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11. 发明授权

US07914503B2 Method and apparatus for selective material delivery via an intra-renal catheter 有权
标题翻译：通过肾内导管选择性物质输送的方法和装置
公开(公告)号：US07914503B2
公开(公告)日：2011-03-29
申请号：US11084738
申请日：2005-03-16
申请人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew W. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
发明人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew W. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
IPC分类号： A61M25/00 , A61M29/00
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.
摘要翻译：两个肾递送部件具有两个远端端口，其适于通过其腹主动脉壁的独特位置处经由其相应的肾口位于两个肾动脉内。近端联接器组件在身体外部并且联接以将材料递送到两个远端端口用于双侧肾疗法。递送部件中的一个或两个可以是自套管到相应的肾口中，或者可以被可控制地引导到相应的口中。非闭塞性锚固件可以与肾动脉或腹主动脉中的锚定位置处的一个或两个递送构件联接，以将肾递送构件固定在肾动脉内。肾活性流体剂联接到双向递送系统。另一种肾脏治疗系统将来自腔静脉的肾静脉插管并控制向相应肾脏逆行递送药剂。

12. 发明申请

US20070287967A1 SELECTIVE RENAL CANNULATION AND INFUSION SYSTEMS AND METHODS 失效
标题翻译：选择性肾移植和输注系统和方法
公开(公告)号：US20070287967A1
公开(公告)日：2007-12-13
申请号：US11758417
申请日：2007-06-05
申请人： Neema Hekmat , Harry Goodson , Aurelio Valencia , Jeffrey Elkins
发明人： Neema Hekmat , Harry Goodson , Aurelio Valencia , Jeffrey Elkins
IPC分类号： A61M25/00
CPC分类号： A61M25/0068 , A61M25/0028 , A61M25/0029 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/008 , A61M25/02 , A61M2025/0034 , A61M2025/0037 , A61M2025/0073 , A61M2025/024 , A61M2025/1045
摘要： Renal infusion systems include an infusion catheter having a bifurcated distal end with a first branch and second branch, the branches being biased to deploy laterally when unconstrained. Systems also include a delivery sheath having a lumen which receives the infusion catheter and constrains the first branch and second branch. A distal opening of the delivery sheath is formed asymmetrically to allow one of the first and second branches to open laterally while the other of the branches remains constrained. Methods of using renal infusion systems are also provided.
摘要翻译：肾输液系统包括具有分叉远端的输注导管，其具有第一分支和第二分支，所述分支被偏置以在无约束时横向展开。系统还包括具有接收输注导管并限制第一分支和第二分支的内腔的输送鞘。输送护套的远端开口不对称地形成，以允许第一和第二分支中的一个横向打开，而另一个分支保持约束。还提供了使用肾输注系统的方法。

13. 发明授权

US08585678B2 Method and apparatus for intra-aortic substance delivery to a branch vessel 有权
标题翻译：用于主动脉内物质输送到分支血管的方法和装置
公开(公告)号：US08585678B2
公开(公告)日：2013-11-19
申请号：US12044230
申请日：2008-03-07
申请人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
发明人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
IPC分类号： A61M31/00
CPC分类号： A61M25/0068 , A61M25/00 , A61M25/0041 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/0082 , A61M39/06 , A61M2025/0073 , A61M2025/105
摘要： A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals. The injection members are delivered to the location in a first radially collapsed condition, and bifurcate across the aorta to inject into the spaced renal ostia. A delivery catheter for upstream interventions is used as a chassis to deliver a bilateral local renal injection assembly to the location within the abdominal aorta.
摘要翻译：肾流系统以一定的方式将一定体积的流体药剂注入腹主动脉内的一个位置，这两种方式通过沿着腹主动脉壁的分别间隔开的两个肾动脉双向流入两个肾动脉。局部注射组件包括两个注射构件，每个注射构件具有连接到病人外部的流体剂源的注射口。注射口可以沿着灌注两个肾动脉的腹主动脉壁的外侧血流区域定位。流动隔离组件可以隔离外部区域内的注射药剂流入肾脏。注射构件在第一径向折叠状态下被输送到该位置，并且跨越主动脉分叉以注入间隔开的肾口。用于上游干预的输送导管用作底架以将双侧局部肾注射组件递送至腹主动脉内的位置。

