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11. 发明授权

US5344454A Closed porous chambers for implanting tissue in a host 失效
标题翻译：用于在组织中植入组织的封闭多孔室
公开(公告)号：US5344454A
公开(公告)日：1994-09-06
申请号：US861952
申请日：1992-04-01
申请人： Robert A Clarke , Robin G. Pauley , Ronald S. Hill , James H. Brauker , Shmuel Sternberg , Daniel R. Boggs
发明人： Robert A Clarke , Robin G. Pauley , Ronald S. Hill , James H. Brauker , Shmuel Sternberg , Daniel R. Boggs
IPC分类号： A61B5/00 , A61F2/02 , A61K9/00 , A61L27/38 , A61L27/56 , A61L29/00 , A61L29/14 , A61F2/54 , A61F13/00 , A61K9/22
CPC分类号： A61K9/0024 , A61F2/022 , A61L27/38 , A61L27/56 , A61L29/005 , A61L29/146 , A61B5/14532 , Y10S623/901
摘要： Improved Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish an improved chamber for holding the implanted cells. The chambers include first and second wall elements and an intermediate sealing element. The first and second wall elements overlie an open area in the sealing member to form a chamber for holding cells for implantation. A sealed region is created between the wall elements and the sealing element body to close the chamber. In one arrangement, the sealed region is created by means of a sonic weld made while the implanted cells are present in the chamber. In another arrangement, the sealed region is created by means of applying an external force to compress the peripheral edges of the wall elements and the sealing element together while the implanted cells are present in the chamber.
摘要翻译：改进的植入物组件和方法为植入的同种异体移植物，异种移植物和同种移植物提供免疫保护。组件和方法建立了用于保持植入细胞的改进室。这些室包括第一和第二壁元件和中间密封元件。第一和第二壁元件覆盖在密封构件中的开放区域以形成用于保持用于植入的细胞的室。在壁元件和密封元件主体之间产生密封区域以关闭室。在一种布置中，通过在植入的细胞存在于腔室中时进行的声波焊接来产生密封区域。在另一种布置中，通过施加外力来产生密封区域，以在腔室中存在植入的细胞的同时将壁元件和密封元件的周边边缘压缩在一起。

12. 发明授权

US5240614A Process for removing unwanted materials from fluids and for producing biological products 失效
标题翻译：从流体中除去未经处理的材料和生产生物产品的方法
公开(公告)号：US5240614A
公开(公告)日：1993-08-31
申请号：US818851
申请日：1992-01-10
申请人： Normal J. Ofsthun , Lee W. Henderson , Richard I. Brown , Robin G. Pauley
发明人： Normal J. Ofsthun , Lee W. Henderson , Richard I. Brown , Robin G. Pauley
IPC分类号： A61M1/18 , B01D61/14 , B01D61/18 , B01D61/24 , B01D63/02 , B01D69/02 , B01D69/08 , B01D71/68 , C12M1/12 , C12M3/06
CPC分类号： B01D61/147 , B01D61/243 , B01D69/02 , B01D69/08 , C12M29/16
摘要： The invention employs dual-skinned membranes useful as one way or rectifying membranes which reduce back filtration of solute molecules in dialysis and which improve nutrient supply and product recovery in membrane bioreactors. The membranes are dual-skinned polymeric materials preferably in the form of hollow fibers. The membranes have sieving coefficient characteristics different for flow of liquids in one direction from that in the opposite direction. Improved dialysis devices are formed by using bundles of the hollow fiber membranes as a dialysis means having rectifying properties. Improved bioreactors are formed by using bundles of hollow fiber as a growth vessel having rectifying properties.
摘要翻译：本发明采用双皮膜，其可用作单向或整流膜，其减少透析中溶质分子的反向过滤并改善膜生物反应器中的营养供应和产物回收。膜是双面聚合材料，优选为中空纤维的形式。该膜具有与在相反方向上的一个方向上的液体流动不同的筛分系数特性。通过使用中空纤维膜束作为具有整流性质的透析装置形成改进的透析装置。通过使用中空纤维束作为具有整流性质的生长容器来形成改良的生物反应器。

