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11. 发明申请

US20090303321A1 System and Computer Readable Medium for Pre-focus of Digital Slides 有权
标题翻译：用于数字幻灯片预聚焦的系统和计算机可读介质
公开(公告)号：US20090303321A1
公开(公告)日：2009-12-10
申请号：US12547386
申请日：2009-08-25
申请人： Allen Olson , Greg Crandall , Dirk G. Soenksen
发明人： Allen Olson , Greg Crandall , Dirk G. Soenksen
IPC分类号： H04N7/18 , H04N5/232
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Methods and apparatus are provided for computing focus information prior to scanning digital microscope slides with a line scan camera. The methods include a point-focus procedure that works by moving the slide to the desired measurement location, moving the objective lens through a predefined set of height values, acquiring imagery data at each height, and determining the height of maximum contrast. The methods also include a ribbon-focus procedure whereby imagery data are acquired continuously, while the slide and objective lens are in motion. Both methods may be applied with either a static or a dynamic implementation.
摘要翻译：提供了用扫描数字显微镜幻灯片与线扫描相机之前计算焦点信息的方法和装置。这些方法包括通过将滑块移动到期望的测量位置，通过预定义的一组高度值移动物镜，获取每个高度处的图像数据以及确定最大对比度的高度而起作用的点对焦过程。所述方法还包括色带聚焦程序，其中在幻灯片和物镜运动时连续获取图像数据。两种方法都可以应用于静态或动态实现。

12. 发明申请

US20060007345A1 System and method for assessing virtual slide image quality 有权
标题翻译：用于评估虚拟幻灯片图像质量的系统和方法
公开(公告)号：US20060007345A1
公开(公告)日：2006-01-12
申请号：US11140589
申请日：2005-05-26
申请人： Allen Olson , Kiran Saligrama , Dirk Soenksen
发明人： Allen Olson , Kiran Saligrama , Dirk Soenksen
IPC分类号： G03B13/00 , H04N5/232
CPC分类号： G02B21/245 , G02B21/002 , G02B21/244 , G02B21/365 , G02B21/367 , G06K9/40 , H04N5/23212
摘要： Systems and methods for assessing virtual microscope slide image quality are provided. In order to determine whether a virtual slide image has any out of focus areas and is therefore a candidate for manual inspection, the various focus points used to scan the virtual slide image are used to calculate a best fit surface for the virtual slide image. The distance of each focus point from the best fit surface is then calculated and the largest distance is compared to a predetermined value. If the largest distance from a focus point to the best fit surface is larger than the predetermined value, then the virtual slide image is designated as needing a manual inspection and possible re-scan.
摘要翻译：提供了评估虚拟显微镜幻灯片图像质量的系统和方法。为了确定虚拟幻灯片图像是否具有任何偏离焦点区域，因此是用于手动检查的候选者，用于扫描虚拟幻灯片图像的各种对焦点用于计算虚拟幻灯片图像的最佳拟合曲面。然后计算每个对焦点与最佳拟合表面的距离，并将最大距离与预定值进行比较。如果从焦点到最佳配合曲面的最大距离大于预定值，则虚拟幻灯片图像被指定为需要手动检查和可能的重新扫描。

13. 发明授权

US08705825B2 Signal to noise ratio in digital pathology image analysis 有权
标题翻译：数字病理图像分析中的信噪比
公开(公告)号：US08705825B2
公开(公告)日：2014-04-22
申请号：US13370124
申请日：2012-02-09
申请人： Allen Olson , Ole Eichhorn
发明人： Allen Olson , Ole Eichhorn
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06F19/00 , G06F19/321 , G06T2207/10056 , G06T2207/30024
摘要： A digital slide analysis system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of digital slide images. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. Prior to the application of selected routine, the system employs a digital pre-processing module to create a metadata mask that reduces undesirable image data such that the image data processed by the selected routine has an improved signal to noise ratio. The pre-processing module uses a classifier that may be implemented as a pattern recognition module, for example. Undesirable image data is therefore excluded from the image data that is processed by the digital pathology image processing and analysis routine, which significantly improves the digital pathology image analysis.
摘要翻译：数字幻灯片分析系统包括维护或者可以访问多个图像处理和分析程序的算法服务器。算法服务器还可以访问多个数字幻灯片图像。算法服务器在识别的数字幻灯片上执行所选择的例程，并提供所得到的数据。在应用所选程序之前，系统采用数字预处理模块来创建一个减少不需要的图像数据的元数据掩码，使得由所选程序处理的图像数据具有改善的信噪比。预处理模块使用例如可以被实现为模式识别模块的分类器。因此，不希望的图像数据被排除在由数字病理图像处理和分析程序处理的图像数据中，这显着地改善了数字病理图像分析。