14. 发明申请

US20080154236A1 METHOD AND APPARATUS FOR INTRA-AORTIC SUBSTANCE DELIVERY TO A BRANCH VESSEL 有权
标题翻译：用于运输物流输送到分支机构的方法和装置
公开(公告)号：US20080154236A1
公开(公告)日：2008-06-26
申请号：US12044230
申请日：2008-03-07
申请人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
发明人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
IPC分类号： A61M31/00
CPC分类号： A61M25/0068 , A61M25/00 , A61M25/0041 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/0082 , A61M39/06 , A61M2025/0073 , A61M2025/105
摘要： A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals. The injection members are delivered to the location in a first radially collapsed condition, and bifurcate across the aorta to inject into the spaced renal ostia. A delivery catheter for upstream interventions is used as a chassis to deliver a bilateral local renal injection assembly to the location within the abdominal aorta.
摘要翻译：肾流系统以一定的方式将一定体积的流体药剂注入腹主动脉内的一个位置，这两种方式通过沿着腹主动脉壁的分别间隔开的两个肾动脉双向流入两个肾动脉。局部注射组件包括两个注射构件，每个注射构件具有连接到病人外部的流体剂源的注射口。注射口可以沿着灌注两个肾动脉的腹主动脉壁的外侧血流区域定位。流动隔离组件可以隔离外部区域内的注射药剂流入肾脏。注射构件在第一径向折叠状态下被输送到该位置，并且跨越主动脉分叉以注入间隔开的肾口。用于上游干预的输送导管用作底架以将双侧局部肾注射组件递送至腹主动脉内的位置。

15. 发明授权

US07364566B2 Method and apparatus for intra-aortic substance delivery to a branch vessel 有权
标题翻译：用于主动脉内物质输送到分支血管的方法和装置
公开(公告)号：US07364566B2
公开(公告)日：2008-04-29
申请号：US11084434
申请日：2005-03-18
申请人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
发明人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
IPC分类号： A61M29/00 , A61M25/00
CPC分类号： A61M25/0068 , A61M25/00 , A61M25/0041 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/0082 , A61M39/06 , A61M2025/0073 , A61M2025/105
摘要： A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals. The injection members are delivered to the location in a first radially collapsed condition, and bifurcate across the aorta to inject into the spaced renal ostia. A delivery catheter for upstream interventions is used as a chassis to deliver a bilateral local renal injection assembly to the location within the abdominal aorta.
摘要翻译：肾流系统以一定的方式将一定体积的流体药剂注入腹主动脉内的一个位置，这两种方式通过沿着腹主动脉壁的分别间隔开的两个肾动脉双向流入两个肾动脉。局部注射组件包括两个注射构件，每个注射构件具有连接到病人外部的流体剂源的注射口。注射口可以沿着灌注两个肾动脉的腹主动脉壁的外侧血流区域定位。流动隔离组件可以隔离外部区域内的注射药剂流入肾脏。注射构件在第一径向折叠状态下被输送到该位置，并且跨越主动脉分叉以注入间隔开的肾口。用于上游干预的输送导管用作底架以将双侧局部肾注射组件递送至腹主动脉内的位置。

