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11. 发明申请

US20100226911A1 Treating or preventing extracellular matrix build-up 有权
标题翻译：治疗或预防细胞外基质积聚
公开(公告)号：US20100226911A1
公开(公告)日：2010-09-09
申请号：US10591527
申请日：2005-03-07
申请人： Allan L. Goldstein
发明人： Allan L. Goldstein
IPC分类号： A61K39/395 , A61K38/08 , A61K38/32 , A61K31/727 , A61P7/02 , A61F2/82 , A61F2/84
CPC分类号： C07K14/57581 , A61K38/00 , G01N33/5088 , G01N2800/323
摘要： A method of treatment for treating, preventing, inhibiting or reducing extracellular matrix build-up in a body tissue or a bodily fluid transport vessel, in a subject, includes administering to a subject in need of such treatment an effective amount of a composition including a peptide agent including amino acid sequence LKKTET, a conservative variant thereof, or a peptide agent that stimulates production of an LKKTET peptide, or a conservative variant thereof, in the tissue.
摘要翻译：用于治疗，预防，抑制或减少受试者体内组织或体液运输容器中的细胞外基质积累的治疗方法包括向需要这种治疗的受试者施用有效量的组合物，其包括其包括氨基酸序列LKKTET，其保守变体或刺激组织中LKKTET肽或其保守变体的产生的肽试剂。

12. 发明申请

US20100048474A1 METHOD OF TREATING OR PREVENTING TISSUE DETERIORATION, INJURY OR DAMAGE DUE TO PERIODONTAL DISEASE OR DISEASE OF ORAL MUCOSA, AND/OR DOWNREGULATING NF-KAPPABETA OR SUPRESSING NF-KAPPABETA-MEDIATED ACTIONS 有权
标题翻译：治疗或预防组织病变的方法，由于口腔溃疡的周围疾病或疾病引起的损伤或损害，和/或降低NF-KAPPABETA或增加NF-KAPPABETA介导的行为
公开(公告)号：US20100048474A1
公开(公告)日：2010-02-25
申请号：US12444331
申请日：2007-10-05
申请人： Gabriel Sosne , Michelle Wheater , Allan L. Goldstein
发明人： Gabriel Sosne , Michelle Wheater , Allan L. Goldstein
IPC分类号： A61K38/17 , A61P43/00
CPC分类号： A61K38/08 , A61K8/64 , A61K38/2292 , A61Q11/00
摘要： A method of treatment for treating, at least partly preventing, inhibiting or reducing tissue deterioration, injury or damage due to a periodontal disease or disease of oral mucosa, or for restoring tissue adversely affected by the disease, in a subject, and/or for downregulating NF-kappaB or suppressing NF-kappaB mediated action in a body, organ, tissue or cell, includes administering to a subject, body, organ, tissue or cell an effective amount of a composition including a peptide agent including at least one of Thymosin beta 4 (Tβ4), an isoform of Tβ4, an N-terminal fragment of Tβ4, a C-terminal fragment of Tβ4, Tβ4 sulfoxide, an LKKTET peptide or conservative variant thereof, an LKKTNT peptide or conservative variant thereof, a KLKKTET peptide or conservative variant thereof, an LKKTETQ peptide or conservative variant thereof, Tβ4ala, Tβ9, Tβ10, Tβ11, Tβ12, Tβ13, Tβ14, Tβ15, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, depactin, DnaseI, vilin, fragmin, severin, capping protein, β-actinin, acumentin, an actin-sequestering peptide, an actin binding peptide, an actin-mobilizing peptide, an actin polymerization-modulating peptide, or a stimulating agent that stimulates production of an effective amount of the peptide agent in the subject, body, organ, tissue or cell.
摘要翻译：一种治疗方法，用于治疗，至少部分地预防，抑制或减少由于牙周疾病或口腔粘膜疾病引起的组织退化，损伤或损伤，或用于恢复患者受到不良影响的组织，和/或用于在身体，器官，组织或细胞中下调NF-κB或抑制NF-κB介导的作用，包括向受试者，身体，器官，组织或细胞施用有效量的组合物，所述组合物包括包含至少一种胸腺素的肽试剂 β4（T＆bgr; 4），T＆bgr的同种型; 4，T＆bgr的N末端片段; 4，T＆bgr; 4，T＆bgr; 4亚砜的C末端片段，LKKTET肽或其保守变体，LKKTNT 肽或其保守变体，KLKKTET肽或其保守变体，LKKTETQ肽或其保守变体，T＆bgr; 4ala，T＆bgr; 9，T＆bgr; 10，T＆bgr; 11，T＆bgr; 12，T＆bgr; 13，T＆bgr; T＆Bgr; 15，凝溶胶蛋白，维生素D结合蛋白（DBP），profilin，cof 肌动蛋白结合肽，肌动蛋白动员肽，肌动蛋白聚合调节肽或刺激剂，肌动蛋白结合肽，肌动蛋白动员肽，肌动蛋白聚合调节肽，其刺激受试者，身体，器官，组织或细胞中有效量的肽试剂的产生。

