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11. 发明申请

US20110125213A1 NON-INVASIVE TREATMENT OF BRONCHIAL CONSTRICTION 有权
标题翻译：非正式协商的协商处理
公开(公告)号：US20110125213A1
公开(公告)日：2011-05-26
申请号：US13018558
申请日：2011-02-01
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle , Steven Mendez
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle , Steven Mendez
IPC分类号： A61N1/36
CPC分类号： A61N2/002 , A61H23/00 , A61H23/004 , A61H23/02 , A61H23/0236 , A61H31/00 , A61H39/002 , A61H2201/123 , A61H2201/1604 , A61H2201/1609 , A61H2201/165 , A61N1/3601 , A61N1/36014 , A61N1/36114 , A61N1/3758 , A61N1/3787 , A61N1/40 , A61N2/006 , A61N2/02 , A61N5/0603 , A61N5/0622 , A61N5/0625 , A61N7/00 , A61N2005/0605 , A61N2005/063 , A61N2007/0026
摘要： Devices, systems and methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation. The transmitted energy impulses, comprising magnetic and/or electrical, mechanical and/or acoustic, and optical and/or thermal energy, stimulate the selected nerve fibers.
摘要翻译：公开了用于治疗与哮喘，过敏反应或慢性阻塞性肺疾病相关的支气管收缩的装置，系统和方法。该治疗包括将能量非侵入性的能量脉冲传递给负责平滑肌扩张的选定神经纤维。包括磁和/或电的机械和/或声学以及光学和/或热能的透射能量脉冲刺激所选择的神经纤维。

12. 发明授权

US09174045B2 Non-invasive electrical and magnetic nerve stimulators used to treat overactive bladder and urinary incontinence 有权
标题翻译：用于治疗膀胱过动症和尿失禁的非侵入式电磁神经刺激器
公开(公告)号：US09174045B2
公开(公告)日：2015-11-03
申请号：US13279437
申请日：2011-10-24
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/18 , A61N1/36 , A61N1/04 , A61N2/00
CPC分类号： A61N1/36007 , A61N1/0456 , A61N1/36014 , A61N2/006
摘要： Transcutaneous electrical and magnetic nerve stimulation devices and methods generate energy that is delivered noninvasively to selected nerve fibers within the patient to treat lower urinary tract disorders. The disorders comprise overactive bladder, urge incontinence, stress, incontinence, urge frequency, non-obstructive urinary retention and interstitial cystitis/painful bladder syndrome. In preferred embodiments, a posterior tibial nerve of a patient is stimulated non-invasively to treat bladder disorders.
摘要翻译：经皮电磁神经刺激装置和方法产生非侵入性地递送到患者内的选定神经纤维以治疗下尿路疾病的能量。这些疾病包括膀胱过度活动，急迫性尿失禁，压力，失禁，呼吸频率，非梗阻性尿潴留和间质性膀胱炎/疼痛膀胱综合征。在优选实施例中，患者的后胫骨神经被非侵入性地刺激以治疗膀胱疾病。

13. 发明申请

US20130238049A1 NON-INVASIVE VAGAL NERVE STIMULATION TO TREAT DISORDERS 有权
公开(公告)号：US20130238049A1
公开(公告)日：2013-09-12
申请号：US13603799
申请日：2012-09-05
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61B5/4836 , A61N1/36014 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.