16. 发明授权

US06994700B2 Apparatus and method for inserting an intra-aorta catheter through a delivery sheath 有权
公开(公告)号：US06994700B2
公开(公告)日：2006-02-07
申请号：US11084295
申请日：2005-03-18
申请人： Jeffrey M. Elkins , Harry B. Goodson , Mark A. Maguire , Aurelio Valencia , Samir R. Patel
发明人： Jeffrey M. Elkins , Harry B. Goodson , Mark A. Maguire , Aurelio Valencia , Samir R. Patel
IPC分类号： A61M25/01
CPC分类号： A61M25/0043 , A61M25/0662 , A61M39/06
摘要： An introducer system delivers therapy locally to a renal system in a patient. A proximal coupler assembly is coupled to an introducer sheath that delivers multiple devices simultaneously into a location within an abdominal aorta associated with first and second renal artery ostia. The coupler assembly has a network of branch lumens arranged to allow for smooth slideable engagement of multiple coupled devices without substantial interference therebetween. A first branch lumen typically introduces a percutaneous translumenal interventional device such as an angiography or guiding catheter into the introducer sheath and is substantially aligned with a longitudinal axis of the sheath. One or more other branch lumen are off-axis from the longitudinal axis by about 30 degrees or less and introduce components of a bilateral renal delivery assembly into the introducer sheath in conjunction with the other device. Novel insertion devices are provided to coordinate the coupling of the multiple devices.

17. 发明授权

US5913854A Fluid cooled ablation catheter and method for making 失效
标题翻译：流体冷却消融导管及其制造方法
公开(公告)号：US5913854A
公开(公告)日：1999-06-22
申请号：US794803
申请日：1997-02-04
申请人： Mark A. Maguire , Hong Li , Joseph M. Karratt , Aurelio Valencia
发明人： Mark A. Maguire , Hong Li , Joseph M. Karratt , Aurelio Valencia
IPC分类号： A61B18/12 , A61B17/12 , A61B18/00 , A61B18/14 , A61M25/00 , A61N1/05
CPC分类号： A61B18/1492 , A61B17/12022 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00357 , A61B2018/00577 , A61B2218/002
摘要： A catheter assembly (2) includes a catheter shaft (6) having a tip portion (10) with a hollow interior (30) and a linear ablation electrode (18, 34, 36, 44, 58) spaced apart from the distal end (22) of the tip portion. The electrode has an inner surface (28) which is effectively fluidly exposed to the hollow interior so that a cooling fluid (32) passing through the interior contacts the inner surface so to effectively cool the electrode. The electrode can include a series of band electrodes (18, 34) or one or more spiral electrodes (36, 44, 58). One method for making the tip portion involves mounting the electrode to a mandrel, filling the spaces between the edges (26) of the electrode with a polymer and then removing the resulting tubular structure from the mandrel. The cooling fluid can pass through a hollow spiral electrode (58) for enhanced cooling effectiveness.
摘要翻译：导管组件（2）包括导管轴（6），其具有具有中空内部（30）的尖端部分（10）和与远端间隔开的线性消融电极（18,34,46,44,58） 22）。电极具有有效地流体地暴露于中空内部的内表面（28），使得穿过内部的冷却流体（32）接触内表面以便有效地冷却电极。电极可以包括一系列带状电极（18,34）或一个或多个螺旋电极（36,44,58）。用于制造尖端部分的一种方法包括将电极安装到心轴上，用聚合物填充电极的边缘（26）之间的空间，然后从心轴移除所得到的管状结构。冷却流体可以通过中空螺旋电极（58），以提高冷却效果。

18. 发明授权

US07771401B2 Selective renal cannulation and infusion systems and methods 失效
标题翻译：选择性肾穿刺和输液系统及方法
公开(公告)号：US07771401B2
公开(公告)日：2010-08-10
申请号：US11758417
申请日：2007-06-05
申请人： Neema Hekmat , Harry B. Goodson , Aurelio Valencia , Jeffrey M. Elkins
发明人： Neema Hekmat , Harry B. Goodson , Aurelio Valencia , Jeffrey M. Elkins
IPC分类号： A61M5/00
CPC分类号： A61M25/0068 , A61M25/0028 , A61M25/0029 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/008 , A61M25/02 , A61M2025/0034 , A61M2025/0037 , A61M2025/0073 , A61M2025/024 , A61M2025/1045
摘要： Renal infusion systems include an infusion catheter having a bifurcated distal end with a first branch and second branch, the branches being biased to deploy laterally when unconstrained. Systems also include a delivery sheath having a lumen which receives the infusion catheter and constrains the first branch and second branch. A distal opening of the delivery sheath is formed asymmetrically to allow one of the first and second branches to open laterally while the other of the branches remains constrained. Methods of using renal infusion systems are also provided.
摘要翻译：肾输液系统包括具有分叉远端的输注导管，其具有第一分支和第二分支，所述分支被偏置以在无约束时横向展开。系统还包括具有接收输注导管并限制第一分支和第二分支的内腔的输送鞘。输送护套的远端开口不对称地形成，以允许第一和第二分支中的一个横向打开，而另一个分支保持约束。还提供了使用肾输注系统的方法。

