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11. 发明申请

US20060264752A1 Electroporation controlled with real time imaging 审中-公开
标题翻译：电穿孔用实时成像控制
公开(公告)号：US20060264752A1
公开(公告)日：2006-11-23
申请号：US11375600
申请日：2006-03-13
申请人： Boris Rubinsky , Paul Mikus , Gary Onik
发明人： Boris Rubinsky , Paul Mikus , Gary Onik
IPC分类号： A61B8/00
CPC分类号： A61B18/1477 , A61B5/0536 , A61B8/0833 , A61B8/4416 , A61B2018/00577 , A61B2018/00613 , A61B2018/00755 , A61B2018/00875 , A61N1/0412 , A61N1/327
摘要： A method and a system for producing the method are disclosed whereby irreversible electroporation pulses are produced across an area of target tissue. A medical imaging device is used to create an image of the irreversible electroporation in real time thereby making it possible to determine the area of electroporation and the extent of results obtained and to adjust the positioning of electrodes and/or the current as needed based on the image being viewed.
摘要翻译：公开了一种用于制造该方法的方法和系统，由此在目标组织的区域上产生不可逆电穿孔脉冲。使用医学成像装置实时产生不可逆电穿孔的图像，从而使得可以确定电穿孔的面积和获得的结果的程度，并根据需要调整电极和/或电流的定位正在查看的图片

12. 发明授权

US5752519A Device and method for detection, localization, and characterization of inhomogeneities in turbid media 失效
标题翻译：用于检测，定位和表征混浊介质中不均匀性的装置和方法
公开(公告)号：US5752519A
公开(公告)日：1998-05-19
申请号：US725239
申请日：1996-10-04
申请人： David A. Benaron , Boris Rubinsky
发明人： David A. Benaron , Boris Rubinsky
IPC分类号： A61B5/00 , A61B17/00 , A61B17/068 , A61B18/00 , A61B18/14 , G01N21/47 , A61B6/00
CPC分类号： A61B5/6848 , A61B18/00 , A61B5/0075 , A61B5/0084 , A61B5/14553 , G01N21/4795 , A61B17/068 , A61B18/14 , A61B2017/00022 , A61B2017/00123 , A61B2017/00508 , A61B2017/00557 , A61B2560/0276 , A61B2562/0242 , A61B2562/08 , A61B5/0073
摘要： The present invention provides a detection or imaging device and method that measures an effect upon the path traveled by a radiative wave through a medium where scattering of the radiative wave is strong, and uses this measured path effect to detect, localize, or characterize inhomogeneities in the medium, as well as of the medium itself, over time or space. In this embodiment, a radiative source (43), temporally modulated or intensity quantitated, is emitted into the medium (47). A detector (48) records radiative effects detected after travel through said medium, and the detected signal is measured for a path effect (45). Based upon one or more of these path effects, such as the distance the latest arriving photons have traveled, a quantifiable parameter of the medium is determined (49). This parameter can be the location, distance, speed, or other characteristic of the medium or inhomogeneity. Measurement over space provides additional information as to spatial distribution; measurement over time provides information as to temporal changes in the medium. The device has application in medical and industrial imaging, detection, and localization of objects and other inhomogeneities, as well as characterization of the medium itself, in media which highly scatters radiative waves emitted into the medium.
摘要翻译：本发明提供了一种检测或成像装置和方法，其测量对辐射波通过辐射波散射强的介质对路径的影响，并使用该测量的路径效应来检测，定位或表征不均匀性媒介以及媒体本身，随着时间或空间。在该实施例中，将经时间调制或强度定量的辐射源（43）发射到介质（47）中。检测器（48）记录在行进通过所述介质之后检测到的辐射效应，并且测量检测到的信号的路径效应（45）。基于这些路径效应中的一个或多个，例如最近到达的光子已经行进的距离，确定介质的可量化参数（49）。该参数可以是介质的位置，距离，速度或其他特性或不均匀性。空间测量提供了关于空间分布的更多信息; 时间的测量提供关于介质中的时间变化的信息。该装置在医疗和工业成像，物体和其他不均匀性的检测和定位以及介质本身的表征中的应用，在高度散射辐射到介质中的辐射波的介质中。

