻译：提供了一种用于起动生物流体液滴喷射装置的起动机构，其具有通向喷射储存器的液滴喷射开口。起动机构包括产生与真空喷嘴连接的真空力的真空单元。真空喷嘴位于液滴喷射口的上方。一次性套筒或管道连接到真空喷嘴并且与液滴喷射口处于操作接触。液体高度检测传感器被定位成感测至少一个一次性管道和真空喷嘴中的流体高度。通过流体高度检测传感器感测到预定的流体高度时，完成起动操作，并且将底漆机构从与液滴喷射口的操作接触部分移开。

16. 发明授权

US06800438B2 Imager for DNA sequencer 有权
标题翻译：成像器DNA测序仪
公开(公告)号：US06800438B2
公开(公告)日：2004-10-05
申请号：US09750560
申请日：2000-12-28
申请人： Jaan Noolandi , Robert A. Street , Neville Connell
发明人： Jaan Noolandi , Robert A. Street , Neville Connell
IPC分类号： C12Q168
CPC分类号： G01N15/1425 , G01N15/1456 , G01N27/44721 , G01N2015/149
摘要： An improved method for the sequencing of DNA fragments is provided. The method includes using a known process for DNA fragment separation, such as capillary electrophoresis, and imaging the resultant gel plate with a full-width array scanner or a two-dimensional amorphous silicon image sensor array. The DNA sample is placed within a well of the separation apparatus, such as a capillary tube or plurality thereof. The separation apparatus is then placed in a buffer. An electric field is then applied, forming a bias between the ends along which the sample is separated. Once separated, the large area detector scans the entire gel plate and resultant image data is provided. By way of the improved method, the entire gel plate can be scanned at the same time and repeatedly, resulting in greater accuracy and a shorter time to sequence.
摘要翻译：提供了一种改进的DNA片段测序方法。该方法包括使用用于DNA片段分离的已知方法，例如毛细管电泳，并用全宽阵列扫描仪或二维非晶硅图像传感器阵列对所得凝胶板进行成像。将DNA样品置于分离装置的孔内，例如毛细管或其多个孔。然后将分离装置放在缓冲液中。然后施加电场，在样品分离的端部之间形成偏压。一旦分离，大面积检测器扫描整个凝胶板，并提供合成的图像数据。通过改进的方法，可以同时和重复地扫描整个凝胶板，导致更高的精度和更短的顺序时间。

17. 发明授权

US06416157B1 Method of marking a substrate employing a ballistic aerosol marking apparatus 有权
标题翻译：使用弹道气溶胶标记装置标记基板的方法
公开(公告)号：US06416157B1
公开(公告)日：2002-07-09
申请号：US09164124
申请日：1998-09-30
申请人： Eric Peeters , Jaan Noolandi , Raj B. Apte , Philip D. Floyd , Jonathan A. Small , Gregory J. Kovacs , Meng H. Lean , Armin R. Volkel , Steven B. Bolte , An-Chang Shi , Frederick J. Endicott , Gregory B. Anderson , Dan A. Hays , Joel A. Kubby , Warren B. Jackson
发明人： Eric Peeters , Jaan Noolandi , Raj B. Apte , Philip D. Floyd , Jonathan A. Small , Gregory J. Kovacs , Meng H. Lean , Armin R. Volkel , Steven B. Bolte , An-Chang Shi , Frederick J. Endicott , Gregory B. Anderson , Dan A. Hays , Joel A. Kubby , Warren B. Jackson
IPC分类号： B41J214
CPC分类号： B41J2/01 , B41J2/14 , B41J2/211 , B41J2202/02
摘要： A method of marking employs a marking apparatus in which a propellant stream is passed through a channel and directed toward a substrate. Marking material, such as ink, toner, etc., is controllably introduced into the propellant stream and imparted with sufficient kinetic energy thereby to be made incident upon a substrate. At sufficient velocity, and with appropriate marking material, the marking material may be kinetically fused to the substrate. A multiplicity of channels for directing the propellant and marking material allow for high throughput, high resolution marking. Multiple marking materials may be introduced into the channel and mixed therein prior to being made incident on the substrate, or mixed or superimposed on the substrate without registration. One example is single-pass, full-color printing.
摘要翻译：标记方法使用标记装置，其中推进剂流通过通道并指向基底。诸如油墨，调色剂等的标记材料被可控地引入推进剂流中并且赋予足够的动能从而被入射到基底上。在足够的速度下，并且使用适当的标记材料，标记材料可以与基底动力学融合。用于引导推进剂和标记材料的多个通道允许高通量，高分辨率标记。可以将多个标记材料引入通道中并在其入射到基板之前混合，或者混合或叠加在基板上而不进行配准。一个例子是单程，全色打印。

