专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US5670493A Aminophenylphosphonic acid compounds 失效
标题翻译：氨基苯膦酸化合物
公开(公告)号：US5670493A
公开(公告)日：1997-09-23
申请号：US684469
申请日：1996-07-19
申请人： Alex Cordi , Patrice Desos , Angela D. Morris , Ghanem Atassi
发明人： Alex Cordi , Patrice Desos , Angela D. Morris , Ghanem Atassi
IPC分类号： A61K31/66 , A61K31/665 , A61K31/67 , A61K31/675 , A61P27/02 , A61P35/00 , C07F9/38 , C07F9/40 , C07F9/572 , C07F9/655 , C07F9/6553
CPC分类号： C07F9/655345 , C07F9/3834 , C07F9/3882 , C07F9/4021 , C07F9/5728 , C07F9/65515
摘要： A compound of formula (I): ##STR1## in which: R.sub.1, R.sub.2, which may be identical or different, represent hydrogen or halogen, or alkyl, alkoxy, nitro or trihalomethyl, X represents CO, SO.sub.2 or CH.sub.2, A.sub.1 represents any one of the groups as defined in the description, A.sub.2 represents --(CH.sub.2).sub.n or --CH.dbd.CH--, R.sub.3, R.sub.4, which may be identical or different, represent hydrogen or alkyl, its isomers as well as its addition salts with a pharmaceutically acceptable base and medicinal product containing the same are useful as angiogenesis inhibitors.
摘要翻译：式（I）化合物：其中：R 1，R 2可以相同或不同，表示氢或卤素，或烷基，烷氧基，硝基或三卤甲基，X表示CO，SO 2或CH 2， A1表示说明书中定义的任何一个基团，A 2表示 - （CH 2）n或-CH = CH-，R 3，R 4可以相同或不同，表示氢或烷基，其异构体及其加成与药学上可接受的碱的盐和含有它们的药物可用作血管发生抑制剂。

12. 发明申请

US20070249594A1 Benzothiazine and benzothiadiazine compounds 失效
标题翻译：苯并噻嗪和苯并噻二嗪化合物
公开(公告)号：US20070249594A1
公开(公告)日：2007-10-25
申请号：US11823439
申请日：2007-06-27
申请人： Patrice Desos , Alex Cordi , Pierre Lestage
发明人： Patrice Desos , Alex Cordi , Pierre Lestage
IPC分类号： A61K31/549 , A61K31/554 , C07D279/16 , C07D285/22
CPC分类号： C07D513/04
摘要： Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 represents hydrogen, a halogen or hydroxy, A represents NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, X is as defined in the description, their isomers, and also addition salts thereof. Medicinal products containing the same which are useful in treating disorders of the AMPA system.
摘要翻译：式（I）的化合物：其中：R 1表示氢，卤素或烷基，R 1a表示氢或烷基，R 2表示氢，卤素或羟基，A表示NR 4，R 3表示氢，烷基或环烷基，R 4表示氢或烷基，X 如说明书中所定义，它们的异构体及其加成盐。含有该药物的药物可用于治疗AMPA系统的病症。

13. 发明授权

US07250411B2 Benzothiazine and benzothiadiazine compounds 失效
标题翻译：苯并噻嗪和苯并噻二嗪化合物
公开(公告)号：US07250411B2
公开(公告)日：2007-07-31
申请号：US10499082
申请日：2002-12-20
申请人： Alex Cordi , Patrice Desos , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , Pierre Lestage
IPC分类号： C07D285/22 , A61K31/5415 , A61P25/24
CPC分类号： C07D285/24 , C07D279/02
摘要： Compounds of formula (I): wherein: R1 represents hydroxy or RCO—O—, R2 represents hydrogen, halogen, hydroxy or R′CO—O, R, R′, which may be identical or different, represent linear or branched (C1-C6)alkyl optionally substituted by aryl, linear or branched (C2-C6)alkenyl optionally substituted by aryl, linear or branched (C1-C6)perhaloalkyl, (C3-C7)cycloalkyl, adamantyl, aryl or heteroaryl, R3 represents hydrogen, linear or branched (C1-C6)alkyl or (C3-C7)cycloalkyl, A represents CR4R5 or NR4, R4 represents hydrogen or linear or branched (C1-C6)alkyl,their isomers and also their addition salts with a pharmaceutically acceptable acid or base.Medicaments.
摘要翻译：式（I）化合物：其中：R 1表示羟基或RCO-O-，R 2表示氢，卤素，羟基或R'CO-O，R， R'可以相同或不同，表示直链或支链（C 1 -C 6 -C 6）烷基，其任选被直链或支链的芳基（C 2 任选被芳基，直链或支链（C 1 -C 6 -C 6）全卤代烷基取代的（C 1 -C 6 - 金刚烷基，芳基或杂芳基，R 3表示直链或支链（C 1 -C 3）烷基的氢， C 1 -C 6烷基或（C 3 -C 7 -C 7）环烷基，A表示CR 4 R 7， R 5或NR 4，R 4表示氢或直链或支链（C 1 -C 6 - /它们的异构体，以及它们与药学上可接受的酸或碱的加成盐。药剂

