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11. 发明授权

US4431085A Method of operating an elevator system 失效
标题翻译：操作电梯系统的方法
公开(公告)号：US4431085A
公开(公告)日：1984-02-14
申请号：US324363
申请日：1981-11-24
申请人： Robert C. MacDonald
发明人： Robert C. MacDonald
IPC分类号： B66B1/18
CPC分类号： B66B1/18
摘要： A new and improved method of serving calls for elevator service in a building. The method independently serve at least two groups of floors using at least two banks of elevator cars, from a single system processor. The full strategy of the system processor is applied to each group as a whole, and not as segments of a strategy, to improve elevator service to each group, while effecting the economies which result from the utilization of a single system processor, a single hall call processor, and a single data transmission system.
摘要翻译：一种新的改进的建筑物电梯服务呼叫方法。该方法使用至少两组电梯轿厢从单个系统处理器独立地服务至少两组楼层。系统处理器的全部策略作为一个整体应用于每个组，而不是作为战略的一部分，以改善每个组的电梯服务，同时实现由单个系统处理器，单个大厅呼叫处理器和单个数据传输系统。

12. 发明授权

US07976743B2 Gas-containing liposomes 有权
标题翻译：含气体的脂质体
公开(公告)号：US07976743B2
公开(公告)日：2011-07-12
申请号：US11873256
申请日：2007-10-16
申请人： Shaoling Huang , Patrick Kee , Robert C. MacDonald , David McPherson
发明人： Shaoling Huang , Patrick Kee , Robert C. MacDonald , David McPherson
IPC分类号： A61K9/127 , A61K51/00 , C12N15/88
CPC分类号： A61K9/127 , A61K9/0009 , A61K9/1277 , A61K9/19 , Y10S977/907
摘要： The present invention provides gas-containing liposomes. In particular, the present invention provide methods of generating gas-containing liposomes where the gas is introduced under pressure, as well as gas-containing liposomes which contain a large volume of gas (e.g., 10 ul of gas per 5 mg of gas-containing liposomes). In certain embodiments, the gas-containing liposomes contain nitric oxide gas. In some embodiments, such nitric oxide containing liposomes are used to treat a medical condition that is treatable by nitric oxide gas (e.g., intimal hyperplasia).
摘要翻译：本发明提供含气体的脂质体。特别地，本发明提供产生气体在压力下引入气体的含气体脂质体的方法，以及含有大量气体的含气体脂质体（例如，每5mg含气体的气体为10μl气体脂质体）。在某些实施方案中，含气体脂质体含有一氧化氮气体。在一些实施方案中，这种含氧化氮的脂质体用于治疗可由一氧化氮气体治疗的医学病症（例如，内膜增生）。

13. 发明授权

US5883343A Downpeak group optimization 失效
标题翻译： Downpeak组优化
公开(公告)号：US5883343A
公开(公告)日：1999-03-16
申请号：US758827
申请日：1996-12-04
申请人： Robert C. MacDonald , Christian Semoroz
发明人： Robert C. MacDonald , Christian Semoroz
IPC分类号： B66B3/00 , B66B1/18 , B66B1/20 , G05B13/02
CPC分类号： B66B1/20
摘要： A system and method for optimally allocating elevator cars of an elevator group to serve downpeak traffic. The system monitors a "snap shot" of pending down hall calls and forms groups based upon an initialized floor separation value or response range. If the number of groups formed is greater than the number of available elevator cars in the elevator group, the system increments the floor separation value by "+1" and regroups the "snap-shot" of pending down hall calls. This procedure may be repeated until the number of formed groups is equal to or less than the number of allocable elevator cars. The system may then allocate each formed group to a respective available elevator car to serve the downpeak traffic.
摘要翻译：一种用于最佳地分配电梯组的电梯轿厢以提供低速交通的系统和方法。该系统基于初始化的楼层间隔值或响应范围来监视未完成的门厅呼叫和窗体组的“快照”。如果形成的组数大于电梯组中可用的电梯轿厢的数量，则系统将楼层间隔值增加“+1”，并重新组合未决的门厅呼叫的“快照”。可以重复该过程，直到所形成的组的数量等于或小于可分配的电梯轿厢的数量。然后，系统可以将每个形成的组分配给相应的可用的电梯轿厢，以服务于低速行驶。