14. 发明申请

US20130066392A1 NON-INVASIVE MAGNETIC OR ELECTRICAL NERVE STIMULATION TO TREAT OR PREVENT DEMENTIA 审中-公开
标题翻译：非侵入式磁刺激或电刺激治疗或预防感染
公开(公告)号：US20130066392A1
公开(公告)日：2013-03-14
申请号：US13671859
申请日：2012-11-08
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36 , A61N1/40
CPC分类号： A61N1/36053 , A61B5/0476 , A61B5/4082 , A61B5/4088 , A61B5/4094 , A61B5/4833 , A61B5/4836 , A61N1/36014 , A61N1/36025 , A61N1/40 , A61N2/006 , A61N2/02
摘要： Devices, systems and methods are disclosed for treating or preventing dementia, such as Alzheimer's disease. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve, that modulate the activity of a patient's locus ceruleus. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to cause the locus ceruleus to release norepinephrine into regions of the brain that contain beta-amyloids. The norepinephrine counteracts neuroinflammation that would damage neurons in those regions and the locus ceruleus, thereby arresting or slowing the progression of the disease in the patient.
摘要翻译：公开了用于治疗或预防痴呆的装置，系统和方法，例如阿尔茨海默病。所述方法包括将能量的脉冲非侵入性地传递到选择的神经纤维，特别是迷走神经中的神经纤维，这些神经纤维调节患者的基因座的活性。包括磁能和/或电能的透射能量脉冲刺激所选择的神经纤维，以使得斑马鱼将去甲肾上腺素释放到含有β-淀粉样蛋白的脑区域中。去甲肾上腺素抵消会损害那些区域和颈部神经元的神经炎症，从而阻止或减缓患者疾病进展。

15. 发明申请

US20120184801A1 NERVE STIMULATION METHODS FOR AVERTING IMMINENT ONSET OR EPISODE OF A DISEASE 审中-公开
标题翻译：用于平均静脉注射或感染疾病的神经刺激方法
公开(公告)号：US20120184801A1
公开(公告)日：2012-07-19
申请号：US13357025
申请日：2012-01-24
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36 , A61N2/04
CPC分类号： A61N1/36064 , A61N1/36014 , A61N1/36025 , A61N2/006
摘要： Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of averting imminent medical attacks using energy that is delivered noninvasively by the devices. In particular, the devices and methods involve handheld devices designed to stimulate the vagus nerve of a patient with a signal sufficient to minimize or avert epileptic seizures.
摘要翻译：公开了经皮电磁神经刺激装置，以及使用由装置非侵入性地传送的能量来避免即将发生的医疗攻击的方法。特别地，装置和方法涉及设计成以足以使癫痫发作最小化或避免的信号刺激患者的迷走神经的手持装置。

16. 发明授权

US10286212B2 Nerve stimulation methods for averting imminent onset or episode of a disease 有权
公开(公告)号：US10286212B2
公开(公告)日：2019-05-14
申请号：US13357025
申请日：2012-01-24
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36 , A61N2/00
摘要： Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of averting imminent medical attacks using energy that is delivered noninvasively by the devices. In particular, the devices and methods involve handheld devices designed to stimulate the vagus nerve of a patient with a signal sufficient to minimize or avert epileptic seizures.

17. 发明授权

US08874227B2 Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient 有权
标题翻译：用于非侵入性电容电刺激的装置和方法及其用于患者颈部的迷走神经刺激
公开(公告)号：US08874227B2
公开(公告)日：2014-10-28
申请号：US13183765
申请日：2011-07-15
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/00 , A61N1/40
CPC分类号： A61N1/36021 , A61M21/00 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61N1/0456 , A61N1/0496 , A61N1/36014 , A61N1/36025 , A61N1/36053 , A61N1/40
摘要： A non-invasive electrical stimulator shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in contact with the electrodes. The conducting medium is also in contact with an interface element that may conform to the contour of a target body surface of the patient when the interface element is applied to that surface. When the interface element is made of insulating (dielectric) material, and disclosed stimulation waveforms are used, the power source need not supply high voltage, in order to capacitively stimulate the target nerve. The stimulator is configured to produce a peak pulse that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie in the vicinity of the target nerve and patient's skin.
摘要翻译：非侵入式电刺激器形成可以平行于长神经（例如患者颈部的迷走神经）定向的细长电场，在患者体内产生所需的生理反应。刺激器包括电源，至少一个电极和与电极接触的连续导电介质。当将界面元件应用于该表面时，导电介质也与接口元件接触，该界面元件可以符合患者的目标体表的轮廓。当界面元件由绝缘（电介质）材料制成并且使用公开的刺激波形时，电源不需要提供高电压，以便电容地刺激目标神经。刺激器被配置为产生峰值脉冲，其足以在目标神经附近产生生理上有效的电场，但是不能基本上刺激位于目标神经和患者皮肤附近的其它神经和肌肉。

