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11. 发明申请

US20100016177A1 TEMPLATED MOLECULES AND METHODS FOR USING SUCH MOLECULES 有权
标题翻译：使用这种分子的模板分子和方法
公开(公告)号：US20100016177A1
公开(公告)日：2010-01-21
申请号：US12330709
申请日：2008-12-09
申请人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Slok , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Thomas Thisted , Per-Ola Freskgard , Anette Holtmann
发明人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Slok , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Thomas Thisted , Per-Ola Freskgard , Anette Holtmann
IPC分类号： C40B40/08 , C07H1/00 , C12P19/34 , C40B50/06
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要： The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译：本发明涉及一种合成模板分子的方法。在本发明的一个方面，模板分子连接到模板，其模板化其合成。该内容允许生成可以被筛选的文库。治疗活动。

12. 发明授权

US08808984B2 Method for synthesising templated molecules 有权
标题翻译：合成模板分子的方法
公开(公告)号：US08808984B2
公开(公告)日：2014-08-19
申请号：US12179323
申请日：2008-07-24
申请人： Henrik Pedersen , Anette Holtmann , Thomas Franch , Alex Haahr Gouliaev , Jakob Felding
发明人： Henrik Pedersen , Anette Holtmann , Thomas Franch , Alex Haahr Gouliaev , Jakob Felding
IPC分类号： C12Q1/68 , C07H21/00 , C07H21/02 , C07H21/04 , C40B40/00 , C40B50/00
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H21/00 , C07H21/04 , C12Q1/6816 , C40B40/06 , C40B40/14
摘要： The invention relates to a method for synthesizing templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
摘要翻译：本发明涉及一种合成连接于模板的模板分子的方法，其指导其合成。该方法涉及模板，脚手架功能实体和连接到构件块的功能实体，其又附接模板。支架功能实体和构建单元的功能实体都具有互补的二聚化结构域，使得当互补结构域彼此相互作用时，功能实体能够接近。该方法可以用于产生可以选择用于生物活性的模板分子的文库。

13. 发明授权

US09109248B2 Method for the synthesis of a bifunctional complex 有权
标题翻译：双功能复合物的合成方法
公开(公告)号：US09109248B2
公开(公告)日：2015-08-18
申请号：US13455223
申请日：2012-04-25
申请人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
发明人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
IPC分类号： C12Q1/68 , C12N15/10
CPC分类号： C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifuntional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
摘要翻译：公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点的初生双功能复合物和用于酶标记添加的引发位点在化学反应位点与一个或多个反应物，并且提供标识起始位点处的反应物的各个标签是使用一种或多种酶。

14. 发明授权

US08206901B2 Method for the synthesis of a bifunctional complex 有权
标题翻译：双功能复合物的合成方法
公开(公告)号：US08206901B2
公开(公告)日：2012-06-26
申请号：US10525817
申请日：2003-10-30
申请人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
发明人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
IPC分类号： C12Q1/68 , C12P19/34 , C40B50/10 , C40B50/16
CPC分类号： C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactants(s) at the priming site using one or more enzymes.
摘要翻译：公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点的初生双功能复合物和用于酶标记添加的引发位点在化学反应位点与一个或多个并且使用一种或多种酶提供标识启动位点处的反应物的各个标签。

15. 发明申请

US20090143232A1 METHOD FOR SYNTHESISING TEMPLATED MOLECULES 有权
标题翻译：用于合成模板分子的方法
公开(公告)号：US20090143232A1
公开(公告)日：2009-06-04
申请号：US12179323
申请日：2008-07-24
申请人： Henrik Pedersen , Anette Holtmann , Thomas Franch , Alex Haahr Gouliaev , Jakob Felding
发明人： Henrik Pedersen , Anette Holtmann , Thomas Franch , Alex Haahr Gouliaev , Jakob Felding
IPC分类号： C40B10/00 , C07H1/00 , C40B40/08 , C40B30/04 , C40B50/14
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H21/00 , C07H21/04 , C12Q1/6816 , C40B40/06 , C40B40/14
摘要： The invention relates to a method for synthesizing templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
摘要翻译：本发明涉及一种合成连接于模板的模板分子的方法，其指导其合成。该方法涉及模板，脚手架功能实体和连接到构件块的功能实体，其又附接模板。支架功能实体和构建单元的功能实体都具有互补的二聚化结构域，使得当互补结构域彼此相互作用时，功能实体能够接近。该方法可以用于产生可以选择用于生物活性的模板分子的文库。