19. 发明申请

US20090105799A1 RENAL ASSESSMENT SYSTEMS AND METHODS 审中-公开
标题翻译： RENAL评估系统和方法
公开(公告)号：US20090105799A1
公开(公告)日：2009-04-23
申请号：US12256154
申请日：2008-10-22
申请人： Neema Hekmat , Courtney Yin , Frank Altamura , Jeff Elkins , Aurelio Valencia , Burt Goodson
发明人： Neema Hekmat , Courtney Yin , Frank Altamura , Jeff Elkins , Aurelio Valencia , Burt Goodson
IPC分类号： A61F2/06 , A61B5/02
CPC分类号： A61B5/6852 , A61B5/1076 , A61B5/201 , A61F2/82 , A61F2250/0002
摘要： Techniques for assessing a physiological profile of a patient include advancing a catheter shaft of a bifurcated renal catheter system into an aorta of the patient, deploying branches of the bifurcated renal catheter system into the renal arteries of the patient, detecting a renal arterial physiological parameter with a sensing mechanism, and assessing the physiological profile of the patient based on the physiological parameter. Related techniques include modifying or initiating pharmacological or surgical treatments for the patient based on the assessment.
摘要翻译：用于评估患者的生理特征的技术包括将分叉的肾导管系统的导管轴推进到患者的主动脉中，将分叉的肾导管系统的分支部署到患者的肾动脉中，检测肾动脉生理参数，感测机制，并且基于生理参数评估患者的生理特征。相关技术包括基于评估修改或启动患者的药理或外科治疗。

20. 发明授权

US06522930B1 Irrigated ablation device assembly 失效
标题翻译：灌肠消融装置组装
公开(公告)号：US06522930B1
公开(公告)日：2003-02-18
申请号：US09073907
申请日：1998-05-06
申请人： Alan K. Schaer , Aurelio Valencia
发明人： Alan K. Schaer , Aurelio Valencia
IPC分类号： A61F200
CPC分类号： A61B18/1492 , A61B2017/22038 , A61B2018/00011 , A61B2018/00029 , A61B2018/00065 , A61B2018/0016 , A61B2018/00214 , A61B2018/00797 , A61B2018/00821 , A61B2018/1437 , A61B2218/002
摘要： A tissue ablation device assembly ablates a region of tissue of a body space wall of a patient. In a tissue ablation device assembly, an ablation member is disposed on the distal end portion of an elongated body. The ablation member includes an ablation element and at least one conductor coupled to the ablation element. A porous membrane covers the ablation element and defines an inner space between the ablation element and an inner surface of the porous membrane. A pressurizable fluid passageway extends between a fluid port on the proximal end portion of the elongated body and the inner space within the porous membrane. Fluid can pass from the fluid port, through the pressurizable fluid passageway, to the inner space. The porous membrane allows a volume of pressurized fluid to pass through the porous membrane to an exterior of the ablation member so as to irrigate the ablation element.
摘要翻译：组织消融装置组件消融患者身体空间壁的组织区域。在组织消融装置组件中，消融构件设置在细长体的远端部分上。消融构件包括消融元件和耦合到消融元件的至少一个导体。多孔膜覆盖消融元件并且限定消融元件与多孔膜的内表面之间的内部空间。可加压流体通道在细长体的近端部分上的流体端口和多孔膜内的内部空间之间延伸。流体可以从流体端口通过可加压的流体通道传递到内部空间。多孔膜允许一定体积的加压流体通过多孔膜到消融构件的外部，以便冲洗消融元件。

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