14. 发明申请

US20050014744A1 Benzothiazine and benzothiadiazine compounds 失效
标题翻译：苯并噻嗪和苯并噻二嗪化合物
公开(公告)号：US20050014744A1
公开(公告)日：2005-01-20
申请号：US10499082
申请日：2002-12-20
申请人： Alex Cordi , Patrice Desos , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , Pierre Lestage
IPC分类号： A61K31/5415 , A61K31/549 , A61P9/10 , A61P25/08 , A61P25/14 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07B61/00 , C07D279/02 , C07D285/24 , C07D279/16 , C07D285/22
CPC分类号： C07D285/24 , C07D279/02
摘要： Compounds of formula (I): wherein: R1 represents hydroxy or RCO—O—, R2 represents hydrogen, halogen, hydroxy or R′CO—O, R, R′, which may be identical or different, represent linear or branched (C1-C6)alkyl optionally substituted by aryl, linear or branched (C2-C6)alkenyl optionally substituted by aryl, linear or branched (C1-C6)perhaloalkyl, (C3-C7)cycloalkyl, adamantyl, aryl or heteroaryl, R3 represents hydrogen, linear or branched (C1-C6)alkyl or (C3-C7)cycloalkyl, A represents CR4R5 or NR4, R4 represents hydrogen or linear or branched (C1-C6)alkyl, their isomers and also their addition salts with a pharmaceutically acceptable acid or base. Medicaments.
摘要翻译：式（I）化合物：其中：R 1表示羟基或RCO-O-，R 2表示氢，卤素，羟基或R'CO-O，R，R'可以相同或不同，表示直链或支链任选被芳基，直链或支链（C1-C6）全卤代烷基，（C3-C7）环烷基，金刚烷基，芳基或杂芳基取代的直链或支链（C2-C6）烯基取代的-C6-烷基，R3代表氢，直链或支链（C1-C6）烷基或（C3-C7）环烷基，A表示CR4R5或NR4，R4表示氢或直链或支链（C1-C6）烷基，它们的异构体，以及它们与药学上可接受的酸的加成盐或基础。药剂