16. 发明授权

US07413854B2 Method for synthesising templated molecules 有权
标题翻译：合成模板分子的方法
公开(公告)号：US07413854B2
公开(公告)日：2008-08-19
申请号：US10507121
申请日：2003-03-14
申请人： Henrik Pedersen , Anette Holtmann , Thomas Franch , Alex Haahr Gouliaev , Jakob Felding
发明人： Henrik Pedersen , Anette Holtmann , Thomas Franch , Alex Haahr Gouliaev , Jakob Felding
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H21/00 , C07H21/04 , C12Q1/6816 , C40B40/06 , C40B40/14
摘要： The invention relates to a method for synthesizing templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
摘要翻译：本发明涉及一种合成连接于模板的模板分子的方法，其指导其合成。该方法涉及模板，脚手架功能实体和连接到构件块的功能实体，其又附接模板。支架功能实体和构建单元的功能实体都具有互补的二聚化结构域，使得当互补结构域彼此相互作用时，功能实体能够接近。该方法可以用于产生可以选择用于生物活性的模板分子的文库。

17. 发明申请

US20050221316A1 Method for synthesising templated molecules 有权
标题翻译：合成模板分子的方法
公开(公告)号：US20050221316A1
公开(公告)日：2005-10-06
申请号：US10507121
申请日：2003-03-14
申请人： Henrik Pedersen , Anette Holtmann , Thomas Franch , Alex Haahr , Jakob Felding
发明人： Henrik Pedersen , Anette Holtmann , Thomas Franch , Alex Haahr , Jakob Felding
IPC分类号： F03D9/00 , C07B20060101 , C07B61/00 , C07D405/04 , C07H20060101 , C07H21/00 , C12N20060101 , C12N15/10 , C12P20060101 , C12P1/00 , C12P19/34 , C12Q1/68 , H02P9/00
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H21/00 , C07H21/04 , C12Q1/6816 , C40B40/06 , C40B40/14
摘要： The invention relates to a method for synthesizing templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
摘要翻译：本发明涉及一种合成连接于模板的模板分子的方法，其指导其合成。该方法涉及模板，脚手架功能实体和连接到构件块的功能实体，其又附接模板。支架功能实体和构建单元的功能实体都具有互补的二聚化结构域，使得当互补结构域彼此相互作用时，功能实体能够接近。该方法可以用于产生可以选择用于生物活性的模板分子的文库。

18. 发明申请

US20060246450A1 Ligational encoding of small molecules 有权
标题翻译：小分子的编码编码
公开(公告)号：US20060246450A1
公开(公告)日：2006-11-02
申请号：US10549619
申请日：2004-03-22
申请人： Thomas Franch , Soeren Jacobsen , Torben Rasmussen , Soeren Neve , Henrik Pedersen , Alex Gouliaev
发明人： Thomas Franch , Soeren Jacobsen , Torben Rasmussen , Soeren Neve , Henrik Pedersen , Alex Gouliaev
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C07H21/04 , C12N15/1068 , C12P21/02 , C40B40/06 , C40B50/04
摘要： The invention relates to a method for synthesising a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, said method comprising the steps of i) providing a) at least one template comprising one or more codons capable of hybridising to an anti-codon, wherein said template is optionally associated with one or more chemical entities, and b) a plurality of building blocks each comprising an anti-codon associated with one or more chemical entities, and ii) hybridising the anti-codon of one or more of the provided building blocks to the template, iii) covalently linking said anti-codons and/or linking the at least one template with the anti-codon of at least one building block, thereby generating an identifier polynucleotide capable of identifying chemical entities having participated in the synthesis of the encoded molecule, iv) separating the template from one or more of the anti-codons hybridised thereto, thereby generating an at least partly single stranded identifier polynucleotide associated with a plurality of chemical entities, v) generating a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, wherein said encoded molecule is generated by reacting at least two of said plurality of chemical entities associated with the identifier polynucleotide, and wherein said at least two chemical entities are provided by separate building blocks.
摘要翻译：本发明涉及一种合成双功能复合物的方法，所述双功能复合物包含编码分子和识别已经参与编码分子合成的化学实体的标识多核苷酸，所述方法包括以下步骤：i）提供a）至少一个包含一个或更多能够与抗密码子杂交的密码子，其中所述模板任选地与一个或多个化学实体相关联，以及b）多个结构单元，每个结构单元包含与一个或多个化学实体相关的抗密码子，以及ii）将一个或多个所提供的构建块的抗密码子与模板杂交，iii）共价连接所述抗密码子和/或将至少一个模板与至少一个构建块的抗密码子连接，由此产生能够识别已经参与编码分子的合成的化学实体的标识符多核苷酸，iv）将模板从一个或多个分离出来更多的与其杂交的抗密码子，从而产生与多个化学实体相关联的至少部分单链标识多核苷酸，v）产生包含编码分子的双功能复合物和识别参与合成的化学实体的标识符多核苷酸的编码分子，其中所述编码的分子通过使与所述标识多核苷酸相关联的所述多个化学实体中的至少两个反应而产生，并且其中所述至少两个化学实体由单独的构建块提供。

