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11. 发明申请

US20090171416A1 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 有权
标题翻译：影响患者神经功能变化的方法和装置
公开(公告)号：US20090171416A1
公开(公告)日：2009-07-02
申请号：US12343454
申请日：2008-12-23
申请人： Andrew D. Firlik , Jeffrey Balzer , Alan J. Levy , Bradford Evan Gliner , Katrina S. Firlik
发明人： Andrew D. Firlik , Jeffrey Balzer , Alan J. Levy , Bradford Evan Gliner , Katrina S. Firlik
IPC分类号： A61N1/18
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/08 , A61N1/36021 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.
摘要翻译：用于治疗患者脑部受损的神经功能的方法和装置。在一个实施方案中，用于治疗患者脑部神经功能的方法包括确定要执行多个治疗期间以恢复与神经功能相对应的功能能力的治疗期。该方法通过识别与神经功能相关联的患者的脑中或其上的刺激部位，并且将电极定位至少接近所识别的刺激部位来继续。然后通过向刺激部位提供电刺激治疗来治疗患者。治疗可以包括在治疗期间向电极传送电刺激信号。在治疗期满后，该方法包括防止电刺激信号传递到刺激部位。

12. 发明申请

US20080215112A1 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
公开(公告)号：US20080215112A1
公开(公告)日：2008-09-04
申请号：US11834638
申请日：2007-08-06
申请人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
发明人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

13. 发明申请

US20080161880A1 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
公开(公告)号：US20080161880A1
公开(公告)日：2008-07-03
申请号：US11834642
申请日：2007-08-06
申请人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
发明人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
IPC分类号： A61N1/362
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

14. 发明申请

US20080161879A1 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
公开(公告)号：US20080161879A1
公开(公告)日：2008-07-03
申请号：US11834621
申请日：2007-08-06
申请人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
发明人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
IPC分类号： A61B1/05
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

15. 发明授权

US08050768B2 Methods and apparatus for effectuating a change in a neural-function of a patient 有权
标题翻译：用于实现患者神经功能变化的方法和装置
公开(公告)号：US08050768B2
公开(公告)日：2011-11-01
申请号：US12343427
申请日：2008-12-23
申请人： Andrew D. Firlik , Bradford Evan Gliner , Alan J. Levy , Katrina S. Firlik
发明人： Andrew D. Firlik , Bradford Evan Gliner , Alan J. Levy , Katrina S. Firlik
IPC分类号： A61N1/00
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36014 , A61N1/36025 , A61N1/36082 , A61N1/375 , A61N1/3756
摘要： The present disclosure is directed generally to methods and apparatus for effectuating a change in a neural function of a patient. A method in accordance with a particular embodiment includes implanting an electrode at a cortical stimulation site selected to promote recovery of the affected neural-function, with the cortical stimulation site being at least proximate to the cortex. The method can further include estimating a threshold for the specific patient at which an electrical signal delivered via the implanted electrode directly triggers a neural reaction associated with the stimulation site in response to the delivered electrical signal, and electrically stimulating the cortical stimulation site by passing an electrical current through the electrode.
摘要翻译：本公开一般涉及用于实现患者的神经功能变化的方法和装置。根据特定实施例的方法包括将电极植入皮质刺激部位，所述皮质刺激位置被选择以促进受影响的神经功能的恢复，皮层刺激部位至少接近皮层。该方法还可以包括估计特定患者的阈值，在该阈值处，经由植入的电极传送的电信号响应于所输送的电信号而直接触发与刺激部位相关的神经反应，并通过传递电刺激部位电刺激皮质刺激部位电流通过电极。