13. 发明授权

US5433717A Magnetic resonance imaging assisted cryosurgery 失效
标题翻译：磁共振成像辅助冷冻手术
公开(公告)号：US5433717A
公开(公告)日：1995-07-18
申请号：US35455
申请日：1993-03-23
申请人： Boris Rubinsky , John Gilbert , Sam Wong , Mark Roos , Grant Pease
发明人： Boris Rubinsky , John Gilbert , Sam Wong , Mark Roos , Grant Pease
IPC分类号： A61B18/02 , A61B19/00 , G01R33/28 , G01R33/561 , A61B17/36
CPC分类号： A61B18/02 , G01R33/28 , A61B2018/0262 , A61B2090/374 , A61B90/10 , G01R33/56308
摘要： Methods and apparatus for magnetic resonance imaging (MRI) assisted cryosurgery. Optimal probe placements and cooling parameters are calculated prior to cryosurgery using MRI data. A MRI compatible cryoprobe and a stereotactic probe positioning device are provided. The resolution of MR images is enhanced by mounting a radio frequency MR coil on the intracorporeal end of a cryoprobe. During cryosurgery the temperature distribution in the frozen region is solved by determining the boundary of the frozen region and solving the heat equation for the known boundary conditions. During cryosurgery the temperature distribution in the unfrozen region is determined by T1 measurements. The process of freezing is controled using information from the solution of the energy equation in the frozen region and temperature measurements in the unfrozen region. After cryosurgery the extent of the tissue damage may be ascertained using phosphorus-31 and/or sodium-23 spectroscopy with a special coil set on the cryosurgical probe.
摘要翻译：磁共振成像（MRI）辅助冷冻手术的方法和装置。在使用MRI数据进行冷冻手术之前计算最佳探针放置和冷却参数。提供MRI兼容的冷冻探针和立体定向探针定位装置。通过将射频MR线圈安装在冷冻探针的体内末端来增强MR图像的分辨率。在冷冻手术中，通过确定冻结区域的边界并求解已知边界条件的热方程来解决冻结区域的温度分布。在冷冻手术中，未冻结区域的温度分布由T1测量确定。使用冷冻区域的能量方程和未冻结区域的温度测量解的信息来控制冷冻过程。在冷冻手术之后，可以使用在冷冻手术探针上设置的特殊线圈的磷-31和/或钠-23光谱来确定组织损伤的程度。

14. 发明授权

US5358931A Interaction of thermal hysteresis proteins with cells and cell membranes and associated applications 失效
标题翻译：热滞后蛋白与细胞和细胞膜的相互作用及相关应用
公开(公告)号：US5358931A
公开(公告)日：1994-10-25
申请号：US4919
申请日：1993-01-15
申请人： Boris Rubinsky , Arthur L. Devries , Amir Arav
发明人： Boris Rubinsky , Arthur L. Devries , Amir Arav
IPC分类号： A01N1/02 , A61K47/48 , C07K14/46 , A61K37/00 , A61K37/10
CPC分类号： A01N1/02 , A01N1/0221 , A61K47/48 , C07K14/461
摘要： A newly discovered property of thermal hysteresis proteins is the interaction of these proteins with cell membranes and thus with cells themselves, protecting cells and their membranes from damage which they would otherwise suffer upon exposure to non-physiological conditions such as temperature abnormalities, including both hyperthermic, hypothermic and sub-freezing temperatures. Improved rates of cell viability are observed over a wide range of conditions which do not involve ice formation, including temperatures above the freezing range as well as temperatures below the freezing range but in vitrification conditions. Heretofore the only known property of these proteins was their ability to interact with ice crystals. In conditions in which ice crystals are formed, it is further discovered that use of the proteins with human cells at the concentrations in which they naturally occur in the source organisms results in aggravating the injury to the cells rather than reducing it, but that the injury is lessened, and the survival rate improved, by using low concentrations. The proteins thus offer benefits in the preservation and improved viability of cell suspensions, tissues and whole organs. The proteins are further discovered to have the ability to block ion channels in mammalian cell membranes, thereby providing a further utility in the treatment of disease conditions.
摘要翻译：新发现的热滞后蛋白质是这些蛋白质与细胞膜的相互作用，因此与细胞本身相互作用，保护细胞和它们的膜免受其它暴露于非生理条件（如温度异常），低温和低温温度。在不涉及冰形成的宽范围条件下观察到细胞存活率的改善，包括高于冷冻范围的温度以及低于冰点范围的温度，但在玻璃化条件下。迄今为止，这些蛋白质唯一已知的性质是它们与冰晶相互作用的能力。在形成冰晶的条件下，进一步发现，使用蛋白质与人类细胞以其天然存在于源生物体中的浓度导致加重对细胞的损伤而不是降低细胞损伤，但是损伤通过使用低浓度降低生存率。因此，蛋白质在细胞悬浮液，组织和整个器官的保存和改善的活力方面提供益处。进一步发现蛋白质具有阻止哺乳动物细胞膜中的离子通道的能力，从而提供治疗疾病状况的另外的效用。