14. 发明申请

US20120281931A1 Image Processing and Analysis Framework 有权
标题翻译：图像处理与分析框架
公开(公告)号：US20120281931A1
公开(公告)日：2012-11-08
申请号：US13494715
申请日：2012-06-12
申请人： Ole Eichhorn , Allen Olson
发明人： Ole Eichhorn , Allen Olson
IPC分类号： G06K9/36
CPC分类号： G06K9/46 , G06T1/00
摘要： A system and method for processing and analyzing virtual microscopy digital images (“digital slides”) is provided. The system comprises an algorithm server that accesses a plurality of image processing and analysis routines. The algorithm server additionally accesses a plurality of digital slides. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. The digital slide is accessed locally or remotely across a network. Similarly, the image processing and analysis routines are accessed locally or remotely across a network, or both. Advantageously, certain common sub-routines may be stored locally for inclusion in other local or remotely accessed routines. Use of image processing and analysis routines may be restricted through a monitor process that authenticates requests to process or view digital slides. Variations in restrictions to images provide rich diversity in access levels that allow sharing of digital slides and demonstrations of image processing algorithms.
摘要翻译：提供了一种用于处理和分析虚拟显微数字图像（数字幻灯片）的系统和方法。该系统包括访问多个图像处理和分析例程的算法服务器。算法服务器还访问多个数字幻灯片。算法服务器在识别的数字幻灯片上执行所选择的例程，并提供所得到的数据。数字幻灯片可以通过网络在本地或远程访问。类似地，图像处理和分析例程通过网络本地或远程访问，或两者兼而有之。有利地，某些公共子例程可以被本地存储以包含在其他本地或远程访问的例程中。图像处理和分析程序的使用可能会通过对进程或查看数字幻灯片的请求进行验证的监视进程来限制。对图像限制的变化提供了访问级别丰富的多样性，允许共享数字幻灯片和图像处理算法的演示。

15. 发明授权

US08116547B2 Signal to noise ratio in digital pathology image analysis 有权
标题翻译：数字病理图像分析中的信噪比
公开(公告)号：US08116547B2
公开(公告)日：2012-02-14
申请号：US13259562
申请日：2010-12-10
申请人： Allen Olson , Ole Eichhorn
发明人： Allen Olson , Ole Eichhorn
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06F19/00 , G06F19/321 , G06T2207/10056 , G06T2207/30024
摘要： A digital slide analysis system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of digital slide images. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. Prior to the application of selected routine, the system employs a digital pre-processing module to create a metadata mask that reduces undesirable image data such that the image data processed by the selected routine has an improved signal to noise ratio. The pre-processing module uses a classifier that may be implemented as a pattern recognition module, for example. Undesirable image data is therefore excluded from the image data that is processed by the digital pathology image processing and analysis routine, which significantly improves the digital pathology image analysis.
摘要翻译：数字幻灯片分析系统包括维护或者可以访问多个图像处理和分析程序的算法服务器。算法服务器还可以访问多个数字幻灯片图像。算法服务器在识别的数字幻灯片上执行所选择的例程，并提供所得到的数据。在应用所选程序之前，系统采用数字预处理模块来创建一个减少不需要的图像数据的元数据掩码，使得由所选程序处理的图像数据具有改善的信噪比。预处理模块使用例如可以被实现为模式识别模块的分类器。因此，不希望的图像数据被排除在由数字病理图像处理和分析程序处理的图像数据中，这显着地改善了数字病理图像分析。

