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    • 15. 发明授权
    • Medical emulsion for lubrication and delivery of drugs
    • 用于润滑和输送药物的医用乳液
    • US06391832B2
    • 2002-05-21
    • US09887039
    • 2001-06-21
    • Robert T. LyonsDavid H. DillardBruce FieggenRobert M. RaukerScott T. Bluni
    • Robert T. LyonsDavid H. DillardBruce FieggenRobert M. RaukerScott T. Bluni
    • C10M17300
    • A61K9/0019A61B17/320758A61K9/1075B82Y5/00Y10S514/937Y10S514/938
    • A medical lubricant suitable for injection into the blood stream of a patient. The lubricant is suitable for use with rotating equipment such as atherectomy drive shafts moving within sheaths and over guide wires and other minimally invasive medical devices introduced into a patient through a catheter like instrument. The lubricant is an oil-in-water emulsion including a surfactant, a co-surfactant, and a pH buffer. The lubricant can further include a cryogenic agent and a pH adjusting agent. One lubricant includes olive oil as an emulsified oil, egg yolk phospholipid as a surfactant, sodium deoxycholate as a co-surfactant, glycerin as a cryogenic agent, L-histidine as a pH buffer, and is pH adjusted using sodium hydroxide. The lubricant also includes a therapeutic agent. The lubricant can withstand freeze/thaw cycles as well as saline dilution, heating, and shear stress without significant creaming, separation, or unacceptable increases in oil droplet size.
    • 适用于注射到患者血液中的医用润滑剂。 润滑剂适用于旋转设备,例如在护套内移动的动脉粥样化组织驱动轴,以及通过导管样仪器引导到患者体内的导丝和其他微创医疗装置。 润滑剂是包括表面活性剂,辅助表面活性剂和pH缓冲剂的水包油乳液。 润滑剂可进一步包括低温剂和pH调节剂。 一种润滑剂包括作为乳化油的橄榄油,作为表面活性剂的蛋黄磷脂,作为辅助表面活性剂的脱氧胆酸钠,作为低温剂的甘油,作为pH缓冲剂的L-组氨酸,并使用氢氧化钠进行pH调节。 润滑剂还包括治疗剂。 润滑剂可以承受冷冻/融化循环以及盐水稀释,加热和剪切应力,而没有显着的奶油,分离或油滴尺寸的不可接受的增加。
    • 16. 发明授权
    • Medical emulsion lubricant
    • 医用乳液润滑剂
    • US06054421A
    • 2000-04-25
    • US935698
    • 1997-09-23
    • Robert T. LyonsDavid H. DillardBruce Fieggen
    • Robert T. LyonsDavid H. DillardBruce Fieggen
    • C10M171/00A61B17/22A61K9/107C10N40/06C10M173/00
    • A61K9/1075A61B17/320758Y10S514/937Y10S514/938
    • A medical lubricant suitable for injection into the blood stream of a patient. The lubricant is suitable for use with rotating equipment such as atherectomy drive shafts moving within sheaths and over guide wires. The lubricant is an oil-in-water emulsion including a surfactant and a co-surfactant. The lubricant can include a cryogenic agent and a pH buffer and be pH adjusted. One lubricant includes olive oil as an emulsified oil, egg yolk phospholipid as a surfactant, sodium deoxycholate as a co-surfactant, glycerin as a cryogenic agent, L-histidine as a pH buffer, and is pH adjusted using sodium hydroxide. The lubricant can withstand freeze/thaw cycles as well as saline dilution, heating, and shear stress without significant creaming, separation, or unacceptable increases in oil droplet size. Compared to saline, the lubricant provides significantly increased lubrication efficiency for rapidly moving parts.