15. 发明授权

US08348921B2 Gels with predetermined conductivity used in electroporation of tissue 有权
标题翻译：具有预定电导率的凝胶用于组织电穿孔
公开(公告)号：US08348921B2
公开(公告)日：2013-01-08
申请号：US13427027
申请日：2012-03-22
申请人： Antoni Ivorra , Boris Rubinsky
发明人： Antoni Ivorra , Boris Rubinsky
IPC分类号： A61M31/00
CPC分类号： A61K9/0009 , A61K9/0024 , A61M5/329 , A61N1/042 , A61N1/327
摘要： Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.
摘要翻译：公开了具有调节的电导率的凝胶组合物，其组合物用于引导细胞和组织的可逆电穿孔和不可逆电穿孔。凝胶组合物也以类似的方式使用，以对细胞和组织进行热疗。

16. 发明申请

US20120146621A1 VOLUMETRIC INDUCTION PHASE SHIFT DETECTION SYSTEM FOR DETERMINING TISSUE WATER CONTENT PROPERTIES 有权
标题翻译：用于确定组织水含量特性的体积感应相位移动检测系统
公开(公告)号：US20120146621A1
公开(公告)日：2012-06-14
申请号：US13329080
申请日：2011-12-16
申请人： Boris Rubinsky , Cesar A. Gonzalez
发明人： Boris Rubinsky , Cesar A. Gonzalez
IPC分类号： G01R25/00
CPC分类号： A61B5/0537 , A61B5/02042 , A61B5/0205 , A61B5/05 , A61B5/053 , A61B5/4064 , A61B5/413 , A61B5/4244 , A61B5/443 , A61B5/4519 , A61B5/4869 , A61B5/4878 , A61B5/7225 , A61B5/7228 , A61B5/725 , A61B2562/143 , G01N27/026 , G01R33/34 , G01R33/36 , G01R33/4828 , G01R33/483
摘要： A method and apparatus of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample.
摘要翻译：通过以下步骤确定体组织样本的状况的方法和装置：将体组织样本定位在一对感应线圈（或天线）之间; 通过感应线圈（或天线）中的第一个通过交流（或电压）的频谱; 测量第二个感应线圈（或天线）中产生的交流（或电压）的频谱; 以及比较第一和第二感应线圈（或天线）中的交流电流（或电压）的频谱之间的相移，由此确定本体组织样本的状况。

17. 发明申请

US20110217730A1 SYSTEMS AND METHODS FOR ANALYZING AND MANIPULATING BIOLOGICAL SAMPLES 审中-公开
标题翻译：用于分析和处理生物样品的系统和方法
公开(公告)号：US20110217730A1
公开(公告)日：2011-09-08
申请号：US13108038
申请日：2011-05-16
申请人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
发明人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
IPC分类号： C12Q1/04 , C12M1/42
CPC分类号： C12Q1/04 , G01N15/1031 , G01N27/745 , G01N2015/1006 , G01N2015/1081
摘要： A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the cell and a sensor for qualifying and/or quantifying an effect of the magnetic field on the cell.
摘要翻译：提供了用磁性或可磁化部分标记的细胞样品的细胞鉴定系统。该系统包括用于保持单元的单元的单元样本保持器和包括用于向单元施加磁场的磁场源的第一单元分析器和用于限定和/或量化磁场对磁场的影响的传感器细胞。