18. 发明授权

US08840537B2 Non-invasive treatment of bronchial constriction 有权
标题翻译：非侵入性治疗支气管收缩
公开(公告)号：US08840537B2
公开(公告)日：2014-09-23
申请号：US13018558
申请日：2011-02-01
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle , Steven Mendez
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle , Steven Mendez
IPC分类号： A61N2/02 , A61N5/06 , A61N2/00 , A61H31/00 , A61N1/40 , A61H39/00 , A61H23/00 , A61H23/02 , A61N7/00 , A61N1/36
CPC分类号： A61N2/002 , A61H23/00 , A61H23/004 , A61H23/02 , A61H23/0236 , A61H31/00 , A61H39/002 , A61H2201/123 , A61H2201/1604 , A61H2201/1609 , A61H2201/165 , A61N1/3601 , A61N1/36014 , A61N1/36114 , A61N1/3758 , A61N1/3787 , A61N1/40 , A61N2/006 , A61N2/02 , A61N5/0603 , A61N5/0622 , A61N5/0625 , A61N7/00 , A61N2005/0605 , A61N2005/063 , A61N2007/0026
摘要： Devices, systems and methods for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease include non-invasive nerve stimulators. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation. The transmitted energy impulses, comprising magnetic and/or electrical, mechanical and/or acoustic, and optical and/or thermal energy, stimulate the selected nerve fibers.
摘要翻译：用于治疗与哮喘，过敏反应或慢性阻塞性肺疾病相关的支气管收缩的装置，系统和方法包括非侵入性神经刺激剂。该治疗包括将能量非侵入性的能量脉冲传递给负责平滑肌扩张的选定神经纤维。包括磁和/或电的机械和/或声学以及光学和/或热能的透射能量脉冲刺激所选择的神经纤维。

19. 发明授权

US08676324B2 Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders 有权
标题翻译：用于治疗偏头痛/窦性头痛，鼻炎，鼻窦炎，鼻鼻窦炎和合并症的电磁刺激剂
公开(公告)号：US08676324B2
公开(公告)日：2014-03-18
申请号：US13183721
申请日：2011-07-15
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/40
CPC分类号： A61N2/006 , A61N1/36021 , A61N1/40 , A61N2/008 , A61N2/02
摘要： Transcutaneous electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including nasal or paranasal sinus symptoms that resemble an immune-mediated response (“sinus” headaches). The devices and methods may also be used to treat rhinitis, sinusitis, or rhinosinusitis, irrespective of whether those disorders are co-morbid with a headache. They may also be used to treat other disorders that may be co-morbid with migraine or cluster headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.
摘要翻译：公开了经皮电神经刺激装置和磁刺激装置，以及使用通过这种装置非侵入地输送的能量来治疗医学病症的方法。这些疾病包括偏头痛和其他原发性头痛，例如丛集性头痛，包括类似于免疫介导的反应（“窦”头痛）的鼻或鼻旁窦症状。装置和方法也可用于治疗鼻炎，鼻窦炎或鼻鼻窦炎，而不管这些疾病是否与头痛并发症。它们也可用于治疗可能与偏头痛或丛集性头痛如焦虑症共病的其他疾病。在所公开的方法的优选实施例中，患者的迷走神经中的一个或两个被非侵入性地刺激。在其它实施方案中，刺激部分交感神经系统和/或肾上腺。

20. 发明申请

US20130245712A1 NON-INVASIVE VAGAL NERVE STIMULATION TO TREAT DISORDERS 有权
公开(公告)号：US20130245712A1
公开(公告)日：2013-09-19
申请号：US13603810
申请日：2012-09-05
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61B5/08 , A61B5/082 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Devices, systems and methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis, chronic obstructive pulmonary disease (COPD), exercise-induced bronchospasm and post-operative bronchospasm. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that activate neural pathways to reduce the release of acetycholine from airway-related vagal preganglionic neurons within the brain of the patient. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to produce the bronchodilation.

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