    • 适用于注射到患者血液中的医用润滑剂。 润滑剂适用于旋转设备,例如在鞘内和导丝上移动的动脉粥样化组织切割驱动轴。 润滑剂是包含表面活性剂和辅助表面活性剂的水包油乳液。 润滑剂可以包括低温剂和pH缓冲液并进行pH调节。 一种润滑剂包括作为乳化油的橄榄油,作为表面活性剂的蛋黄磷脂,作为辅助表面活性剂的脱氧胆酸钠,作为低温剂的甘油,作为pH缓冲剂的L-组氨酸,并使用氢氧化钠进行pH调节。 润滑剂可以承受冷冻/融化循环以及盐水稀释,加热和剪切应力,而没有显着的奶油,分离或油滴尺寸的不可接受的增加。 与盐水相比,润滑剂为快速移动的部件提供了显着提高的润滑效率。
    • 17. 发明授权
    • Ablation atherectomy burr
    • 消融粥样斑块切除术
    • US06569177B1
    • 2003-05-27
    • US09769191
    • 2001-01-19
    • David H. DillardGarrett R. BegetVittorino Monni
    • David H. DillardGarrett R. BegetVittorino Monni
    • A61B1732
    • A61B17/320758A61B2017/320004
    • An ablation burr for a rotational atherectomy device that may reduce the risk of damage to a vessel wall while providing ablative cutting surfaces out to the maximum diameter of the burr. Two different abrasive surfaces are provided on the leading surface of the ablation burr. A less aggressive or finer abrasiveness is provided near the ablation burr maximum diameter, which is the portion of the burr nearest the vessel wall. This portion of the burr also presents a relatively shallow angle of attach to the vessel wall. A more aggressive or coarser abrasive is applied to portions of the burr disposed further from the vessel wall. In one embodiment, the more aggressive abrasive portion of the burr has a concave profile, thereby further reducing the possibility that the more aggressive abrasive will contact the vessel wall, even when the burr is rotated significantly away from the vessel axis. The ablation burr body may be profiled with an offset or stepped sections on the leading surface that are dimensioned such that the abrasive particles do not extend radially beyond the maximum diameter of the smooth back surface of the ablation burr.
    • 用于旋转粥样斑块切除装置的消融毛刺,其可以减少损伤血管壁的风险,同时将烧蚀切割表面提供到毛刺的最大直径。 两个不同的研磨表面设置在消融毛刺的前表面上。 在消融毛刺最大直径附近提供较少的侵蚀性或更细的磨蚀性,其是最靠近血管壁的毛刺部分。 毛刺的这一部分也呈现出相对较浅的附着于血管壁的角度。 将较为侵蚀性或较粗糙的研磨剂施加到设置在血管壁之外的毛刺部分。 在一个实施例中,毛刺的更具侵蚀性的研磨部分具有凹形轮廓,从而进一步降低了更具侵蚀性的磨料将与血管壁接触的可能性,即使当毛刺被显着地远离血管轴线旋转时。 消融毛刺体可以在引导表面上具有偏移或阶梯部分的形状,其尺寸被设计成使得磨料颗粒不会径向延伸超出消融毛刺的平滑后表面的最大直径。
    • 19. 发明授权
    • Medical emulsion for lubrication and delivery of drugs
    • 用于润滑和输送药物的医用乳液
    • US06281175B1
    • 2001-08-28
    • US09534056
    • 2000-03-24
    • Robert T. LyonsDavid H. DillardBruce Fieggen
    • Robert T. LyonsDavid H. DillardBruce Fieggen
    • C10M17300
    • A61K9/0019A61B17/320758A61K9/1075B82Y5/00Y10S514/937Y10S514/938
    • A medical lubricant suitable for injection into the blood stream of a patient. The lubricant is suitable for use with rotating equipment such as atherectomy drive shafts moving within sheaths and over guide wires and other minimally invasive medical devices introduced into a patient through a catheter like instrument. The lubricant is an oil-in-water emulsion including a surfactant, a co-surfactant, and a pH buffer. The lubricant can further include a cryogenic agent and a pH adjusting agent. One lubricant includes olive oil as an emulsified oil, egg yolk phospholipid as a surfactant, sodium deoxycholate as a co-surfactant, glycerin as a cryogenic agent, L-histidine as a pH buffer, and is pH adjusted using sodium hydroxide. The lubricant can also include a therapeutic agent. The lubricant can withstand freeze/thaw cycles as well as saline dilution, heating, and shear stress without significant creaming, separation, or unacceptable increases in oil droplet size. Compared to saline, the lubricant provides significantly increased lubrication efficiency for rapidly moving parts.
    • 适用于注射到患者血液中的医用润滑剂。 润滑剂适用于旋转设备,例如在护套内移动的动脉粥样化组织驱动轴,以及通过导管样仪器引导到患者体内的导丝和其他微创医疗装置。 润滑剂是包括表面活性剂,辅助表面活性剂和pH缓冲剂的水包油乳液。 润滑剂可进一步包括低温剂和pH调节剂。 一种润滑剂包括作为乳化油的橄榄油,作为表面活性剂的蛋黄磷脂,作为辅助表面活性剂的脱氧胆酸钠,作为低温剂的甘油,作为pH缓冲剂的L-组氨酸,并使用氢氧化钠进行pH调节。 润滑剂还可以包括治疗剂。 润滑剂可以承受冷冻/融化循环以及盐水稀释,加热和剪切应力,而没有显着的奶油,分离或油滴尺寸的不可接受的增加。 与盐水相比,润滑剂为快速移动的部件提供了显着提高的润滑效率。