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11. 发明申请

US20070155950A1 Alkylated poly(allylamine) polymers and methods of use 有权
标题翻译：烷基化聚（烯丙胺）聚合物和使用方法
公开(公告)号：US20070155950A1
公开(公告)日：2007-07-05
申请号：US11491788
申请日：2006-07-24
申请人： W. Mandeville , Stephen Holmes-Farley
发明人： W. Mandeville , Stephen Holmes-Farley
IPC分类号： C08G63/08
CPC分类号： C08F220/60 , A61K31/785 , A61K31/787 , C08F8/00 , C08F8/02 , C08F8/44 , C08F26/00 , C08F220/34 , C08L39/02 , C08F220/00 , C08F226/02 , C08F26/02
摘要： The invention relates to a method for removing bile salts from a patient in need thereof and compositions useful in the method. The method comprises administering to the patient a therapeutically effective amount of a salt of an alkylated and crosslinked polymer. The alkylated and crosslinked polymer salt comprises the reaction product of crosslinked polymers, or salts and copolymers thereof having amine containing repeat units, with at least one aliphatic alkylating agent.
摘要翻译：本发明涉及从有需要的患者中除去胆汁盐的方法和用于该方法的组合物。该方法包括向患者施用治疗有效量的烷基化和交联聚合物的盐。烷基化和交联的聚合物盐包括具有含有重复单元的胺的交联聚合物或其盐和共聚物与至少一种脂族烷基化剂的反应产物。

12. 发明申请

US20070021509A1 Phosphate transport inhibitors 审中-公开
标题翻译：磷酸盐转运抑制剂
公开(公告)号：US20070021509A1
公开(公告)日：2007-01-25
申请号：US11489286
申请日：2006-07-19
申请人： Thomas Jozefiak , Cecilia Bastos , Andrew Papoulis , Stephen Holmes-Farley
发明人： Thomas Jozefiak , Cecilia Bastos , Andrew Papoulis , Stephen Holmes-Farley
IPC分类号： A61K31/18
CPC分类号： A61K45/06 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/415 , A61K31/63 , A61K33/38 , A61K2300/00
摘要： Disclosed are compounds which have been identified as inhibitors of phosphate transport. Many of the compounds are represented by Structural Formula (I): Ar1—W—X—Y—Ar2; or a pharmaceutically acceptable salt thereof. Ar1 and Ar2 are independently a substituted or unsubstituted aryl group or an optionally substituted five membered or six membered non-aromatic heterocylic group fused to an optionally substituted monocylic aryl group. W and Y are independently a covalent bond or a C1-C3 substituted or unsubstituted alkylene group. X is a heteroatom-containing functional group, an aromatic heterocyclic group, substituted aromatic heterocyclic group, non-aromatic heterocyclic group, substituted non-aromatic heterocyclic group, an olefin group or a substituted olefin group. Also disclosed are methods of treating a subject with a disease associated with hyperphosphatemia, as well as a disease mediated by phosphate-transport function. The methods comprise the step of administering an effective amount of the one of the compounds described above.
摘要翻译：公开了已被鉴定为磷酸盐转运抑制剂的化合物。许多化合物由结构式（I）表示：<？in-line-formula description =“In-line Formulas”end =“lead”？> Ar -WXY-Ar _{2 <？in-line-formula description =“In-line Formulas”end =“tail”？>或其药学上可接受的盐。 Ar 1和Ar 2独立地是与任选取代的单环芳基稠合的取代或未取代的芳基或任选取代的五元或六元非芳族杂环基。 W和Y独立地是共价键或C1-C3取代或未取代的亚烷基。 X为含杂原子的官能团，芳香族杂环基，取代芳香族杂环基，非芳香族杂环基，取代非芳香族杂环基，烯基或取代烯基。还公开了治疗患有与高磷酸盐血症相关的疾病的受试者以及由磷酸盐转运功能介导的疾病的方法。所述方法包括施用有效量的上述一种化合物的步骤。}

13. 发明申请

US20060239959A1 Method for treating hypercholesterolemia with polyallylamine polymers 审中-公开
公开(公告)号：US20060239959A1
公开(公告)日：2006-10-26
申请号：US11344862
申请日：2006-02-01
申请人： Stephen Holmes-Farley , W. Mandeville , Steven Burke , Dennis Goldberg
发明人： Stephen Holmes-Farley , W. Mandeville , Steven Burke , Dennis Goldberg
IPC分类号： A61K31/785
CPC分类号： A61K31/785
摘要： A method for removing bile salts from a patient that includes administering to the patient a therapeutically effective amount of a non-absorbable amine polymers characterized by a repeat unit having the formula: and salts thereof, where n is a positive integer and x is zero or an integer between 1 and about 4.