13. 发明授权

US4543340A Radioimmunoassay of thymosin .beta..sub.4 失效
标题翻译：胸腺素β4的放射免疫测定
公开(公告)号：US4543340A
公开(公告)日：1985-09-24
申请号：US482384
申请日：1983-04-07
申请人： Allan L. Goldstein , Teresa L. K. Low , John McClure , Paul H. Naylor
发明人： Allan L. Goldstein , Teresa L. K. Low , John McClure , Paul H. Naylor
IPC分类号： G01N33/53 , A61K38/22 , A61K39/385 , A61K51/00 , C07K14/00 , C07K14/435 , C07K16/00 , C07K19/00 , G01N33/534 , G01N33/74 , A61K39/00
CPC分类号： G01N33/74 , Y10S436/804 , Y10S436/815 , Y10S930/18
摘要： A radioimmunoassay for the polypeptide thymic hormone thymosin .beta..sub.4 is described. The assay employs a radiolabelled Tyr-C13-thymosin .beta..sub.4 -analogue as probe and a thymosin .beta..sub.4 antibody.
摘要翻译：描述了多肽胸腺激素胸腺素β4的放射免疫测定。该测定采用放射性标记的Tyr-C13-胸腺素β4-类似物作为探针和胸腺素β4抗体。

14. 发明授权

US4297276A Thymosin beta 3 and beta 4 失效
标题翻译：胸腺素β3和β4
公开(公告)号：US4297276A
公开(公告)日：1981-10-27
申请号：US159430
申请日：1980-06-16
申请人： Allan L. Goldstein , Teresa L. K. Low
发明人： Allan L. Goldstein , Teresa L. K. Low
IPC分类号： A61K38/00 , C07K14/575 , C07C103/52 , A61K37/00
CPC分类号： C07K14/57581 , A61K38/00 , Y10S930/18
摘要： Two related polypeptides, thymosin .beta..sub.3 and thymosin .beta..sub.4, have been isolated from Thymosin fraction 5. These peptides have been characterized and sequenced. Thymosin .beta..sub.3 has 50 amino acid residues while thymosin .beta..sub.4 has 43 amino acid residues corresponding identically to the amino terminal 43 amino acids of thymosin .beta..sub.3. The compounds have useful biological activity as evidenced by their ability to induce terminal deoxynucleotidyl transferase (TdT) positive cells in T-cell populations. The invention described herein was made in part in the course of work under a grant or award from the Department of Health, Education and Welfare.
摘要翻译：已经从胸腺素级分5中分离了两种相关多肽，胸腺素β3和胸腺素β4。这些肽已被表征和测序。胸腺素β3具有50个氨基酸残基，而胸腺素β4具有与胸腺素β3的氨基末端43个氨基酸相同的43个氨基酸残基。化合物具有有益的生物学活性，其诱导末端脱氧核苷酸转移酶（TdT） T细胞群体中的阳性细胞。本文描述的发明部分是在卫生，教育和福利部的授予或奖励下的工作过程中进行的。

