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11. 发明授权

US08725232B2 Therapeutic apparatus 失效
标题翻译：治疗仪器
公开(公告)号：US08725232B2
公开(公告)日：2014-05-13
申请号：US13519145
申请日：2010-12-21
申请人： Erkki Tapani Vahala , Shunmugavelu Sokka , Julius Koskela , Max Oskar Kohler
发明人： Erkki Tapani Vahala , Shunmugavelu Sokka , Julius Koskela , Max Oskar Kohler
IPC分类号： A61B5/055 , A61B8/00 , A61H1/00 , A61B18/04 , A61F7/00
CPC分类号： A61N7/02 , A61B2017/00084 , A61B2018/00642 , A61B2090/374 , G01R33/4804 , G01R33/4814
摘要： A therapeutic apparatus comprising a high intensity focused ultrasound system (302) for sonicating a sonication volume (324) of a subject (320). The therapeutic apparatus further comprises a magnetic resonance imaging system (300) for acquiring magnetic resonance thermometry data (350) within an imaging volume (316). The sonication volume is within the imaging volume. The therapeutic apparatus further comprises a controller (304) for controlling the therapeutic apparatus. The treatment plan comprises instructions for controlling the operation of the high intensity focused ultrasound system. The controller is adapted for sonicating (100) the target volume using the high intensity focused ultrasound system. The controller is adapted for repeatedly acquiring (102) magnetic resonance thermometry data using the magnetic resonance imaging system during execution of the treatment plan. The controller is adapted for modifying (104) the treatment plan during execution of the treatment plan using the magnetic resonance thermometry data.
摘要翻译：一种治疗装置，包括用于超声处理受试者（320）的超声处理体积（324）的高强度聚焦超声系统（302）。治疗装置还包括用于在成像体积（316）内获取磁共振测温数据（350）的磁共振成像系统（300）。超声处理体积在成像体积内。治疗装置还包括用于控制治疗装置的控制器（304）。治疗方案包括用于控制高强度聚焦超声系统的操作的指令。控制器适用于使用高强度聚焦超声系统超声处理（100）目标体积。控制器适于在执行治疗计划期间使用磁共振成像系统反复获取（102）磁共振测温数据。控制器适用于使用磁共振测温数据修改（104）处理计划执行期间的治疗计划。

12. 发明授权

US08496587B2 Therapy system for depositing energy 有权
标题翻译：放电能量治疗系统
公开(公告)号：US08496587B2
公开(公告)日：2013-07-30
申请号：US13061566
申请日：2009-09-03
申请人： Max Oskar Kohler , Teuvo Vaara , Shunmugavelu Sokka , Gosta Jakob Ehnholm
发明人： Max Oskar Kohler , Teuvo Vaara , Shunmugavelu Sokka , Gosta Jakob Ehnholm
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B18/18 , A61B2017/00084 , A61B2090/374
摘要： A therapy system includes a therapy module, e.g., a high-intensity-focused ultrasound transmitter, to perform successive deposits of energy in a target zone. The successive deposits being separated by a cool down period. The therapy system further includes a thermometry module, e.g. by a magnetic resonance examination system, configured for thermometry to measure temperature in a measurement field. A control module regulates the cool down period in dependence of the measured off-focus maximum temperature during the energy deposit preceding the cool down period.
摘要翻译：治疗系统包括治疗模块，例如高强度聚焦超声波发射器，以在目标区域中执行能量的连续沉积。连续的沉积物被冷却时间隔开。治疗系统还包括温度测量模块，例如，通过磁共振检查系统，被配置为用于在测量场中测量温度的温度测量。控制模块根据在冷却时段之前的能量存储期间测量的离焦最大温度来调节冷却时间。

