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11. 发明申请

US20080139973A1 Particle Enhancement Agent For High Intensity Focused Ultrasound Treatment And Use Thereof 审中-公开
标题翻译：用于高强度聚焦超声治疗和使用的粒子增强剂
公开(公告)号：US20080139973A1
公开(公告)日：2008-06-12
申请号：US11794931
申请日：2005-09-02
申请人： Zhibiao Wang , Faqi Li , Yanbing Xiao , Ziwen Xiao , Liping Liu , Zhilong Wang
发明人： Zhibiao Wang , Faqi Li , Yanbing Xiao , Ziwen Xiao , Liping Liu , Zhilong Wang
IPC分类号： A61N7/02
CPC分类号： A61K41/0033 , A61K9/0019 , A61K9/107 , A61K9/127 , A61K31/685
摘要： The present invention discloses a particle enhancement agent for high intensity focused ultrasound (HIFU) treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a discontinuous phase comprised of a core material encapsulated by a membrane-forming material and a continuous phase comprising of aqueous medium. The discontinuous phase is uniformly dispersed in the continuous phase and the particle size of the discontinuous phase ranges from 0.1-8 μm; the amount of the membrane-forming material in the enhancement agent is 0.1-100 g/L; the core material is comprised of a liquid that does not undergo a liquid-gas phase transition at 38-100° C., and the amount of core material in the enhancement agent is 5-200 g/L.
摘要翻译：本发明公开了一种用于高强度聚焦超声（HIFU）处理的颗粒增强剂，其可以在HIFU处理期间增加目标位置处的声能沉积。增强剂包括由膜形成材料包封的芯材料和包含水性介质的连续相组成的不连续相。不连续相均匀分散在连续相中，不连续相的粒径为0.1-8μm; 增塑剂中的成膜材料的量为0.1-100g / L; 核心材料由在38-100℃不经历液 - 气相变的液体组成，增强剂中芯材的量为5-200g / L。

12. 发明申请

US20070259428A1 Use of Cloud Point System in Biotransformation 审中-公开
标题翻译：使用云点系统进行生物转化
公开(公告)号：US20070259428A1
公开(公告)日：2007-11-08
申请号：US10567439
申请日：2004-07-05
申请人： Daijie Chen , Zhilong Wang , Mei Ge , Yiping Jin , Weidong Ye
发明人： Daijie Chen , Zhilong Wang , Mei Ge , Yiping Jin , Weidong Ye
IPC分类号： C12N15/87
CPC分类号： C12P33/02 , C12N1/38
摘要： The invention relates to the field of microbial technology. It discloses a method to apply the cloud point system (CPS) in biotransformation by selecting one or more types of nonionic surfactant to form a aqueous system with a cloud point below the microbial transformation temperature, which serves as transformation medium. The method disclosed is suitable in particular for microbial transformation of hydrophobic compounds, for the system where substrate or product inhibits microbial growth or where product is further degraded by microbes. The CPS in the present invention forms a microemulsion of water-in-oil and oil-in-water, where the drops of surfactant is able to solubilize, serving as substrate reservoir and product extractant. This enhances bioavailability of substrates and elimination of product inhibition. The large water vesicles existing in the continuous surfactant phase provide aqueous environment to the cells where they can be sheltered from detrimental effects of surfactants, resulting in improvement of biocompatibililty.
摘要翻译：本发明涉及微生物技术领域。它公开了一种通过选择一种或多种类型的非离子表面活性剂来应用浊点系统（CPS）进行生物转化的方法，以形成低于微生物转化温度的浊点的水系，其作为转化介质。所公开的方法特别适用于疏水化合物的微生物转化，其中底物或产物抑制微生物生长或其中产物被微生物进一步降解的系统。本发明中的CPS形成了油包水和水包油的微乳液，其中表面活性剂的液滴能够溶解，作为底物贮存器和产物萃取剂。这增强了底物的生物利用度和消除了产物的抑制作用。存在于连续表面活性剂相中的大水泡为细胞提供水环境，在那里可以避免表面活性剂的不利影响，导致生物相容性的提高。

13. 发明申请

US20130270180A1 CERAMIC NANOWIRE MEMBRANES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：陶瓷纳米薄膜及其制备方法
公开(公告)号：US20130270180A1
公开(公告)日：2013-10-17
申请号：US13881016
申请日：2011-10-28
申请人： Xinjie Zhang , Anthony E. Allegrezza, JR. , Qi Zhao , Zhilong Wang
发明人： Xinjie Zhang , Anthony E. Allegrezza, JR. , Qi Zhao , Zhilong Wang
IPC分类号： B01D71/02
CPC分类号： B01D71/024 , B01D46/546 , B01D67/0046 , B01D67/0051 , B01D69/02 , B01D71/025 , B01D71/027 , B01D2239/025 , B01D2325/24 , Y10T156/10
摘要： Embodiments of the present invention disclose ceramic membranes having bonded ceramic nanowires. Methods of making ceramic membranes having bonded ceramic nanowires are also disclosed.
摘要翻译：本发明的实施方案公开了具有结合陶瓷纳米线的陶瓷膜。还公开了制造具有结合陶瓷纳米线的陶瓷膜的方法。

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