14. 发明授权

US06903557B2 Microwave moisture sensing via waveguide with slot array 失效
标题翻译：微波湿度传感通过波导与槽阵列
公开(公告)号：US06903557B2
公开(公告)日：2005-06-07
申请号：US10399220
申请日：2001-10-11
申请人： Wayne Stephen Holmes , Stephen Geoffrey Riley
发明人： Wayne Stephen Holmes , Stephen Geoffrey Riley
IPC分类号： F26B25/22 , G01N22/04 , G01R27/26 , G01R27/32
CPC分类号： G01N22/04 , F26B25/22
摘要： A generator (6) directs microwave signals to a waveguide (1) having a linear array of slots (2), and the signals are received by measuring device (5). The local permittivity or moisture content of material adjacent the waveguide (1), such as a stack of timber, may be determined at each slot (2) via regression analysis. The total permittivity or moisture may be determined by averaging measurements obtained for both transmission directions of the waveguide (1). The apparatus may be used for controlling drying parameters, such as drying time, for the material.
摘要翻译：发生器（6）将微波信号引导到具有线性阵列阵列（2）的波导（1），并且该信号由测量装置（5）接收。可以通过回归分析在每个槽（2）处确定邻近波导（1）的材料（例如一堆木材）的局部介电常数或水分含量。总介电常数或湿度可以通过对波导（1）的两个透射方向获得的测量值进行平均来确定。该装置可用于控制材料的干燥参数，例如干燥时间。

15. 外观设计

USD354563S Endoscopic forceps 失效
公开(公告)号：USD354563S
公开(公告)日：1995-01-17
申请号：US10794
申请日：1993-07-19
申请人： J. Stephen Holmes , Timothy LaMartina
设计人： J. Stephen Holmes , Timothy LaMartina

16. 发明授权

US09127419B2 Vehicle mounted apparatus for high-pressure fluid blasting 有权
标题翻译：用于高压液体喷砂的车载装置
公开(公告)号：US09127419B2
公开(公告)日：2015-09-08
申请号：US13518543
申请日：2010-12-23
申请人： Stephen Holmes Robinson
发明人： Stephen Holmes Robinson
IPC分类号： E01C23/12 , B08B3/02 , B08B5/04 , E01C23/08 , E01H1/10
CPC分类号： E01C23/12 , B08B3/024 , B08B5/04 , E01C23/08 , E01C23/128 , E01H1/103
摘要： A vehicle mounted apparatus for high-pressure fluid blasting to remove material from or otherwise treat a surface, the apparatus comprising: a high-pressure fluid supply connected to a nozzle assembly containing at least one nozzle, the nozzle assembly being supported for movement along a track mounted transversely on the vehicle; and a suction device for conveying airflow and removed material through a conduit from the nozzle assembly to a treatment zone within the vehicle, the treatment zone having a separation means for accumulating removed material, a means for conveying airflow from the separation means to the suction device, and a means for conveying the removed material to a storage zone.
摘要翻译：一种用于高压流体喷砂从而从表面去除或以其他方式处理表面的车载装置，所述装置包括：连接到包含至少一个喷嘴的喷嘴组件的高压流体供应装置，所述喷嘴组件被支撑以沿着轨道横向安装在车辆上; 以及用于将气流和去除的材料通过导管从喷嘴组件输送到车辆内的处理区的抽吸装置，处理区具有用于积聚去除的材料的分离装置，用于将气流从分离装置输送到抽吸装置的装置，以及用于将去除的材料输送到储存区的装置。

17. 发明申请

US20060263853A1 Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders 失效
标题翻译：可用于治疗IL4介导的疾病的重组IL4抗体
公开(公告)号：US20060263853A1
公开(公告)日：2006-11-23
申请号：US11493692
申请日：2006-07-26
申请人： Stephen Holmes , Mitchell Gross , Daniel Sylvester
发明人： Stephen Holmes , Mitchell Gross , Daniel Sylvester
IPC分类号： C12P21/06 , C07H21/04 , C12N5/06 , C07K16/24
CPC分类号： C07K16/247 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/6869
摘要： Chimeric and humanized IL4 A MAbs derived from affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided.
摘要翻译：嵌合和人源化IL4A提供衍生自亲和性MAb的MAb，含有它们的药物组合物和治疗方法。