16. 发明申请

US20100131030A1 METHODS AND APPARATUS FOR EFFECTUATING A CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
标题翻译：影响患者神经功能改变的方法和装置
公开(公告)号：US20100131030A1
公开(公告)日：2010-05-27
申请号：US12698409
申请日：2010-02-02
申请人： Andrew D. Firlik , Bradford Evan Gliner , Alan J. Levy , Katrina S. Firlik
发明人： Andrew D. Firlik , Bradford Evan Gliner , Alan J. Levy , Katrina S. Firlik
IPC分类号： A61N1/36
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36014 , A61N1/36025 , A61N1/36082 , A61N1/375 , A61N1/3756
摘要： The present disclosure is directed generally to methods and apparatus for effectuating a change in a neural function of a patient. A method in accordance with a particular embodiment includes implanting an electrode at a cortical stimulation site selected to promote recovery of the affected neural-function, with the cortical stimulation site being at least proximate to the cortex. The method can further include estimating a threshold for the specific patient at which an electrical signal delivered via the implanted electrode directly triggers a neural reaction associated with the stimulation site in response to the delivered electrical signal, and electrically stimulating the cortical stimulation site by Passing an electrical current through the electrode.
摘要翻译：本公开一般涉及用于实现患者的神经功能变化的方法和装置。根据特定实施例的方法包括将电极植入皮质刺激部位，所述皮质刺激位置被选择以促进受影响的神经功能的恢复，皮层刺激部位至少接近皮层。该方法还可以包括估计特定患者的阈值，在该阈值处，经由植入的电极传送的电信号响应于所输送的电信号直接触发与刺激部位相关联的神经反应，并通过传递电刺激皮质刺激部位电流通过电极。

17. 发明申请

US20090319000A1 METHODS AND APPARATUS FOR EFFECTUATING A CHANGE IN A NEURAL-FUNCTION OF A PATIENT 有权
标题翻译：影响患者神经功能改变的方法和装置
公开(公告)号：US20090319000A1
公开(公告)日：2009-12-24
申请号：US12343427
申请日：2008-12-23
申请人： Andrew D. Firlik , Bradford Evan Gliner , Alan J. Levy , Katrina S. Firlik
发明人： Andrew D. Firlik , Bradford Evan Gliner , Alan J. Levy , Katrina S. Firlik
IPC分类号： A61N1/05
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36014 , A61N1/36025 , A61N1/36082 , A61N1/375 , A61N1/3756
摘要： The present disclosure is directed generally to methods and apparatus for effectuating a change in a neural function of a patient. A method in accordance with a particular embodiment includes implanting an electrode at a cortical stimulation site selected to promote recovery of the affected neural-function, with the cortical stimulation site being at least proximate to the cortex. The method can further include estimating a threshold for the specific patient at which an electrical signal delivered via the implanted electrode directly triggers a neural reaction associated with the stimulation site in response to the delivered electrical signal, and electrically stimulating the cortical stimulation site by Passing an electrical current through the electrode.
摘要翻译：本公开一般涉及用于实现患者的神经功能变化的方法和装置。根据特定实施例的方法包括将电极植入皮质刺激部位，所述皮质刺激位置被选择以促进受影响的神经功能的恢复，皮层刺激部位至少接近皮层。该方法还可以包括估计特定患者的阈值，在该阈值处，经由植入的电极传送的电信号响应于所输送的电信号直接触发与刺激部位相关联的神经反应，并通过传递电刺激皮质刺激部位电流通过电极。