18. 发明授权

US07718409B2 Controlled electroporation and mass transfer across cell membranes 有权
标题翻译：受控的电穿孔和跨细胞膜的传质
公开(公告)号：US07718409B2
公开(公告)日：2010-05-18
申请号：US11340176
申请日：2006-01-25
申请人： Boris Rubinsky , Yong Huang
发明人： Boris Rubinsky , Yong Huang
IPC分类号： C12N13/00 , C12N15/01 , C12N15/87
CPC分类号： G01N33/48728 , C12M35/02 , C12N15/87
摘要： Electroporation is performed in a controlled manner in either individual or multiple biological cells or biological tissue by monitoring the electrical impedance, defined herein as the ratio of current to voltage in the electroporation cell. The impedance detects the onset of electroporation in the biological cell(s), and this information is used to control the intensity and duration of the voltage to assure that electroporation has occurred without destroying the cell(s). This is applicable to electroporation in general. In addition, a particular method and apparatus are disclosed in which electroporation and/or mass transfer across a cell membrane are accomplished by securing a cell across an opening in a barrier between two chambers such that the cell closes the opening. The barrier is either electrically insulating, impermeable to the solute, or both, depending on whether pore formation, diffusive transport of the solute across the membrane, or both are sought. Electroporation is achieved by applying a voltage between the two chambers, and diffusive transport is achieved either by a difference in solute concentration between the liquids surrounding the cell and the cell interior or by a differential in concentration between the two chambers themselves. Electric current and diffusive transport are restricted to a flow path that passes through the opening.
摘要翻译：通过监测电气阻抗（以本文定义为电穿孔细胞中的电流与电压之比），以受控的方式在单个或多个生物细胞或生物组织中进行电穿孔。阻抗检测生物细胞中电穿孔的发生，并且该信息用于控制电压的强度和持续时间，以确保电穿孔已经发生而不破坏细胞。这适用于一般的电穿孔。此外，公开了一种特定的方法和装置，其中穿过细胞膜的电穿孔和/或质量传递通过将细胞固定在两个室之间的屏障中的开口上而使细胞封闭开口来实现。屏障是电绝缘的，不溶于溶质的，或两者都是，这取决于是否需要孔形成，溶质在膜上的扩散传输或两者。通过在两个室之间施加电压来实现电穿孔，并且通过围绕电池和电池内部的液体之间的溶质浓度差或通过两个室本身之间的浓度差来实现扩散输送。电流和漫射传输限于通过开口的流路。

19. 发明申请

US20080132885A1 Methods for treating tissue sites using electroporation 审中-公开
标题翻译：使用电穿孔处理组织部位的方法
公开(公告)号：US20080132885A1
公开(公告)日：2008-06-05
申请号：US11945781
申请日：2007-11-27
申请人： Boris Rubinsky , Gary Onik , Paul Mikus
发明人： Boris Rubinsky , Gary Onik , Paul Mikus
IPC分类号： A61B18/12
CPC分类号： A61N1/327 , A61B5/0536 , A61B5/055 , A61B8/13 , A61B18/1206 , A61B18/1477 , A61B90/37 , A61B2018/00702 , A61B2018/00875 , A61N1/0512
摘要： Methods for treating a tissue site. Introducing at least first and second mono-polar electrodes to a tissue site of the patient. Positioning the at least first and second mono-polar electrodes at or near the tissue site. Applying an electric field in a controlled manner to the tissue site in an amount sufficient to produce electroporation of cells at the tissue site and below an amount that causes thermal damage to a majority of the tissue site.
摘要翻译：治疗组织部位的方法将至少第一和第二单极电极引入患者的组织部位。将至少第一和第二单极极放置在组织部位处或附近。以足以在组织部位产生细胞电穿孔并且低于对大部分组织部位造成热损伤的量的量以受控的方式将电场施加到组织部位。

20. 发明申请

US20080132884A1 Systems for treating tissue sites using electroporation 审中-公开
标题翻译：使用电穿孔处理组织部位的系统
公开(公告)号：US20080132884A1
公开(公告)日：2008-06-05
申请号：US11945772
申请日：2007-11-27
申请人： Boris Rubinsky , Gary Onik , Paul Mikus
发明人： Boris Rubinsky , Gary Onik , Paul Mikus
IPC分类号： A61B18/12
CPC分类号： A61B18/1477 , A61B2018/00577 , A61B2018/00613 , A61B2018/143 , A61N1/327
摘要： A systems for treating a tissue site. At least first and second mono-polar electrodes are configured to be introduced at or near a tissue site of the patient. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply sufficient electrical pulses between the first and second mono-polar electrodes to induce electroporation of cells in the tissue site, to create necrosis of cells of the tissue site, but insufficient to create a thermal damaging effect to a majority of the tissue site.
摘要翻译：用于治疗组织部位的系统。至少第一和第二单极电极被配置为在患者的组织部位处或附近引入。电压脉冲发生器耦合到第一和第二单极电极。电压脉冲发生器被配置为在第一和第二单极电极之间施加足够的电脉冲以诱导组织部位中的细胞的电穿孔，以产生组织部位的细胞的坏死，但不足以对其产生热损伤作用大部分组织部位。

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