13. 发明申请

US20120296197A1 Therapeutic Apparatus 失效
标题翻译：治疗仪
公开(公告)号：US20120296197A1
公开(公告)日：2012-11-22
申请号：US13519145
申请日：2010-12-21
申请人： Erkki Tapani Vahala , Shunmugavelu Sokka , Julius Koskela , Max Oskar Kohler
发明人： Erkki Tapani Vahala , Shunmugavelu Sokka , Julius Koskela , Max Oskar Kohler
IPC分类号： A61B5/055 , A61N7/02
CPC分类号： A61N7/02 , A61B2017/00084 , A61B2018/00642 , A61B2090/374 , G01R33/4804 , G01R33/4814
摘要： A therapeutic apparatus comprising a high intensity focused ultrasound system (302) for sonicating a sonication volume (324) of a subject (320). The therapeutic apparatus further comprises a magnetic resonance imaging system (300) for acquiring magnetic resonance thermometry data (350) within an imaging volume (316). The sonication volume is within the imaging volume. The therapeutic apparatus further comprises a controller (304) for controlling the therapeutic apparatus. The treatment plan comprises instructions for controlling the operation of the high intensity focused ultrasound system. The controller is adapted for sonicating (100) the target volume using the high intensity focused ultrasound system. The controller is adapted for repeatedly acquiring (102) magnetic resonance thermometry data using the magnetic resonance imaging system during execution of the treatment plan. The controller is adapted for modifying (104) the treatment plan during execution of the treatment plan using the magnetic resonance thermometry data.
摘要翻译：一种治疗装置，包括用于超声处理受试者（320）的超声处理体积（324）的高强度聚焦超声系统（302）。治疗装置还包括用于在成像体积（316）内获取磁共振测温数据（350）的磁共振成像系统（300）。超声处理体积在成像体积内。治疗装置还包括用于控制治疗装置的控制器（304）。治疗方案包括用于控制高强度聚焦超声系统的操作的指令。控制器适用于使用高强度聚焦超声系统超声处理（100）目标体积。控制器适于在执行治疗计划期间使用磁共振成像系统反复获取（102）磁共振测温数据。控制器适用于使用磁共振测温数据修改（104）处理计划执行期间的治疗计划。

14. 发明申请

US20090306497A1 CALIBRATION METHOD FOR CATHETER TRACKING SYSTEM USING MEDICAL IMAGING DATA 审中-公开
标题翻译：使用医学成像数据进行导管跟踪系统的校准方法
公开(公告)号：US20090306497A1
公开(公告)日：2009-12-10
申请号：US12301312
申请日：2007-04-10
申请人： Robert Manzke , Raymond Chan , Shunmugavelu Sokka , Volker Rasche
发明人： Robert Manzke , Raymond Chan , Shunmugavelu Sokka , Volker Rasche
IPC分类号： A61B5/06 , A61B6/12
CPC分类号： A61B5/06 , A61B5/055 , A61B5/063 , A61B6/12 , A61B6/466 , A61B6/503 , A61B6/504 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/0891 , A61B34/20 , A61B90/36 , A61B2017/00725 , A61B2034/2051 , A61B2090/364 , A61B2090/3929
摘要： This invention discloses an improved method for the calibration and tracking of an electromagnetic or acoustic based catheter within a catheter tracking space for use in cardiac intervention for a specific patient, utilizing prior-acquired medical imaging data for the patient.
摘要翻译：本发明公开了一种改进的方法，用于在使用用于患者的先前获取的医学成像数据的情况下，在导管跟踪空间内校准和跟踪用于特定患者的心脏干预的导管跟踪空间中的基于电磁或声学的导管。

15. 发明申请

US20120203098A1 ULTRASOUND POWER SUPPLY FOR AN ULTRASOUND TRANSDUCER 审中-公开
标题翻译：用于超声波传感器的超声波电源
公开(公告)号：US20120203098A1
公开(公告)日：2012-08-09
申请号：US13501571
申请日：2010-09-24
申请人： Balasundara Iyyavu Raju , Shiwei Zhou , Shunmugavelu Sokka
发明人： Balasundara Iyyavu Raju , Shiwei Zhou , Shunmugavelu Sokka
IPC分类号： A61N7/02 , H05B1/02 , A61B5/055
CPC分类号： A61N7/02 , A61B90/04 , A61B2017/00084 , A61B2017/00092 , A61B2018/00642 , A61B2018/00666 , A61B2090/374 , A61N7/022 , A61N2007/0078
摘要： An ultrasound power supply (100) adapted for supplying electrical power for driving an ultrasound transducer (202, 702) in contact with a subject (208), wherein the ultrasound power supply comprises:—a communications interface (102) adapted for receiving a first temperature measurement of a first volume (211, 318) of the subject and a second temperature measurement of a second volume (214, 320) of the subject;—a controller (108) adapted for modulating the output of electrical power for driving the ultrasound transducer such that via ultrasonic heating by the ultrasound transducer: a. the first temperature measurement is maintained above a first predetermined threshold, b. the first temperature measurement is maintained below a second predetermined threshold, and c. the second temperature measurement is maintained below a third predetermined threshold; and wherein the first predetermined threshold is above the third predetermined threshold.
摘要翻译：一种超声波电源（100），适于提供用于驱动与被摄体（208）接触的超声换能器（202,702）的电力，其中所述超声波电源包括： - 通信接口（102），适于接收第一测量对象的第一体积（211,318）的温度测量和对象的第二体积（214,320）的第二温度测量值; - 适于调制用于驱动超声波的电力输出的控制器（108）换能器，使得通过超声波换能器的超声波加热：a。第一温度测量保持在第一预定阈值以上，b。第一温度测量值保持在第二预定阈值以下，c。第二温度测量值保持在第三预定阈值以下; 并且其中所述第一预定阈值高于所述第三预定阈值。