13. 发明申请

US20100063445A1 Device to Indicate Priming of an Infusion Line 有权
标题翻译：指示灌注线灌注的装置
公开(公告)号：US20100063445A1
公开(公告)日：2010-03-11
申请号：US12555606
申请日：2009-09-08
申请人： Shmuel Sternberg , Siddharth B. Desai , Larry Black , Robin G. Pauley
发明人： Shmuel Sternberg , Siddharth B. Desai , Larry Black , Robin G. Pauley
IPC分类号： A61J1/18 , A61M39/00 , G08B21/00
CPC分类号： G01D7/005 , A61M5/141 , A61M5/3146 , A61M5/385 , A61M39/10 , A61M39/20 , A61M2005/1402 , A61M2005/3125 , A61M2039/205 , A61M2205/331 , A61M2205/7536
摘要： A priming indicator for a fluid infusion system includes a luer cap or other component of the infusion system having an indicator surface covered by a membrane. The membrane exhibits a first visual characteristic, such as being opaque, when dry and exhibits a second characteristic, such as becoming less opaque, when wet. Once the membrane becomes wet, indicia on the surface, which may be provided on a rod at least partially covered by the membrane, becomes visible, thereby indicating an intravenous tube to which the luer cap is secured has been primed or is nearly primed. The indicator may alternately be employed at an upstream end of an infusion set, such as at the port of a medical bag providing a supply of fluid, to indicate a low level of fluid in the medical bag.
摘要翻译：用于流体输注系统的起动指示器包括输注系统的路厄帽或其他组件，其具有由膜覆盖的指示器表面。当膜干燥时，膜呈现第一视觉特征，例如不透明的，并且当湿时呈现第二特性，例如变得不透明。一旦膜变湿，可以设置在至少部分地被膜覆盖的杆上的表面上的标记变得可见，从而指示固定有鲁尔帽的静脉内管已经被引发或几乎被引发。可以在输液器的上游端（例如在提供流体供应的医疗袋的端口处）使用指示器，以指示医疗袋中的低水平的流体。

14. 发明授权

US6060640A Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue 失效
标题翻译：用于在宿主组织中植入细胞的多层形成的免疫隔离膜结构
公开(公告)号：US6060640A
公开(公告)日：2000-05-09
申请号：US446210
申请日：1995-05-19
申请人： Robin G. Pauley , Donna L. McLarty , Atul R. Khare , Shmuel Sternberg , Daniel R. Boggs , Steven Neuenfeldt , Mark Jones , James H. Brauker , Laura A. Martinson
发明人： Robin G. Pauley , Donna L. McLarty , Atul R. Khare , Shmuel Sternberg , Daniel R. Boggs , Steven Neuenfeldt , Mark Jones , James H. Brauker , Laura A. Martinson
IPC分类号： A61F2/02 , A61K9/00 , A61L27/38 , C12N5/08 , A61D7/00 , A61M31/00
CPC分类号： A61K9/0024 , A61F2/022 , A61L27/38
摘要： A permeable structure forms a chamber to hold living cells. The structure includes a first permeable region surrounding at least a portion of the chamber having a conformation that, when implanted in host tissue, substantially blocks penetration of host cells into the chamber while permitting solute transport. The structure also includes a second permeable region overlying the first permeable region having a conformation that, when implanted in host tissue, forms a permeable interface with host tissue that permits solute transport. A third permeable region is located between the first and second permeable regions. The third region comprises a solution of polymer material formed in place between the first and second permeable regions. The third permeable region bonds the first and second permeable regions together. The third permeable region also has a conformation that, when implanted in host tissue, permits solute transport between the first and second permeable regions. The third, formed-in-place region bonds the first and second permeable regions together, providing a robust, laminated structure that resists delamination during implantation caused by cellular infiltration into discontinuous spaces between the first and second regions. The third, formed-in-place region can also have a conformation providing an immunoisolation effect. Furthermore, the permeability of the third, formed-in-place membrane is sufficient high that it does not adversely effect the permeability value desired for the overall multiple layer membrane structure.
摘要翻译：可渗透结构形成容纳活细胞的室。所述结构包括围绕所述腔室的至少一部分的第一可渗透区域，其具有当植入宿主组织时基本上阻挡宿主细胞渗入所述腔室同时允许溶质运输的构象。该结构还包括覆盖第一可渗透区域的第二可渗透区域，其具有当植入宿主组织中时形成允许溶质运输的宿主组织的可渗透界面的构象。第三可渗透区域位于第一和第二可渗透区域之间。第三区域包括在第一和第二可渗透区域之间形成的聚合物材料溶液。第三可渗透区域将第一和第二可渗透区域结合在一起。第三可渗透区域还具有当植入宿主组织时允许溶质在第一和第二可渗透区域之间传输的构象。第三个就地区域将第一和第二可渗透区域结合在一起，提供坚固的层压结构，其抵抗由于细胞浸润到第一和第二区域之间的不连续空间而在植入过程中的分层。第三个就地区域也可以具有提供免疫隔离作用的构象。此外，第三成形膜的渗透性足够高，使得其不会对整个多层膜结构所期望的渗透性值产生不利影响。