18. 发明申请

US20060128664A1 Aryl boronic acids for treating obesity 有权
公开(公告)号：US20060128664A1
公开(公告)日：2006-06-15
申请号：US11343598
申请日：2006-01-31
申请人： Stephen Holmes-Farley , W. Mandeville , Pradeep Dhal , Chad Huval , Xinhua Li
发明人： Stephen Holmes-Farley , W. Mandeville , Pradeep Dhal , Chad Huval , Xinhua Li
IPC分类号： A61K31/69 , C07F5/02
CPC分类号： C07F5/025 , A61K31/74 , A61K31/785
摘要： Disclosed is a phenyl boronic acid compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aryl group. Z and Z′ are independently —O—. —NH— or —S—. X is an electron withdrawing group. R is a substituted or unsubstituted straight chained hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups and Y is —H, an amine, —[NH—(CH2)q]r—NH2, halogen, —CF3, thiol, ammonium, alcohol, —COOH, —SO3H, —OSO3H or phosphonium group covalently bonded to the terminal position of R. Each —NH— in —[NH—(CH2)q]r—NH2 is optionally N-alkylated or N,N-dialkylated and —NH2 in —[NH—CH2)q]r—NH2 is optionally N-alkylated, N,N-dialkylated or N,N,N-trialkylated. q is an integer from 2 to about 10 and r is an integer from 1 to about 5. R1 and R1′ are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or, taken together, are a C2-C5 substituted or unsubstituted alkylene group optionally comprising an amine linking group [—N+(R1a)—]. Each R1 is Structural Formula (I) is preferably —H. R1a is —H, alkyl, substituted alkyl phenyl or substituted phenyl. Also disclosed is a method of treating obesity in a subject by administering an effective amount of a compound represented by Structural Formula (I) and a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier or diluent.

19. 发明申请

US20060128663A1 Aryl boronate functionalized polymers for treating obesity 审中-公开
公开(公告)号：US20060128663A1
公开(公告)日：2006-06-15
申请号：US11342129
申请日：2006-01-27
申请人： Stephen Holmes-Farley , W. Mandeville , Pradeep Dhal , Chad Huval , Xinhua Li , Steven Polomoscanik
发明人： Stephen Holmes-Farley , W. Mandeville , Pradeep Dhal , Chad Huval , Xinhua Li , Steven Polomoscanik
IPC分类号： A61K31/69 , C08G79/08 , A01N55/08
CPC分类号： C08F8/42 , A61K31/74 , A61K31/785 , A61K47/58 , C08F8/44 , C08G65/331 , C08G73/0206 , C08G79/08 , C08F20/60 , C08F26/02
摘要： Disclosed are polymers comprising one or more phenyl boronate ester, boronamide or boronate thioester groups. The phenyl boronate ester, boronamide and boronate thioester groups are represented by one of the following structural formulas: Ar in Structural Formulas (I) and (II) is substituted or unsubstituted; and each Z is —O—, —NH— or —S— and is independently selected. Pharmaceutically acceptable salts of the polymer are also included. The aryl boronate ester, boronamide or boronate thioester can be cleaved to release the corresponding aryl boronic acid. Also disclosed are pharmaceutical compositions comprising the polymers of the present invention and a pharmaceutically acceptable carrier or diluent; and methods of treating a subject for obesity with the polymers of the present invention.

20. 发明申请

US20060127353A1 Fat-binding polymers 审中-公开
公开(公告)号：US20060127353A1
公开(公告)日：2006-06-15
申请号：US11349357
申请日：2006-02-06
申请人： Stephen Holmes-Farley
发明人： Stephen Holmes-Farley
IPC分类号： A61K31/785
CPC分类号： A61K31/785 , A61K31/74
摘要： The present invention provides fat-binding polymers, which comprise dialkanolamine, dialkanolammonium, aminoalkylpolyol, and ammoniumalkylpolyol pendant groups for subjects in need of fat removal from the gastrointestinal tract, particularly subjects suffering from steatorrhea and/or experiencing side effects from lipase inhibitors. Patients being administered with lipase inhibitors are typically being treated for Type II Diabetes, streatorrhea, and hypertriglyceridemia. The fat binding polymers of this invention are also suitable for use with obese subjects.

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