18. 发明授权

US07945330B2 Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators 有权
标题翻译：用于自动优化神经刺激器的刺激参数和电极配置的系统和方法
公开(公告)号：US07945330B2
公开(公告)日：2011-05-17
申请号：US12244610
申请日：2008-10-02
申请人： Bradford Evan Gliner , Jeffrey Balzer , Andrew D. Firlik
发明人： Bradford Evan Gliner , Jeffrey Balzer , Andrew D. Firlik
IPC分类号： A61N1/36
CPC分类号： A61N1/36021 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/0553 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36185 , A61N1/375 , A61N1/3756 , G06F19/00
摘要： Methods and devices for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient. In one embodiment, a system includes an electrode array having an implantable support member configured to be implanted into a patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller operatively, coupled to the pulse system and to the sensing device. The controller includes a computer operable medium that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.
摘要翻译：用于自动优化刺激参数和/或电极配置以向患者提供神经刺激的方法和装置。在一个实施例中，系统包括电极阵列，其具有被配置为植入病人的可植入支撑构件和由支撑构件承载的多个治疗电极。系统还可以具有可操作地耦合到治疗电极的脉冲系统以将刺激传递到治疗电极，以及被配置为附接到患者的感测位置的感测装置。感测装置响应于刺激产生响应信号。该系统还可以包括可操作地耦合到脉冲系统和感测装置的控制器。控制器包括计算机可操作介质，其产生定义由脉冲系统传递的刺激的命令信号，评估来自感测装置的响应信号，并且确定用于治疗电极的期望配置和/或期望的刺激以被传送到治疗电极。

19. 发明授权

US07305268B2 Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators 有权
标题翻译：用于自动优化神经刺激器的刺激参数和电极配置的系统和方法
公开(公告)号：US07305268B2
公开(公告)日：2007-12-04
申请号：US09978134
申请日：2001-10-15
申请人： Bradford Evan Gliner , Jeffrey Balzer , Andrew D. Firlik
发明人： Bradford Evan Gliner , Jeffrey Balzer , Andrew D. Firlik
IPC分类号： A61N1/18
CPC分类号： A61N1/36021 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/0553 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36185 , A61N1/375 , A61N1/3756 , G06F19/00
摘要： Methods and devices for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient. In one embodiment, a system includes an electrode array having an implantable support member configured to be implanted into a patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller operatively coupled to the pulse system and to the sensing device. The controller includes a computer operable medium that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.
摘要翻译：用于自动优化刺激参数和/或电极配置以向患者提供神经刺激的方法和装置。在一个实施例中，系统包括电极阵列，其具有被配置为植入病人的可植入支撑构件和由支撑构件承载的多个治疗电极。系统还可以具有可操作地耦合到治疗电极的脉冲系统以将刺激传递到治疗电极，以及被配置为附接到患者的感测位置的感测装置。感测装置响应于刺激产生响应信号。该系统还可以包括可操作地耦合到脉冲系统和感测装置的控制器。控制器包括计算机可操作介质，其产生定义由脉冲系统传递的刺激的命令信号，评估来自感测装置的响应信号，并且确定用于治疗电极的期望配置和/或期望的刺激以被传送到治疗电极。

20. 发明授权

US07236831B2 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 有权
标题翻译：用于实现患者神经功能持续变化的方法和装置
公开(公告)号：US07236831B2
公开(公告)日：2007-06-26
申请号：US10410526
申请日：2003-04-08
申请人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner
发明人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner
IPC分类号： A61N1/00
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36014 , A61N1/36025 , A61N1/36082 , A61N1/361 , A61N1/375 , A61N1/3756
摘要： The present disclosure suggests methods of selecting a stimulation site for stimulating a patient's brain or methods of effectuating a neural-function of a patient associated with an impaired body function. In one exemplary implementation, such a neural function may be effectuated by selecting a stimulation site, positioning at least a first electrode at the stimulation site, and applying an electrical potential to pass a current through the first electrode. If one aspect, this stimulation site may be selected by a) identifying a second body function that is a corollary to the impaired body function, and b) determining a corollary location of the patient's brain that is associated with the second body function and is ipsilateral to the impaired body function.
摘要翻译：本公开内容提出了选择用于刺激患者的大脑的刺激部位的方法或者与受损的身体功能相关联的患者的神经功能的方法。在一个示例性实施方案中，可以通过选择刺激部位，在刺激部位定位至少第一电极，以及施加电势以使电流通过第一电极来实现这样的神经功能。在一个方面，该刺激部位可以通过以下方式来选择：a）识别作为受损身体功能的必然结果的第二身体功能，以及b）确定与第二身体功能相关并且是同侧的患者的大脑的推论位置对身体功能受损。

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