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1. 发明授权

US5433717A Magnetic resonance imaging assisted cryosurgery 失效
标题翻译：磁共振成像辅助冷冻手术
公开(公告)号：US5433717A
公开(公告)日：1995-07-18
申请号：US35455
申请日：1993-03-23
申请人： Boris Rubinsky , John Gilbert , Sam Wong , Mark Roos , Grant Pease
发明人： Boris Rubinsky , John Gilbert , Sam Wong , Mark Roos , Grant Pease
IPC分类号： A61B18/02 , A61B19/00 , G01R33/28 , G01R33/561 , A61B17/36
CPC分类号： A61B18/02 , G01R33/28 , A61B2018/0262 , A61B2090/374 , A61B90/10 , G01R33/56308
摘要： Methods and apparatus for magnetic resonance imaging (MRI) assisted cryosurgery. Optimal probe placements and cooling parameters are calculated prior to cryosurgery using MRI data. A MRI compatible cryoprobe and a stereotactic probe positioning device are provided. The resolution of MR images is enhanced by mounting a radio frequency MR coil on the intracorporeal end of a cryoprobe. During cryosurgery the temperature distribution in the frozen region is solved by determining the boundary of the frozen region and solving the heat equation for the known boundary conditions. During cryosurgery the temperature distribution in the unfrozen region is determined by T1 measurements. The process of freezing is controled using information from the solution of the energy equation in the frozen region and temperature measurements in the unfrozen region. After cryosurgery the extent of the tissue damage may be ascertained using phosphorus-31 and/or sodium-23 spectroscopy with a special coil set on the cryosurgical probe.
摘要翻译：磁共振成像（MRI）辅助冷冻手术的方法和装置。在使用MRI数据进行冷冻手术之前计算最佳探针放置和冷却参数。提供MRI兼容的冷冻探针和立体定向探针定位装置。通过将射频MR线圈安装在冷冻探针的体内末端来增强MR图像的分辨率。在冷冻手术中，通过确定冻结区域的边界并求解已知边界条件的热方程来解决冻结区域的温度分布。在冷冻手术中，未冻结区域的温度分布由T1测量确定。使用冷冻区域的能量方程和未冻结区域的温度测量解的信息来控制冷冻过程。在冷冻手术之后，可以使用在冷冻手术探针上设置的特殊线圈的磷-31和/或钠-23光谱来确定组织损伤的程度。

2. 外观设计

USD677169S1 Bottle 有权
公开(公告)号：USD677169S1
公开(公告)日：2013-03-05
申请号：US29398507
申请日：2011-08-01
申请人： Mark Roos , Pieter Jelle Braaksma , John Comitis , Leo Noppen
设计人： Mark Roos , Pieter Jelle Braaksma , John Comitis , Leo Noppen

3. 发明授权

US5706810A Magnetic resonance imaging assisted cryosurgery 失效
标题翻译：磁共振成像辅助冷冻手术
公开(公告)号：US5706810A
公开(公告)日：1998-01-13
申请号：US461253
申请日：1995-06-02
申请人： Boris Rubinsky , John Gilbert , San Wong , Mark Roos , Grant Pease
发明人： Boris Rubinsky , John Gilbert , San Wong , Mark Roos , Grant Pease
IPC分类号： A61B18/02 , A61B19/00 , G01R33/28 , G01R33/561 , A61B5/055
CPC分类号： A61B18/02 , G01R33/28 , A61B2018/0262 , A61B2090/374 , A61B90/10 , G01R33/56308
摘要： Methods and apparatus for magnetic resonance imaging (MRI) assisted cryosurgery. Optimal probe placements and cooling parameters are calculated prior to cryosurgery using MRI data. A MRI compatible cryoprobe and a stereotactic probe positioning device are provided. The resolution of MR images is enhanced by mounting a radio frequency MR coil on the intracorporeal end of a cryoprobe. During cryosurgery the temperature distribution in the frozen region is solved by determining the boundary of the frozen region and solving the heat equation for the known boundary conditions. During cryosurgery the temperature distribution in the unfrozen region is determined by T1 measurements. The process of freezing is controlled using information from the solution of the energy equation in the frozen region and temperature measurements in the unfrozen region. After cryosurgery the extent of the tissue damage may be ascertained using phosphorus-31 and/or sodium-23 spectroscopy with a special coil set on the cryosurgical probe.
摘要翻译：磁共振成像（MRI）辅助冷冻手术的方法和装置。在使用MRI数据进行冷冻手术之前计算最佳探针放置和冷却参数。提供MRI兼容的冷冻探针和立体定向探针定位装置。通过将射频MR线圈安装在冷冻探针的体内末端来增强MR图像的分辨率。在冷冻手术中，通过确定冻结区域的边界并求解已知边界条件的热方程来解决冻结区域的温度分布。在冷冻手术中，未冻结区域的温度分布由T1测量确定。使用来自冻结区域的能量方程的解和来自未冻结区域的温度测量的信息来控制冷冻过程。在冷冻手术之后，可以使用在冷冻手术探针上设置的特殊线圈的磷-31和/或钠-23光谱来确定组织损伤的程度。

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