15. 发明授权

US4079127A Thymosin alpha 1 失效
标题翻译：胸腺素α1
公开(公告)号：US4079127A
公开(公告)日：1978-03-14
申请号：US766638
申请日：1977-02-08
申请人： Allan L. Goldstein , Teresa L. K. Low , Chun-Yen Lai , Su-Sun Wang
发明人： Allan L. Goldstein , Teresa L. K. Low , Chun-Yen Lai , Su-Sun Wang
IPC分类号： A61K38/00 , C07K14/575 , A61K37/00 , C07C103/52
CPC分类号： C07K14/57581 , A61K38/00 , Y10S930/18
摘要： The amino acid sequence of a biologically active polypeptide hormone isolated from calf thymus termed thymosin .alpha..sub.1 has been determined. Thymosin .alpha..sub.1 is a heat stable acidic molecule composed of 28 amino acid residues. This peptide is one of several present in thymosin fraction 5 which participate in the regulation, differentiation and function of thymic dependent lymphocytes (T cells).
摘要翻译：已经确定了从称为胸腺素α1的小牛胸腺分离的生物活性多肽激素的氨基酸序列。胸腺素α1是由28个氨基酸残基组成的热稳定酸性分子。该肽是参与胸腺依赖淋巴细胞（T细胞）的调节，分化和功能的胸腺素组分5中存在的几种之一。

16. 发明授权

US09056087B2 Methods of healing or preventing inflammation, damage and other changes that occur prior to, during or immediately after a myocardial event with thymosin beta 4, analogues, isoforms and other derivatives 有权
标题翻译：在胸腺素β4，类似物，同种型和其他衍生物的心肌事件之前，期间或之后发生的炎症，损伤和其他变化的愈合或预防的方法
公开(公告)号：US09056087B2
公开(公告)日：2015-06-16
申请号：US10488084
申请日：2002-08-29
申请人： Allan L. Goldstein , Jack Finkelstein, Jr.
发明人： Allan L. Goldstein , Jack Finkelstein, Jr.
IPC分类号： A61K38/22 , C07K16/26 , A61K39/00
CPC分类号： A61K38/2292 , A61K2039/505 , C07K16/26
摘要： Inflammation or damage associated with myocardial events is treated or prevented by administration of an angiogenesis-inducing, anti-inflammatory peptide such as Thymosin β4, an isoform of Thymosin β4 or oxidized Thymosin β4.
摘要翻译：通过施用血管发生诱导的抗炎肽，例如胸腺素4，Thymosin和bgr 4的同种型或氧化的胸腺素4，治疗或预防与心肌事件相关的炎症或损伤。

17. 发明授权

US08399609B2 Treating or preventing extracellular matrix build-up 有权
标题翻译：治疗或预防细胞外基质积聚
公开(公告)号：US08399609B2
公开(公告)日：2013-03-19
申请号：US10591527
申请日：2005-03-07
申请人： Allan L. Goldstein
发明人： Allan L. Goldstein
IPC分类号： A61K39/395
CPC分类号： C07K14/57581 , A61K38/00 , G01N33/5088 , G01N2800/323
摘要： A method of treatment for treating, preventing, inhibiting or reducing extracellular matrix build-up in a body tissue or a bodily fluid transport vessel, in a subject, includes administering to a subject in need of such treatment an effective amount of a composition including a peptide agent including amino acid sequence LKKTET, a conservative variant thereof, or a peptide agent that stimulates production of an LKKTET peptide, or a conservative variant thereof, in the tissue.
摘要翻译：用于治疗，预防，抑制或减少受试者体内组织或体液运输容器中的细胞外基质积累的治疗方法包括向需要这种治疗的受试者施用有效量的组合物，其包括其包括氨基酸序列LKKTET，其保守变体或刺激组织中LKKTET肽或其保守变体的产生的肽试剂。