15. 发明授权

US5527467A Rectifying dialyzer, bioreactor and membrane 失效
标题翻译：整形透析器，生物反应器和膜
公开(公告)号：US5527467A
公开(公告)日：1996-06-18
申请号：US259279
申请日：1994-06-13
申请人： Norma J. Ofsthun , Lee W. Henderson , Richard I. Brown , Robin G. Pauley
发明人： Norma J. Ofsthun , Lee W. Henderson , Richard I. Brown , Robin G. Pauley
IPC分类号： B01D61/14 , B01D61/24 , B01D65/08 , B01D69/02 , B01D69/08 , C12M1/12 , C12M3/06 , B01D61/28
CPC分类号： B01D65/08 , B01D61/147 , B01D61/243 , B01D69/02 , B01D69/08 , B01D2321/2083
摘要： The invention provides dual-skinned membranes useful as one way or rectifying membranes which reduce back filtration of solute molecules in dialysis and which improve nutrient supply and product recovery in membrane bioreactors. The membranes are dual-skinned polymeric materials preferably in the form of hollow fibers. The membranes have skins of polymer on the opposite sides with differing permeability to solutes and sieving coefficient characteristics. The skin on each side have pores that are invisible at 10,000 times magnification, the microporous structure between said skins contains pores capable of retaining solutes in a molecular weight range of about 5000 to 200000 in an increased concentration between the interior and the exterior skins. Improved dialysis devices are formed by using bundles of the hollow fiber membranes as a dialysis means having rectifying properties.
摘要翻译：本发明提供双皮肤膜，其可用作单向或整流膜，其减少透析中溶质分子的反向过滤并改善膜生物反应器中的营养供应和产物回收。膜是双面聚合材料，优选为中空纤维的形式。膜在相对侧具有聚合物的表面，对溶质和筛分系数特性具有不同的渗透性。每侧的皮肤具有在10,000倍放大率下不可见的孔，所述表皮之间的微孔结构包含能够以内在和外表皮之间增加的浓度保持在约5000至200000的分子量范围内的溶质的孔。通过使用中空纤维膜束作为具有整流性质的透析装置形成改进的透析装置。

16. 发明申请

US20080021381A1 MEDICAL FLUID ACCESS DEVICE WITH ANTISEPTIC INDICATOR 有权
标题翻译：具有抗菌指示器的医用流体访问装置
公开(公告)号：US20080021381A1
公开(公告)日：2008-01-24
申请号：US11780917
申请日：2007-07-20
申请人： Kent L. LURVEY , Shmuel STERNBERG , Vadim V. KRONGAUZ , Rosa H. YEH , Robin G. PAULEY , Dustin C. CAWTHON , Ton That HAI , Lecon L. WOO , Ashok K. KHANNA , Birendra K. LAL , Michael Tung-Kiung LING , William S. HOERLE , Craig L. SANDFORD , Mark A. NORDHAUS , Alexander SAVITSKI , Nicklaus J. KIRICHKOW , Kenneth Glen SUH , Sivaramakrishnan KRISHNAMOORTHY , Hsinjin E. YANG , Robert A. CLARKE
发明人： Kent L. LURVEY , Shmuel STERNBERG , Vadim V. KRONGAUZ , Rosa H. YEH , Robin G. PAULEY , Dustin C. CAWTHON , Ton That HAI , Lecon L. WOO , Ashok K. KHANNA , Birendra K. LAL , Michael Tung-Kiung LING , William S. HOERLE , Craig L. SANDFORD , Mark A. NORDHAUS , Alexander SAVITSKI , Nicklaus J. KIRICHKOW , Kenneth Glen SUH , Sivaramakrishnan KRISHNAMOORTHY , Hsinjin E. YANG , Robert A. CLARKE
IPC分类号： A61M37/00
CPC分类号： G01N21/78 , A61M39/02 , A61M39/045 , A61M39/16 , A61M39/26 , A61M2039/1033 , A61M2039/1072 , A61M2205/583 , A61M2205/584 , G01N31/22
摘要： A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.
摘要翻译：公开了一种医疗装置，例如血管通路装置，用于提供对医用流体流路的通路，用于将医用流体引入或取出流路。访问装置包括用于当访问装置已经暴露于防腐剂时提供视觉指示的指示器。

17. 发明授权

US06908553B1 Composite membrane with particulate matter substantially immobilized therein 失效
标题翻译：复合膜，其中颗粒物质基本上固定在其中
公开(公告)号：US06908553B1
公开(公告)日：2005-06-21
申请号：US09111915
申请日：1998-07-08
申请人： Daniel R. Boggs , Shmuel Sternberg , Robin G. Pauley , Donna L. McLarty
发明人： Daniel R. Boggs , Shmuel Sternberg , Robin G. Pauley , Donna L. McLarty
IPC分类号： B01D69/12 , A61M1/36 , B01D69/14 , B01D71/20 , B01D71/30 , B01D71/38 , B01D71/54 , B01J20/28 , B01D39/00
CPC分类号： B01J20/28033 , A61M1/3686 , B01D69/141 , B01J20/28004 , B01J20/28026 , B01J20/28035
摘要： Membranes and methods for making membranes are disclosed. The membranes include a polymeric matrix and a particulate material immobilized within the matrix. The membranes may find particular application in methods and apparatus for removing organic compounds from a biological fluid as part of a pathogen inactivation treatment.
摘要翻译：公开了膜和膜的制造方法。膜包括聚合物基质和固定在基质内的颗粒物质。作为病原体灭活处理的一部分，膜可以特别适用于从生物液体中除去有机化合物的方法和装置。

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