19. 发明申请

US20080193983A1 Quasirandom Structure and Function Guided Synthesis Methods 有权
标题翻译： Quasirandom结构与功能引导合成方法
公开(公告)号：US20080193983A1
公开(公告)日：2008-08-14
申请号：US10539288
申请日：2003-12-19
申请人： Alex Haahr Gouliaev , Anette Holtmann , Henrik Pedersen , Thomas Franch
发明人： Alex Haahr Gouliaev , Anette Holtmann , Henrik Pedersen , Thomas Franch
IPC分类号： C12P19/34 , C07H21/04 , C07K5/08 , G01N33/50
CPC分类号： C40B30/04 , C12N15/1068 , C40B20/04 , C40B40/06 , C40B50/04 , C40B50/08 , Y10T436/145555
摘要： The present invention is directed to the synthesis of molecules guided b connector polynucleotides (CPNs capable of hybridizing to complementary connector polynucleotides (CCPNs) harbouring at least one functional entity comprising at least one reactive group. At least one of said CCPNs capable of hybridize to at least two CPNs. Each CPN will “call” for one or more CCPNs capable of hybridization to the CPN. Following the formation of a supramolecular hybridization complex comprising a plurality of CPNs and a plurality of CCPNs, the reaction of functional entity reactive groups result I the formation of a molecule comprising covalently linked functional entities. The formation of the molecule involves the transfer of functional entities from one or more “donor CCPNs” to at least on “acceptor CCPN” with which the transferred functional entities were not associated prior to the transfer.
摘要翻译：本发明涉及分子引导的b连接体多核苷酸（能够与包含至少一个包含至少一个反应性基团的至少一个功能实体的互补连接子多核苷酸（CCPN）杂交）的分子的合成，所述至少一种能够与至少两个CPN，每个CPN将“呼叫”一个或多个能够与CPN杂交的CCPN，形成包含多个CPN和多个CCPN的超分子杂交复合物后，功能性实体反应性基团的反应导致I 分子的形成包括共价连接的功能实体。分子的形成涉及将功能性实体从一个或多个“供体CCPN”转移至至少在“受体CCPN”之间，转移的功能实体在其之前不相关联转让。

20. 发明申请

US20060099589A1 Gene shuffling by template switching 审中-公开
标题翻译：基因改组通过模板切换
公开(公告)号：US20060099589A1
公开(公告)日：2006-05-11
申请号：US10522171
申请日：2003-07-11
申请人： Henrik Pedersen , Thomas Thisted , Hans Moller
发明人： Henrik Pedersen , Thomas Thisted , Hans Moller
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12P19/34 , C12N15/1027 , C12N15/1096 , C12Q1/6811
摘要： The present invention provides a new approach to creating novel polynucleotide sequences by point mutation and recombination in vitro of a set of parental sequences. The new polynucleotide sequences can be useful in themselves or they can be used for the templated synthesis of polymers, e.g. polypeptides composed of α-amino acids as occurring naturally in protein synthesis or polymers comprised of β-amino acids or other building blocks as described (Templated molecules).
摘要翻译：本发明提供了通过点突变和体外重组一组亲本序列来产生新的多核苷酸序列的新方法。新的多核苷酸序列本身可以有用，或者它们可以用于聚合物的模板化合成，例如，由蛋白质合成中天然存在的α-氨基酸组成的多肽或由β-氨基酸或所述的其他结构单元（模板分子）组成的聚合物。

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