18. 发明授权

US07638483B2 Cell nucleus-entering compositions 有权
公开(公告)号：US07638483B2
公开(公告)日：2009-12-29
申请号：US11240636
申请日：2005-10-03
申请人： Ewald Hannappel , Thomas Huff , Allan L. Goldstein , David Crockford
发明人： Ewald Hannappel , Thomas Huff , Allan L. Goldstein , David Crockford
IPC分类号： A61K38/00 , A61K51/00 , A61K38/04
摘要： A pharmaceutically acceptable composition and method for entering a cell nucleus utilizes a cell nucleus-entering polypeptide including at least one of amino acid sequence LKKTET (SEQ ID NO:1), amino acid sequence LKKTNT (SEQ ID NO:2) or amino acid sequence KSKLKK (SEQ ID NO:3), or a conservative variant thereof, linked to a physiologically active agent having at least one of therapeutic or diagnostic application in the cell nucleus.

19. 发明申请

US20080214456A1 Lkktet and/or Lkktnt Peptide Compositions and Methods 审中-公开
标题翻译： Lkktet和/或Lkktnt肽组合物和方法
公开(公告)号：US20080214456A1
公开(公告)日：2008-09-04
申请号：US11917883
申请日：2006-06-19
申请人： Gabriel Sosne , Ewald Hannppel , David Crockford , Allan L. Goldstein
发明人： Gabriel Sosne , Ewald Hannppel , David Crockford , Allan L. Goldstein
IPC分类号： A61K38/08 , A61K38/00 , A61K38/22
CPC分类号： A61K38/2292 , A61K9/0048 , A61K9/08 , A61K9/10 , A61K9/14 , A61K38/08 , A61K47/186
摘要： A composition including a peptide agent including amino acid sequence LKKTET or LKKTNT, a conservative variant thereof, or a stimulating agent that stimulates production of an LKKTET or LKKTNT peptide, or a conservative variant thereof, and an ophthalmically acceptable carrier, an antimicrobially effective preservative, a tonicity agent for providing the composition with an ophthalmically acceptable tonicity, a comfort enhancing agent, at least one of an acidic or basic pH adjusting agent capable of adjusting pH of the composition to a desired ophthalmically acceptable pH level, and a buffer to substantially maintain the desired pH level.
摘要翻译：包含包含氨基酸序列LKKTET或LKKTNT的肽试剂，其保守变体或刺激LKKTET或LKKTNT肽生产的刺激剂或其保守变体的组合物和眼科可接受的载体，抗微生物有效的防腐剂，用于向组合物提供眼睛可接受的张力的张度剂，舒适增强剂，能够将组合物的pH调节至所需眼睛可接受的pH水平的酸性或碱性pH调节剂中的至少一种，以及基本保持所需的pH值。

20. 发明授权

US06197751B1 Thymosin &agr;1 promotes tissue repair, angiogenesis and cell migration 有权
标题翻译：胸腺素α1促进组织修复，血管生成和细胞迁移
公开(公告)号：US06197751B1
公开(公告)日：2001-03-06
申请号：US09186476
申请日：1998-11-04
申请人： Katherine M. Malinda , Hynda K. Kleinman , Allan L. Goldstein
发明人： Katherine M. Malinda , Hynda K. Kleinman , Allan L. Goldstein
IPC分类号： A61K3817
CPC分类号： A61K38/1841 , A61K38/2292 , A61K2300/00
摘要： The present invention relates to methods for promoting tissue repair, angiogenesis and cell migration. The method of the invention utilizes thymosin a1 (T&agr;1) peptide to promote tissue repair, angiogenesis and cell migration. The invention further relates to modulating T&agr;1 activity in tissues.
摘要翻译：本发明涉及促进组织修复，血管生成和细胞迁移的方法。本发明的方法利用胸腺素a1（Talpha1）肽促进组织修复，血管生成和细胞迁移。本发明还涉及调节组织中的Talpha1活性。

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