16. 发明申请

US20090208134A1 Image Processing and Analysis Framework 有权
标题翻译：图像处理与分析框架
公开(公告)号：US20090208134A1
公开(公告)日：2009-08-20
申请号：US12428394
申请日：2009-04-22
申请人： Ole Eichhorn , Allen Olson
发明人： Ole Eichhorn , Allen Olson
IPC分类号： G06K9/36
CPC分类号： G06K9/46 , G06T1/00
摘要： A system and method for processing and analyzing virtual microscopy digital images (“digital slides”) is provided. The system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of digital slides. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. The digital slide can be accessed locally or remotely across a network. Similarly, the image processing routines can be obtained from local storage or across a network, or both. Advantageously, certain common sub-routines may be stored locally for inclusion in other local or remotely obtained routines. Access to image processing and analysis may be restricted through a monitor process that authenticates requests to process or view digital slides. Variations in restrictions to images provide a rich diversity in access levels that allow sharing of digital slides and demonstrations of image processing algorithms.
摘要翻译：提供了一种用于处理和分析虚拟显微数字图像（“数字幻灯片”）的系统和方法。该系统包括维护或访问多个图像处理和分析例程的算法服务器。算法服务器还可以访问多个数字幻灯片。算法服务器在识别的数字幻灯片上执行所选择的例程，并提供所得到的数据。数字幻灯片可以在本地或通过网络远程访问。类似地，图像处理例程可以从本地存储器或网络或两者获得。有利地，某些公共子例程可以被本地存储以包含在其他本地或远程获得的例程中。对图像处理和分析的访问可以通过认证要处理或查看数字幻灯片的监视进程来限制。对图像限制的变化提供了访问级别丰富的多样性，允许共享数字幻灯片和图像处理算法的演示。

17. 发明申请

US20070036462A1 System and Method for Data Management in a Linear-Array-Based Microscope Slide Scanner 有权
标题翻译：基于线性阵列的显微镜幻灯片扫描仪中数据管理的系统与方法
公开(公告)号：US20070036462A1
公开(公告)日：2007-02-15
申请号：US11379648
申请日：2006-04-21
申请人： Greg Crandall , Ole Eichhorn , Allen Olson , Dirk Soenksen
发明人： Greg Crandall , Ole Eichhorn , Allen Olson , Dirk Soenksen
IPC分类号： G06K9/36 , G06K9/32 , G06K9/00
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： A data management system and method for processing, storing, and viewing the extremely large imagery data that is rapidly produced by a linear-array-based microscope slide scanner is provided. The system receives, processes, and stores imagery data produced by the linear-array-based microscope slide scanner at approximately 3 GB per minute. The data are received as a series of overlapping image stripes and combined into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The data management system enables imagery data compression while scanning and capturing new image stripes. This advantageously eliminates the overhead associated with storing uncompressed image stripes. The image compression also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The data management system efficiently converts image stripes into a high quality virtual slide that allows rapid panning and zooming by image viewing software in accordance with the individually addressed regions. The virtual slide also allows efficient processing by an algorithm framework. The data management system is costs effective and scaleable, employs standard image file formats and supports the use of virtual slides in desirable applications such as telemedicine, telepathology, microscopy education, and the analysis of high value specimens such as tissue arrays.
摘要翻译：提供了一种用于处理，存储和查看由基于线性阵列的显微镜幻灯片扫描仪快速产生的极大图像数据的数据管理系统和方法。系统以每分钟3 GB的速度接收，处理和存储由基于线性阵列的显微镜幻灯片扫描仪生成的图像数据。数据被接收为一系列重叠的图像条纹并组合成无缝和连续的基线图像。基线图像被逻辑地映射到单独寻址的多个区域中，以便于观察和操纵基线图像。数据管理系统在扫描和捕获新的图像条纹时可以进行图像数据压缩。这有利地消除了与存储未压缩图像条纹相关联的开销。图像压缩还创建中间级图像，从而将基线图像组织成称为虚拟幻灯片的可变级金字塔结构。数据管理系统有效地将图像条纹转换成高质量的虚拟幻灯片，其允许通过图像查看软件根据单独寻址的区域进行快速平移和缩放。虚拟幻灯片还允许通过算法框架进行有效的处理。数据管理系统具有成本效益和可扩展性，采用标准图像文件格式，并支持虚拟幻灯片在远程医疗，远程病理学，显微镜教育等理想应用中的应用，以及组织阵列等高价值标本的分析。