15. 发明授权

US5646132A 2(1H)-quinolone compounds 失效
标题翻译： 2（1H） - 喹诺酮化合物
公开(公告)号：US5646132A
公开(公告)日：1997-07-08
申请号：US499946
申请日：1995-07-10
申请人： Alex Cordi , Patrice Desos , Jean Lepagnol
发明人： Alex Cordi , Patrice Desos , Jean Lepagnol
IPC分类号： A61K31/675 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/28 , A61P43/00 , C07F9/576 , C07F9/60
CPC分类号： C07F9/5765 , C07F9/60
摘要： Compound of formula (I): ##STR1## in which: R.sub.1, R.sub.2 and R.sub.3, which are identical or different, represent hydrogen or halogen or alkyl, nitro, cyano or aminosulfonyl, or alternatively, when two of them are located on adjacent carbons, form, with the carbon atoms to which they are attached, (C.sub.3 -C.sub.7) cycloalkyl ring or substituted or unsubstituted benzene ring,R.sub.4 represents hydrogen, linear or branched (C.sub.1 -C.sub.6) alkyl, substituted or unsubstituted phenyl or a group ##STR2## in which R.sub.6 and R.sub.7, which are identical or different, represent hydrogen or substituted or unsubstituted, linear or branched (C.sub.1 -C.sub.6) alkyl,R.sub.5 represents hydrogen, hydroxyl, linear or branched (C.sub.1 -C.sub.6) alkoxy, phenoxy, mercapto, linear or branched (C.sub.1 -C.sub.6) alkylthio, substituted or unsubstituted, linear or branched (C.sub.1 -C.sub.6) alkyl, substituted or unsubstituted phenyl or substituted or unsubstituted amino, or a group ##STR3## in which R.sub.6 and R.sub.7 are as defined above, their isomers as well as their addition salts with a pharmaceutically acceptable acid or base, and medicinal product containing the same are useful as inhibitor of the pathological phenomena associated with hyperactivation of the excitating amino acid-dependant pathways of neurotransmission.
摘要翻译：式（I）化合物：其中：R 1，R 2和R 3相同或不同，表示氢或卤素或烷基，硝基，氰基或氨基磺酰基，或者当其中两个位于（C 3 -C 7）环烷基环或取代或未取代的苯环，R 4表示氢，直链或支链（C 1 -C 6）烷基，取代或未取代的苯基或取代或未取代的苯基基团其中R6和R7相同或不同，表示氢或取代或未取代的直链或支链（C1-C6）烷基，R5表示氢，羟基，直链或支链（C1-C6）烷氧基，苯氧基（C1-C6）烷基，取代或未取代的直链或支链（C1-C6）烷基，取代或未取代的苯基或取代或未取代的氨基，或其中R6和R7为它们的异构体以及它们与药物的加成盐可接受的酸或碱，以及含有它们的药物可用作与神经传递的兴奋性氨基酸依赖性途径的高活化相关的病理现象的抑制剂。

16. 发明授权

US07262189B2 Benzothiazine and benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same 失效
标题翻译：苯并噻嗪和苯并噻二嗪衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US07262189B2
公开(公告)日：2007-08-28
申请号：US10499164
申请日：2002-12-20
申请人： Alex Cordi , Patrice Desos , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , Pierre Lestage
IPC分类号： C07D513/04 , A61K31/542 , A61P25/24
CPC分类号： C07D513/04 , C07D279/02
摘要： Compounds of formula (I): wherein: R1 represents aryl or heteroaryl, R2 represents hydrogen, halogen or hydroxy, X represents oxygen or sulphur, Y represents oxygen, sulphur or NR wherein R represents hydrogen or alkyl, A represents CR4R5 or NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, or A represents nitrogen and, together with adjacent —CHR3—, forms the ring wherein m represents 1, 2 or 3, R5 represents hydrogen or halogen, their isomers and also their addition salts Medicaments.
摘要翻译：式（I）化合物：其中：R 1表示芳基或杂芳基，R 2表示氢，卤素或羟基，X表示氧或硫，Y表示氧，硫或NR，其中R表示氢或烷基，A表示CR 4 R 5或NR 4，R 3表示氢，烷基或环烷基，R 4表示氢或烷基，或A表示氮，并且与相邻的-CHR 3 - 一起形成环，其中m表示1,2 或3，R 5表示氢或卤素，它们的异构体以及它们的加成盐药物。

17. 发明授权

US07253161B2 Benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same 失效
标题翻译：苯并噻嗪和苯并噻二嗪衍生物的制备方法和含有它们的药物组合物
公开(公告)号：US07253161B2
公开(公告)日：2007-08-07
申请号：US10498948
申请日：2002-12-20
申请人： Alex Cordi , Patrice Desos , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , Pierre Lestage
IPC分类号： C07D513/04 , A61K31/542 , A61P25/24
CPC分类号： C07D513/04 , C07D279/02
摘要： Compounds of formula (I): wherein: R1 represents aryl or heteroaryl, R2 represents hydrogen, halogen or hydroxy, A represents CR4R5 or NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, or A represents nitrogen and, together with adjacent —CHR3—, forms the ring wherein m represents 1, 2 or 3, R5 represents hydrogen or halogen, their isomers and also their addition salts. Medicaments.
摘要翻译：式（I）化合物：其中：R 1表示芳基或杂芳基，R 2表示氢，卤素或羟基，A表示CR 4 R 5或NR 4，R 3表示氢，烷基或环烷基，R 4表示氢或烷基，或A表示氮，并且与相邻的-CHR 3 - 一起形成环，其中m表示1,2或3，R 5表示氢或卤素，它们的异构体和也是它们的加成盐。药剂