14. 发明授权

US5855910A Cationic phospholipids for transfection 失效
标题翻译：用于转染的阳离子磷脂
公开(公告)号：US5855910A
公开(公告)日：1999-01-05
申请号：US470928
申请日：1995-06-06
申请人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
发明人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
IPC分类号： C12P9/00 , A61K9/127 , C07F9/09 , C07F9/10 , C07F9/113 , C07F9/653 , C12N15/88
CPC分类号： C12N15/88 , A61K9/1272 , B82Y5/00 , C07F9/10 , C07F9/113 , C07F9/65324
摘要： A novel class of cationic phospholipids and novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids. It has been unexpectedly found that liposomes comprising one or more of these cationic phospholipids are effective in the lipofection of nucleic acids. These novel phospholipids are particularly attractive because of they are not only effective in lipofection, but are extremely cheap and easy to make.
摘要翻译：公开了一类新型的阳离子磷脂及其合成方法。磷脂类包括磷酸甘油酯和鞘脂的磷酸三酯衍生物。意外地发现包含这些阳离子磷脂中的一种或多种的脂质体在核酸的脂质体转染中是有效的。这些新型磷脂是特别有吸引力的，因为它们不仅在脂质体转染中有效，而且非常便宜且易于制备。

15. 发明授权

US5695780A Cationic phospholipids for transfection 失效
标题翻译：用于转染的阳离子磷脂
公开(公告)号：US5695780A
公开(公告)日：1997-12-09
申请号：US468379
申请日：1995-06-06
申请人： Gary W. Ashley , Robert C. MacDonald
发明人： Gary W. Ashley , Robert C. MacDonald
IPC分类号： C12P9/00 , A61K9/127 , C07F9/09 , C07F9/10 , C07F9/113 , C07F9/653 , C12N15/88 , A61K31/66 , A61K31/675
CPC分类号： C12N15/88 , A61K9/1272 , B82Y5/00 , C07F9/10 , C07F9/113 , C07F9/65324
摘要： A novel class of cationic phospholipids and a novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids. It has been unexpectedly found that liposomes comprising one or more of these cationic phospholipids are effective in the lipofection of nucleic lacids. These novel phospholipids are particularly attractive because they are extremely cheap and easy to make.
摘要翻译：公开了一类新型的阳离子磷脂及其合成方法。磷脂类包括磷酸甘油酯和鞘脂的磷酸三酯衍生物。意外地发现包含这些阳离子磷脂中的一种或多种的脂质体在核酸的脂质转染中是有效的。这些新型磷脂是特别有吸引力的，因为它们是非常便宜和容易制造的。

16. 发明授权

US4875554A Dynamic selection of elevator call assignment scan direction 失效
标题翻译：电梯呼叫分配扫描方向的动态选择
公开(公告)号：US4875554A
公开(公告)日：1989-10-24
申请号：US238941
申请日：1988-08-31
申请人： Robert C. MacDonald , Elsa Abrego
发明人： Robert C. MacDonald , Elsa Abrego
IPC分类号： B66B1/20 , B66B1/24
CPC分类号： B66B1/2458 , B66B2201/102 , B66B2201/211 , B66B2201/226
摘要： A method of assigning hall calls to a plurality of elevator cars (0, 1, N) which biases the assignment process to balance the number of cars serving up and down service directions. Prior to each call assignment update the method determines the number of cars serving each service direction (78, 80, 82). A predetermined relationship (88) between there two numbers is used to determine if up hall calls should be assigned first, or down hall calls (90, 92, 94, 96). The balancing of cars serving the two service directions lowers the average waiting time, and it results in dispersing the cars throughout a building when service subsides, to enable prompt service for newly entered calls without the necessity of moving the cars during periods of low service to be in position for new calls.

17. 发明授权

US4790412A Anti-bunching method for dispatching elevator cars 失效
标题翻译：用于调度电梯轿厢的防ching方法
公开(公告)号：US4790412A
公开(公告)日：1988-12-13
申请号：US169210
申请日：1988-03-16
申请人： Robert C. MacDonald , Elsa Abrego
发明人： Robert C. MacDonald , Elsa Abrego
IPC分类号： B66B1/18
CPC分类号： B66B1/2458 , B66B2201/102 , B66B2201/226
摘要： A method of assigning hall calls to a plurality of elevator cars in an ETA strategy in which up hall calls are scanned upwardly and down calls downwardly. A hall call floor at which the scan has stopped for the purpose of assigning or reassigning a hall call at the floor is called a "scan floor". The floor of the advanced position of the car being considered for assignment is called the "AVP floor". In order to favor the clustering of closely adjacent stops in a given car, and thus minimize car bunching, when a car has an intervening stop between the AVP floor and the scan floor, either the travel distance between the AVP floor and the scan floor, or the travel distance from an intervening stop to the scan floor, is used to develop a dynamic bias for the ETA of the associated car. The dynamic or variable bias is inversely proportional to the travel distance, i.e., the number of floors, between the relevant floors.
摘要翻译：在ETA策略中向多个电梯轿厢分配门厅呼叫的方法，向上和向下扫描向上和向下向上和向下向上扫描向上电梯呼叫。扫描已停止的门厅呼叫楼层是为了在楼层分配或重新分配门厅呼叫而被称为“扫描楼层”。正在考虑分配的汽车的先进位置的地板称为“AVP楼层”。为了有利于在给定轿厢中紧密相邻的停靠点的聚集，并且因此使汽车聚束最小化，当汽车在AVP楼层和扫描楼层之间有中间停止时，AVP楼层与扫描楼层之间的行进距离，或从中间站到扫描楼的行驶距离用于为相关联的汽车的ETA开发动态偏差。动态或可变偏压与相关楼层之间的行进距离，即楼层数成反比。