16. 发明申请

US20120035464A1 CONTROL APPARATUS FOR CONTROLLING A THERAPEUTIC APPARATUS 审中-公开
标题翻译：用于控制治疗设备的控制装置
公开(公告)号：US20120035464A1
公开(公告)日：2012-02-09
申请号：US13265142
申请日：2010-04-13
申请人： Balasundara Raju , Shunmugavelu Sokka
发明人： Balasundara Raju , Shunmugavelu Sokka
IPC分类号： A61B5/055 , A61B8/00
CPC分类号： A61N7/02 , A61B34/10 , A61B2017/00084 , A61B2090/374 , G01R33/4814 , G01R33/485
摘要： A control apparatus (106) for controlling a therapeutic apparatus (100), wherein the control apparatus comprises: —an ultrasound control interface (110) for controlling a therapeutic ultrasound system (102), —a magnetic resonance control interface (112) for controlling a magnetic resonance apparatus (104) adapted for acquiring magnetic resonance imaging data from a subject and for acquiring magnetic resonance spectroscopy data from a subject (244), —an image processing module (124, 126, 128) for generating at least one magnetic resonance imaging image (500) from the magnetic resonance imaging data and for generating at least one magnetic resonance spectroscopy map (502, 514, 516, 518, 520) from the magnetic resonance spectroscopy data, —a planning module (120) adapted for receiving the magnetic resonance imaging image and the magnetic resonance spectroscopy map and for outputting planning data (732), —a control module (122) adapted for controlling the therapeutic ultrasound system using the ultrasound control apparatus using the planning data, wherein the control module is further adapted for controlling the acquisition of the acquiring magnetic resonance imaging data and magnetic resonance spectroscopy data using the magnetic resonance control interface.
摘要翻译：一种用于控制治疗装置（100）的控制装置（106），其中所述控制装置包括： - 用于控制治疗性超声系统（102）的超声控制接口（110）， - 用于控制的磁共振控制接口（112）一种适于从受检者获取磁共振成像数据并用于从受检者（244）获取磁共振波谱数据的磁共振设备（104）， - 一个图像处理模块（124,126,128），用于产生至少一个磁共振来自磁共振成像数据的成像图像（500）和用于从磁共振波谱数据产生至少一个磁共振谱图（502,514,516,518,520）， - 规划模块（120），适于接收磁共振成像图像和磁共振谱图，并用于输出规划数据（732）， - 适于控制治疗性超声波的控制模块（122）使用所述规划数据使用所述超声波控制装置，其中所述控制模块还适于使用所述磁共振控制接口来控制获取磁共振成像数据和磁共振波谱数据的采集。

17. 发明申请

US20110313329A1 THERAPY SYSTEM FOR DEPOSITING ENERGY 有权
标题翻译：用于放电能量的治疗系统
公开(公告)号：US20110313329A1
公开(公告)日：2011-12-22
申请号：US13061985
申请日：2009-09-04
申请人： Max O. Kohler , Teuvo J. Vaara , Shunmugavelu Sokka , Gosta J. Ehnholm
发明人： Max O. Kohler , Teuvo J. Vaara , Shunmugavelu Sokka , Gosta J. Ehnholm
IPC分类号： A61N7/02 , A61N5/02 , A61N5/00 , A61F7/00
CPC分类号： A61N7/02 , A61B18/14 , A61B18/18 , A61B2017/00084 , A61B2017/00194 , A61B2018/183 , A61B2090/374
摘要： A therapy system comprises a therapy module to perform successive deposits of energy in a target zone, the therapy system being provided with a control module is configured to prior the deposits of energy produce an a priori estimate of the induced heating. For example a thermometry module is provided to measure temperature in a measurement field. The induced heating may be derived on the basis of a tissue model from the settings of the therapy module. In particular the therapy module is a high-intensity focuses ultrasound transmitter. A magnetic resonance examination system configured for thermometry is employed as the thermometry module.
摘要翻译：治疗系统包括治疗模块，以在目标区域中执行能量的连续沉积，设置有控制模块的治疗系统被配置为在能量沉积之前产生感应加热的先验估计。例如，提供测温模块以测量测量场中的温度。感应加热可以基于来自治疗模块的设置的组织模型得出。特别地，治疗模块是高强度聚焦超声发射器。采用配置用于测温的磁共振检查系统作为测温模块。