18. 发明申请

US20120269409A1 SIGNAL TO NOISE RATIO IN DIGITAL PATHOLOGY IMAGE ANALYSIS 有权
标题翻译：在数字病理学图像分析中的噪声比率信号
公开(公告)号：US20120269409A1
公开(公告)日：2012-10-25
申请号：US13370124
申请日：2012-02-09
申请人： Allen Olson , Ole Eichhorn
发明人： Allen Olson , Ole Eichhorn
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06F19/00 , G06F19/321 , G06T2207/10056 , G06T2207/30024
摘要： A digital slide analysis system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of digital slide images. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. Prior to the application of selected routine, the system employs a digital pre-processing module to create a metadata mask that reduces undesirable image data such that the image data processed by the selected routine has an improved signal to noise ratio. The pre-processing module uses a classifier that may be implemented as a pattern recognition module, for example. Undesirable image data is therefore excluded from the image data that is processed by the digital pathology image processing and analysis routine, which significantly improves the digital pathology image analysis.
摘要翻译：数字幻灯片分析系统包括维护或者可以访问多个图像处理和分析程序的算法服务器。算法服务器还可以访问多个数字幻灯片图像。算法服务器在识别的数字幻灯片上执行所选择的例程，并提供所得到的数据。在应用所选程序之前，系统采用数字预处理模块来创建一个减少不需要的图像数据的元数据掩码，使得由所选程序处理的图像数据具有改善的信噪比。预处理模块使用例如可以被实现为模式识别模块的分类器。因此，不希望的图像数据被排除在由数字病理图像处理和分析程序处理的图像数据中，这显着地改善了数字病理图像分析。

19. 发明授权

US08199358B2 Digital slide image analysis 有权
标题翻译：数字幻灯片分析
公开(公告)号：US08199358B2
公开(公告)日：2012-06-12
申请号：US12428394
申请日：2009-04-22
申请人： Ole Eichhorn , Allen Olson
发明人： Ole Eichhorn , Allen Olson
IPC分类号： G06K15/00 , G06F3/12
CPC分类号： G06K9/46 , G06T1/00
摘要： A system and method and non-transitory computer readable medium for processing and analyzing virtual microscopy digital images (“digital slides”) is provided. The non-transitory computer readable medium includes instructions that implement an algorithm server that maintains or has access to a plurality of image processing and analysis routines and digital slides. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data.
摘要翻译：提供了一种用于处理和分析虚拟显微数字图像（“数字幻灯片”）的系统和方法以及非暂时的计算机可读介质。非暂时性计算机可读介质包括实现维护或访问多个图像处理和分析例程和数字幻灯片的算法服务器的指令。算法服务器在识别的数字幻灯片上执行所选择的例程，并提供所得到的数据。

20. 发明授权

US07116440B2 Image processing and analysis framework 有权
公开(公告)号：US07116440B2
公开(公告)日：2006-10-03
申请号：US10787330
申请日：2004-02-26
申请人： Ole Eichhorn , Allen Olson
发明人： Ole Eichhorn , Allen Olson
IPC分类号： G06F15/00
CPC分类号： G06K9/46 , G06T1/00
摘要： A system and method for processing and analyzing virtual microscopy digital images (“virtual slides”) is provided. The system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of virtual slides. The algorithm server executes a selected routine on an identified virtual slide and provides the resulting data. The virtual slide can be accessed locally or remotely across a network. Similarly, the image processing routines can be obtained from local storage or across a network, or both. Advantageously, certain common sub-routines may be stored locally for inclusion in other local or remotely obtained routines. Access to image processing and analysis may be restricted through a monitor process that authenticates requests to process or view virtual slides. Variations in restrictions to images provide a rich diversity in access levels that allow sharing of virtual slides and demonstrations of image processing algorithms.

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