18. 发明授权

US4532089A Method of preparing giant size liposomes 失效
标题翻译：制备巨型脂质体的方法
公开(公告)号：US4532089A
公开(公告)日：1985-07-30
申请号：US570950
申请日：1984-01-14
申请人： Robert C. MacDonald
发明人： Robert C. MacDonald
IPC分类号： A61K9/127 , B01J13/02 , A61K9/52
CPC分类号： A61K9/1277 , Y10S436/829 , Y10T428/2984
摘要： Large size liposomes are produced from small unilamellar vesicles by incorporating a polar compound in an aqueous dispersion of the vesicles, subjecting the dispersion to repeated freeze-thaw cycles, and thereafter dialyzing the vesicles against a hypoosmotic medium. The freeze-thaw cycles aggregate the vesicles and increase their internal concentration of polar compound. During dialysis the vesicles imbibe water, rupture, and form enlarged liposomes.
摘要翻译：通过在小泡的水性分散体中加入极性化合物，使分散体经受反复冻融循环，然后将透泡液与渗透不良的培养基进行透析，从小单层囊泡中制备大尺寸脂质体。冻融循环聚集囊泡并增加其极性化合物的内部浓度。在透析期间，囊泡吸收水分，破裂并形成脂质体扩大。

19. 发明申请

US20090048198A1 COMPOSITIONS AND METHODS FOR NUCLEIC ACID DELIVERY SYSTEMS 审中-公开
标题翻译：核酸递送系统的组成和方法
公开(公告)号：US20090048198A1
公开(公告)日：2009-02-19
申请号：US12040977
申请日：2008-03-03
申请人： Rumiana Koynova-Tenchova , Li Wang , Robert C. MacDonald
发明人： Rumiana Koynova-Tenchova , Li Wang , Robert C. MacDonald
IPC分类号： A61K31/7088 , C12N15/64 , A61K47/12 , A61P43/00 , C12N15/88
CPC分类号： A61K31/7088 , A61K9/1272 , A61K9/1274 , A61K48/0025 , C12N15/87 , C12N15/88
摘要： The present invention relates to compositions and methods for use in delivering nucleic acids and other agents into cells and tissues. In particular, the present invention provides lipid mixtures at the gel-liquid crystalline phase transition providing superior lipofection activity for transferring materials into cells and tissues.
摘要翻译：本发明涉及用于将核酸和其它试剂递送到细胞和组织中的组合物和方法。特别地，本发明提供了凝胶 - 液晶相转变时的脂质混合物，为将材料转移到细胞和组织中提供优异的脂转染活性。

20. 发明申请

US20080175893A1 GAS-CONTAINING LIPOSOMES 有权
标题翻译：含气体脂质体
公开(公告)号：US20080175893A1
公开(公告)日：2008-07-24
申请号：US11873256
申请日：2007-10-16
申请人： Shaoling Huang , Robert C. MacDonald , Patrick Kee , David McPherson
发明人： Shaoling Huang , Robert C. MacDonald , Patrick Kee , David McPherson
IPC分类号： A61K9/127 , A61P9/10
CPC分类号： A61K9/127 , A61K9/0009 , A61K9/1277 , A61K9/19 , Y10S977/907
摘要： The present invention provides gas-containing liposomes. In particular, the present invention provide methods of generating gas-containing liposomes where the gas is introduced under pressure, as well as gas-containing liposomes which contain a large volume of gas (e.g., 10 ul of gas per 5 mg of gas-containing liposomes). In certain embodiments, the gas-containing liposomes contain nitric oxide gas. In some embodiments, such nitric oxide containing liposomes are used to treat a medical condition that is treatable by nitric oxide gas (e.g., intimal hyperplasia).
摘要翻译：本发明提供含气体的脂质体。特别地，本发明提供产生气体在压力下引入气体的含气体脂质体的方法，以及含有大量气体的含气体脂质体（例如，每5mg含气体的气体为10μl气体脂质体）。在某些实施方案中，含气体脂质体含有一氧化氮气体。在一些实施方案中，这种含氧化氮的脂质体用于治疗可由一氧化氮气体治疗的医学病症（例如，内膜增生）。

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