18. 发明申请

US20110152730A1 THERAPY SYSTEM FOR DEPOSITING ENERGY 有权
标题翻译：用于放电能量的治疗系统
公开(公告)号：US20110152730A1
公开(公告)日：2011-06-23
申请号：US13061566
申请日：2009-09-03
申请人： Max Oskar Kohler , Teuvo Vaara , Shunmugavelu Sokka , Gosta Jakob Ehnholm
发明人： Max Oskar Kohler , Teuvo Vaara , Shunmugavelu Sokka , Gosta Jakob Ehnholm
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61B18/18 , A61B2017/00084 , A61B2090/374
摘要： A therapy system comprising a therapy module, e.g. a high-intensity- focused ultrasound transmitter, to perform successive deposits of energy in a target zone, the successive deposits being separated by a cool down period. The therapy system being provided with a thermometry module, e.g. by a magnetic resonance examination system configured for thermometry to measure temperature in a measurement field. A control module regulates the cool down period in dependence of the measured off-focus maximum temperature during the energy deposit preceding the cool down period.
摘要翻译：一种治疗系统，包括治疗模块，例如，高强度聚焦超声波发射器，以在目标区域中执行能量的连续沉积，所述连续的沉积物被冷却时段隔开。治疗系统设置有温度测量模块，例如。通过配置用于在测量场中测量温度的温度测量的磁共振检查系统。控制模块根据在冷却时段之前的能量存储期间测量的离焦最大温度来调节冷却时间。

19. 发明授权

US09669240B2 Therapy system for depositing energy 有权
公开(公告)号：US09669240B2
公开(公告)日：2017-06-06
申请号：US13061985
申请日：2009-09-04
申请人： Max Oskar Köhler , Teuvo Vaara , Shunmugavelu Sokka , Gosta Jakob Ehnholm
发明人： Max Oskar Köhler , Teuvo Vaara , Shunmugavelu Sokka , Gosta Jakob Ehnholm
IPC分类号： A61N7/02 , A61B18/14 , A61B18/18 , A61B17/00 , A61B90/00
CPC分类号： A61N7/02 , A61B18/14 , A61B18/18 , A61B2017/00084 , A61B2017/00194 , A61B2018/183 , A61B2090/374
摘要： A therapy system includes a therapy module to perform successive deposits of energy in a target zone. The therapy system further includes a control module configured to, prior to deposits of energy, produce an a priori estimate of the induced heating. A thermometry module is configured to measure temperature in a measurement field. The induced heating may be derived based on a tissue model from the settings of a therapy module. The therapy module includes a high-intensity focused ultrasound transmitter. A magnetic resonance examination system configured for thermometry is employed as the thermometry module.

20. 发明申请

US20140005521A1 CATHETER COMPRISING CAPACITIVE MICROMACHINED ULTRASONIC TRANSDUCERS WITH AN ADJUSTABLE FOCUS 有权
标题翻译：包含具有可调焦点的电容式微超声波超声波传感器的导管
公开(公告)号：US20140005521A1
公开(公告)日：2014-01-02
申请号：US13885791
申请日：2011-11-15
申请人： Max Oskar Köhler , Peter Dirksen , Shunmugavelu Sokka , Ronald Dekker
发明人： Max Oskar Köhler , Peter Dirksen , Shunmugavelu Sokka , Ronald Dekker
IPC分类号： A61N7/02 , A61B5/055 , A61B5/01 , A61B6/00 , A61B8/12 , A61B8/00 , A61B5/00 , A61B6/03
CPC分类号： A61B5/015 , A61B5/055 , A61B5/064 , A61B5/4836 , A61B6/03 , A61B6/12 , A61B6/4057 , A61B8/0841 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B8/54 , A61B8/58 , A61B2018/00023 , A61B2090/064 , A61B2090/374 , A61B2562/028 , A61N7/022 , A61N2007/0095 , B06B1/0292 , G06F19/00
摘要： A catheter (700, 800, 1206) comprising: a shaft with distal (808, 906, 1004, 208) and proximal ends (1006),wherein the distal end comprises at least one array of capacitive micromachined ultrasound transducers (308, 402, 404, 500, 512, 600, 604, 802, 008) with an adjustable focus for controllably heating a target zone (806, 1014, 1210); and a connector (1012) at the proximal end for supplying the at least one array of capacitive micromachined ultrasound transducers with electrical power and for controlling the adjustable focus.
摘要翻译：导管（700,800,1206）包括：具有远端（808,906,1004,208）和近端（1006）的轴，其中所述远端包括至少一个电容微加工超声换能器阵列（308,402，具有可调焦点，用于可控制地加热目标区域（806,104,1210）; 以及在所述近端处的用于向所述至少一个电容微加工超声换能器阵列供电并用于控制所述可调焦点的连接器（1012）。

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