18. 发明授权

US06293659B1 Particulate source, circulation, and valving system for ballistic aerosol marking 有权
标题翻译：用于弹道气溶胶标记的颗粒源，循环和阀门系统
公开(公告)号：US06293659B1
公开(公告)日：2001-09-25
申请号：US09476010
申请日：1999-12-29
申请人： Philip D. Floyd , David K. Biegelsen , Eric Peeters , Frederick J. Endicott , Richard P. N. Veregin , Gregory B. Anderson , Karen A. Moffat , Maria N. V McDougall , Jaan Noolandi , Armin R. Volkel , Tuan Anh Vo , Kaiser H. Wong , Peter M. Kazmaier
发明人： Philip D. Floyd , David K. Biegelsen , Eric Peeters , Frederick J. Endicott , Richard P. N. Veregin , Gregory B. Anderson , Karen A. Moffat , Maria N. V McDougall , Jaan Noolandi , Armin R. Volkel , Tuan Anh Vo , Kaiser H. Wong , Peter M. Kazmaier
IPC分类号： B41J2175
CPC分类号： B41J2/14008 , B41J2/14 , B41J2202/02
摘要： A ballistic aerosol marking device includes, marking material which flows from a material reservoir to a delivery channel via a port. Flow of marking material is facilitated by the creation of a fluidized bed or aerosol of marking material in the reservoir. Gas flow together with mechanical or electromechanical assistance can be used to assist in the generation of the fluidized bed or aerosol.
摘要翻译：弹道气溶胶标记装置包括从材料储存器经由端口流到输送通道的标记材料。通过在储存器中产生标记材料的流化床或气溶胶来促进标记材料的流动。可以使用气流与机械或机电辅助来帮助产生流化床或气溶胶。

19. 发明授权

US08122880B2 Inhaler that uses focused acoustic waves to deliver a pharmaceutical product 有权
标题翻译：吸入器使用聚焦声波来递送药品
公开(公告)号：US08122880B2
公开(公告)日：2012-02-28
申请号：US09740209
申请日：2000-12-18
申请人： Jaan Noolandi , Babur B. Hadimioglu , Robert A. Sprague
发明人： Jaan Noolandi , Babur B. Hadimioglu , Robert A. Sprague
IPC分类号： B05B17/06 , A61M15/00 , A61M11/00
CPC分类号： B05B17/06 , A61M11/005 , A61M15/0085 , A61M15/02 , A61M15/025
摘要： An improved method and apparatus for delivering medication to the lungs is described. Acoustic ink printing technology is modified to operate as an inhaler that generates tiny droplets near a patient's nose or mouth. The tiny droplets are easily carried by air currents into the patient's lungs. The inhaler itself is preferably a battery operated portable device that can be easily carried and easily cleaned to avoid contaminating the medication.
摘要翻译：描述了用于将药物递送至肺部的改进方法和装置。声学油墨印刷技术被修改为作为在患者的鼻子或嘴部附近产生微小液滴的吸入器。微小的液滴容易被气流携带到病人的肺部。吸入器本身优选地是电池操作的便携式装置，其可以容易地携带并容易地清洁以避免污染药物。

20. 发明授权

US07172712B2 Preparation of micromultichromal spheres 失效
标题翻译：微复合球的制备
公开(公告)号：US07172712B2
公开(公告)日：2007-02-06
申请号：US10249483
申请日：2003-04-14
申请人： Peter M. Kazmaier , Barkev Keoshkerian , George Liebermann , Naveen Chopra , Hadi K. Mahabadi , Jaan Noolandi , Francisco E. Torres
发明人： Peter M. Kazmaier , Barkev Keoshkerian , George Liebermann , Naveen Chopra , Hadi K. Mahabadi , Jaan Noolandi , Francisco E. Torres
IPC分类号： B29D11/00 , G02B26/00
CPC分类号： G02B26/026 , B01J13/04 , B01J13/08 , B01J13/16 , Y10T428/2991
摘要： A method of making a multichromal sphere includes the steps of preparing a composition of at least (1) a matrix material and (2) at least two sets of particles, each of the sets of particles having a color different from at least one of another of the sets of particles and a segregation (e.g., an electrical or magnetic) property different from at least one of another of the sets of particles, encapsulating the composition within a shell to form an encapsulated sphere, immobilizing the encapsulated sphere in a manner to restrict at least rotation of the encapsulated sphere, subjecting the immobilized encapsulated sphere to an external field associated with the segregation property different among the sets of particles, under conditions in which the sets of particles are able to migrate within the matrix material, thereby producing color segregation in the immobilized encapsulated sphere, and solidifying the matrix material while substantially maintaining the color segregation. In the multichromal spheres, each of the sets of particles is segregated within a separate segment of the solidified matrix material of the core on the basis of the different segregation property.
摘要翻译：制备多重色球的方法包括以下步骤：制备至少（1）基质材料的组合物和（2）至少两组颗粒，每组颗粒具有不同于其它颗粒中的至少一种的颜色的颗粒组以及不同于另一组颗粒的分离（例如，电或磁）性质，将组合物包封在壳体内以形成封装的球体，将封装的球体以限制封装球体的至少旋转，使固定的包封球体在与该组颗粒之间不同的分离特性相关联的外部场中，在该组颗粒能够在基体材料内迁移的条件下，由此产生颜色在固定化的包封球体中分离，并固化基质材料，同时基本上保持颜色偏析。在多重色粉球中，基于不同的分离性质，将这些颗粒组中的每一组分离在核心的固化基质材料的单独部分内。

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