18. 发明申请

US20050124606A1 Novel benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same 失效
标题翻译：新颖的苯并噻嗪和苯并噻二嗪衍生物的制备方法和含有它们的药物组合物
公开(公告)号：US20050124606A1
公开(公告)日：2005-06-09
申请号：US10498948
申请日：2002-12-20
申请人： Alex Cordi , Patrice Desos , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , Pierre Lestage
IPC分类号： C07D285/24 , A61K31/549 , A61K31/662 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D279/02 , C07D417/12 , C07D513/04 , C07D498/14
CPC分类号： C07D513/04 , C07D279/02
摘要： Compounds of formula (I): wherein: R1 represents aryl or heteroaryl, R2 represents hydrogen, halogen or hydroxy, A represents CR4R5 or NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, or A represents nitrogen and, together with adjacent —CHR3—, forms the ring wherein m represents 1, 2 or 3, R5 represents hydrogen or halogen, their isomers and also their addition salts. Medicaments.
摘要翻译：式（I）化合物：其中：R 1表示芳基或杂芳基，R 2表示氢，卤素或羟基，A表示CR 4 R 5或NR 4，R 3表示氢，烷基或环烷基，R 4表示氢或烷基，或A表示氮，并且与相邻的-CHR 3 - 一起形成环，其中m表示1,2或3，R 5表示氢或卤素，它们的异构体和也是它们的加成盐。药剂

19. 发明授权

US06635635B2 Benzothiadiazine compounds 失效
标题翻译：苯并噻二嗪化合物
公开(公告)号：US06635635B2
公开(公告)日：2003-10-21
申请号：US09916479
申请日：2001-07-27
申请人： Alex Cordi , Patrice Desos , François Lefoulon , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , François Lefoulon , Pierre Lestage
IPC分类号： C07D51304
CPC分类号： C07D513/04
摘要： Compound of formula (I): wherein: R1 represents hydroxy, RCO—O— or RCO—NRa—, R2 represents hydrogen, halogen, or hydroxy, R′CO—O or R′CO—NR′a—, R and R′, which may be identical or different, represent linear or branched (C1-C6)alkyl optionally substituted by aryl, linear or branched (C2-C6)alkenyl optionally substituted by aryl, linear or branched (C1-C6)perhaloalkyl, (C3-C7)cycloalkyl, adamantyl, aryl or heteroaryl, Ra and R′a, which may be identical or different, represent hydrogen or linear or branched (C1-C6)alkyl, linear or branched (C1-C6)perhaloalkyl, linear or branched (C1-C6)acyl, aryl or heteroaryl, its isomer and addition salts thereof with a pharmaceutically acceptable acid or base and medicinal products containing the same are useful as AMPA modulators.
摘要翻译：式（I）化合物：其中：R1代表羟基，RCO-O-或RCO-NRa-，R2代表氢，卤素或羟基，R'CO-O或R'CO-NR'a-，R和R （C 1 -C 6）烷基，任选被芳基，直链或支链（C 1 -C 6）全卤代烷基取代的直链或支链（C 1 -C 6）烷基，任选被芳基，直链或支链（C 2 -C 6） -C 7）环烷基，金刚烷基，芳基或杂芳基，R a和R a可以相同或不同，表示氢或直链或支链（C1-C6）烷基，直链或支链（C1-C6）全卤代烷基，直链或支链（C 1 -C 6）酰基，芳基或杂芳基，其异构体和其药学上可接受的酸或碱的加成盐和含有它们的药物可用作AMPA调节剂。

20. 发明授权

US06518258B1 6-sulphamoyl -3-quinolyphosphonic acid compounds 失效
标题翻译： 6-氨磺酰基-3-喹啉基膦酸化合物
公开(公告)号：US06518258B1
公开(公告)日：2003-02-11
申请号：US09783650
申请日：2001-02-14
申请人： Alex Cordi , Patrice Desos , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , Pierre Lestage
IPC分类号： A61K31675
CPC分类号： C07F9/60 , Y10S514/878 , Y10S514/879 , Y10S514/907
摘要： The invention relates to a compound of formula (I): wherein: X represents chlorine or fluorine or CF3, R represents hydrogen or a group and methods for using the same.
摘要翻译：本发明涉及式（I）化合物：其中： X表示氯或氟或CF 3， R表示氢或一个基团及其使用方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式